Recent Publications
Our full departmental research profile can be found on Scholars@UK.
A Benchmark Study on Available Data of Henry's Law Constants and Vapor Pressures for 30 Per- and Polyfluoroalkyl Substances (PFAS) and Considerations for Vapor Intrusion
Robinson, A., Thompson, P. T., Tay, H. C., Gutierrez, A. M., Moseley, H. N. B., Tratnyek, P. G. & Pennell, K. G., Jun 1 2026, In: GroundWater Monitoring and Remediation. 46, 3, p. 101-113 13 p.Research output: Contribution to journal › Article › peer-review
A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen Streptococcus suis
Shi, Y., Widmalm, G., Sorieul, C., Roodsant, T. J., Rush, J. S., Korotkova, N., Vrieling, M., Jacobs, A. A. C., Spaninks, M., Grommen, R., Domínguez-Medina, C. C., Schimmel, I. M., van der Wel, N. N., Kenner, C. W., Heiss, C., Azadi, P., Tan, L., Codée, J. D. C., Stegeman, A. & Schultsz, C. & 2 others, , Mar 25 2026, In: Science advances. 12, 13, eadz1854.Research output: Contribution to journal › Article › peer-review
A live cell biosensor protocol for high-resolution screening of therapy-resistant cancer cells
Oza, V. D., Williams, C. S. & Blackburn, J. S., Feb 2026, In: PLoS ONE. 21, 2 February, e0343016.Research output: Contribution to journal › Article › peer-review
A Major Update and Improved Validation Functionality in the mwtab Python Library and the Metabolomics Workbench File Status Website
Thompson, P. T. & Moseley, H. N. B., Jan 2026, In: Metabolites. 16, 1, 22 p., 76.Research output: Contribution to journal › Article › peer-review
Animal Models of Aortic Aneurysm and Dissection: A Comparative Guide for Mechanism, Therapeutic Testing, and Translational Readouts
Mohammadmoradi, S. & Whiteheart, S. W., Jan 2026, In: Biomedicines. 14, 1, 17 p., 170.Research output: Contribution to journal › Review article › peer-review
A Unique Protein Adjuvant for Precision Immunotherapy to Prevent Recurrence of Surgically Resected Colorectal Cancer
Suzuki, Y., Mani, R. & Evers, B. M., Mar 2026, In: Cancers. 18, 6, 1003.Research output: Contribution to journal › Review article › peer-review
Chemical Structure Representation Standardization Is Needed to Generalize Metabolite-Pathway Involvement Prediction Across KEGG, Reactome, and MetaCyc Knowledgebases
Huckvale, E. D. & Moseley, H. N. B., Jun 2026, In: Metabolites. 16, 6, 19 p., 357.Research output: Contribution to journal › Article › peer-review
Chronic alcohol consumption disrupts the gut microbial and metabolic landscapes
Blanton, M. B., Napier, E. G., Keen, K. E., Stuart, E. V., Cinco, I. R., Hemati, H., Bruntz, R. C., Wilson, L., Barnes, S., Khadka, R., Grant, K. A. & Messaoudi, I., May 13 2026, In: Frontiers in Microbiology. 17, 1794794.Research output: Contribution to journal › Article › peer-review
Circadian rhythm of amyloid-β in the olfactory bulb and cerebellum of wild-type and APPxPS1 knock-in mice indicates a loss of rhythmicity in regions more vulnerable to amyloid pathology
Buzinova, V. A., Johnson, C. E., Turton, S. M., Barth, S. E., Padgett, S., Maisel, M. T., Kohler, K., Whitlock, H. R., Bachstetter, A. D., Sunderam, S., O’Hara, B. F., Duncan, M. J. & Murphy, M. P., Feb 2026, In: Biogerontology. 27, 1, 11.Research output: Contribution to journal › Article › peer-review
Colon cancer in Appalachian Kentucky: Unique genetic, microbiome and obesity findings in a cohort comparison
Chow, Z., Liu, J., He, D., Wang, C., Gan, T., Mansour, A., Shaker, N., Dravillas, C., Hoyd, R., Durbin, E., Napier, D., Gao, T., Schaberg, K., Huang, L., Ulrich, N., Siegel, E., Edge, S., Cook, L., Salhia, B. & Churchman, M. & 4 others, , Jan 15 2026, In: Human Genetics and Genomics Advances. 7, 1, 100527.Research output: Contribution to journal › Article › peer-review
