CURE-KY Podcast and Publication Spotlights

This page features a curated collection of podcast episodes and research publications relevant to infectious disease, public health, and translational science, with a particular emphasis on work connected to the CURE-KY community.

Each month, we highlight two publications selected by CURE-KY leadership for its relevance, insight, or impact. In addition to these monthly spotlights, we regularly share other notable content—including external podcast episodes and recent peer-reviewed publications authored by CURE-KY members. All featured publications include at least one CURE-affiliated author and are accompanied by an AI-generated audio summary to help make the research more accessible to broader audiences.

Whether you're catching up on timely studies or tuning into expert conversations, we invite you to explore the content below—and if you know of a podcast or paper that aligns with our mission or includes a member of the CURE-KY network, please share it with us.


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PMID: 40541539

Journal: EBioMedicine

Title: MyD88 signalling in B cells and antibody responses during Oropouche virus-induced neurological disease in mice.

Authors:  Toledo-Teixeira DA,Parise PL,Pereira da Silva BB, Simeoni CL, Vieira A, Forato J, Martini MC, Amorim MR, Bispo-Dos-Santos K, Brunetti NS, Fabiano de Souza G, Coimbra LD, Fontoura MA, Muraro SP, Barbosa PP, Matheus VA, Hua X, Mendes de Moraes Vieira PM, Granja F, Lalwani P, Ramirez Vinolo MA, Milanez GP, Marques RE, Fielding CA, Marciel de Souza W, Farias ADS, Price DA, Diamond MS, Silveira ELV, Proenca-Modena JL

Funding:  São Paulo Research Foundation (FAPESP), National Council for Scientific and Technological Development (CNPq), Coordination for the Improvement of Higher Education Personnel (CAPES), Unicamp Research Affairs Office, PIPAE University of São Paulo, Wellcome Trust, and National Institute of Science and Technology on Photonics Applied to Cell Biology (INFABIC, Unicamp).

Impact on KY: Increases understanding of the immune signaling and correlates of protection in mice exposed to Oropouche virus currently found in central and South America, but risk is elevated in the US as spread is likely. Dr. de Souza quoted here describing potential impacts.

Published online: June 21, 2025

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PMID: 40519989

Journal: Blood Vessel Thromb Hemost

Title: Unfolded von Willebrand factor binds protein S and reduces anticoagulant activity.

Authors: Sim MMS, Mollica MY, Alfar HR, Hollifield M, Chung DW, Fu X, Gandhapudi S, Coenen DM, Prakhya KS, Mahmood DFD, Banerjee M, Peng C, Li X, Thornton AC, Porterfield JZ, Sturgill JL, Sievert GA, Barton-Baxter M, Zheng Z, Campbell KS, Woodward JG, López JA, Whiteheart SW, Garvy BA, Wood JP

Funding: NIH: R01HL138179, R35HL150818, K99HL129193, TL1TR001997, T32HL007093

Impact on KY: Excellent demonstration of collaboration across CURE-KY with at least 6 PIs as coauthors. Provides an explanation for the risk of thrombosis during viral infection, like SARS-CoV-2, in which free protein S is depleted and loses its anticoagulant capacity.

Published online: June 16, 2025

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PMID: 40422074

Journal: ASM - Journal of Virology

Title:  Screening bacterial effectors and human virus proteins in yeast to identify host factors driving tombusvirus RNA recombination: a role for autophagy and membrane phospholipid content.

Authors: Pogany J, Inaba J-i, Liu Y, Nagy PD

Funding: National Science Foundation (IOS-1922895) National Institute of Food and Agriculture (2020-70410-32901, KY012042)

Impact on KY: This study provides tools to identify bacterial effectors that can improve pathogen detection and disease prevention in Kentucky’s agriculture and biosafety sectors.

Published online: May 27th, 2025

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PMID: 40391958

Journal: ASM - Antimicrobial Agents and Chemotherapy

Title:  Optimizing cefazolin dosing for central nervous system infections: insights from population pharmacokinetics and Monte Carlo simulations.

Authors: Pitcock C, Burgess DS, Olney KB

Funding: N/A

Impact on KY: Findings can help improve antibiotic stewardship and patient outcomes in Kentucky, where rates of serious staph infections and antibiotic use remain high.

Published online: May 20th, 2025

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PMID: 40173371

Journal: JMIR Form Res

Title: The Impact of a Human Papillomavirus Facebook-Based Intervention (#HPVVaxTalks) Among Young Black (African American and Sub-Saharan African Immigrants) Adults: Pilot Pre- and Poststudy.

