Our full departmental research profile can be found on Scholars@UK.

Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content

Kipp, Z. A., Martinez, G. J., Bates, E. A., Maharramov, A. B., Flight, R. M., Moseley, H. N. B., Morris, A. J., Stec, D. E. & Hinds, T. D., Feb 2023, In: Metabolites. 13, 2, 215.

Research output: Contribution to journalArticlepeer-review

Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition

Maghsoud, Y., Vázquez-Montelongo, E. A., Yang, X., Liu, C., Jing, Z., Lee, J., Harger, M., Smith, A. K., Espinoza, M., Guo, H. F., Kurie, J. M., Dalby, K. N., Ren, P. & Cisneros, G. A., Feb 13 2023, In: Journal of Chemical Information and Modeling. 63, 3, p. 986-1001 16 p.

Research output: Contribution to journalArticlepeer-review

Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation

Li, C., Zhou, Y., Wei, R., Napier, D. L., Sengoku, T., Alstott, M. C., Liu, J., Wang, C., Zaytseva, Y. Y., Weiss, H. L., Wang, Q. & Evers, B. M., Jan 2023, In: CMGH. 15, 4, p. 931-947 17 p.

Research output: Contribution to journalArticlepeer-review

NF-<bold>κ</bold>B represses retinoic acid receptor–mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia

Song, H., Ye, X., Liao, Y., Zhang, S., Xu, D., Zhong, S., Jing, B., Wang, T., Sun, B., Xu, J., Guo, W., Li, K., Hu, M., Kuang, Y., Ling, J., Zhang, T., Wu, Y., Du, J., Yao, F., Chin, Y. E., & 3 othersWang, Q., Zhou, B. P. & Deng, J., Jan 10 2023, In: JCI insight. 8, 1, e153976.

Research output: Contribution to journalArticlepeer-review

Opioid Use After Colorectal Resection: Identifying Preoperative Risk Factors for Postoperative Use

Levy, B. E., Castle, J. T., Ebbitt, L. M., Kennon, C., McAtee, E., Davenport, D. L., Evers, B. M. & Bhakta, A., Mar 2023, In: Journal of Surgical Research. 283, p. 296-304 9 p.

Research output: Contribution to journalArticlepeer-review

Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors

Chen, F., Byrd, A. L., Liu, J., Flight, R. M., DuCote, T. J., Naughton, K. J., Song, X., Edgin, A. R., Lukyanchuk, A., Dixon, D. T., Gosser, C. M., Esoe, D. P., Jayswal, R. D., Orkin, S. H., Moseley, H. N. B., Wang, C. & Brainson, C. F., Dec 2023, In: Nature Communications. 14, 1, 336.

Research output: Contribution to journalArticlepeer-review

Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity

Hepowit, N. L., Blalock, E., Lee, S., Bretland, K. M., MacGurn, J. A. & Dickson, R. C., 2023, In: Aging. 15, 2, p. 472-491 20 p.

Research output: Contribution to journalArticlepeer-review

Structure-function analysis of the dual functioning mycobacterial virulence factors EspE and EspF

Prest, R. J., Korotkov, K. V. & Champion, P. A., Feb 10 2023, In: Biophysical Journal. 122, 3S1, p. 41a

Research output: Contribution to journalArticlepeer-review

Susan S. Smyth (1965-2022)

Parise, L. V., Coller, B. S., Whiteheart, S. W. & Patterson, C., Mar 1 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43, 3, p. 385-387 3 p.

Research output: Contribution to journalArticlepeer-review

Zebrafish Cancer Avatars: A Translational Platform for Analyzing Tumor Heterogeneity and Predicting Patient Outcomes

Al-Hamaly, M. A., Turner, L. T., Rivera-Martinez, A., Rodriguez, A. & Blackburn, J. S., Feb 2023, In: International Journal of Molecular Sciences. 24, 3, 2288.

Research output: Contribution to journalReview articlepeer-review

Academic Tracker: Software for tracking and reporting publications associated with authors and grants

Thompson, P. T., Powell, C. D. & Moseley, H. N. B., Nov 2022, In: PLoS ONE. 17, 11 November, e0277834.

Research output: Contribution to journalArticlepeer-review

Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice

Loon, A., Zamudio, F., Sanneh, A., Brown, B., Smeltzer, S., Brownlow, M. L., Quadri, Z., Peters, M., Weeber, E., Nash, K., Lee, D. C., Gordon, M. N., Morgan, D. & Selenica, M. L. B., Feb 2022, In: GeroScience. 44, 1, p. 173-194 22 p.

