Scott M. Gordon, PhD
Connect
(859) 323-8134scott.gordon@uky.edu
Positions
- Associate Professor
College Unit(s)
Other Affiliation(s)
- Physiology - Joint Faculty
- CVRC - Core Faculty
- Nutritional Sciences Graduate Faculty
Biography and Education
Education
- National Institutes of Health, NHLBI
- Postdoctoral fellowship
- University of Cincinnati College of Medicine
- Ph.D. - Pathobiology and Molecular Medicine
- State University of New York College at Brockport
- B.S. - Biological Sciences (Minor: Chemistry)
Research
The Gordon lab studies metabolism and atherosclerotic cardiovascular disease in two primary lines of investigation:
Mechanisms regulating dietary fat absorption by the intestine.
- Genes that control chylomicron secretion.
- The influence of fat absorption on body weight, metabolism, and atherosclerosis.
Inflammatory protease activity in the artery wall and suppression by lipoproteins.
- Natural mechanisms of inflammatory regulation involving lipoproteins.
- Development of lipoprotein-targeting protease inhibitors.
Research techniques:
- Mouse models for atherosclerosis and intestinal lipid absorption studies.
- Cell culture including genetically altered cell lines and transendothelial transport experiments.
- Genetic manipulation using CRISPR.
- Confocal microscopy including immunofluorescence.
- Electron microscopy.
- Molecular biology: PCR, quantitative real-time PCR, agarose gel electrophoresis, mouse genotyping.
- Next-generation sequencing: RNAseq gene-expression analysis.
- Protein expression techniques: SDS-PAGE, western blotting, immunohistochemistry.
- Mass spectrometry: Proteomics and structural cross-linking.
Selected Publications
See Dr. Gordon's profiles on: PubMed ResearchGate Google Scholar
Selected Publications:
Cell-free high-density lipoprotein-specific phospholipid efflux predicts incident cardiovascular disease (2023) Journal of Clinical Investigation. PMID: 37471145
Dennd5b-deficient mice are resistant to PCSK9-induced hypercholesterolemia and diet-induced hepatic steatosis (2022) Journal of Lipid Research. PMID: 36243100
The HDL Proteome Watch: Compilation of studies leads to new insights on HDL function (2021) Davidson WS, Shah AS, Sexmith H, Gordon SM. Biochim Biophys Acta Mol Cell Biol Lipids. PMID: 34800735
Effect of metformin on the high-density lipoprotein proteome in youth with type 1 diabetes (2021) Gourgari E, Nadeau KJ, Pyle L, Playford MP, Ma J, Mehta NN, Remaley AT, Gordon SM. Endocrinol Diabetes Metab. PMID: 34277985
Effect of niacin monotherapy on high density lipoprotein composition and function (2020) Gordon SM, Amar MJ, Jeiran K, Stagliano M, Staller E, Playford MP, Mehta NN, Vaisar T, Remaley AT. Lipids Health Dis. PMID: 32825822
Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults (2020) Yang ZH, Amar M, Sampson M, Courville AB, Sorokin AV, Gordon SM, Aponte AM, Stagliano M, Playford MP, Fu YP, Yang S, Mehta NN, Remaley AT. Nutrients. PMID: 32178279
Protease Activity in Vascular Disease (2019) Slack MA, Gordon SM. Arterioscler Thromb Vasc Biol. PMID: 31553665
ApoA-I-Mediated Lipoprotein Remodeling Monitored with a Fluorescent Phospholipid (2019) Neufeld EB, Sato M, Gordon SM, Durbhakula V, Francone N, Aponte A, Yilmaz G, Sviridov D, Sampson M, Tang J, Pryor M, Remaley AT. Biology. PMID: 31336888
Proteomic alterations of HDL in youth with type 1 diabetes and their associations with glycemic control: a case-control study (2019) Evgenia Gourgari, Junfeng Ma, Martin P. Playford, Nehal N. Mehta, Radoslav Goldman, Alan T. Remaley, and Scott M. Gordon. Cardiovascular Diabetology. PMID: 30922315
DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass (2019) Scott M. Gordon, Edward B. Neufeld, Zhihong Yang, Milton Pryor, Xiao Fan, Iftikhar J. Kullo, Leslie G. Biesecker, and Alan T. Remaley. Scientific Reports. PMID: 30837651
