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David M. Mannino, MD

111 Washington Avenue 40536


  • Faculty, Preventive Medicine and Environmental Health

College Unit(s)

Other Affiliation(s)
  • Internal Medicine - Pulmonary

Biography and Education


Fellowship: West Virginia University
Residency: Lankenau Hospital, Philadelphia
Medical School: Jefferson Medical College


My research focuses on the epidemiology of lung diseases, predominantly asthma and COPD. I’m interested in risk factors for the development and progression of disease, with a special interest among people who have never smoked, as this comprises an ignored population in most clinical research.

A recent area of interest involves comorbid disease in COPD along with biomarkers of disease, in particular, fibrinogen (a marker of systemic inflammation).

I’m also interested in the overlap between asthma and COPD, as these patients have been, typically, ignored by both the asthma and COPD clinical researchers, yet they have more symptoms and worse outcomes than patients who simply report one or the other of these diseases.

As a professor in the College of Public Health, I also assist students in their research, which covers a large array of different topics. Some recent work has involved looking at data from the Women’s Health Registry. This has resulted in several publications, such as one looking at the relation between smoking and chronic pain and another looking at the relation between adverse pregnancy events and cardiovascular disease.

Selected Publications

Mitchell MD, Mannino DM, Steinke DT, Kryscio RJ, Bush HM, Crofford LJ. Association of smoking and chronic pain syndromes in Kentucky women. J Pain. 2011;12(8):892-9.

Ford ES, Mannino DM, Zhao G, Li C, Croft JB. Changes in Mortality among United States Adults with Chronic Obstructive Pulmonary Disease in Two National Cohorts Recruited during 1971 through 1975 and 1988 through 1994. Chest. 2011 Jun 23. [Epub ahead of print]

Mannino DM, Diaz-Guzman E. Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality. Chest. 2011 Jun 9. [Epub ahead of print]

Lamprecht B, Schirnhofer L, Kaiser B, Buist SA, Mannino DM, Studnicka M. Subjects with Discordant Airways Obstruction: Lost between Spirometric Definitions of COPD. Pulm Med. 2011;2011:780215.

Mintz ML, Yawn BP, Mannino DM, Donohue JF, Hanania NA, Grellet CA, Gilsenan AW, McLeod LD, Dalal AA, Raphiou IH, Prillaman BA, Crater GD, Cicale MJ, Mapel DW. Prevalence of airway obstruction assessed by lung function questionnaire. Mayo Clin Proc. 2011;86(5):375-81.

Garcia-Aymerich J, Serra Pons I, Mannino DM, Maas AK, Miller DP, Davis KJ. Lung function impairment, COPD hospitalizations and subsequent mortality. Thorax. 2011;66(7):585-90.

Law HZ, Oraka E, Mannino DM. The role of income in reducing racial and ethnic disparities in emergency room and urgent care center visits for asthma-United States, 2001-2009. J Asthma. 2011;48(4):405-13.

Mannino DM. The natural history of chronic obstructive pulmonary disease. Pneumonol Alergol Pol. 2011;79(2):139-43.