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Abdominal aortic aneurysm (AAA) formation involves a complex process of aortic medial destruction through degradation of extracellular matrix proteins, elastin, and collagen. AAA exhibits sexual dimorphism because male sex is a major risk factor of AAA in both mice and humans.1 In mice, testosterone has been implicated as a major contributor to sexual dimorphism of angiotensin II (AngII)–induced AAAs.2 However, the mechanism by which testosterone drives sexual dimorphism of AAA is unknown.

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A position is available in the Department of Physiology. The position is to assist with tissue culture, electrophysiology, molecular biology and biochemistry techniques. S/he will be responsible for performing many of the proposed experiments. The applicant will need to isolate different types of mouse cardiomyocytes (nodal, atrial, ventricular) to perform single cell electrophysiology. The electrophysiology experiments include acquisition and analysis of voltage and current clamp data.

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LEXINGTON, Ky. (Sept. 17, 2020) — A new University of Kentucky College of Medicine study may provide answers for why so many COVID-19 patients experience thrombosis, or the formation of blood clots that obstruct blood flow through the circulatory system.

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Saha Cardiovascular Research Center at the University of Kentucky College of Medicine is recognizing five employees who provide outstanding patient-centered care and live the direct values of UK HealthCare to foster diversity, innovation, respect, compassion and teamwork.

Each nominee has a unique set of skills and values that they exhibit daily, as well as a high commitment to patients and quality of care. They were chosen based on stories collected from patients, as well as feedback from their peers.

The 2020 winners are:

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LEXINGTON, Ky. (Sept. 1, 2020) — Alan Daugherty, senior associate dean for research at the University of Kentucky College of Medicine, has been selected to serve as chair of Scientific Committee of the Sarnoff Cardiovascular Research Foundation, an organization that trains medical students to be leaders in cardiovascular science and medicine.

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LEXINGTON, Ky. (Sept. 2, 2020) — A new University of Kentucky College of Medicine study provides insight into how a protein called angiotensinogen (AGT) contributes to blood pressure regulation and atherosclerosis.

AGT is a member of the renin-angiotensin system, a hormone system in the human body that regulates blood pressure and fluid balance. AGT produces angiotensin II, which regulates blood pressure and contributes to atherosclerosis, or the buildup of plaque in the arteries.

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LEXINGTON, Ky. (July 27, 2020) — The Kentucky Network for Innovation and Commercialization (KYNETIC), funded by the National Institutes of Health (NIH), is excited to announce that five of the seven projects recently awarded $50,000 to bring their innovations toward product development are from the University of Kentucky.

These projects include:

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The NIH Center of Biomedical Research Excellence (COBRE) on Obesity and Cardiovascular Diseases, in collaboration with the Center for Clinical and Translational Sciences (CCTS) announce the availability of limited funds to support pilot projects focused on research examining obesity-associated diseases.

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Recent Insights Into the Regulation of Coagulation and Thrombosis
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Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases. Kim S1, Subramanian V1,2, Abdel-Latif A1,3, Lee S1,4. Author information 1 Saha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, Kentucky. 2 Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky. 3 Department of Medicine-Cardiology, and University of Kentucky College of Medicine, Lexington, Kentucky. 4 Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lex

The University of Kentucky Saha Cardiovascular Research Center is pleased to announce that applications are being accepted for the Saha Awards.  These awards are given to encourage and support staff and students with an interest in and dedication to cardiovascular medicine.  Each award includes an unrestricted $1000 prize, a certificate and recognition at the University of Kentucky, Saha Cardiovascular Research Center Cardiovascular Research Day held on September 25, 2020 at the Gatton Student Center.

 Award Categories

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A position is available in the Department of Physiology. The position is to assist with tissue culture, electrophysiology, molecular biology and biochemistry techniques. S/he will be responsible for performing many of the proposed experiments. The applicant will need to isolate different types of mouse cardiomyocytes (nodal, atrial, ventricular) to perform single cell electrophysiology. The electrophysiology experiments include acquisition and analysis of voltage and current clamp data.

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https://www.wkyt.com/content/news/UK-surgeon-offers-new-option-for-people-with-carotid-artery-disease-566659871.html?jwsource=cl

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Heart disease is the leading cause of death in the United States and, according to the Centers for Disease Control and Prevention (CDC), Kentucky consistently ranks in the top 10 states for heart disease deaths. The CDC reports more than 10,000 Kentuckians died of heart disease in 2017. A new biomarker, uncovered by researchers in the University of Kentucky College of Pharmacy, could change cardiovascular care for patients with high risk of disease.
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The University of Kentucky Gill Heart and Vascular Institute is now accepting nominations for the 2020 Gill Awards. This year’s awards include the Early Career Award and the Outstanding Contributions to Cardiovascular Research. Nominations including self-nominations will be accepted until January 3, 2020. Award eligibility details along with the nomination form can be accessed by clicking here.

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Identification of Human Very Small Embryonic like Stem Cells (VSELS) in Human Heart Tissue Among Young and Old Individuals.
El-Helw M1, Chelvarajan L1, Abo-Aly M1
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University of Kentucky Professor of Pharmacology and Nutritional Sciences Nancy Webb, Ph.D., has been honored by the American Heart Association with the Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) Distinguished Achievement Award.

The ATVB Council engages scientists and clinicians working to improve the prevention, diagnosis and treatment of heart disease. This annual accolade recognizes a member who has made major contributions to the council and substantial professional contributions to the field.