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Nathan R. Shelman, MD

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nathan.shelman@uky.edu
MS 116-b

Positions

  • Assistant Professor
  • AP Associate Director - Pathology Residency Program
  • Director - GI Pathology Fellowship

College Unit(s)

Biography and Education

Education

  • University of Southern Indiana (BS, Biology)
  • Ross University School of Medicine (Doctor of Medicine)
  • MedStar Georgetown University Hospital (Residency, Anatomic & Clinical Pathology)
  • Boston Children's Hospital (Fellowship, Pediatric and Perinatal Pathology)
  • Indiana University Hospital (Fellowship, Gastrointestinal/Hepatopathology)

Selected Publications

  • Holcomb NC, Harrington AM, Pu H, Halilovic B, Shelman NR, Zhang S, Sears C, Armstrong T, Shelton B, Corum L, D'Orazio JA. Characterization of p53 p.T253I as a pathogenic mutation underlying Li-Fraumeni Syndrome. PLoS One. 2025 Dec 5;20(12):e0320036. doi: 10.1371/journal.pone.0320036. PMID: 41348740; PMCID: PMC12680149.
  • True HE, Doratt BM, Wagner S, Malherbe DC, Shelman NR, Boroujeni ME, Cockerham C, O'Brien J, Messaoudi I. Maternal opioid use with and without hepatitis C infection disrupts the structure and immune landscape of the maternal-fetal interface. bioRxiv [Preprint]. 2025 Jul 31:2025.07.30.667651. doi: 10.1101/2025.07.30.667651. PMID: 40766448; PMCID: PMC12324527.
  • Zhu B, Pitts MG, Buoncristiani MD, Bryant LT, Lopez-Nunez O, Gurria JP, Shedlock C, Ribas R, Keohane S, Liu J, Wang C, Gentry MS, Shelman NR, Allison DB, Evers BM, Sun RC, Rellinger EJ. GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis. Oncogene. 2025 May;44(18):1272-1283. doi: 10.1038/s41388-025-03297-0. Epub 2025 Feb 16. PMID: 39956863; PMCID: PMC12048354.
  • Khot R, Shelman NR, Ludwig DR, Nair RT, Anderson MA, Venkatesh SK, Paspulati RM, Parker RA, Menias CO. Acquired ductopenia: an insight into imaging findings. Abdom Radiol (NY). 2025 Jan;50(1):152-168. doi: 10.1007/s00261-024-04462-x. Epub 2024 Jul 2. PMID: 38954003; PMCID: PMC11711635.
  • O'Neill AF, Church AJ, Feraco A, Spidle J, Wall CB, Kim HB, Elisofon S, Vakili K, Pimkin M, Dharia NV, Shelman NR, Perez-Atayde AR, Rodriguez-Galindo C. Clinical and immunophenotype correlating with response to immunotherapy in paediatric patients with primary liver carcinoma. A case series. EBioMedicine. 2024 Jun;104:105147. doi: 10.1016/j.ebiom.2024.105147. Epub 2024 May 14. PMID: 38749302; PMCID: PMC11108818.

  • Zelows MM, Cady C, Dharanipragada N, Mead AE, Kipp ZA, Bates EA, Varadharajan V, Banerjee R, Park SH, Shelman NR, Clarke HA, Hawkinson TR, Medina T, Sun RC, Lydic TA, Hinds TD Jr, Brown JM, Softic S, Graf GA, Helsley RN. Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice. Mol Metab. 2023 Dec;78:101815. doi: 10.1016/j.molmet.2023.101815. Epub 2023 Oct 4. PMID: 37797918; PMCID: PMC10568566.

    See full list of publications at PubMed. https://pubmed.ncbi.nlm.nih.gov/?term=Shelman%20N