Saha Cardiovascular Research Center Seminars and Journal Clubs Cardiovascular Journal Club Previous Cardiovascular Journal Club Meetings Cardiovascular Journal Club Archive of Previous Meetings Date Event Title Speaker 12/06/2023 The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase–Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development Julianne Sharpe 11/29/2023 Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species Cheavar Blair 11/22/2023 Thanksgiving Break 11/15/2023 Single-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT-Expressing Smooth Muscle Cells Sohei Ito 11/08/2023 Prolonged QT intervals in mice with cardiomyocyte-specific deficiency of the molecular clock Brian Delisle 11/01/2023 Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis Shu Liu 10/25/2023 Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1 Olivia Hage 10/18/2023 Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans Anna Mead 10/11/2023 A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis Gregory Graf 10/04/2023 Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis Zachary Kipp 09/27/2023 The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy Garrett Elmore 09/20/2023 Intracellular tPA–PAI-1 interaction determines VLDL assembly in hepatocytes Alex Pettey 09/13/2023 Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis Preetha Shridas 09/06/2023 Severe hypertriglyceridemia caused by Gpihbp1 deficiency facilitates vascular remodeling through increasing endothelial activation and oxidative stress Ryan Temel 08/30/2023 Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis Shayan Mohammadmoradi 08/30/2023 Blair Lab TBD 08/23/2023 Alsiraj Lab TBD 08/23/2023 Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes Congqing Wu 04/25/2023 Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity Cheavar Blair 04/18/2023 STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion Jian Cui, PhD 04/11/2023 Atherosclerosis Regression and Cholesterol Efflux in Hypertriglyceridemic Mice Lei Cai 04/04/2023 Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration Sohei Ito 03/28/2023 Ablation of CaMKIId oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease Nicholas McVay 03/21/2023 CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development Naofumi Amioka 03/14/2023 No Meeting, Spring Break 03/07/2023 Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function Mikala Zelows 02/28/2023 Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis Mina Lin 02/21/2023 MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity Gregory Graf 02/14/2023 A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity Raj Neupane 02/07/2023 Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms Shu Liu 01/31/2023 Slowing Heart Rate Protects Against Pathological Cardiac Hypertrophy Brian Delisle 01/24/2023 Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome Alex Pettey 01/17/2023 ILRUN Promotes Atherosclerosis Through LipidDependent and Lipid-Independent Factors Gregory Graf 11/29/2022 Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood 11/22/2022 Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice Bryana Levitan Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Next Last