Recent Publications
Our full departmental research profile can be found on Scholars@UK.
A Coaching-Based Training for Underrepresented Mentors in STEM
Tuck, M. E., Palomino, K. A., Bradley, J. A., Mohr-Schroeder, M. & Bradley, L. H., Mar 2025, In: Education Sciences. 15, 3Research output: Contribution to journal › Article › peer-review
ACTC1 Variants Result in Isolated and Syndromic Cardiac Phenotypes
Zarate, Y. A., Abdelmoti, L., Oh, S., White, A., Starks, C., Au, M. G., Chen, J., Weaver, N. K., Korotkov, K. V. & Galperin, E., 2025, (Accepted/In press) In: Clinical Genetics.Research output: Contribution to journal › Article › peer-review
ACTC1 Variants Result in Isolated and Syndromic Cardiac Phenotypes
Zarate, Y. A., Abdelmoti, L., Oh, S., White, A., Starks, C., Au, M. G., Chen, J., Weaver, N. K., Korotkov, K. V. & Galperin, E., May 27 2025, (E-pub ahead of print) In: Clinical Genetics.Research output: Contribution to journal › Article › peer-review
Age-related differences in resting glutamate levels and glutamate uptake in the hippocampus and frontal cortex of C57BL/6 mice
Pomerleau, F., Sulkowski, B. A., Suhail, C., Quintero, J. E., Littrell, O. M., Murphy, M. P., Huettl, P. & Gerhardt, G. A., Jun 2025, In: Neurobiology of Aging. 150, p. 146-156 11 p.Research output: Contribution to journal › Article › peer-review
A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation
Gao, L., Liu, J., Zhang, R., Chen, X., Wang, M., Dong, Y., Frasinyuk, M. S., Zhang, W., Watt, D., Meng, W., Xue, J., Liu, C., Cheng, Y. & Liu, X., Mar 2025, In: Biochemical Pharmacology. 233, 116783.Research output: Contribution to journal › Article › peer-review
Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain
Dutta, A., Roy, R., Pandey, M., Chhetry, S., Phukan, B. C., Roy, A., Bhattacharya, P. & Borah, A., Mar 15 2025, In: Brain Research. 1851, 149493.Research output: Contribution to journal › Article › peer-review
Astrocyte involvement in metabolic regulation and disease
Naveed, M., Smedlund, K., Zhou, Q. G., Cai, W. & Hill, J. W., Mar 2025, In: Trends in Endocrinology and Metabolism. 36, 3, p. 219-234 16 p.Research output: Contribution to journal › Review article › peer-review
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
SantaCruz-Calvo, S., Saraswat, S., Kalantar, G. H., Zukowski, E., Marszalkowski, H., Javidan, A., Gholamrezaeinejad, F., Bharath, L. P., Kern, P. A., Zhang, X. D. & Nikolajczyk, B. S., Jun 2025, In: GeroScience. 47, 3, p. 3725-3739 15 p.Research output: Contribution to journal › Article › peer-review
Challenges and opportunities in training cancer researchers
Keith, B., Welch, D. R., Agarwal, N., Blair, C., Chukwudozie, I. B., Shevde, L. A., Boise, L. H., Burnstein, K. L., Antalis, T. M., O’Connor, K. L., Dalal, S. N., Ellis, S. & Nakshatri, H., Feb 2025, In: Nature Cancer. 6, 2, p. 223-225 3 p.Research output: Contribution to journal › Comment/debate
Circular RNAs from the MAPT and TARDBP genes: Novel players in neurodegeneration?
Bagheri, N., Margvelani, G., Chiang, T. W., Nelson, P., Chuang, T. J. & Stamm, S., Oct 2025, In: Neurochemistry International. 189, 106019.Research output: Contribution to journal › Review article › peer-review
Cloning, expression, and characterization of collagen galactosyltransferases from human, sponge, and sea walnut
Kim, J. S., Chen, T., Zhang, B., Miller, T. M., Gilliam, M. E. & Guo, H., May 2025, In: Protein Expression and Purification. 229, 106685.Research output: Contribution to journal › Article › peer-review
Commentary: is trogocytosis relevant for chimeric antigen receptor-T cells?
