Recent Publications Molecular and Cellular Biochemistry Notable Achievements Biochemistry Publications Our full departmental research profile can be found on Scholars@UK. Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat ContentKipp, Z. A., Martinez, G. J., Bates, E. A., Maharramov, A. B., Flight, R. M., Moseley, H. N. B., Morris, A. J., Stec, D. E. & Hinds, T. D., Feb 2023, In: Metabolites. 13, 2, 215.Research output: Contribution to journal › Article › peer-review Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) InhibitionMaghsoud, Y., Vázquez-Montelongo, E. A., Yang, X., Liu, C., Jing, Z., Lee, J., Harger, M., Smith, A. K., Espinoza, M., Guo, H. F., Kurie, J. M., Dalby, K. N., Ren, P. & Cisneros, G. A., Feb 13 2023, In: Journal of Chemical Information and Modeling. 63, 3, p. 986-1001 16 p.Research output: Contribution to journal › Article › peer-review Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and DifferentiationLi, C., Zhou, Y., Wei, R., Napier, D. L., Sengoku, T., Alstott, M. C., Liu, J., Wang, C., Zaytseva, Y. Y., Weiss, H. L., Wang, Q. & Evers, B. M., Jan 2023, In: CMGH. 15, 4, p. 931-947 17 p.Research output: Contribution to journal › Article › peer-review NF-<bold>κ</bold>B represses retinoic acid receptor–mediated GPRC5A transactivation in lung epithelial cells to promote neoplasiaSong, H., Ye, X., Liao, Y., Zhang, S., Xu, D., Zhong, S., Jing, B., Wang, T., Sun, B., Xu, J., Guo, W., Li, K., Hu, M., Kuang, Y., Ling, J., Zhang, T., Wu, Y., Du, J., Yao, F., Chin, Y. E., & 3 othersWang, Q., Zhou, B. P. & Deng, J., Jan 10 2023, In: JCI insight. 8, 1, e153976.Research output: Contribution to journal › Article › peer-review Opioid Use After Colorectal Resection: Identifying Preoperative Risk Factors for Postoperative UseLevy, B. E., Castle, J. T., Ebbitt, L. M., Kennon, C., McAtee, E., Davenport, D. L., Evers, B. M. & Bhakta, A., Mar 2023, In: Journal of Surgical Research. 283, p. 296-304 9 p.Research output: Contribution to journal › Article › peer-review Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitorsChen, F., Byrd, A. L., Liu, J., Flight, R. M., DuCote, T. J., Naughton, K. J., Song, X., Edgin, A. R., Lukyanchuk, A., Dixon, D. T., Gosser, C. M., Esoe, D. P., Jayswal, R. D., Orkin, S. H., Moseley, H. N. B., Wang, C. & Brainson, C. F., Dec 2023, In: Nature Communications. 14, 1, 336.Research output: Contribution to journal › Article › peer-review Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevityHepowit, N. L., Blalock, E., Lee, S., Bretland, K. M., MacGurn, J. A. & Dickson, R. C., 2023, In: Aging. 15, 2, p. 472-491 20 p.Research output: Contribution to journal › Article › peer-review Structure-function analysis of the dual functioning mycobacterial virulence factors EspE and EspFPrest, R. J., Korotkov, K. V. & Champion, P. A., Feb 10 2023, In: Biophysical Journal. 122, 3S1, p. 41aResearch output: Contribution to journal › Article › peer-review Susan S. Smyth (1965-2022)Parise, L. V., Coller, B. S., Whiteheart, S. W. & Patterson, C., Mar 1 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43, 3, p. 385-387 3 p.Research output: Contribution to journal › Article › peer-review Zebrafish Cancer Avatars: A Translational Platform for Analyzing Tumor Heterogeneity and Predicting Patient OutcomesAl-Hamaly, M. A., Turner, L. T., Rivera-Martinez, A., Rodriguez, A. & Blackburn, J. S., Feb 2023, In: International Journal of Molecular Sciences. 24, 3, 2288.Research output: Contribution to journal › Review article › peer-review Academic Tracker: Software for tracking and reporting publications associated with authors and grantsThompson, P. T., Powell, C. D. & Moseley, H. N. B., Nov 2022, In: PLoS ONE. 17, 11 November, e0277834.Research output: Contribution to journal › Article › peer-review Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged miceLoon, A., Zamudio, F., Sanneh, A., Brown, B., Smeltzer, S., Brownlow, M. L., Quadri, Z., Peters, M., Weeber, E., Nash, K., Lee, D. C., Gordon, M. N., Morgan, D. & Selenica, M. L. B., Feb 2022, In: GeroScience. 