Davis et al. Publishes on SMC deletion of LDL and AAA augmentation

Davis FM, Rateri DL, Balakrishnan A, Howatt DA, Strickland DK, Muratoglu SC, Haggerty CM, Fornwalt BK, Cassis LA, Daugherty A. Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor-Related Protein 1 Augments Angiotensin II-Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms. Arterioscler Thromb Vasc Biol. 2014 Nov 13. pii: ATVBAHA.114.304683.  PMID: 25395615

Abstract

Low-density lipoprotein receptor-related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to several vascular pathologies when deleted in vascular smooth muscle cells (SMCs). The purpose of this study was to determine whether LRP1 deletion in SMCs influenced angiotensin II-induced arterial pathologies.