[From August 7, 2014 "Grants Bulletin"]

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University of Kentucky associate professor Dr. Matthew Gentry, a biochemist who studies the very basic makeup of living things, can count very few "Eureka!" moments in his scientific career.

[From NIH]

Revised Policy: Descriptions on the Use of Individual Development Plans (IDPs) for Graduate Students and Postdoctoral Researchers Required in Annual Progress Reports beginning October 1, 2014

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Prabhakara R Nagareddy, a scientist with the Saha Cardiovascular Research Institute at the University of Kentucky, has received a prestigious K99/R00 award from the National Institutes of Health. Also known as the Pathway to Independence (PI) Award, this grant provides two years of mentored postdoctoral support followed by three years of independent support.

The Federal Office of Management and Budget (OMB) took 8 separate circulars applicable to different types of grantee organizations and combined them into a single document referred to as the Uniform Guidance.  Much remains that looks familiar but there is the potential for both major and minor changes to our policies and procedures.    To further complicate matters,  the OMB document is actually guidance to federal agencies and each granting agency must issue its own implementing regula

University of Kentucky Endowed Chair of Neuroscience Dr. Diane Snow was recently elected by her colleagues to serve as president-elect of the National Neurotrauma Society (NNS). With this appointment, Snow will hold the position of president in 2015-2016. Since joining the NNS in 2003, Snow has championed women's contributions to neurotrauma research and mentorship opportunities for young members of the profession, including students, postdoctoral fellows and young professors.
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Dr. Mikel Smith, the Alberto Mazzoleni Professor of Cardiology and the director of echocardiography at the Gill Heart Institute, has been given the American Society of Echocardiography's 2014 Richard Popp Excellence in Teaching Award. The award recognizes an outstanding teacher who epitomizes the ideal qualities of a mentor and role model. According to Dr. Vincent Sorrell, director of advanced cardiovascular imaging at the Gill Heart Institute, the Popp Award is particularly meaningful because the awardee must be nominated by one of his or her students or peers.
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Tetsuhiro Yasuma, postdoctoral Fellow in the Department of Ophthalmology and Visual Sciences at the University of Kentucky College of Medicine, has been selected to receive the 2014 Fight for Sight Postdoctoral Award from Fight for Sight, a non-profit organization that promotes eye research by providing pilot funding to promising new researchers. Yasuma received training in biomedical research as an undergraduate student in Japan and general ophthalmology and surgery in graduate school. Yasuma joined the Ambati lab at UK in 2012.

The University of Kentucky Center for Molecular Medicine sponsors three scientific cores for use by researchers at the University of Kentucky.  These include a Protein core providing services for the production and characterization of proteins, an Organic Synthesis core synthesizing small molecules not commercially available, and a Genetic Technologies core producing recombinant virus and oth

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[From the July 17 NIH “eSubmission Items of Interest”]

You may have noticed that newer NIH funding opportunity announcements (FOAs) have a different look. Some aspects of the old format (e.g., table structure) did not allow for easy page resizing across electronic devices and had to be reworked. You should now find it easier to view FOAs on various screen sizes of phones, tablets, laptops, desktops and other electronic devices. Despite challenges, NIH is striving to retain the integrity of the FOA information in a responsive format.

OSPA’s Useful Proposal Information page (http://www.research.uky.edu/ospa/info.html) has been updated.  One item in particular is that previously they had recommended a health insurance escalation of more than 10% in multi-year grant proposal budgets.  After looking at the actual increases over the past 5 years, they determined that number was no longer an accurate reflection.  It has been changed so that they now recommend a 3% escalation for health care costs.   The SRAS will incorporate this reduction

A new study by University of Kentucky researchers shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer. Fair-skinned people who tend to burn (rather than tan) from sun exposure have a much higher risk for melanoma than darker-skinned people. On the surface, it appears that the amount of melanin, the natural substance in the skin that determines pigment and acts as the skin's "natural sunscreen," would be the only determinant of melanoma risk.
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The Bright Focus Foundation has announced that three different researchers from the Sanders-Brown Center on Aging at the University of Kentucky have received Bright Focus grants for 2014. Professor Steve Estus and associate professors Harry LeVine and Paul Murphy were each recognized for their work on Alzheimer's disease. "Only 25 Bright Focus grants are awarded worldwide each year, so it's an achievement to get one. But three Bright Focus grants in a single year is truly exceptional," said Dr. Michael Karpf, UK HealthCare's executive vice president of health affairs.
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A year ago, a crowd of hundreds gathered in Pavilion A of the University of Kentucky Chandler Hospital to celebrate a long-awaited special announcement – the unveiling of the UK Markey Cancer Center as the state's first and only National Cancer Institute-designated cancer center. The designation was the culmination of years of tireless work by the faculty and staff of Markey and its supporting service lines and colleges – all guided by Director Dr.

Have you submitted a proposal or do you plan to do so in the next few months?

In the July 2014 edition of the Biosafety Newsletter, two College of Medicine laboratories were recognized for outstanding lab housekeeping and maintenance.  Join us in congratulating Dr. Rabchevsky's group in BBSRB and Dr. Gerhardt's group in the Combs building. 

Researchers from the Sanders-Brown Center on Aging at the University of Kentucky have been able to confirm anecdotal information on patients with both Alzheimer's disease (AD) and cerebrovascular disease (CVD) using mouse models in two different studies. The findings of these two studies, which were recently published in Acta Neuropathologica and Alzheimer's Research & Therapy, have potentially significant implications for patients with both disorders. Both papers studied CVD in Alzheimer's disease mouse models using different lifestyle factors.
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Scientists at the University of Kentucky, led by nano-biotechnologist Peixuan Guo, have made some critical discoveries over the past year into the operation of biomotors, the molecular machines used by viruses and bacteria in the packaging of DNA. Biomotors function similarly to mechanical motors but on a nano-scale. Last year, Guo's team reported the discovery of a new, third class of biomotor, unique in that it uses a "revolution without rotation" mechanism. Rotation is the turning of an object around its own axle, as the Earth does every 24 hours.
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Not all learning experiences are created equally – and at the Learning Center at Linlee, an innovative partnership with the University of Kentucky College of Medicine allows young students to get rich, hands-on experience in the sciences and better their chances of succeeding in college and beyond. As part of the Fayette County Public School System, The Learning Center (TLC) is an alternative school for at-risk students who are facing personal challenges that might impede their ability to learn. These include socioeconomic factors, and, perhaps surprisingly, intellectual giftedness.