STRAW V: Understanding Stroke: Novel Insights into Prognostics and Treatments

STRAW V: Understanding Stroke: Novel Insights into Prognostics and Treatments will focus on a translational approach to stroke and related cerebrovascular diseases. Topics will include new insights into novel approaches to pharmacotherapies for cerebrovascular diseases, as presented and discussed by clinical and basic scientists. 

This meeting regularly attracts researchers and clinicians interested in stroke across the Commonwealth and throughout the USA. 

As per tradition, there will be no registration fee. The event will also feature an optional excursion around Lexington, Ky., the ‘land of horses and bourbon’, facilitating opportunities for networking with like-minded research scientists.

Embassy Suites


Wednesday, April 24, 2024
8:00 A.M. ET

Thursday, April 25, 2024
1:00 P.M. ET

Embassy Suites by Hilton Lexington Green
245 Lexington Green Circle
Lexington, KY 40503

STRAW Registration

Hotel Registration

Excursion Registration

Gary K Steinberg, MD, PhD, Stanford University

Dr. Steinberg is the Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and the Neurosciences at Stanford University. He founded the Stanford Stroke Center in 1991 and is currently the co-director, as well as founder and director of the Stanford Moyamoya Center. He served as chair of the department of neurosurgery at Stanford from 1995-2020, during which time he expanded the department from a faculty of 5 to more than 60 neurosurgeons and scientists.

Dr. Steinberg maintains a busy clinical practice specializing in cerebrovascular surgery. His clinical research is focused on developing innovative surgical, endovascular, and radiosurgical approaches for treating patients with difficult intracranial aneurysms, complex vascular malformations and occlusive cerebrovascular disorders. He has also spearheaded several early-phase clinical trials of stem cell transplantation for chronic stroke and subacute spinal cord injury. Dr. Steinberg's lab investigates pathomechanisms of cerebral ischemia, develops neuroprotective agents, and employs novel approaches such as stem cell transplantation and optogenetic stimulation to enhance post-stroke recovery. He has published over 450 peer -reviewed articles, more than 135 book chapters, and edited five books primarily related to clinical and basic aspects of cerebrovascular disease. He has served as principal Investigator on several grants from the AHA and California Institute for Regenerative Medicine, and has held continuous NIH funding since 1987, including R01, R21 and P01 Grants.

The many honors Dr. Steinberg has received include the CNS Charles Drake Lecturer; Stanford University Lifetime Achievement Award in Medicine; AHA/ASA Stroke Progress and Innovation Award; Society of Neurological Surgeons Winn Prize; Smithsonian American Ingenuity Award; AANS/CNS Dacey Medal for Outstanding Cerebrovascular Research; CANS Cone Pevehouse Distinguished Service Award and Western Neurosurgical Society Cloward Award for epochal innovations and/or pioneering applications. Dr. Steinberg has been a visiting professor at numerous academic institutions internationally, giving more than 700 invited talks at scientific meetings throughout the world. He has been a member of NIH NINDS Study Sections, the NIH NASCET Monitoring Committee, and served on the editorial boards of the Journal of Cerebral Blood Flow and Metabolism, Neurosurgery, Cerebrovascular Diseases, the Journal of Stroke and Cerebrovascular Diseases, Indian Journal of Neurosurgery and World Neurosurgery.

Kazuhide Hayakawa, PhD, Massachusetts General Hospital, Harvard Medical School

Kazuhide Hayakawa, PhD,  is an assistant investigator in radiology at Massachusetts General Hospital and an assistant professor of radiology at Harvard Medical School and his goal is to develop new therapies to promote brain remodeling for patients with stroke and neurodegenerative disease. In particular, his lab focuses on signaling between multiple cell types in the neurovascular unit. He investigates new mechanisms in the neurovascular unit, whereby cells are surprisingly capable of releasing and transferring mitochondria into another cell. He hopes that the therapeutic use of extracellular mitochondria will lead to new approaches for devastating CNS injury after stroke, trauma, and neurodegeneration. 

Selva Baltan, MD, PhD, Oregon Health and Sciences University

Dr. Baltan is currently an endowed professor and vice chair for research of anesthesiology and peri-operative medicine (APOM) at Oregon Health & Science University (OHSU). Dr. Baltan grew up in Ankara, Turkey, earning her MD from Hacettepe University in Turkey, and her PhD in neurophysiology from McGill University in Montreal, Canada. After completing an American Heart and Stroke fellowship at Washington University Department of Neurology in St. Louis, Mo., she joined the neurology department at the University of Washington in Seattle, Wa., and continued her academic career as assistant and associate professor. In 2011 Dr. Baltan joined the Neurosciences and Neurological Institute at the Cleveland Clinic and remained there until she joined OHSU in 2019 as a professor and vice chair of basic research.