Corrrection to: Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction(Neuron., (2003), 39, (3), (409-21), (S0896627303004343), 10.1016/s0896-6273(03)00434-3)
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y. & LaFerla, F. M., May 20 2026, In: Neuron. 114, 10, p. 1878 1 p.Research output: Contribution to journal › Comment/debate
Current and Emerging Therapeutic Strategies for the Treatment of Duchenne Muscular Dystrophy
Lopez Perez, M. A. & Weisleder, N. L., May 2026, In: Genes. 17, 5, 533.Research output: Contribution to journal › Review article › peer-review
Dim light at night impacts circadian rhythms and Alzheimer’s disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice
Duncan, M. J., Hawkins, M. R., Bytyqi, L., Whitlock, H. R., Shepard, S. M., Cox, M. K. F., Drinkard, E. G., Macheda, T., Roberts, K. N., Kohler, K., Schmidt, M. C., Johnson, C. E., Sunderam, S., O'Hara, B. F., Murphy, M. P. & Bachstetter, A. D., Jun 2026, In: Sleep. 49, 6, 15 p., zsag041.Research output: Contribution to journal › Article › peer-review
Dysferlin's C2A domain supports normal Ca2+ signaling and membrane repair in dysferlin-null myofibers
Lukyanenko, V., Muriel, J., Banford, K. K., Kwiatkowski, T. A., Bulgart, H. R., Weisleder, N. & Bloch, R. J., Jul 6 2026, In: Journal of General Physiology. 158, 4, 22 p., e202513844.Research output: Contribution to journal › Article › peer-review
Enterococcus faecalis autolysin EpaU binds the enterococcal polysaccharide antigen via its teichoic acid-like repeats and modulates c-di-AMP signaling
Chaton, C. T., Murner, N. R., Zamakhaeva, S., Rush, J. S., Kenner, C. W., Yarawsky, A. E., Huang, L., Azadi, P., Herr, A. B., Korotkova, N. & Korotkov, K. V., Jun 15 2026, In: mBio. 17, 7, 28 p., e00988-26.Research output: Contribution to journal › Article › peer-review
Expression of the High-affinity Neurotensin Receptor Defines an Immune‑cold, Poor‑prognosis Colorectal Cancer Subtype
Wu, H., Wang, Y., Song, J., Yan, B., Wang, C., Liu, J., He, D., Weiss, H. L., Rychahou, P., Banerjee, M., Li, J. & Evers, B. M., Sep 1 2026, In: Annals of Surgery. 284, 3, p. 458-471 14 p.Research output: Contribution to journal › Article › peer-review
FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response
Banerjee, M., Zaytseva, Y. Y., Reusch, E. M., Napier, D. L., Hasani, S., Rychahou, P., Izumi, T., Cheek, D. A., Li, J., Flight, R. M., Moseley, H. N. B., Weiss, H. L., McCulloch, W., Evers, B. M. & Gao, T., May 15 2026, In: Cancer Research. 86, 10, p. 2522-2536 15 p.Research output: Contribution to journal › Article › peer-review
Get a GRIP: How cargo gets to platelet α-granules
Whiteheart, S. W., Apr 6 2026, In: Journal of Cell Biology. 225, 4, 2 p., e202602014.Research output: Contribution to journal › Article › peer-review
Glial cytokine modulation improves sleep and circadian disruption in female SAA knock-in mice of Alzheimer's-related pathology
Macheda, T., Hawkins, M. R., Johnson, C. E., Lapid, M. G., Whitlock, H. R., Shepard, S. M., Cox, M. K. F., Roberts, K. N., Bytyqi, L., Hash, H. M., El-Ezz, O. A. A., El-Ezz, M. A., Kohler, K., Sunderam, S., O'Hara, B. F., Van Eldik, L. J., Murphy, M. P., Duncan, M. J. & Bachstetter, A. D., Apr 2026, In: Alzheimer's and Dementia. 22, 4, e71314.Research output: Contribution to journal › Article › peer-review
High-Quality Predicted Metabolite-Pathway Annotations Expand Pathway Coverage and Increase Enriched Pathway Detection Across Metabolomics Datasets