High Density Lipoprotein Proteome is Associated with Cardiovascular Risk Factors and Atherosclerosis Burden as Evaluated by Coronary CT Angiography (2018) Scott M. Gordon, Jonathan H. Chung, Martin P. Playford, Amit K. Dey, Denis Sviridov, Fayaz Seifuddin, Mehdi Pirooznia, Marcus Y. Chen, Nehal N. Mehta, Alan T. Remaley. Atherosclerosis. PMID: 30347343
Resolution of Lipoprotein Subclasses by Charge Detection Mass Spectrometry (2018) Corinne A Lutomski, Scott M Gordon, Alan T Remaley, Martin F Jarrold. Analytical Chemistry. PMID: 29756771
Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux (2018) Rafique M Islam, Mohsen Pourmousa, Denis Sviridov, Scott M Gordon, Edward B Neufeld, Lita A Freeman, B S Perrin, Richard W Pastor, Alan T Remaley. Scientific Reports. PMID: 29440748
High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis (2017) Scott M Gordon and Alan T Remaley. Atherosclerosis. PMID: 28242049
The Changing Face of HDL and the Best Way to Measure It (2017) Sotirios K Karathanasis, Lita A Freeman, Scott M Gordon, Alan T Remaley. Clinical chemistry. PMID: 27879324
Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr-/- mice (2017) Zhi-Hong H Yang, Scott M Gordon, Denis Sviridov, Shuibang Wang, Robert L Danner, Milton Pryor, Boris Vaisman, Yuka Shichijo, Nobushige Doisaki, Alan T Remaley. Atherosclerosis. PMID: 28486149
Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease (2017) W S Davidson, Anna Heink, Hannah Sexmith, Lawrence M Dolan, Scott M Gordon, James D Otvos, John T Melchior, Deborah A Elder, Jane Khoury, Esmond Geh, Amy S Shah. Journal of lipid research. PMID: 28743729
Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome (2016) Scott M Gordon, Hailong Li, Xiaoting Zhu, Patrick Tso, Catherine A Reardon, Amy S Shah, L J Lu, W S Davidson. Journal of Proteomics. PMID: 27385375
The effects of apolipoprotein B depletion on HDL subspecies composition and function (2016) W S Davidson, Anna Heink, Hannah Sexmith, John T Melchior, Scott M Gordon, Zsuzsanna Kuklenyik, Laura Woollett, John R Barr, Jeffrey I Jones, Christopher A Toth, Amy S Shah. Journal of Lipid Research. PMID: 26908829
A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins (2015) Scott M Gordon; Hailong Li; Xiaoting Zhu; Amy S Shah; L J Lu; W S Davidson. Journal of proteome research. PMID: 25894274
Rosuvastatin Alters the Proteome of High Density Lipoproteins: Generation of alpha-1-antitrypsin Enriched Particles with Anti-inflammatory Properties (2015) Scott M Gordon, Benjamin McKenzie, Georgina Kemeh, Maureen Sampson, Shira Perl, Neal S Young, Michael B Fessler, Alan T Remaley. Molecular & cellular proteomics. PMID: 26483418
High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice (2013) Maarit Lehti, Elizabeth Donelan, William Abplanalp, Omar Al-Massadi, Kirk M Habegger, Jon Weber, Chandler Ress, Johannes Mansfeld, Sonal Somvanshi, Chitrang Trivedi, Michaela Keuper, Teja Ograjsek, Cynthia Striese, Sebastian Cucuruz, Paul T Pfluger, Radhakrishna Krishna, Scott M Gordon, R A Silva, Serge Luquet, Julien Castel, Sarah Martinez, David D'Alessio, W S Davidson, Susanna M Hofmann. Circulation. PMID: 24170386
Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies (2013) Scott M Gordon; Jingyuan Deng; Alex B Tomann; Amy S Shah; L J Lu; W S Davidson. Molecular & cellular proteomics. PMID: 23882025
The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth (2013) Scott M Gordon, W S Davidson, Elaine M Urbina, Lawrence M Dolan, Anna Heink, Huaiyu Zang, L J Lu, Amy S Shah. Diabetes. PMID: 23835332
High density lipoprotein: it's not just about lipid transport anymore (2011) Scott M Gordon, Susanna Hofmann, David S Askew, W S Davidson. Trends in endocrinology and metabolism. PMID: 21067941
Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography (2010) Scott M Gordon, Jingyuan Deng, L J Lu, W S Davidson. Journal of proteome research. PMID: 20718489