44, 1, p. 173-194 22 p.Research output: Contribution to journal › Article › peer-review Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancerXiong, X., Hasani, S., Young, L. E. A., Rivas, D. R., Skaggs, A. T., Martinez, R., Wang, C., Weiss, H. L., Gentry, M. S., Sun, R. C. & Gao, T., Oct 2022, In: Cell Death and Differentiation. 29, 10, p. 1913-1927 15 p.Research output: Contribution to journal › Article › peer-review Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbiditiesSantaCruz-Calvo, S., Bharath, L., Pugh, G., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B. & Nikolajczyk, B. S., Jan 2022, In: Nature Reviews Endocrinology. 18, 1, p. 23-42 20 p.Research output: Contribution to journal › Review article › peer-review Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranesMills, R., Vogler, R. J., Bernard, M., Concolino, J., Hersh, L. B., Wei, Y., Hastings, J. T., Dziubla, T., Baldridge, K. C. & Bhattacharyya, D., Dec 2022, In: Communications Materials. 3, 1, 34.Research output: Contribution to journal › Article › peer-review Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremorOstrakhovitch, E. A., Song, E. S., Macedo, J. K. A., Gentry, M. S., Quintero, J. E., van Horne, C. & Yamasaki, T. R., Jan 19 2022, In: Neuroscience Letters. 769, 136428.Research output: Contribution to journal › Article › peer-review Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cellsGedaly, R., Cornea, V., Turcios, L., Edmisson, J. S., Harris, D. D., Watt, D. S., Chapelin, F., Khurana, A., Mei, X., Liu, C., Taylor, I., Gonzalez-Valdivieso, J., Mitchel, H., Ruffing, A., Chishti, A., Orozco, G., Zwischenberger, J., Evers, B. M. & Marti, F., Dec 2022, In: Scientific Reports. 12, 1, 19112.Research output: Contribution to journal › Article › peer-review Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 AlleleGal, J., Katsumata, Y., Zhu, H., Srinivasan, S., Chen, J., Johnson, L. A., Wang, W. X., Golden, L. R., Wilcock, D. M., Jicha, G. A., Cykowski, M. D. & Nelson, P. T., Mar 2022, In: American Journal of Pathology. 192, 3, p. 564-578 15 p.Research output: Contribution to journal › Article › peer-review A sensitive and adaptable method to measure platelet-fibrin clot contraction kineticsPrakhya, K. S., Luo, Y., Adkins, J., Hu, X., Wang, Q. J. & Whiteheart, S. W., Jul 2022, In: Research and Practice in Thrombosis and Haemostasis. 6, 5, e12755.Research output: Contribution to journal › Article › peer-review A sensitive and adaptable method to measure platelet-fibrin clot contraction kineticsPrakhya, K. S., Luo, Y., Adkins, J., Hu, X., Wang, Q. J. & Whiteheart, S., Jul 1 2022, In: Research and Practice in Thrombosis and Haemostasis. 6, 5Research output: Contribution to journal › Article › peer-review ASK1 Regulates Bleomycin-induced Pulmonary FibrosisValenca, S. S., Dong, B. E., Gordon, E. M., Sun, R. C. & Waters, C. M., May 2022, In: American Journal of Respiratory Cell and Molecular Biology. 66, 5, p. 484-496 13 p.Research output: Contribution to journal › Article › peer-review Biliverdin regulates NR2E3 and zebrafish retinal photoreceptor developmentLee, Y-S., Connor, B., Titialii-Torres, K. F., Rockenhaus, A., Passamonte, S. & Morris, A., 2022, In: Scientific Reports. 12, 1, p. 7310Research output: Contribution to journal › Article › peer-review Characterization of Smoothened Phosphorylation and ActivationJia, J., Han, Y., Cho, Y. S. & Jiang, J., 2022, Methods in Molecular Biology. p. 121-137 17 p. (Methods in Molecular Biology; vol. 2374).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's DiseaseDuncan, M. J., Guerriero, L. E., Kohler, K., Beechem, L. E., Gillis, B. D., Salisbury, F., Wessel, C., Wang, J., Sunderam, S., Bachstetter, A. D., O'Hara, B. F. & Murphy, M. P., Jan 15 2022, In: Neuroscience. 481, p. 111-122 12 p.Research output: Contribution to journal › Article › peer-review COMManding platelet α-granule cargoLykins, J. T. & Whiteheart, S. W., Feb 10 2022, In: Blood. 139, 6, p. 809-811 3 p.Research output: Contribution to journal › Editorial Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirusWu, W., Kim, J. S., Bailey, A. O., Russell, W. K., Richards, S. J., Chen, T., Chen, T., Chen, Z., Liang, B., Yamauchi, M. & Guo, H., Dec 2022, In: Scientific Reports. 