Hematology and Oncology Research

Divisional Clinical Research Office

We are committed to clinical research and scholarship that transforms the landscape of pediatric hematology and oncology. About our research:

• 30 open therapeutic studies
  • Children’s Oncology Group (COG), Beat Childhood Cancer, Sunshine Kids
• 12 non-therapeutic open clinical studies
• 5 investigator-initiated studies
• We are in the top 20% of all COG institutions for enrollments on therapeutic clinical trials

• Characterization of TP53 mutations
• Variants of uncertain significance in cancer genes
• Pharmacogenomic variants - medication toxicity
• Germline and neuro-oncology molecular tumor boards
• Calcitonin gene-related peptide in NF1
• Biobank repository at the Markey Cancer Center
• ATM heterozygosity - therapeutic toxicity
• Incidence of ped CNS tumors in KY
• Exercise intervention in PHO clinic
• Psychosocial aspects of inherited cancer

• Financial toxicity of pediatric cancer
• Clinical trial enrollments - COG, others
• Zebrafish avatars - DIPG
• Hemophilia projects
• Collaboration with Norton Children's Hospital
• Circulating tumor DNA - leukemia
• PAR4 tumor suppressor - Wilm's tumor
• Project Inherited Cancer Risk