About Jo Laboratory

The Jo laboratory is committed to promoting women’s health through conducting basic laboratory research on ovarian function. 

The primary research focus in my laboratory has been to elucidate the cellular and molecular mechanisms involved in the periovulatory process of the expansion of cumulus-oocyte complex (COC), ovulation (releasing an egg), and subsequent corpus luteum formation in the ovary. These processes are essential for female fertility. The failure or compromise of these processes results in pathological conditions in women, such as polycystic ovarian syndrome, luteinized unruptured follicle syndrome, and corpus luteum insufficiency. Thus, understanding the mechanisms underlying these processes is crucial for improving female fertility. On the other hand, physiological manipulation of the ovulatory process is a promising target for developing selective and effective contraceptives. 

The overarching goal of our research is to develop novel clinical approaches to improve female fertility or manage infertility-associated disorders.

Ovulation and Corpus Luteum Formation

ovulation and corpus luteum formation, depicting ovulating cumulus oocyte complex, preovulatory follicle, ruptured follicle, and forming corpus luteum

Why do we care?

(Defects of ovulation and corpus luteum formation)

1. Polycystic ovarian syndrome 2. Anovulatory cystic follicle 3. Luteinized, unruptured follicle