12, 1, 16806.Research output: Contribution to journal › Article › peer-review Contrasting roles for two conserved arginines: Stabilizing flavin semiquinone or quaternary structure, in bifurcating electron transfer flavoproteinsMohamed-Raseek, N. & Miller, A. F., Apr 1 2022, In: Journal of Biological Chemistry. 298, 4, 101733.Research output: Contribution to journal › Article › peer-review Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolitesLee, J. H., Mosher, E. P., Lee, Y. S., Bumpus, N. N. & Berger, J. M., Mar 17 2022, In: Cell Chemical Biology. 29, 3, p. 476-489.e6Research output: Contribution to journal › Article › peer-review Correction to: Oncogenic RIT1 mutations in lung adenocarcinoma (Oncogene, (2014), 33, 35, (4418-4423), 10.1038/onc.2013.581)Berger, A. H., Imielinski, M., Duke, F., Wala, J., Kaplan, N., Shi, G. X., Andres, D. A. & Meyerson, M., May 6 2022, In: Oncogene. 41, 19, p. 2788 1 p.Research output: Contribution to journal › Comment/debate Correction to: Co-Targeting Plk1 and DNMT3a in Advanced Prostate Cancer (Advanced Science, (2021), 8, 13, (2101458), 10.1002/advs.202101458)Zhang, Z., Cheng, L., Zhang, Q., Kong, Y., He, D., Li, K., Rea, M., Wang, J., Wang, R., Liu, J., Li, Z., Yuan, C., Liu, E., Fondufe-Mittendorf, Y. N., Li, L., Wang, C., Liu, X. & Han, T., Jul 15 2022, In: Advanced Science. 9, 20, 2202572.Research output: Contribution to journal › Comment/debate Demonstration of Hollow Fiber Membrane-Based Enclosed Space Air Remediation for Capture of an Aerosolized Synthetic SARS-CoV-2 Mimic and Pseudovirus ParticlesBaldridge, K. C., Edmonds, K., Dziubla, T., Hilt, J. Z., Dutch, R. E. & Bhattacharyya, D., Feb 11 2022, In: ACS ES and T Engineering. 2, 2, p. 251-262 12 p.Research output: Contribution to journal › Article › peer-review Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer CellsGuo, L., Zhang, W., Xie, Y., Chen, X., Olmstead, E. E., Lian, M., Zhang, B., Zaytseva, Y. Y., Mark Evers, B., Peter Spielmann, H., Liu, X., Watt, D. S. & Liu, C., May 2022, In: Molecular Cancer Therapeutics. 21, 5, p. 740-750 11 p.Research output: Contribution to journal › Article › peer-review Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly?Huang, P., Zhao, C., Chen, C., Whiteheart, S. W. & Liu-Chen, L. Y., 2022, Handbook of Experimental Pharmacology. p. 83-96 14 p. (Handbook of Experimental Pharmacology; vol. 271).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review Dysregulation of Protein S in COVID-19Sim, M. M. S. & Wood, J. P., Sep 2022, In: Best Practice and Research in Clinical Haematology. 35, 3, 101376.Research output: Contribution to journal › Review article › peer-review Early life stress exacerbates obesity in adult female mice via mineralocorticoid receptor-dependent increases in adipocyte triglyceride and glycerol contentLeachman, J. R., Cincinelli, C., Ahmed, N., Dalmasso, C., Xu, M., Gatineau, E., Nikolajczyk, B. S., Yiannikouris, F., Hinds, T. D. & Loria, A. S., Sep 1 2022, In: Life Sciences. 304, 120718.Research output: Contribution to journal › Article › peer-review Enhanced Inactivation of Pseudoparticles Containing SARS-CoV-2 S Protein Using Magnetic Nanoparticles and an Alternating Magnetic FieldPaul, P., Edmonds, K. L., Baldridge, K. C., Bhattacharyya, D., Dziubla, T., Dutch, R. E. & Hilt, J. Z., 2022, (Accepted/In press) In: ACS Applied Bio Materials.Research output: Contribution to journal › Article › peer-review Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of 13C-Bicarbonate IncorporationShon, H., Matveeva, E. A., Jull, E. C., Hu, Y., Coupet, T. A. & Lee, Y. S., Apr 5 2022, In: Biochemistry. 61, 7, p. 575-582 8 p.Research output: Contribution to journal › Article › peer-review Evidence supporting substrate channeling between domains of PAICS: A time-course analysis of 13C-bicarbonate incorporationShon, H., Lee, Y-S., Matveeva, E. A., Jull, E., Jou, V. & Hu, Y., 2022, In: Biochemistry. 61, 7, p. 575 582 p.Research output: Contribution to journal › Article › peer-review Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell DeathZhang, Y., Wu, C., Li, L., Pandeya, A., Zhang, G., Cui, J., Kirchhofer, D., Wood, J. P., Smyth, S. S., Wei, Y. & Li, Z., Jun 1 2022, In: International Journal of Molecular Sciences. 