Huckvale, E. D., Thompson, P. T., Flight, R. M. & Moseley, H. N. B., Aug 2026, In: Metabolites. 16, 8, 545.Research output: Contribution to journal › Article › peer-review
Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure
Welch, N., Kannan, P., Davuluri, G., Bellar, A., Attaway, A. H., Mishra, S., Cunningham, J. A., Kumar, A., Musich, R., Ertugral, E. G., Agrawal, V., Hsu, I. L., Harford, T. J., Weisleder, N. L., Vachharajani, V. T., Kothapalli, C. R., de la Motte, C. A., Nagy, L. E. & Dasarathy, S., Feb 2026, In: American Journal of Physiology - Heart and Circulatory Physiology. 330, 2, p. E212-E232Research output: Contribution to journal › Article › peer-review
Hyperglycosylation is a metabolic driver of Alzheimer’s disease
Hawkinson, T. R., Liu, Z., Ribas, R. A., Medina, T., Nielsen, R. S., Clarke, H. A., Ma, X., Mueller, A. C., Plasencia, A. F., Sheer, A. L., Simpson, S. T., Soto, C. M., Sudderth, J., Cai, F., Cantrell, A. R., Colpaert, M. G., Shedlock, C. J., Wu, L., Young, L. E. A. & Kooser, D. D. & 19 others, , Jun 2026, In: Nature Metabolism. 8, 6, p. 1410-1425 16 p.Research output: Contribution to journal › Article › peer-review
Identification of scavenger receptor BI as a scavenger of free heme that is essential for protection against hemolysis
Ito, M., Xue, J., Guo, L., Hao, D., Wang, Q., Williams, A. H., Zhan, C.-G., Ji, A., Shridas, P., Su, W., Liu, S., Guo, Z., Gong, M., Gordon, S., Huang, B., Jia, J., Mineo, C., Shaul, P. W. & Li, X., Dec 2026, In: Nature Communications. 17, 1, 12 p., 9108.Research output: Contribution to journal › Article › peer-review
Information-Content-Informed Kendall-Tau Correlation Methodology: Interpreting Missing Values in Metabolomics as Potentially Useful Information
Flight, R. M., Bhatt, P. S. & Moseley, H. N. B., Apr 2026, In: Metabolites. 16, 4, 245.Research output: Contribution to journal › Article › peer-review
Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice
Becker, I. C., Branfield, S., Barrachina, M. N., Camacho, V., Lykins, J., Stone, A. P., Walsey, E., Bennani, M., Chua, B. A., Signer, R. A. J., Machlus, K. R., Whiteheart, S. W., Roweth, H. G. & Italiano, J. E., Dec 2026, In: Nature Communications. 17, 1, 9750.Research output: Contribution to journal › Article › peer-review
Integrated multi-omic analyses reveal novel gene–metabolite relationships in human steatohepatitic hepatocellular carcinoma
Anspach, G. B., Flight, R. M., Park, S., He, D., Wang, C., Moseley, H. N. B. & Helsley, R. N., Jun 17 2026, In: Journal of Lipid Research. 67, 7, p. 1-18 18 p., 101081.Research output: Contribution to journal › Article › peer-review
Intracranial hypocapnia is associated with parenchymal ischemia and worsened outcomes following stroke
Dornbos, D., Frank, J. A., McLouth, C. J., Bender, A., Deschner, S., Franz, E., Millson, N., Bauerle, L., Brandenburg, S., Manhart, M., DiNitto, J., Karnik, K., Trout, A., Whiteheart, S., Sizdahkhani, S., Al-Kawaz, M., Fraser, J. F. & Pennypacker, K. R., 2026, (Accepted/In press) In: Journal of NeuroInterventional Surgery.Research output: Contribution to journal › Article › peer-review
In Vivo Electroporation of Plasmid DNA into the Skeletal Muscle of Dystrophic Mouse Models
Lopez Perez, M. A., Giarrano, G. N. & Weisleder, N. L., 2026, Methods in Molecular Biology. Vol. 2975. p. 239-249 11 p. (Methods in Molecular Biology; vol. 2975).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Lactobacillus iners at the nexus of microbiota, immunity, and pregnancy
Stemen, E. L. & Radka, C. D., Jun 2026, In: Journal of Reproductive Immunology. 175, 9 p., 104909.Research output: Contribution to journal › Review article › peer-review
