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Lance A. Johnson, PhD


760 Press Ave, Healthy Kentucky Research Building 135, Lexington, KY 40536


  • Associate Professor
  • Director of Graduate Studies, Department of Physiology

College Unit(s)

Other Affiliation(s)
  • Nutritional Sciences Graduate Faculty

Biography and Education


Postdoctoral, Behavioral Neuroscience, Oregon Health & Science University

PhD, Molecular & Cellular Pathology, University of North Carolina

BA, Journalism & Mass Communication, University of North Carolina


Research in our lab is dedicated to understanding the role of the Alzheimer's disease risk factor Apolipoprotein E (APOE) in cerebral metabolism.  With a special focus on glia and their contributions to neurodegeneration, we employ a variety of transcriptomic and metabolomic approaches (from cells to mice to humans) in order to identify early-life changes in metabolism associated with APOE.  Our lab's overarching goal is to discover new therapeutic targets that will allow us to reprogram metabolism in individuals at-risk for Alzheimer's disease in order to enhance cognitive resilience and to extend the brain’s health span.

Selected Publications

Google Scholar Pubmed Publications