Recent Publications
2018
N. Kerur; S. Fukuda; D. Banerjee; Y. Kim; D. Fu; I. Apicella; A. Varshney; R. Yasuma; B.J. Fowler; E. Baghdasaryan; K.M. Marion; X. Huang; T. Yasuma; Y. Hirano; V. Serbulea; M. Ambati; V.L. Ambati; Y. Kajiwara; K. Ambati; S. Hirahara; A. Bastos-Carvalho; Y. Ogura; H. Terasaki; T. Oshika; K.B. Kim; D.R. Hinton; N. Leitinger; J.C. Cambier; J.D. Buxbaum; M.C. Kenney; S.M. Jazwinski; H. Nagai; I. Hara; A.P. West; K.A. Fitzgerald; S.R. Sadda; B.D. Gelfand; J. Ambati. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature medicine 2018 Jan
2016
B.D. Gelfand; J. Ambati. A Revised Hemodynamic Theory of Age-Related Macular Degeneration. Trends in molecular medicine 2016 Aug.
S. Bogdanovich; Y. Kim; T. Mizutani; R. Yasuma; L. Tudisco; V. Cicatiello; A. Bastos-Carvalho; N. Kerur; Y. Hirano; J.Z. Baffi; V. Tarallo; S. Li; T. Yasuma; P. Arpitha; B.J. Fowler; C.B. Wright; I. Apicella; A. Greco; A. Brunetti; M. Ruvo; A. Sandomenico; M. Nozaki; R. Ijima; H. Kaneko; Y. Ogura; H. Terasaki; B.K. Ambati; J.H. Leusen; W.Y. Langdon; M.R. Clark; K.L. Armour; P. Bruhns; J.S. Verbeek; B.D. Gelfand; S. De Falco; J. Ambati. Human IgG1 antibodies suppress angiogenesis in a target-independent manner. Signal transduction and targeted therapy 2016
R. Yasuma; V. Cicatiello; T. Mizutani; L. Tudisco; Y. Kim; V. Tarallo; S. Bogdanovich; Y. Hirano; N. Kerur; S. Li; T. Yasuma; B.J. Fowler; C.B. Wright; I. Apicella; A. Greco; A. Brunetti; B.K. Ambati; S.B. Helmers; I.E. Lundberg; O. Viklicky; J.H. Leusen; J.S. Verbeek; B.D. Gelfand; A. Bastos-Carvalho; S. De Falco; J. Ambati. Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal transduction and targeted therapy 2016
2015
T. Mizutani; B.J. Fowler; Y. Kim; R. Yasuma; L.A. Krueger; B.D. Gelfand; J. Ambati. Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. Investigative ophthalmology & visual science 2015 Nov
B.D. Gelfand; C.B. Wright; Y. Kim; T. Yasuma; R. Yasuma; S. Li; B.J. Fowler; A. Bastos-Carvalho; N. Kerur; A. Uittenbogaard; Y.S. Han; D. Lou; M.E. Kleinman; W.H. McDonald; G. Núñez; P. Georgel; J.L. Dunaief; J. Ambati. Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. Cell reports 2015 Jun 23
2014
B.J. Fowler; B.D. Gelfand; Y. Kim; N. Kerur; V. Tarallo; Y. Hirano; S. Amarnath; D.H. Fowler; M. Radwan; M.T. Young; K. Pittman; P. Kubes; H.K. Agarwal; K. Parang; D.R. Hinton; A. Bastos-Carvalho; S. Li; T. Yasuma; T. Mizutani; R. Yasuma; C. Wright; J. Ambati. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science (New York, N.Y.) 2014 Nov 21
Y. Kim; V. Tarallo; N. Kerur; T. Yasuma; B.D. Gelfand; A. Bastos-Carvalho; Y. Hirano; R. Yasuma; T. Mizutani; B.J. Fowler; S. Li; H. Kaneko; S. Bogdanovich; B.K. Ambati; D.R. Hinton; W.W. Hauswirth; R. Hakem; C. Wright; J. Ambati. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 11
Y. Hirano; T. Yasuma; T. Mizutani; B.J. Fowler; V. Tarallo; R. Yasuma; Y. Kim; A. Bastos-Carvalho; N. Kerur; B.D. Gelfand; S. Bogdanovich; S. He; X. Zhang; M. Nozaki; R. Ijima; H. Kaneko; Y. Ogura; H. Terasaki; H. Nagai; I. Haro; G. Núñez; B.K. Ambati; D.R. Hinton; J. Ambati. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nature medicine 2014 Dec