Authors: Adegboyega A,Wiggins A,Wuni A,Ickes M

Funding: American Cancer Society Institutional Grant (#IRG 19-140-31-IRG)

Impact on KY: Use of social media to improve vaccine and infection information as a strategy to improve vaccine uptake and provides a platform for continued expansion of this study to larger groups throughout KY.

Published online: February 4th, 2025

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PMID: 40187345

Journal: Cell

Title:  Molecular basis for shifted receptor recognition by an encephalitic arbovirus

Authors: Fan X,Li W,Oros J,Plante JA,Mitchell BM,Plung JS,Basu H,Nagappan-Chettiar S,Boeckers JM,Tjang LV,Mann CJ,Brusic V,Buck TK,Varnum H,Yang P,Malcolm LM,Choi SY,de Souza WM,Chiu IM,Umemori H,Weaver SC,Plante KS,Abraham J

Funding: (deSouza): Wellcome Trust grant 226075/Z/22/Z

Impact on KY: After a recent outbreak of Western equine encephalitis virus (WEEV) in humans and horses in South America, this team studied ancestral strains of WEEV to elucidate structure and function with cell receptors that explain the dynamics of viral evolution and have implications in outbreak preparedness.

Published online: May 29, 2025

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UK and COVID-19, 5 Years Later

CURE-KY Leadership Member Vince Venditto, PhD, is featured in this episode of "Behind the Blue." This episode includes eight longtime employees from the medical side of UK’s campus, ranging from administrators to frontline health care providers to researchers reflect on those scary, early days of the pandemic, how it impacted their professional and personal lives and some of the lessons learned from living through such a significant moment in history.

Published: March 6, 2025


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PMID: 40131773

Journal: Nucleic Acids Res

Title: Structure and cooperative formation of a FLI1 filament on contiguous GGAA DNA sites.

Authors: Hou C,Tsodikov OV

Funding: NIH R01CA243529

Impact on KY: Improves our understanding of the DNA interactions that drive oncogenesis in Ewing’s sarcoma.

Published online: March 25, 2025

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PMID: 40138989

Journal: Vet Microbiol

Title: Retrospective investigation of 43 necropsy cases of Tyzzer disease in foals and partial genome sequence of Clostridium piliforme by shotgun metagenomics.

Authors: Uprety T, Swan M, Kennedy L, Bryant U, Cassone L, Loynachan A, Janes J, Evely MM, Calvaruso FC, Quick M, Morgan J, Abdelrazek S, Lahmers K, Carter C, Erol E

Funding: UK Veterinary Diagnostic Laboratory

Impact on KY: First partial genome sequence of rare bacterial infection that causes Tyzzer disease, a predominantly fatal disease in foals.

Published online: March 22, 2025

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PMID: 39938315

Title: Protective efficacy of a bivalent equine influenza H3N8 virus-like particle vaccine in horses

Authors: O’Kennedy MM, et al….(Chambers TM)

Journal: Vaccine

Funding: Kentucky Agricultural Experiment Station; the Grayson-Jockey Club Research Foundation; the Lucille P. Markey Charitable Trust

Impact on KY: The research provides a scalable and rapid plant produced virus like particles to generate safe and effective vaccines for equine influenza virus, which exhibit outbreaks worldwide. While not fatal, results in respiratory disease that requires months for treatment and recovery resulting in significant impact on the KY economy.

Published online: February 11, 2025


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PMID: 39843487

Title: Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide.

Authors: Rush JS, et. al….(Korotkova N)

JournalNature Communications

Funding: Veterans Affairs (IK6 BX006469/BX/BLRD VA/United States)

Impact on KY: Advances our understanding of cell wall biosynthesis and organization in S mutans, the primary pathogen responsible for dental cavities. These studies provide new potential targets to inhibit streptococcal driven tooth decay.

Published online: January 22, 2025

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PMID: 39749891

Title: Bringing Pandemic Science to the Classroom: Building Public Health Capacity at a Rural Kentucky High School

Authors: Sahar Alameh, PhD; Anna G. Hoover, PhD; James W. Keck, MD, MPH; Scott M. Berry, PhD, MBA; Sagan Goodpaster, PhD; Savannah Tucker, MPH; and Ashley Goodin, MA

Published online: January 3, 2025