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Trevor P. Creamer, PhD




  • Professor
  • Director of Graduate Studies

College Unit(s)

Other Affiliation(s)
  • Diversity Departmental Ambassadors

Biography and Education


Research Associate

Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine.

Postdoctoral Fellow

Department of Biochemistry and Molecular Biophysics, Washington University at St. Louis.

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill.

Department of Biochemistry and Molecular Biology, The Milton S. Hershey Medical Center, The Pennsylvania State University.


Ph.D. (Physical Chemistry), University of Western Australia.

B.Sc. with 1st Class Honours (Physical and Inorganic Chemistry), University of Western Australia.


Structural and biophysical studies of calcineurin regulation and activity

The Creamer lab is applying its expertise to the characterization of the function and conformational properties of intrinsically disordered regions (IDRs) within proteins. IDRs are regions of protein sequence that do not appear to adopt a well-defined structure. Our current studies are focused on calcineurin (CaN), a Ser/Thr phosphatase that is activated by calmodulin (CaM) binding. CaN plays essential roles in memory development and retention, cardiac growth, and immune system activation. It has been implicated in numerous disorders including Alzheimer's disease, Down syndrome, cardiac hypertrophy, and autoimmune disorders. The regulatory domain of CaN, which is a CaM substrate, is an IDR. We are investigating the CaM-CaN interaction and how this regulates CaN function.



Selected Publications

Google Scholar Pubmed Publications