Charles Coomer
Connect
charles.coomer@uky.eduPositions
- MD/PhD Student
College Unit(s)
Biography and Education
Education
University of Oxford (2017-2021, anticipated) University College London (2014-2015) MSc Infection and Immunity Western Kentucky University (2010-2014) BA Biology; BA Chemistry
Summary:
Current Year: M4Research
My dissertation project underscores the intersection between cell-intrinsic immunity, virus fusion and the biophysical properties which regulate this process using biochemical and quantitative microscopy approaches.
Selected Publications
C. Coomer, K. Rahman, A. Compton (2020). The CD225 proteins: a family portrait of fusion regulators. Accepted to Trends in Genetics.
K. Rahman*, C. Coomer*, S. Majdoul, S. Ding, S. Lockett, S. Padilla-Parra, A. Compton (2020). A conserved motif functionally links the antiviral activity of IFITM3 with its oligomeric state in membranes. eLife. 9:e58537 DOI: 10.7554/eLife.58537
C. Coomer, I. Carlon-Andres, M. Iliopoulou, M. Dustin, E. Compeer, A. Compton, S. Padilla-Parra (2020). Single-cell glycolytic activity regulates membrane tension and HIV-1 fusion. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1008359
C. Coomer and S. Padilla-Parra (2020). Towards quantitative imaging of HIV-1 transmission in tissue. Submitted to Encyclopedia of Virology. M. Iliopoulou, R. Nolan, L. Alvarez, Y. Watanabe, C. Coomer, et al (2018). A dynamic three step mechanism drives the HIV-1 prefusion reaction. Nature Structural and Molecular Biology. https://doi.org/10.1038/s41594-018-0113-x.
Kearney, M.F., Anderson, E.M., Coomer, C., Smith, L., Shao, W., Johnson, N., Kline, C., Spindler, J., Mellors, J.W., Coffin, J.M., and Ambrose, Z. (2015) Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy. Retrovirology 12: 93.
Pope, W.H., et al (2015). Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity. eLife; 4: e06416
M.F. Kearney; L. Smith; C. Coomer; G.J. Besson; J. Spindler; E.M. Anderson; W. Shao; T. Tanzosh; C. Rehm; J.W. Mellors; J.M. Coffin; F. Maldarelli. No Evidence for Evolution of Plasma HIV-1 RNA or PBMC HIV-1 DNA During Long-Term Suppressive Antiretroviral Therapy. In preparation for PLoS Pathogens. Hatfull, G.F., et al (2012). Complete Genome Sequences of 138 Mycobacteriophages. Journal of Virology. 86: 2382-2384