Janna Neltner, MD

Publications & Other Scholarly Work:

1              Levering adult learning principles into a residency core curriculum. Neltner J, Bocklage T.Cancer Cytopathol. 2021 Mar 19. doi: 10.1002/cncy.22418. Online ahead of print.PMID: 33739608

2              Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain.  Shahidehpour RK, Higdon RE, Crawford NG, Neltner JH, Ighodaro ET, Patel E, Price D, Nelson PT, Bachstetter AD.Neurobiol Aging. 2021 Mar;99:19-27. PMID: 33422891 doi:10.1016/j.neurobiolaging.2020.12.003. Epub 2021 Jan 7.

3              Rheumatoid meningitis: A case report and review of the literature. Qin Z, Kim J, Valencia D, Hamoodi L, Neltner J, Sizemore T, Lightfoot R Jr.Neurol Clin Pract. 2020 Feb;10(1):73-83. doi: 10.1212/CPJ.0000000000000678.PMID: 32190423 Review. PMID 32190423

4              Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.  Katsumata Y, Fardo DW, Bachstetter AD, Artiushin SC, Wang WX, Wei A, Brzezinski LJ, Nelson BG, Huang Q, Abner EL, Anderson S, Patel I, Shaw BC, Price DA, Niedowicz DM, Wilcock DW, Jicha GA, Neltner JH, Van Eldik LJ, Estus S, Nelson PT.J Neuropathol Exp Neurol. 2020 Jan 1;79(1):3-21. doi: 10.1093/jnen/nlz116. PMID: 31748784

5              High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis.  Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA.Brain Pathol. 2020 Jan;30(1):46-62. doi: 10.1111/bpa.12747. Epub 2019 Jun 10. PMID: 31104347

6              Initial management of meningiomas: Analysis of the National Cancer Database. Garcia CR, Slone SA, Chau M, Neltner JH, Pittman T, Villano JL.Cancer Epidemiol. 2019 Jun;60:16-22. doi: 10.1016/j.canep.2019.02.018. Epub 2019 Mar 14. PMID: 30878798

7              Primary central nervous system tumor treatment and survival in the United States, 2004-2015. Garcia CR, Slone SA, Dolecek TA, Huang B, Neltner JH, Villano JL. J Neurooncol. 2019 Aug;144(1):179-191. doi: 10.1007/s11060-019-03218-8. Epub 2019 Jun 28. PMID: 31254264

8              Abner EL, Neltner JH, Jicha GA, Patel E, Anderson SL, Wilcock DM, Van Eldik LJ, Nelson PT. Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques. J Alzheimers Dis. 2018;64(4):1307-1324. doi: 10.3233/JAD-180514.

9              Tulloch J, Leong L, Chen S, Keene CD, Millard SP, Shutes-David A, Lopez OL, Kofler J, Kaye JA, Woltjer R, Nelson PT, Neltner JH, Jicha GA, Galasko D, Masliah E, Leverenz JB, Yu CE, Tsuang D. APOE DNA methylation is altered in Lewy body dementia. Alzheimers Dement. 2018 Mar 12. pii: S1552-5260(18)30047-5. doi:10.1016/j.jalz.2018.02.005. [Epub ahead of print]

10           Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.

11           Berger JR, Miller CS, Danaher RJ, Doyle K, Simon KJ, Norton E, Gorelik L, Cahir-McFarland E, Singhal D, Hack N, Owens JR, Nelson PT, Neltner JH. “Distribution and Quantity of Sites of John Cunningham Virus Persistence in Immunologically Healthy Patients: Correlation With John Cunningham Virus Antibody and Urine John Cunningham Virus DNA.  JAMA Neurol. 2017 Feb 27. doi: 10.1001/jamaneurol.2016.5537. [Epub ahead of print]

12           Bachstetter AD, Ighodaro ET, Hassoun Y, Aldeiri D, Neltner JH, Patel E, Abner EL, Nelson PT. “Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.” Neurobiol Aging. 2017 Apr;52:98-105. doi: 10.1016/j.neurobiolaging.2016.12.028. Epub 2017 Jan 5.

13           Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET."New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).  J Neuropathol Exp Neurol. 2016 Jun;75(6):482-98. doi: 10.1093/jnen/nlw033. Epub 2016 May 21. Review.

14           Ighodaro E, Abner EL, et al “Risk Factors and Global Cognitive Status Related to Brain Arteriolosclerosis in Elderly Individuals.” J Cereb Blood Flow Metab. 2016 Jan 6. pii: 0271678X15621574.

15           Neltner JH, Abner EL, Jicha GA et al.  “Brain pathologies in extreme old age.” Neurobiol Aging. 2016 Jan; 37:1-11.