Research output: Contribution to journalArticlepeer-review

Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer

Xiong, X., Hasani, S., Young, L. E. A., Rivas, D. R., Skaggs, A. T., Martinez, R., Wang, C., Weiss, H. L., Gentry, M. S., Sun, R. C. & Gao, T., Oct 2022, In: Cell Death and Differentiation. 29, 10, p. 1913-1927 15 p.

Research output: Contribution to journalArticlepeer-review

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities

SantaCruz-Calvo, S., Bharath, L., Pugh, G., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B. & Nikolajczyk, B. S., Jan 2022, In: Nature Reviews Endocrinology. 18, 1, p. 23-42 20 p.

Research output: Contribution to journalReview articlepeer-review

Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes

Mills, R., Vogler, R. J., Bernard, M., Concolino, J., Hersh, L. B., Wei, Y., Hastings, J. T., Dziubla, T., Baldridge, K. C. & Bhattacharyya, D., Dec 2022, In: Communications Materials. 3, 1, 34.

Research output: Contribution to journalArticlepeer-review

Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor

Ostrakhovitch, E. A., Song, E. S., Macedo, J. K. A., Gentry, M. S., Quintero, J. E., van Horne, C. & Yamasaki, T. R., Jan 19 2022, In: Neuroscience Letters. 769, 136428.

Research output: Contribution to journalArticlepeer-review

Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells

Gedaly, R., Cornea, V., Turcios, L., Edmisson, J. S., Harris, D. D., Watt, D. S., Chapelin, F., Khurana, A., Mei, X., Liu, C., Taylor, I., Gonzalez-Valdivieso, J., Mitchel, H., Ruffing, A., Chishti, A., Orozco, G., Zwischenberger, J., Evers, B. M. & Marti, F., Dec 2022, In: Scientific Reports. 12, 1, 19112.

Research output: Contribution to journalArticlepeer-review

Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele

Gal, J., Katsumata, Y., Zhu, H., Srinivasan, S., Chen, J., Johnson, L. A., Wang, W. X., Golden, L. R., Wilcock, D. M., Jicha, G. A., Cykowski, M. D. & Nelson, P. T., Mar 2022, In: American Journal of Pathology. 192, 3, p. 564-578 15 p.

Research output: Contribution to journalArticlepeer-review

A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics

Prakhya, K. S., Luo, Y., Adkins, J., Hu, X., Wang, Q. J. & Whiteheart, S. W., Jul 2022, In: Research and Practice in Thrombosis and Haemostasis. 6, 5, e12755.

Research output: Contribution to journalArticlepeer-review

A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics

Prakhya, K. S., Luo, Y., Adkins, J., Hu, X., Wang, Q. J. & Whiteheart, S., Jul 1 2022, In: Research and Practice in Thrombosis and Haemostasis. 6, 5

Research output: Contribution to journalArticlepeer-review

ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis

Valenca, S. S., Dong, B. E., Gordon, E. M., Sun, R. C. & Waters, C. M., May 2022, In: American Journal of Respiratory Cell and Molecular Biology. 66, 5, p. 484-496 13 p.

Research output: Contribution to journalArticlepeer-review

Biliverdin regulates NR2E3 and zebrafish retinal photoreceptor development

Lee, Y-S., Connor, B., Titialii-Torres, K. F., Rockenhaus, A., Passamonte, S. & Morris, A., 2022, In: Scientific Reports. 12, 1, p. 7310

Research output: Contribution to journalArticlepeer-review

Characterization of Smoothened Phosphorylation and Activation

Jia, J., Han, Y., Cho, Y. S. & Jiang, J., 2022, Methods in Molecular Biology. p. 121-137 17 p. (Methods in Molecular Biology; vol. 2374).

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's Disease

Duncan, M. J., Guerriero, L. E., Kohler, K., Beechem, L. E., Gillis, B. D., Salisbury, F., Wessel, C., Wang, J., Sunderam, S., Bachstetter, A. D., O'Hara, B. F. & Murphy, M. P., Jan 15 2022, In: Neuroscience. 481, p. 111-122 12 p.

Research output: Contribution to journalArticlepeer-review

COMManding platelet α-granule cargo

Lykins, J. T. & Whiteheart, S. W., Feb 10 2022, In: Blood. 139, 6, p. 809-811 3 p.

Research output: Contribution to journalEditorial

Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus

Wu, W., Kim, J. S., Bailey, A. O., Russell, W. K., Richards, S. J., Chen, T., Chen, T., Chen, Z., Liang, B., Yamauchi, M. & Guo, H., Dec 2022, In: Scientific Reports. 12, 1, 16806.

Research output: Contribution to journalArticlepeer-review

Contrasting roles for two conserved arginines: Stabilizing flavin semiquinone or quaternary structure, in bifurcating electron transfer flavoproteins

Mohamed-Raseek, N. & Miller, A. F., Apr 1 2022, In: Journal of Biological Chemistry. 298, 4, 101733.