Toolabi, B., Whiteheart, S. W. & Munker, R., Jun 1 2025, In: Oncologist. 30, 6, oyaf150.Research output: Contribution to journal › Comment/debate
Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward
Huang, Q., Lee, H. H., Volpe, B., Zhang, Q., Xue, C., Liu, B. C., Abuhasan, Y. R., Li, L., Yang, J. S., Egholm, J., Gutierrez-Vazquez, C., Li, A., Lee, A., Tang, S., Wong, C. W., Liu, T., Huang, Y., Ramos, R. L., Stout, R. F. & El Ouaamari, A. & 5 others, , Feb 2025, In: Molecular Psychiatry. 30, 2, p. 506-520 15 p., 33609.Research output: Contribution to journal › Article › peer-review
Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase
Lin, J., He, R., Qu, Z., Dong, J., Krabill, A. D., Wu, L., Bai, Y., Conroy, L. R., Bruntz, R. C., Miao, Y., Jassim, B. A., Babalola, B., Nguele Meke, F. G. B., Sun, R., Gentry, M. & Zhang, Z. Y., May 8 2025, In: Journal of Medicinal Chemistry. 68, 9, p. 9220-9240 21 p.Research output: Contribution to journal › Article › peer-review
Early changes in inflammation-related proteins in the cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage
Braun, D. J., Hatton, K. W., Fraser, J. F., Flight, R. M., Moseley, H. N. B., Bailey, C. S., Morganti, J. M., Zhang, B., Ariyapala, I. S., Kim, T. K. & Van Eldik, L. J., Jun 2025, In: Journal of Stroke and Cerebrovascular Diseases. 34, 6, 108304.Research output: Contribution to journal › Article › peer-review
Electrochemical Observation and pH Dependence of All Three Expected Redox Couples in an Extremophilic Bifurcating Electron Transfer Flavoprotein with Fused Subunits
Das, D., El Housseini, W., Brachi, M., Minteer, S. D. & Miller, A. F., Apr 28 2025, In: JACS Au. 5, 4, p. 1689-1706 18 p.Research output: Contribution to journal › Article › peer-review
Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer’s Disease Models
Bulgart, H. R., Lopez Perez, M. A. & Weisleder, N., Mar 2025, In: Biomolecules. 15, 3, 418.Research output: Contribution to journal › Article › peer-review
Epithelial-mesenchymal transition promotes metabolic reprogramming to suppress ferroptosis
Guo, W., Duan, Z., Wu, J. & Zhou, B. P., Jul 2025, In: Seminars in Cancer Biology. 112, p. 20-35 16 p.Research output: Contribution to journal › Review article › peer-review
Examining Geographic Disparity: Variation in Cancer Outcomes Within Appalachia
Burus, T., Hull, P. C., Lang Kuhs, K. A., Gao, T., Brainson, C. F. & Evers, B. M., Apr 1 2025, In: Journal of the American College of Surgeons. 240, 4, p. 425-436 12 p.Research output: Contribution to journal › Article › peer-review
Exploring Oxylipins in Host–Microbe Interactions and Their Impact on Infection and Immunity
Neff, R. J. & Radka, C. D., Mar 2025, In: Current Issues in Molecular Biology. 47, 3, 190.Research output: Contribution to journal › Review article › peer-review
GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis
Zhu, B., Pitts, M. G., Buoncristiani, M. D., Bryant, L. T., Lopez-Nunez, O., Gurria, J. P., Shedlock, C., Ribas, R., Keohane, S., Liu, J., Wang, C., Gentry, M., Shelman, N. R., Allison, D. B., Evers, B. M., Sun, R. & Rellinger, E. J., May 23 2025, In: Oncogene. 44, 18, p. 1272-1283 12 p., 100304.Research output: Contribution to journal › Article › peer-review
Glycogen drives tumour initiation and progression in lung adenocarcinoma