16           Hensley P, Hilal T, Neltner J, Kumar B. Maintaining sharp focus on a grainy film: miliary pattern in an elderly woman with acute respiratory failure. BMJ Case Rep. 2015 Jul 22; 2015

17           Ighodaro ET, Jicha GA, Schmitt FA, Neltner JH, Abner EL, Kryscio RJ, Smith CD, Duplessis T, Anderson S, Patel E, Bachstetter A, Van Eldik LJ, Nelson PT. Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature. J Neuropathol Exp Neurol. 2015 Jul;74(7):642-52.

18           Yu T, Chen X, Zhang W, Liu J, Avdiushko R, Napier DL, Liu AX, Neltner JM, Wang C, Cohen D, Liu C. KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer. Cell Death Differ. 2016 Feb;23(2):207-15

19           Hance JM, Harris JW, Vilchez V, Tzeng CW, Maynard E, Gedaly R, Shah MB, Neltner J. Hepatobiliary mucinous cystadenoma resulting in biliary obstruction. Am Surg. 2015 Jun;81(6):E238-9.

20           Bachstetter AD, Van Eldik LJ, Schmitt FA, Neltner JH, Ighodaro EI, et al “Disease-related microglia heterogeneity in thehippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis ofaging.” Acta Neuropathologica Communications (2015) 3:32

21           Berger JR, Neltner J, Smith C, Cambi F. “Posterior reversible encephalopathy syndrome masquerading as progressive multifocal leukoencephalopathy in rituximab treated neuromyelitis optica. Mult Scler Relat Disord. 2014 Nov;3(6):728-31.

22           Attems J, Neltner JH, Nelson PT. Quantitative neuropathological assessment to investigate cerebral multi-morbidity. Alzheimers Res Ther. 2014 Nov 28;6(9):85. eCollection 2014.

23           Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, et. al. “Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 2014 Dec;128(6):755-66.

24           Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, et al. “Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression.”  Stem Cells. 2014 Jul;32(7):1746-58.

25           Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, et al.  “ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.”  Acta Neuropathol. 2014 Jun;127(6):825-43.

26           Scheff SW, Neltner JH, Nelson PT. “Is synaptic loss a unique hallmark of Alzheimer's disease?”  Biochem Pharmacol. 2014 Apr 15;88(4):517-528.

27           Wang WX, Danaher RJ, Miller CS, Berger JR, Nubia VG, Wilfred BS, Neltner JH, Norris CM, Nelson PT.  “Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells.”  Genomics Proteomics Bioinformatics. 2014 Feb;12(1):19-30.

28           Xing F, Su H, Neltner J, Yang L. “Automatic ki-67 counting using robust cell detection and online dictionary learning.” IEEE Trans Biomed Eng. 2014 Mar;61(3):859-70.

29           Zaytseva YY, Elliott VA, Rychahou P, Mustain WC, Kim JT, Valentino J, Gao T, O'Connor KL, Neltner JM, Lee EY, Weiss HL, Evers BM. “Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer.” Carcinogenesis. 2014 Jun;35(6):1341-51.

30           Fiore, LS, Ganguly, SS, Sledziona, J, Cibull, ML, Wang C, Richards, DL, Neltner, JM, et al.  “c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.” Oncogene. 2014 Sep 4;33(36):4508-20.

31           Gilbert, MR, Liu, Y; Neltner, J, et al. “Autophagy and oxidative stress in gliomas with IDH1 mutations.” Acta Neuropathol. February 2014, Volume 127 (2) 221-233.

32           Neltner, Janna; Abner, Erin; Baker, S; et. al.  “Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing.” Brain. 2013 Nov 21. [Epub ahead of print]

33           Nelson PT, Smith CD, Abner EL, Wilfred BJ, Wang WX, Neltner JH, Baker M, Fardo DW, Kryscio RJ, Scheff SW, Jicha GA, Jellinger KA, Van Eldik LJ, Schmitt FA.  “Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease.” Acta Neuropathol. 2013 Aug;126(2):161-77.

34           Neltner, J and Horbinski, C.  “A 29 year old woman with mental status changes.” Brain Pathol. 2013 Jul;23(4):479-82.

35           Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, Irwin DJ, Rick J, Schellenberg GD, Watson GS, Kukull W, Nelson PT, Jicha GA, Neltner JH, Galasko D, Masliah E, Quinn JF, Chung KA, Yearout D, Mata IF, Wan JY, Edwards KL, Montine TJ, Zabetian CP. “APOE ε4 increases risk for dementia in pure synucleinopathies. JAMA Neurol. 2013 Feb;70(2):223-8.

36           Neltner, Janna;  Abner, Erin; Schmitt, Frederick; Dension, Stephanie; Anderson, Sonya; Nelson, Peter T. "Digital Pathology and Image Analysis for Robust High-Throughput Quantitative Assessment of Alzheimer Disease Neuropathologic Changes." J Neuropathol Exp Neurol, 2012 Dec; 71(12):1075-85.