Research output: Contribution to journalArticlepeer-review

Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites

Lee, J. H., Mosher, E. P., Lee, Y. S., Bumpus, N. N. & Berger, J. M., Mar 17 2022, In: Cell Chemical Biology. 29, 3, p. 476-489.e6

Research output: Contribution to journalArticlepeer-review

Correction to: Oncogenic RIT1 mutations in lung adenocarcinoma (Oncogene, (2014), 33, 35, (4418-4423), 10.1038/onc.2013.581)

Berger, A. H., Imielinski, M., Duke, F., Wala, J., Kaplan, N., Shi, G. X., Andres, D. A. & Meyerson, M., May 6 2022, In: Oncogene. 41, 19, p. 2788 1 p.

Research output: Contribution to journalComment/debate

Correction to: Co-Targeting Plk1 and DNMT3a in Advanced Prostate Cancer (Advanced Science, (2021), 8, 13, (2101458), 10.1002/advs.202101458)

Zhang, Z., Cheng, L., Zhang, Q., Kong, Y., He, D., Li, K., Rea, M., Wang, J., Wang, R., Liu, J., Li, Z., Yuan, C., Liu, E., Fondufe-Mittendorf, Y. N., Li, L., Wang, C., Liu, X. & Han, T., Jul 15 2022, In: Advanced Science. 9, 20, 2202572.

Research output: Contribution to journalComment/debate

Demonstration of Hollow Fiber Membrane-Based Enclosed Space Air Remediation for Capture of an Aerosolized Synthetic SARS-CoV-2 Mimic and Pseudovirus Particles

Baldridge, K. C., Edmonds, K., Dziubla, T., Hilt, J. Z., Dutch, R. E. & Bhattacharyya, D., Feb 11 2022, In: ACS ES and T Engineering. 2, 2, p. 251-262 12 p.

Research output: Contribution to journalArticlepeer-review

Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

Guo, L., Zhang, W., Xie, Y., Chen, X., Olmstead, E. E., Lian, M., Zhang, B., Zaytseva, Y. Y., Mark Evers, B., Peter Spielmann, H., Liu, X., Watt, D. S. & Liu, C., May 2022, In: Molecular Cancer Therapeutics. 21, 5, p. 740-750 11 p.

Research output: Contribution to journalArticlepeer-review

Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly?

Huang, P., Zhao, C., Chen, C., Whiteheart, S. W. & Liu-Chen, L. Y., 2022, Handbook of Experimental Pharmacology. p. 83-96 14 p. (Handbook of Experimental Pharmacology; vol. 271).

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Dysregulation of Protein S in COVID-19

Sim, M. M. S. & Wood, J. P., Sep 2022, In: Best Practice and Research in Clinical Haematology. 35, 3, 101376.

Research output: Contribution to journalReview articlepeer-review

Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol content

Leachman, J. R., Cincinelli, C., Ahmed, N., Dalmasso, C., Xu, M., Gatineau, E., Nikolajczyk, B. S., Yiannikouris, F., Hinds, T. D. & Loria, A. S., Sep 1 2022, In: Life Sciences. 304, 120718.

Research output: Contribution to journalArticlepeer-review

Enhanced Inactivation of Pseudoparticles Containing SARS-CoV-2 S Protein Using Magnetic Nanoparticles and an Alternating Magnetic Field

Paul, P., Edmonds, K. L., Baldridge, K. C., Bhattacharyya, D., Dziubla, T., Dutch, R. E. & Hilt, J. Z., 2022, (Accepted/In press) In: ACS Applied Bio Materials.

Research output: Contribution to journalArticlepeer-review

Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of 13C-Bicarbonate Incorporation

Shon, H., Matveeva, E. A., Jull, E. C., Hu, Y., Coupet, T. A. & Lee, Y. S., Apr 5 2022, In: Biochemistry. 61, 7, p. 575-582 8 p.

Research output: Contribution to journalArticlepeer-review

Evidence supporting substrate channeling between domains of PAICS: A time-course analysis of 13C-bicarbonate incorporation

Shon, H., Lee, Y-S., Matveeva, E. A., Jull, E., Jou, V. & Hu, Y., 2022, In: Biochemistry. 61, 7, p. 575 582 p.

Research output: Contribution to journalArticlepeer-review

Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death

Zhang, Y., Wu, C., Li, L., Pandeya, A., Zhang, G., Cui, J., Kirchhofer, D., Wood, J. P., Smyth, S. S., Wei, Y. & Li, Z., Jun 1 2022, In: International Journal of Molecular Sciences. 23, 12, 6800.