Clarke, H. A., Hawkinson, T. R., Shedlock, C. J., Medina, T., Ribas, R. A., Wu, L., Liu, Z., Ma, X., Xia, Y., Huang, Y., He, X., Chang, J. E., Young, L. E. A., Juras, J. A., Buoncristiani, M. D., James, A. N., Rushin, A., Merritt, M. E., Mestas, A. & Lamb, J. F. & 11 others, , May 2025, In: Nature Metabolism. 7, 5, p. 952-965 14 p., e44235.Research output: Contribution to journal › Article › peer-review
Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci
Rahman, M. M., Zamakhaeva, S., Rush, J. S., Chaton, C. T., Kenner, C. W., Hla, Y. M., Tsui, H.-C. T., Uversky, V. N., Winkler, M. E., Korotkov, K. V. & Korotkova, N., Apr 29 2025, In: Nature Communications. 16, 1, p. 4011Research output: Contribution to journal › Article › peer-review
Hsp47 drives obesity-associated breast cancer progression by enhancing asporin deposition in adipose tissue
Xiong, G., He, D., Napier, D., Chen, J., Shi, H., Li, C., Hurley, P. J., Wang, C., Zhu, H., Zhou, C., Bocklage, T. J. & Xu, R., Dec 2025, In: Breast Cancer Research. 27, 1, 125.Research output: Contribution to journal › Article › peer-review
Impact of aspirin therapy on progression of thoracic and abdominal aortic aneurysms
Mohammadmoradi, S., Heier, K., Driehaus, E. R., Alfar, H. R., Tyagi, S., McQuerry, K. & Whiteheart, S. W., Aug 2025, In: Atherosclerosis. 407, 119224.Research output: Contribution to journal › Article › peer-review
In-Silico Predictions of Drug Resistance in Lung Cancers With EGFR Mutation
Imam, I., Abbas, U. L., Gosser, C. M., Brainson, C. F., de Jong, W., Liu, X., Moseley, H. N. B., Qing, S., Zhang, S., Zinner, R. & Ellingson, S. R., Jun 20 2025, PASC 2025 - Platform for Advanced Scientific Computing Conference, Proceedings. (PASC 2025 - Platform for Advanced Scientific Computing Conference, Proceedings).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Interactions between daily sleep-wake rhythms, γ-secretase, and amyloid-β peptide pathology point to complex underlying relationships
Turton, S. M., Padgett, S., Maisel, M. T., Johnson, C. E., Buzinova, V. A., Barth, S. E., Kohler, K., Spearman, H. M., Macheda, T., Manauis, E. C., Guo, L. Z., Whitlock, H. R., Bachstetter, A. D., Sunderam, S., O'Hara, B. F., Duncan, M. J. & Murphy, M. P., Aug 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 6, 167840.Research output: Contribution to journal › Article › peer-review
Isoleucine Binding and Regulation of Escherichia coli and Staphylococcus aureus Threonine Dehydratase (IlvA)
Yun, M. K., Subramanian, C., Miller, K., Jackson, P., Radka, C. D. & Rock, C. O., Jul 1 2025, In: Biochemistry. 64, 13, p. 2793-2810 18 p.Research output: Contribution to journal › Article › peer-review
L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer
Xiao, J., Wang, J., Li, J., Xiao, J., Liu, C. C., Tan, L., Tu, Y., Yang, R., Pei, Y., Wang, M., Wong, J., Zhou, B. P., Li, J. & Feng, J., Dec 2025, In: Nature Communications. 16, 1, 231.Research output: Contribution to journal › Article › peer-review
L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds
Imam, I. A., Al Adawi, S., Liu, X., Ellingson, S., Brainson, C. F., Moseley, H. N. B., Zinner, R., Zhang, S. & Shao, Q., Mar 2025, In: Proteins: Structure, Function and Bioinformatics. 93, 3, p. 673-683 11 p.Research output: Contribution to journal › Article › peer-review
Lrtm1: A Novel Sensor of Insulin Signaling and Regulator of Metabolism and Activity
