News

The 18th Annual Gill Heart Institute Cardiovascular Research Day is scheduled for October 2, 2015.  The event will take place at the Lexington Convention Center.  This year, the event is thrilled to host Gary Gibbons, MD as Keynote Speaker.  Dr. Gibbons is Director of the National Heart, Lung and Blood Institute at the National Institute of Health.  Our Featured Speakers will include Peter Tontonoz, MD, PhD from UCLA and Mike Synder, PhD from Stanford University. 

Mueller, P.; Ye, S.; Morris, A.; Smyth, S.S.  Lysophospholipid mediators in the vasculature.  Experimental cell research  2015 [PubMed Link] | [Full Text]

Introduction

Thompson, J.C.; Jayne, C.; Thompson, J.; Wilson, P.G.; Yoder, M.H.; Webb, N.; Tannock, L.R.A brief elevation of serum amyloid A is sufficient to increase atherosclerosis.Journal of lipid research562

Prabha Nagareddy, PhD, was recently notified as a finalist for the American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology Irvine H. Page Young Investigator Research Award. The award is given to new investigators in arteriosclerosis and vascular biology. The award recognizes investigators in the formative years of their careers who have the potential to become future leaders in cardiovascular research. Dr.

Binggang Xiang, PhD, core faculty of the Saha Cardiovascular Research Center was recently notified as a finalist for the American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology Kenneth M. Brinkhous Young Investigator Prize in Thrombosis. The award recognizes outstanding endeavors by new investigators in fundamental and applied research in thrombosis including the mechanism, detection, treatment, and prevention of thrombotic disorders. Dr.

Paul Mueller recently received the American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology Travel Award for Young Investigators. The $1000 award will be used to attend the ATVB|PVD 2015 Scientific Sessions in San Francisco in May. The award is distributed to a select number of young investigators based on the score of a submitted abstract.

A postdoctoral position is available immediately at the University of Kentucky to study the molecular mechanisms of metabolic disorders and atherosclerosis.  Our laboratory mainly focuses on the role of NF-kB (J Exp Med, 2014; Arterioscler Thromb Vasc Biol, 2012) and nuclear receptor PXR (Environ Health Perspect, 2012; Mol Pharmacol, 2013; JAHA 2014; Mol Endocrinol, 2015) in the pathogenesis of obesity and cardiovascular disease.  More details can be found at the following webpage: http://pharmns.med.uky.edu/use

Yipeng Sui from Changcheng Zhou’s laboratory recently received the American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology Travel Award for Young Investigators. The $1000 award will be used to attend the ATVB|PVD 2015 Scientific Sessions in San Francisco in May. The award is distributed to a select number of young investigators based on the score of a submitted abstract. Yipeng’s abstract is entitled “Intestinal Pregnane X Receptor Links Xenobiotic Exposure And Hypercholesterolemia”.

The 2015 Saha Awards application process is now open. 

The application process will close on Monday, June 1, 2015.

Xiang-An Li, Ph.D., of the University of Kentucky Saha Cardiovascular Research Center and Department of Pediatrics, has been awarded a $3 million grant from the National Institutes of Health to study synthetic HDL (sHDL) as a potential therapy for sepsis. Sepsis -- also called septicemia -- is a life-threatening condition caused by an overwhelming immune response to infection. Immune chemicals released by the body into the bloodstream to fight the infection trigger widespread inflammation that can damage multiple organ systems.

In 2013, as part of the Diabetes and Obesity Research Day at UK, the inaugural Fred and Marcielle de Beer Award was awarded to the de Beer’s for their contributions to the development of the Barnstable Brown Diabetes and Obesity Research Center (BBDOC) and for their long-standing research accomplishments at the University of Kentucky.  The 2014 recipient was Dr. Lisa Cassis.

 

 

Friday, February 6 is National Wear Red Day. 

Wear Red
In recognition of National Wear Red Day, Go Red for Women
asks that men and women GO RED by wearing red, living a healthy lifestyle and spreading the message
that heart diseaese is killing our mothers, daughters, sisters and friends.

Cell Metabolism 10th Anniversary Top 10 Breakthroughs in Immunometabolism. 

Now with the University of Kentucky Saha Cardiovascular Research Center, Dr. Prabhakara R. Nagareddy publication is at top of list.

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

Qing, H., Liu, Y., Zhao, Y., Aono, J., Jones, K. L., Heywood, E. B., Howatt, D., Binkley, C. M., Daugherty, A., Liang, Y. and Bruemmer, D. (2014), Deficiency of the NR4A Orphan Nuclear Receptor NOR1 in Hematopoietic Stem Cells Accelerates Atherosclerosis. STEM CELLS, 32: 2419–2429. doi: 10.1002/stem.1747 Abstract The NR4A orphan nuclear receptor NOR1 functions as a constitutively active transcription factor regulating cellular inflammation and proliferation.

Davis FM, Rateri DL, Balakrishnan A, Howatt DA, Strickland DK, Muratoglu SC, Haggerty CM, Fornwalt BK, Cassis LA, Daugherty A. Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor-Related Protein 1 Augments Angiotensin II-Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms. Arterioscler Thromb Vasc Biol. 2014 Nov 13. pii: ATVBAHA.114.304683.  PMID: 25395615

Abstract

Thompson JC, Jayne C, Thompson J, Wilson PG, Yoder MH, Webb N, Tannock LR. A brief elevation of serum amyloid A is sufficient to increase atherosclerosis. J Lipid Res. 2014 Nov 26. pii: jlr.M054015. PMID: 25429103.

Abstract

On Oct. 17, the Lexington Convention Center teemed with more than 200 students and scientists sharing their latest research on cardiovascular health for the 17th annual Gill Heart Institute Cardiovascular Research Day. Nigel Mackman, Ph.D., director of the McAllister Heart Institute at the University of North Carolina at Chapel Hill, presented "Hematosis, Thrombosis and Immunity," demonstrating the diverse roles of hemostasis and thrombosis in cardiovascular diseases, cancers and infections. Kathryn J.

University of Kentucky faculty, students, and postdoctoral fellows recently represented the institution at the second annual SEC Symposium, a program of the Southeastern Conference's academic initiative known as SECU, in Atlanta from Sept. 21 - 23.

Yipeng Sui was awarded the American Heart Association (AHA) Atherosclerosis Thrombosis and Vascular Biology (ATVB) Travel Award for Young Investigators. The international meeting will be held in Chicago at the upcoming American Heart Association Scientific Sessions. This award recognizes meritorious work by young investigators in training, encourages participation in the AHA Scientific Sessions, and provides a stipend to help defer travel expenses to present their work at the AHA Scientific Sessions.

Paul Mueller was awarded the American Heart Association (AHA) Atherosclerosis Thrombosis and Vascular Biology (ATVB) Travel Award for Young Investigators.  The international meeting will be held in Chicago at the upcoming American Heart Association Scientific Sessions. This award recognizes meritorious work by young investigators in training, encourages participation in the AHA Scientific Sessions, and provides a stipend to help defer travel expenses to present their work at the AHA Scientific Sessions.