[From the July 17 NIH “eSubmission Items of Interest”]

You may have noticed that newer NIH funding opportunity announcements (FOAs) have a different look. Some aspects of the old format (e.g., table structure) did not allow for easy page resizing across electronic devices and had to be reworked. You should now find it easier to view FOAs on various screen sizes of phones, tablets, laptops, desktops and other electronic devices. Despite challenges, NIH is striving to retain the integrity of the FOA information in a responsive format.

OSPA’s Useful Proposal Information page (http://www.research.uky.edu/ospa/info.html) has been updated.  One item in particular is that previously they had recommended a health insurance escalation of more than 10% in multi-year grant proposal budgets.  After looking at the actual increases over the past 5 years, they determined that number was no longer an accurate reflection.  It has been changed so that they now recommend a 3% escalation for health care costs.   The SRAS will incorporate this reduction

A new study by University of Kentucky researchers shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer. Fair-skinned people who tend to burn (rather than tan) from sun exposure have a much higher risk for melanoma than darker-skinned people. On the surface, it appears that the amount of melanin, the natural substance in the skin that determines pigment and acts as the skin's "natural sunscreen," would be the only determinant of melanoma risk.
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The Bright Focus Foundation has announced that three different researchers from the Sanders-Brown Center on Aging at the University of Kentucky have received Bright Focus grants for 2014. Professor Steve Estus and associate professors Harry LeVine and Paul Murphy were each recognized for their work on Alzheimer's disease. "Only 25 Bright Focus grants are awarded worldwide each year, so it's an achievement to get one. But three Bright Focus grants in a single year is truly exceptional," said Dr. Michael Karpf, UK HealthCare's executive vice president of health affairs.
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A year ago, a crowd of hundreds gathered in Pavilion A of the University of Kentucky Chandler Hospital to celebrate a long-awaited special announcement – the unveiling of the UK Markey Cancer Center as the state's first and only National Cancer Institute-designated cancer center. The designation was the culmination of years of tireless work by the faculty and staff of Markey and its supporting service lines and colleges – all guided by Director Dr.

Have you submitted a proposal or do you plan to do so in the next few months?

In the July 2014 edition of the Biosafety Newsletter, two College of Medicine laboratories were recognized for outstanding lab housekeeping and maintenance.  Join us in congratulating Dr. Rabchevsky's group in BBSRB and Dr. Gerhardt's group in the Combs building. 

Researchers from the Sanders-Brown Center on Aging at the University of Kentucky have been able to confirm anecdotal information on patients with both Alzheimer's disease (AD) and cerebrovascular disease (CVD) using mouse models in two different studies. The findings of these two studies, which were recently published in Acta Neuropathologica and Alzheimer's Research & Therapy, have potentially significant implications for patients with both disorders. Both papers studied CVD in Alzheimer's disease mouse models using different lifestyle factors.
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Scientists at the University of Kentucky, led by nano-biotechnologist Peixuan Guo, have made some critical discoveries over the past year into the operation of biomotors, the molecular machines used by viruses and bacteria in the packaging of DNA. Biomotors function similarly to mechanical motors but on a nano-scale. Last year, Guo's team reported the discovery of a new, third class of biomotor, unique in that it uses a "revolution without rotation" mechanism. Rotation is the turning of an object around its own axle, as the Earth does every 24 hours.
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Not all learning experiences are created equally – and at the Learning Center at Linlee, an innovative partnership with the University of Kentucky College of Medicine allows young students to get rich, hands-on experience in the sciences and better their chances of succeeding in college and beyond. As part of the Fayette County Public School System, The Learning Center (TLC) is an alternative school for at-risk students who are facing personal challenges that might impede their ability to learn. These include socioeconomic factors, and, perhaps surprisingly, intellectual giftedness.
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UK HealthCare and Norton Healthcare are building upon their history of collaboration to expand research and educational collaborations between the two institutions, with the goal of improving health and health care for all Kentuckians. Beginning July 1, educational and research initiatives between UK and Norton will be lead by Dr. Stephen Wyatt, who most recently served two successful terms as the founding dean of the University of Kentucky College of Public Health.

The RO1 Consultant Review Program is available to faculty wihtin the University of Kentucky College of Medicine. The program is designed to allow faculty to engage an authoritative external consultant to provide an assessment of a complete but not yet submitted RO1 or equivalent application. For more information on the program, click here.

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The University of Kentucky's Sanders-Brown Center on Aging is participating in a landmark multi-center clinical trial of an experimental drug that has the potential to prevent Alzheimer's disease (AD). The A4 Study will recruit 1,000 participants ages 65-85 to test an amyloid antibody that may prevent memory loss caused by Alzheimer's disease. Amyloid is a protein normally produced in the brain that can build up in older people, forming plaque deposits in the brain.
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New researchers in any field face challenges--limited research experience, competing demands for time, diminished levels of and increased competition for funding.
The National Institutes of Health has renewed a 5-year, $1.2 million grant to the University of Kentucky to help prepare clinical scholars for leadership positions in cardiovascular research. The UK Training Program for Clinical Scholars in Cardiovascular Science prepares clinical and postdoctoral fellows in medicine, nursing and pharmacy to assume leadership positions directing multidisciplinary research in the field of cardiovascular medicine. "The University of Kentucky has invested substantial resources to develop a highly collaborative training environment that leverages our strength

NIH has recently announced improvements to the Inclusion Data Reporting and Management toolsfor clinical trials. For more information on the new system, click here.

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The Barnstable Brown Kentucky Diabetes and Obesity Center hosted its fourth annual Diabetes Day on Tuesday, May 20. With a focus on current findings in obesity and diabetes research, the day's program featured presentations by nationally prominent physician-scientists as well as regional researchers chosen from abstract submissions.
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Scientists at the University of Kentucky College of Medicine have gained a new understanding of an enzyme essential for breaking down plant starch, a process used in agriculture, manufacturing and biotechnology. Dr. Matthew Gentry and Dr. Craig Vander Kooi, associate professors of molecular and cellular biochemistry at the University of Kentucky, and graduate student David Meekins, have decoded the natural process plants use to break down starch.
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With an anticipated 1 billion soccer fans around the world watching, a paraplegic Brazilian will signal the start of the 2014 World Cup on June 12 with a miraculous movement. Suited in a futuristic exoskeleton developed by researchers part of the Walk Again Project, the young man will send a message from his brain to a robotically controlled leg, driving the first kick of the world's most viewed sporting event.