Yu, Y., Wang, G., Chen, W., Liu, X., Munoz, V. R., Cai, W., Gomes, A. S. & Kahn, C. R., May 2025, In: Diabetes. 74, 5Research output: Contribution to journal › Article › peer-review
Lysyl hydroxylase 2 glucosylates collagen VI to drive lung cancer progression
Wang, S., Guo, H., Fukushima, R., Terajima, M., Liu, M., Xiao, G. Y., Koudelková, L., Wu, C., Liu, X., Yu, J., Burris, E., Xu, J., Schiavinato, A., Russell, W. K., Yamauchi, M., Tan, X. & Kurie, J. M., Apr 1 2025, In: Journal of Clinical Investigation. 135, 7, e189197.Research output: Contribution to journal › Article › peer-review
Membrane Filtration of Nanoscale Biomaterials: Model System and Membrane Performance Evaluation for AAV2 Viral Vector Clarification and Recovery
Leach, M., Edmonds, K., Ingram, E., Dutch, R., Wickramasinghe, R., Chwatko, M. & Bhattacharyya, D., Feb 2025, In: Nanomaterials. 15, 4, 310.Research output: Contribution to journal › Article › peer-review
miR-181a-5p mediates the effects of BMP4 on intestinal cell proliferation and differentiation
Li, C., Zhou, Y., Yin, Z., Jiang, Y., Liu, J., Weiss, H. L., Wang, Q. & Evers, B. M., Dec 2025, In: Cell Death and Disease. 16, 1, 420.Research output: Contribution to journal › Article › peer-review
miR-27a-3p regulates intestinal cell proliferation and differentiation through Wnt/β-catenin signalling
Li, C., Zhou, Y., Jiang, Y., Yin, Z., Weiss, H. L., Wang, Q. & Evers, B. M., Feb 2025, In: Cell Proliferation. 58, 2, e13757.Research output: Contribution to journal › Article › peer-review
Neurotensin inhibits AMPK activity and concurrently enhances FABP1 expression in small intestinal epithelial cells associated with obesity and aging
Li, J., Song, J., Yan, B., Wu, H., Banerjee, M., Magnuson, L., Liu, Y., Zhang, S., Liu, J., Wang, C., Gao, T., Jia, J., Weiss, H. L. & Evers, B. M., Jun 2025, In: Experimental and Molecular Medicine. 57, 6, p. 1189-1201 13 p.Research output: Contribution to journal › Article › peer-review
Neurotensin promotes hepatic steatosis by regulating lipid uptake and mitochondrial adaptation in hepatocytes
Banerjee, M., Song, J., Yan, B., Wu, H., Norouzi, S., Sengoku, T., Sharma, S., Fan, T. W. M., Lee, E., He, D., Wang, C., Liu, J., Schmitt, T. M., Gao, T., Weiss, H. L., Li, J. & Evers, B. M., Dec 2025, In: Cell Death and Disease. 16, 1, 347.Research output: Contribution to journal › Article › peer-review
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity
Devilée, L. A. C., Salama, A. B. M., Miller, J. M., Reid, J. D., Ou, Q., Baraka, N. M., Abou Farraj, K., Jamal, M., Nong, Y., Rosengart, T. K., Andres, D., Satin, J., Mohamed, T. M. A., Hudson, J. E. & Abouleisa, R. R. E., Dec 2025, In: npj Regenerative Medicine. 10, 1, 1.Research output: Contribution to journal › Article › peer-review
Phosphatidylinositol 3-Kinase Signaling Enhances Intestinal Crypt Epithelial Cell Recovery after Radiation
Lynch, E. B., Kapur, N., Goretsky, T., Bradford, E. M., Vekaria, H., Bhogoju, S., Hassan, S. A., Pauw, E., Avdiushko, M. G., Lee, G., Gao, T., Sullivan, P. & Barrett, T., Aug 2025, In: American Journal of Pathology. 195, 8, p. 1411-1427 17 p.Research output: Contribution to journal › Article › peer-review
Predicting the Pathway Involvement of Compounds Annotated in the Reactome Knowledgebase
Huckvale, E. D. & Moseley, H. N. B., Mar 2025, In: Metabolites. 15, 3, 161.Research output: Contribution to journal › Article › peer-review