Her research focuses on mechanisms of white matter injury to develop ideal stroke therapeutics that are directed towards neuronal and axonal protection across age, to restore function when applied after injury. Experimental approaches in her lab include optic nerve and corpus callosum slice models, employing electrophysiological recordings, and advanced microscopy techniques such as confocal, two-photon microscopy, and 3D electron microscopy. The current focus of her lab is on elucidating the mechanisms of preconditioning conferred by Class I HDAC inhibition in young and aging white matter and the gene regulatory mechanisms underlying this protective phenomenon. Studying the role of protein acetylation and mitochondrial dynamics in white matter stroke expands her findings to neurodegenerative diseases such as Multiple Sclerosis and Alzheimer’s disease that involve white matter. Her research is funded by multiple NIH grants.

Dr. Baltan serves on the editorial boards of several journals including Conditional Medicine, Translational Stroke Research, and Stroke, and has become a Handling Editor for ASN Neuro in 2021. Dr. Baltan has been a member of the National Institutes of Health Brain Injury and Neurovascular Pathologies (BINP) Study Section since 2012 and has become the chair of BINP Study Section in 2020. She also serves as a member of the American Heart Association (AHA) Brain and Stroke Study Section. She has been the chair of Membership Committee for ASN since 2013 and acted as a Council member of ASN in 2019.

Jason M. Davies, MD, PhD, University of Buffalo

Dr. Jason Davies is an assistant professor of neurosurgery and biomedical informatics at the State University of New York (SUNY) at Buffalo. He specializes in cerebrovascular and skull base neurosurgery. He has extensive experience treating aneurysms, arteriovenous malformations, cavernous malformations, arteriovenous fistulae, stroke, carotid stenosis, cerebral bypass, and other vascular diseases, using both open and endovascular approaches. He also has experience in the management of intracranial tumors and skull base and pituitary disease using the latest technological advances in endoscopy and minimally invasive methods.

He has a significant research background, starting with molecular and cell biology research. His active research interests focus on using bioinformatics tools to advance personalized medicine. He is working to develop bioinformatics tools to improve the quantity and quality of data available for medical research and to lower barriers to entry for all clinicians to contribute to medical knowledge. Furthermore, he is working to bring to bear more advanced machine learning and data analytic methods to better understand the insights contained within these rich data resources.

He has co-founded and grown several early-stage medical-related companies, including in the medical device and medical informatics realms. He has experience developing intellectual property, conducting early-phase clinical device trials, and raising capital. He relishes working in technology-driven fields like endovascular neurosurgery and creating new solutions to address problems that impact human health.

Jeremy J. Heit, MD, PhD, Stanford University

Dr. Jeremy Heit is the chief of neuroimaging and neurointervention and an associate professor of radiology and neurosurgery at Stanford University. He is a practicing diagnostic and interventional neuroradiologist who specializes in the diagnosis and minimally invasive treatment of ischemic and hemorrhagic stroke. Dr. Heit’s research seeks to understand the genetic, developmental, and pathophysiologic basis of cerebrovascular disease. He has authored over 200 publications and is an investigator on multiple NIH grants, including the CRISP 2 and DEFUSE 3 studies. He is the co-PI of the NIH-funded PRECISE basilar artery thrombectomy study.

Day 1 Wednesday, April 24, 2024


8:00-8:20 Registration, Continental Breakfast

8:20-8:30 Welcome Remarks (University of Kentucky: Keith Pennypacker, Director, CATSS)

8:30-9:30 Stem cell therapy for stroke: from preclinical research to clinical trials (Gary Steinberg, Stanford University)

9:30-10:30 Mitochondria transfer as a novel therapy in stroke (Kazuhide Hayakawa, Massachusetts General Hospital)

10:30-10:45 Coffee Break

10:45-11:45 miRNA regulation of white matter stroke (Selva Baltan, Oregon Health and Sciences University)

11:45-12:45 Advanced Imaging Before Basilar Artery Thrombectomy (Jeremy Heit, Stanford University)

12:45-1:15 Networking Lunch (University of Kentucky: Keith Pennypacker, Justin Fraser, Ann Stowe, Jill Roberts, Amanda Trout, Chirayukumar Pandya, Jordan Harp)

1:30 Board Buses for Taste of the Bluegrass Excursion

2:30-4:00 Keeneland: Thoroughbred Horse Racing

4:15-9:00 Tour & Dinner: Jeptha Creed Distillery

Day 2 Thursday, April 25, 2024


8:00-9:00 Continental Breakfast and Announcements

9:00-10:00 Machine learning to predict stroke and aneurysm outcomes (Jason Davies, University of Buffalo)

10:00-11:00 CATSS Alliance (Ann Stowe, University of Kentucky)

Jill Roberts
Amanda Trout

11:00-11:15 Coffee Break 

11:15-12:15 CATSS Alliance (Cont.)

Andrew Clarkson
Jordan Harp

12:15-1:15 Lunch

1:15 Workshop Concludes