23, 12, 6800.Research output: Contribution to journal › Article › peer-review Functional Analysis of EspM, an ESX-1-Associated Transcription Factor in Mycobacterium marinumSanchez, K. G., Prest, R. J., Nicholson, K. R., Korotkov, K. V. & Champion, P. A., Dec 2022, In: Journal of Bacteriology. 204, 12Research output: Contribution to journal › Article › peer-review Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodentsCreeden, J. F., Kipp, Z. A., Xu, M., Flight, R. M., Moseley, H. N. B., Martinez, G. J., Lee, W. H., Alganem, K., Imami, A. S., McMullen, M. R., Roychowdhury, S., Nawabi, A. M., Hipp, J. A., Softic, S., Weinman, S. A., McCullumsmith, R., Nagy, L. E. & Hinds, T. D., Nov 2022, In: Hepatology. 76, 5, p. 1376-1388 13 p.Research output: Contribution to journal › Article › peer-review High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneityConroy, L. R., Chang, J. E., Sun, Q., Clarke, H. A., Buoncristiani, M. D., Young, L. E. A., McDonald, R. J., Liu, J., Gentry, M. S., Allison, D. B. & Sun, R. C., Jan 2022, Stromal Signaling in Cancer. Angel, P. M. (ed.). p. 227-251 25 p. (Advances in Cancer Research; vol. 154).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review How additives for tin halide perovskites influence the Sn4+ concentrationJoy, S., Atapattu, H. R., Sorensen, S., Pruett, H., Olivelli, A. B., Huckaba, A. J., Miller, A. F. & Graham, K. R., Jun 6 2022, In: Journal of Materials Chemistry A. 10, 25, p. 13278-13285 8 p.Research output: Contribution to journal › Article › peer-review hPG80 (Circulating Progastrin), a Novel Blood-Based Biomarker for Detection of Poorly Differentiated Neuroendocrine Carcinoma and Well Differentiated Neuroendocrine TumorsChauhan, A., Prieur, A., Kolesar, J., Arnold, S., Payen, L., Mahi, Y., Vire, B., Sands, M., Evers, B. M., Joubert, D. & Anthony, L., Feb 1 2022, In: Cancers. 14, 4, 863.Research output: Contribution to journal › Article › peer-review Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like BodiesBoggs, K. B., Edmonds, K., Cifuentes-Munoz, N., Najjar, F. E., Ossandón, C., Roe, M., Wu, C., Moncman, C. L., Creamer, T. P., Amarasinghe, G. K., Leung, D. W. & Dutch, R. E., Jun 2022, In: mBio. 13, 3Research output: Contribution to journal › Article › peer-review Identification of Active Bronchioalveolar Stem Cells as the Cell of Origin in Lung AdenocarcinomaYin, H., Jing, B., Xu, D., Guo, W., Sun, B., Zhang, J., Liao, Y., Song, H., Wang, T., Liu, S., Kuang, Y., Hu, M., Li, K., Zhang, S., Zhang, H., Xu, J., Li, X., Du, J., Wu, Y., Wu, Y., & 5 othersWang, Q., Yao, F., Chin, Y. E., Zhou, B. P. & Deng, J., Mar 15 2022, In: Cancer Research. 82, 6, p. 1025-1037 13 p.Research output: Contribution to journal › Article › peer-review Impact of the Affordable Care Act Medicaid Expansion on Reimbursement in Emergency General SurgeryMadabhushi, V. V., Bautista, R. M. F., Davenport, D. L., Evers, B. M., Judge, J. M. & Bhakta, A. S., Jan 2022, In: Journal of Gastrointestinal Surgery. 26, 1, p. 191-196 6 p.Research output: Contribution to journal › Article › peer-review In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissuesYoung, L. E. A., Conroy, L. R., Clarke, H. A., Hawkinson, T. R., Bolton, K. E., Sanders, W. C., Chang, J. E., Webb, M. B., Alilain, W. J., Vander Kooi, C. W., Drake, R. R., Andres, D. A., Badgett, T. C., Wagner, L. M., Allison, D. B., Sun, R. C. & Gentry, M. S., Nov 8 2022, In: EMBO Molecular Medicine. 14, 11, e16029.Research output: Contribution to journal › Article › peer-review In situ spatial glycomic imaging of mouse and human Alzheimer's disease brainsHawkinson, T. R., Clarke, H. A., Young, L. E. A., Conroy, L. R., Markussen, K. H., Kerch, K. M., Johnson, L., Nelson, P. T., Wang, C., Allison, D. B., Gentry, M. S. & Sun, R., Oct 2022, In: Alzheimer's and Dementia. 18, 10, p. 1721-1735 15 p.Research output: Contribution to journal › Article › peer-review Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growthQi, L., Knifley, T., Chen, M. & O’Connor, K. L., Jan 2022, In: Journal of Cell Science. 135, 2, 258471.Research output: Contribution to journal › Article › peer-review
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