Protocol for high-power, brain-focused microwave fixation to define rodent metabolism
Cantrell, A. R., Hawkinson, T. R., Juras, J. A., Webb, M. B., Medina, T., Ribas, R. A., Collins, J., Bunnell, A. A., Young, L. E. A., Markussen, K. H., Andres, D. A., Long, J. R., Vander Kooi, C. W., Smith, B. N., Sun, R. C. & Gentry, M. S., Jun 20 2025, In: STAR Protocols. 6, 2, 103794.Research output: Contribution to journal › Article › peer-review
RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression
Kim, M., Liu, J., Zhang, Y., Wang, R., Goettl, R., Grasso, J., Allison, D. B., Wang, C., Gao, T., Liu, X. & Fong, K. W., Jun 16 2025, In: Journal of Clinical Investigation. 135, 12, e185119.Research output: Contribution to journal › Article › peer-review
S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance
Ganguly, S., Burikhanov, R., Sviripa, V. M., Ellingson, S., Jiang, J., Gosser, C. M., Orren, D., Goellner, E. M., Shenoy, G. G., Rao, M., D’orazio, J., Brainson, C. F., Zhan, C. G., Spielmann, P. H., Watt, D. S. & Rangnekar, V. M., 2025, In: International Journal of Biological Sciences. 21, 2, p. 454-472 19 p.Research output: Contribution to journal › Article › peer-review
Serglycin controls megakaryocyte retention of platelet factor 4 and influences megakaryocyte fate in bone marrow
Lykins, J., Becker, I. C., Camacho, V., Alfar, H. R., Park, J. W., Italiano, J. & Whiteheart, S. W., Jan 14 2025, In: Blood advances. 9, 1, p. 15-28 14 p.Research output: Contribution to journal › Article › peer-review
Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide
Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., Dec 2025, In: Nature Communications. 16, 1, 954.Research output: Contribution to journal › Article › peer-review
Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide
Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., Jan 22 2025, In: Nature Communications. 16, 1, p. 954Research output: Contribution to journal › Article › peer-review
Structure of an Fe2+-binding-deficient mimiviral collagen lysyl hydroxylase
Chen, T., Buhlheller, C. & Guo, H., Jun 1 2025, In: Acta Crystallographica Section F:Structural Biology Communications. 81, Pt 6, p. 235-240 6 p.Research output: Contribution to journal › Article › peer-review
Survival Disparity and the Unique Genomic and Microbiome Profiles of Colon Cancer in Appalachian Kentucky
McDonald, H. G., Reagan, A. M., Faisal, A. S. M., Goettl, R., Wang, C., Hoyd, R., Spakowicz, D., Evers, B. M., Kim, J. & Bhakta, A. S., Apr 1 2025, In: Journal of the American College of Surgeons. 240, 4, p. 612-624 13 p.Research output: Contribution to journal › Article › peer-review
Systematic Quality Assurance/Quality Control Framework for a Volatile Organic Compound Real-Time Monitoring Instrument, Autonomous Rugged Optical Multigas Analyzer for VOCs
Tay, H. C., Miller, A., Moseley, H. N. B., Beckley, L. & Pennell, K. G., Jun 10 2025, In: ACS Omega. 10, 22, p. 22627-22636 10 p.Research output: Contribution to journal › Article › peer-review
Temporal immune profiling in the cerebrospinal fluid and blood of patients with aneurysmal subarachnoid hemorrhage
Ujas, T. A., Anderson, K. L., Lutshumba, J., Hart, S. N., Turchan-Cholewo, J., Hatton, K. W., Bachstetter, A. D., Nikolajczyk, B. S. & Stowe, A. M., May 1 2025, In: Journal of Leukocyte Biology. 117, 5, qiaf038.Research output: Contribution to journal › Article › peer-review