Mass Spectrometry-Based Spatial Imaging of the Cochlea
Ribas, R. A., Tang, Q., Caffee, S. I., Shedlock, C. J., Hawkinson, T. R., Dragich, A. K., Ziani, B. E. C., Bucco Paolasso, F., Black, A. P., Ma, X., Kota, H. C., Chen, L., Frolenkov, G. I., Allison, D. B., Gentry, M. S., Sun, R. C. & Vander Kooi, C. W., May 6 2026, In: Journal of the American Society for Mass Spectrometry. 37, 5, p. 1187-1195 9 p.Research output: Contribution to journal › Article › peer-review
Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment
Rhee, S. W., Pokrovskaya, I. D., Ball, K. K., Webb, M. W., Kamykowski, J. A., Aronova, M. A., Leapman, R. D., Driehaus, E. R., Franz, E. S., Whiteheart, S. W. & Storrie, B., May 2026, In: Blood Vessels, Thrombosis and Hemostasis. 3, 2, 100154.Research output: Contribution to journal › Article › peer-review
NHE1-Mediated Metabolic Reprogramming in Cancer
Al-Hamaly, M. A., Forester, B. R. & Blackburn, J. S., Mar 2026, In: Metabolites. 16, 3, 195.Research output: Contribution to journal › Review article › peer-review
Nicotine self-administration suppresses both pro- and anti-inflammatory accumbens cytokines but does not induce apoptosis in female rats
White, A. M., Richie, D. L., Kendrick, P. T., McNealy, K. R., Flight, R. M., Moseley, H. N. B., Corley, C. L. & Gipson, C. D., Sep 2026, In: Addiction Neuroscience. 20, 12 p., 100263.Research output: Contribution to journal › Article › peer-review
Peripheral amylin modulation rebalances brain glycolysis and Tau-Ser214 phosphorylation via cAMP-PKA signaling
Davargaon, R. S., Verma, N., Kotiya, D., Leibold, N., Velmurugan, G. V., Coburn, H., Chen, K. C., Ruiz, D., Corces, V., Liu, H., Kachroo, P., Singh, P. K., Gentry, M. S., Despa, S. & Despa, F., Mar 20 2026, In: iScience. 29, 3, 115157.Research output: Contribution to journal › Article › peer-review
Platelet α-granule cargo packaging and endocytosis are important for normal mouse skin wound healing
Coenen, D. M., Alfar, H. R., Mohammadmoradi, S. & Whiteheart, S. W., Apr 14 2026, In: Blood advances. 10, 7, p. 2376-2394 19 p.Research output: Contribution to journal › Article › peer-review
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
Rao, X., Allison, D. B., Flight, R. M., Lin, P., He, D., Li, Z., Zhang, Y., Wang, R., Li, C., Wang, J., Wang, X., Peng, J., Fong, K. W., Shao, Q., Wang, C., Ali, E. S., Moseley, H. N. B. & Liu, X., Aug 4 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 31, e2618349123.Research output: Contribution to journal › Article › peer-review
Predicting the pathway involvement of metabolites annotated in the MetaCyc knowledgebase
Huckvale, E. D. & Moseley, H. N. B., Jan 7 2026, In: BMC Bioinformatics. 27, 1, 18 p., 36.Research output: Contribution to journal › Article › peer-review
Preoperative Glucagon-like Peptide-1 Therapy in Bariatric Surgery Patients with Morbid Obesity (PreMO): Rationale and Study Design for a Randomized Controlled Trial
Jain, V., McMullen, C. A., Kimbrough, J. I., Rockich, A. K., Davenport, D. L., Hawk, G. S., Nikolajczyk, B. S., Kern, P. A., Fisher, S. J., Steiner, J. P., Inabnet, W. B. & Starr, M. E., Mar 2026, In: Journal of Surgical Research. 319, p. 58-65 8 p., PMID 376340.Research output: Contribution to journal › Article › peer-review
Protocol for stable isotope tracing of primary human peripheral blood mononuclear cells
Hart, S. N., Williams, H., Inabnet, W. B., Steiner, J. P., Jain, V., Kern, P. A., Wood, C. R., Nikolajczyk, B. S. & Johnson, L. A., Jun 19 2026, In: STAR Protocols. 7, 2, 104450.Research output: Contribution to journal › Article › peer-review