Research output: Contribution to journalArticlepeer-review

Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinum

Sanchez, K. G., Prest, R. J., Nicholson, K. R., Korotkov, K. V. & Champion, P. A., Dec 2022, In: Journal of Bacteriology. 204, 12

Research output: Contribution to journalArticlepeer-review

Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents

Creeden, J. F., Kipp, Z. A., Xu, M., Flight, R. M., Moseley, H. N. B., Martinez, G. J., Lee, W. H., Alganem, K., Imami, A. S., McMullen, M. R., Roychowdhury, S., Nawabi, A. M., Hipp, J. A., Softic, S., Weinman, S. A., McCullumsmith, R., Nagy, L. E. & Hinds, T. D., Nov 2022, In: Hepatology. 76, 5, p. 1376-1388 13 p.

Research output: Contribution to journalArticlepeer-review

High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity

Conroy, L. R., Chang, J. E., Sun, Q., Clarke, H. A., Buoncristiani, M. D., Young, L. E. A., McDonald, R. J., Liu, J., Gentry, M. S., Allison, D. B. & Sun, R. C., Jan 2022, Stromal Signaling in Cancer. Angel, P. M. (ed.). p. 227-251 25 p. (Advances in Cancer Research; vol. 154).

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

How additives for tin halide perovskites influence the Sn4+ concentration

Joy, S., Atapattu, H. R., Sorensen, S., Pruett, H., Olivelli, A. B., Huckaba, A. J., Miller, A. F. & Graham, K. R., Jun 6 2022, In: Journal of Materials Chemistry A. 10, 25, p. 13278-13285 8 p.

Research output: Contribution to journalArticlepeer-review

hPG80 (Circulating Progastrin), a Novel Blood-Based Biomarker for Detection of Poorly Differentiated Neuroendocrine Carcinoma and Well Differentiated Neuroendocrine Tumors

Chauhan, A., Prieur, A., Kolesar, J., Arnold, S., Payen, L., Mahi, Y., Vire, B., Sands, M., Evers, B. M., Joubert, D. & Anthony, L., Feb 1 2022, In: Cancers. 14, 4, 863.

Research output: Contribution to journalArticlepeer-review

Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies

Boggs, K. B., Edmonds, K., Cifuentes-Munoz, N., Najjar, F. E., Ossandón, C., Roe, M., Wu, C., Moncman, C. L., Creamer, T. P., Amarasinghe, G. K., Leung, D. W. & Dutch, R. E., Jun 2022, In: mBio. 13, 3

Research output: Contribution to journalArticlepeer-review

Identification of Active Bronchioalveolar Stem Cells as the Cell of Origin in Lung Adenocarcinoma

Yin, H., Jing, B., Xu, D., Guo, W., Sun, B., Zhang, J., Liao, Y., Song, H., Wang, T., Liu, S., Kuang, Y., Hu, M., Li, K., Zhang, S., Zhang, H., Xu, J., Li, X., Du, J., Wu, Y., Wu, Y., & 5 othersWang, Q., Yao, F., Chin, Y. E., Zhou, B. P. & Deng, J., Mar 15 2022, In: Cancer Research. 82, 6, p. 1025-1037 13 p.

Research output: Contribution to journalArticlepeer-review

Impact of the Affordable Care Act Medicaid Expansion on Reimbursement in Emergency General Surgery

Madabhushi, V. V., Bautista, R. M. F., Davenport, D. L., Evers, B. M., Judge, J. M. & Bhakta, A. S., Jan 2022, In: Journal of Gastrointestinal Surgery. 26, 1, p. 191-196 6 p.

Research output: Contribution to journalArticlepeer-review

In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues

Young, L. E. A., Conroy, L. R., Clarke, H. A., Hawkinson, T. R., Bolton, K. E., Sanders, W. C., Chang, J. E., Webb, M. B., Alilain, W. J., Vander Kooi, C. W., Drake, R. R., Andres, D. A., Badgett, T. C., Wagner, L. M., Allison, D. B., Sun, R. C. & Gentry, M. S., Nov 8 2022, In: EMBO Molecular Medicine. 14, 11, e16029.

Research output: Contribution to journalArticlepeer-review

In situ spatial glycomic imaging of mouse and human Alzheimer's disease brains

Hawkinson, T. R., Clarke, H. A., Young, L. E. A., Conroy, L. R., Markussen, K. H., Kerch, K. M., Johnson, L., Nelson, P. T., Wang, C., Allison, D. B., Gentry, M. S. & Sun, R., Oct 2022, In: Alzheimer's and Dementia. 18, 10, p. 1721-1735 15 p.

Research output: Contribution to journalArticlepeer-review

Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growth

Qi, L., Knifley, T., Chen, M. & O’Connor, K. L., Jan 2022, In: Journal of Cell Science. 135, 2, 258471.

Research output: Contribution to journalArticlepeer-review