37           Bachstetter, Adam D;  Norris, Christopher M; Sompol, Pradoldej; Wilcock, Donna M; Goulding, Danielle; Neltner, Janna H; St Clair, Daret; Watterson, D Martin; Van Eldik, Linda J.  “Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.” J Neurosci, 2012 Jul 25;32(30):10201-10.

38           Tsuang, Debby; Leverenz, James B; Galasko, Doug, Hamilton, Ronald; Kaye, Jeffrey; Lopez, Oscar; Trojanowski, John Q.; Clark, Christopher, Masliah, Eliezer, Larson, Eric; Crane, Paul; Kukull, Walter; Yearout, Dora; Huston, Haley; Fritts-Penniman, Allison; Kramer, Patricia; Woltjer, Randy; Neltner, Janna; Nelson, Peter; Mata, Ignacio; Snappinn, Katherine; Edwards, Karen L.; Schellendberg, Gerard; Montine, Thomas; Zabetian, Cyrus.  “GBA mutations increase risk for Lewy body disease with and without Alzheimer’s disease pathology.”  Neurology. 2012 Nov 6;79(19):1944-1950. 

39           Diaz-Guzman, Enrique; Neltner, Janna; Hoopes, Charles.  “Organ Donation and Moyamoya syndrome.” Letter, Amer J Transplantation, 2012 May;12(5):1353-5. 

40           Abner, E. L., R. J. Kryscio, Schmitt, FA; Santacruz, KS; Jicha, GA; Lin, Y; Neltner, JM; Smith, CD; Van Eldik, LJ, Nelson, PT. "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?" J Alzheimers Dis. 2011, 25(3): 445-453.

41           Nelson, P.; Schmitt, F.; Lin, Y.; Abner, E.; Jicha, G.; Patel, E.; Thomason, Paula; Neltner, J.; Smith, C.; Santacruz, K.; Poon, L.; Sonnen, J.; Green, R.; Gearing, M.; Woodard, J.; Van Eldik, L.; Kryscio, R..  “Hippocampal Sclerosis in advanced age: clinical and pathologic features in 106 cases.”  Brain, 2011, 134:1506-1518.

42           Abner, Erin L., Kryscio, Richard J., Schmitt, Frederick A., SantaCruz, Karen S., Jicha, Gregory A., Lin, Yushun, Neltner, Janna H., Smith, Charles D.,  Van Eldik, Linda J., Nelson, Peter T. “End-stage” neurofibrillary tangle pathology in preclinical Alzheimer’s disease—fact or fiction? J. Alz. Dis. 2011, Jan 1;25(3):445-53.

43           Nelson, Peter T., Head, Elizabeth, Schmitt, Frederick A., Davis, Paulina R., Neltner, Janna H., Jicha, Gregory A., Abner, Erin L., Smith, Charles D., Van Eldik, Linda J., Kryscio, Richard J., Scheff, Stephen W. “Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.” Acta Neuropathologica. 2011,  May;121(5):571-87.

44           Lauderback, C.M.; Drake, J.; Zhou, D.; Hackett, JM; Castegna, A; Kanski, J; Tsoras, M.; Varadarajan, S.; Butterfield, DA.  “Derivatives of Xanthic Acid are Novel Antioxidants: Applications to Synaptosomes”.  Free Rad. Res.  2003, 37(4), 355-365.

45           Lauderback, C.M.; Kanski, J.; Hackett, J.M.; Maeda, N.; Kindy, M.S.; Butterfield. D.A. “Apolipoprotein E Modulates Alzheimer’s Aβ(1-42)-Induced Oxidative Damage to Synaptosomes in an Allele-Specific Manner.”  Brain Res., 2002, 924, 90-97.

46           Lauderback, C.M.; Hackett, J.M.; Huang, F.F.; Keller, J.N.; Szweda, L.I., Markesbery, W.R.; Butterfield. D.A.  “The Glial Glutamate Transporter, GLT-1, Is Oxidatively Modified by 4-hydroxy-2-nonenal in the Alzheimer’s Disease Brain: the Role of Aβ(1-42).”  J. Neurochem.  2001, 78, 413-416.

47           Lauderback, C.M.; Hackett, J.M.; Keller, J.N.; Varadarajan, S.; Szweda, L.I.; Kindy, M.S.; Markesbery, W.R.; Butterfield. D.A.  “Vulnerability of synaptosomes from ApoE Knock-Out Mice to Structural and Oxidative Modifications Induced by Aβ(1-42): Implications for Alzheimer’s Disease.  Biochem., 2001, 40, 2548-2554.

48           Lauderback, C.M.; Breier, A.M.; Hackett, J.M.; Varadarajan, S.; Goodlett-Mercer, J.; Butterfield. D.A.  “The Pyrrolopyrimidine U101033E is a Potent Free Radical Scavenger and Prevents Fe(II)-Induced Lipid Peroxidation in Synaptosomal Membranes.” Bioch. Biophys. Acta, 2000, 1501, 149-161.