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OBJECTIVE:

The upregulated expression of heparin binding EGF-like growth factor (HB-EGF) in the vessel and circulation is associated with risk of cardiovascular disease. In this study, we tested the effects of HB-EGF targeting using HB-EGF-specific antisense oligonucleotide (ASO) on the development of aortic aneurysm in a mouse aneurysm model.

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The Saha Cardiovascular Research Center recently announced the winners of the 2017 Saha Awards. These annual awards are given to Medical and Nursing students as well as to a nurse educator. The awards are designed to reward creativity, dedication and knowledge in areas of cardiovascular research, disease prevention and patient education. The 2017 recipients are:

MD/PhD Student Award – Zheying “Jeff” Chen

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Abstract
PURPOSE:

Group X (GX) and group V (GV) secretory phospholipase A2 (sPLA2) potently release arachidonic acid (AA) from the plasma membrane of intact cells. We previously demonstrated that GX sPLA2 negatively regulates glucose-stimulated insulin secretion (GSIS) by a prostaglandin E2 (PGE2)-dependent mechanism.

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The Saha Cardiovascular Research Center is now accepting applications for the 2017 Saha Awards.

The application process will close on Friday, September 15, 2017.

 

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Dysfunction of the renin-angiotensin-aldosterone system (RAAS) has been implicated in the etiologies of many cardiovascular diseases, including aortic aneurysm. In particular, the infusion of angiotensin II (Ang II) in the apolipoprotein E-deficient mice (apoE-/-) and low density lipoprotein receptor knockout mice (LDLR-/-) to induce aortic aneurysm has been extensively used in the field. In contrast, whether aldosterone (Aldo), an essential component of RAAS and a downstream effector of Ang II, is involved in aortic aneurysm is largely unknown.

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Click here to be directed to the 2017 SELRC

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Tori Stromp, PhD, a recent graduate of the Department of Physiology and a member of the Saha Cardiovascular Research Center, recently received the prestigious Summa Cum Laude Award at the International Society of Magnetic Resonance in Medicine Conference.  The award is presented to less than 1% of the abstracts submitted to the conference and is rarely awarded to graduate students.  Tori will present her work at the annual conference April 22-27, 2017 in Honolulu, HI.

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Click here to be directed to the 2017 Cardiovascular Research Day homepage

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Healthy Hearts @ Discovery Night -- Thursday, February 2nd 6-8pm

Celebrate HEART month this February at the Living Arts & Science Center with special guest doctors and scientists from the University of Kentucky!

Explore heart science and health in a fun, hands-on fashion: 

Enjoy heart healthy snacks!

Check out REAL human hearts!

Learn CPR!

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Alan Daugherty, senior associate dean for research at the University of Kentucky College of Medicine, was recently approved to renew his contract as editor-in-chief of Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association (ATVB) for a second five-year term. ATVB is one of the five core journals of the American Heart Association. As editor of ATVB, Daugherty’s primary focus is on publishing the most important new research studies related to a spectrum of vascular diseases.
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Yasir Al-Siraj, a Ph.D. candidate in the University of Kentucky College of Medicine Department of Pharmacology and Nutritional Sciences, is the lead author of a paper published in Circulation, a leading journal on cardiovascular medicine. 

The article, “Female Mice with an XY Sex Chromosome Complement Develop Severe Angiotensin II-Induced Abdominal Aortic Aneurysms,” was co-authored by UK colleagues Sean E. Thatcher, Richard Charnigo, Kuey Chen, Eric Blalock, Alan Daugherty and Lisa Cassis.

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Clinicians and basic scientists convened to discuss challenges, triumphs and future directions in cardiovascular disease research during the 19th Annual Gill Heart Institute Cardiovascular Research Day on Nov. 4. Hosted by the UK Gill Heart Institute, the annual research day showcased scientific advancement in understanding and treating the various diseases of the blood vessels and heart. Topics presented at the conference ranged from identifying genomic markers correlated with heart disease to urging members of the public to put CPR training to action during an emergency.
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Registration 19th Annual Gill Heart Institute
Cardiovascular Research Day Closes on October 21.

19th Annual Gill Heart Institute
Cardiovascular Research Day

November 4, 2016
Lexington Convention Center 

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The Saha Cardiovascular Research Center recently announced the winners of the 2016 Saha Awards.  These annual awards are given to Medical and Nursing students as well as to a nurse educator.  The awards are designed to reward creativity, dedication and knowledge in areas of cardiovascular research, disease prevention and patient

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The Board of Directors of South East Lipid Research Conference is excited to announce the 2016 South East Lipid Research Conference (SELRC). This year we have a new venue and a great program of lectures, training, and social events. The 2016 SELRC will be held November 3-5 in Lexington, Kentucky. This year’s conference will be hosted by the University of Kentucky and held in conjunction with the 19th Annual University of Kentucky Cardiovascular Research Day.

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THE TRANSLATIONAL GILL AWARD

CALL FOR NOMINATIONS

Recognizing a young investigator within five years of first faculty appointment for innovation and creativity that has impacted cardiovascular research and/or advancements in clinical care.

The Translational Gill Award recipient will receive a plaque and a cash prize of $10,000. The award will be presented at a ceremony during the Annual Cardiovascular Research Day at the University of Kentucky in the Fall of 2017.

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All heart attacks are serious, but one type – called STEMI — is particularly deadly. “A STEMI, or ST Segment Elevation Myocardial Infarction, means an artery to the heart is 100 percent blocked, which is associated with a much higher short-term risk of death or disability compared to other types of heart attack,” Dr.