Reduced Synaptophysin-like 2 (MG29/SYPL2) Levels Mimic Age-Related Alterations in Skeletal Muscle Calcium Homeostasis and Lipid Signaling
Awad, K., Huang, J., Aziz, M. N., Wang, Z., Brotto, L., Lee, K. E., Kim, J., Karthikraj, R., Gushchina, L. V., Weisleder, N. & Brotto, M., Jul 2026, In: Biomolecules. 16, 7, 29 p., 988.Research output: Contribution to journal › Article › peer-review
RNA-Micelles as Self-Assembling Structures for Efficient Co-Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis
Jin, K., Rychahou, P., Binzel, D. W., Evers, B. M. & Guo, P., Apr 27 2026, In: Advanced Functional Materials. 36, 34, e21863.Research output: Contribution to journal › Article › peer-review
Role of Rubicon in platelets: a promoter of thrombosis but not an autophagy repressor
Alfar, H. R., Driehaus, E. R., Smith, A. N., Coenen, D. M., Mahmood, D. F. D., Wood, J. P. & Whiteheart, S. W., Feb 24 2026, In: Blood advances. 10, 4, p. 1413-1425 13 p.Research output: Contribution to journal › Article › peer-review
Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation
Ocegueda, E., Chase, G., Niceforo, M., Javidan, A., Gugliuzza, L., Yu, J., Kang, R. Y., Lankowski, A., Stefanik, O., Leclerc, K., Valentine, Y., Drummond, M. J., Deeney, J. T., Modica-Napolitano, J. S., Proctor, E. A., Hasturk, H., Nikolajczyk, B. S. & Bharath, L. P., Apr 2026, In: Aging Cell. 25, 4, e70451.Research output: Contribution to journal › Article › peer-review
Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses
Wilson, P., Vishwakarma, V., Norcross, R., Khaire, K., Pham, V. N., Weinstein, B. M., Jung, H. M. & Galperin, E., 2026, (Accepted/In press) In: Cell Death and Differentiation.Research output: Contribution to journal › Article › peer-review
Spatial control of myosin regulatory light chain phosphorylation modulates cardiac thick filament mechanosensing
Squarci, C., Koch, D., Anaya, P., Campbell, K. S. & Kampourakis, T., Feb 10 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 6, e2520471123.Research output: Contribution to journal › Article › peer-review
Synthesis and Evaluation of Sulfobacin A and Analogues for Their Roles in Immunological Recognition
Chaudhary, C. L., Lages, P. C., Peña, A. M., Pinto, A. K., Radka, C. D. & Tidgewell, K. J., May 14 2026, In: ACS Medicinal Chemistry Letters. 17, 5, p. 1050-1056 7 p.Research output: Contribution to journal › Letter › peer-review
The platelet transcriptome after stem cell transplantation
Lin, L. I., Whiteheart, S. W. & Munker, R., Apr 2026, In: Clinical and Translational Discovery. 6, 2, 7 p., e70121.Research output: Contribution to journal › Letter › peer-review
The role of the myosin dimer in the contractility of the heart
Kampourakis, T., Sevrieva, I. R. & Irving, M., 2026, (Accepted/In press) In: Biophysical Reviews.Research output: Contribution to journal › Review article › peer-review
Understanding cardiac toxicity and immune responses to thoracic radiation therapy in non-small cell lung cancer – implications for future research
Chow, Z., McGarry, R. C., Miller, J., Mourad, W. F., Zinner, R., Evers, B. M. & Yan, W., 2026, In: Frontiers in Oncology. 16, p. 1-8 8 p., 1702343.Research output: Contribution to journal › Review article › peer-review
Understanding the role of age and U.S. acculturation factors on the relationship between allostatic load and cancer mortality risk in Hispanic Americans
Amezcua, J., Miranda, V., Lopez-Pentecost, M., Islam, J. Y., Vernon, M. M., O’Connor, K. & Moore, J. X., Jun 2026, In: Cancer Causes and Control. 37, 6, 86.Research output: Contribution to journal › Article › peer-review