Recent Publications
Our full departmental research profile can be found on Scholars@UK.
A Major Update and Improved Validation Functionality in the mwtab Python Library and the Metabolomics Workbench File Status Website
Thompson, P. T. & Moseley, H. N. B., Jan 2026, In: Metabolites. 16, 1, 76.Research output: Contribution to journal › Article › peer-review
Animal Models of Aortic Aneurysm and Dissection: A Comparative Guide for Mechanism, Therapeutic Testing, and Translational Readouts
Mohammadmoradi, S. & Whiteheart, S. W., Jan 2026, In: Biomedicines. 14, 1, 170.Research output: Contribution to journal › Review article › peer-review
A Unique Protein Adjuvant for Precision Immunotherapy to Prevent Recurrence of Surgically Resected Colorectal Cancer
Suzuki, Y., Mani, R. & Evers, B. M., Mar 2026, In: Cancers. 18, 6, 1003.Research output: Contribution to journal › Review article › peer-review
Circadian rhythm of amyloid-β in the olfactory bulb and cerebellum of wild-type and APPxPS1 knock-in mice indicates a loss of rhythmicity in regions more vulnerable to amyloid pathology
Buzinova, V. A., Johnson, C. E., Turton, S. M., Barth, S. E., Padgett, S., Maisel, M. T., Kohler, K., Whitlock, H. R., Bachstetter, A. D., Sunderam, S., O’Hara, B. F., Duncan, M. J. & Murphy, M. P., Feb 2026, In: Biogerontology. 27, 1, 11.Research output: Contribution to journal › Article › peer-review
Colon cancer in Appalachian Kentucky: Unique genetic, microbiome and obesity findings in a cohort comparison
Chow, Z., Liu, J., He, D., Wang, C., Gan, T., Mansour, A., Shaker, N., Dravillas, C., Hoyd, R., Durbin, E., Napier, D., Gao, T., Schaberg, K., Huang, L., Ulrich, N., Siegel, E., Edge, S., Cook, L., Salhia, B. & Churchman, M. & 4 others, , Jan 15 2026, In: Human Genetics and Genomics Advances. 7, 1, 100527.Research output: Contribution to journal › Article › peer-review
Get a GRIP: How cargo gets to platelet α-granules
Whiteheart, S. W., Apr 6 2026, In: Journal of Cell Biology. 225, 4Research output: Contribution to journal › Article › peer-review
Glial cytokine modulation improves sleep and circadian disruption in female SAA knock-in mice of Alzheimer's-related pathology
Macheda, T., Hawkins, M. R., Johnson, C. E., Lapid, M. G., Whitlock, H. R., Shepard, S. M., Cox, M. K. F., Roberts, K. N., Bytyqi, L., Hash, H. M., El-Ezz, O. A. A., El-Ezz, M. A., Kohler, K., Sunderam, S., O'Hara, B. F., Van Eldik, L. J., Murphy, M. P., Duncan, M. J. & Bachstetter, A. D., Apr 2026, In: Alzheimer's and Dementia. 22, 4, e71314.Research output: Contribution to journal › Article › peer-review
Hyaluronan 35 prevents endotoxin-mediated dysregulated skeletal muscle proteostasis during ethanol exposure
Welch, N., Kannan, P., Davuluri, G., Bellar, A., Attaway, A. H., Mishra, S., Cunningham, J. A., Kumar, A., Musich, R., Ertugral, E. G., Agrawal, V., Hsu, I. L., Harford, T. J., Weisleder, N. L., Vachharajani, V. T., Kothapalli, C. R., de la Motte, C. A., Nagy, L. E. & Dasarathy, S., Feb 2026, In: American Journal of Physiology - Heart and Circulatory Physiology. 330, 2, p. E212-E232Research output: Contribution to journal › Article › peer-review
In Vivo Electroporation of Plasmid DNA into the Skeletal Muscle of Dystrophic Mouse Models
Lopez Perez, M. A., Giarrano, G. N. & Weisleder, N. L., 2026, Methods in Molecular Biology. p. 239-249 11 p. (Methods in Molecular Biology; vol. 2975).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Murine thrombus organization limits access to high platelet activation states while supporting platelet recruitment
Rhee, S. W., Pokrovskaya, I. D., Ball, K. K., Webb, M. W., Kamykowski, J. A., Aronova, M. A., Leapman, R. D., Driehaus, E. R., Franz, E. S., Whiteheart, S. W. & Storrie, B., May 2026, In: Blood Vessels, Thrombosis and Hemostasis. 3, 2, 100154.Research output: Contribution to journal › Article › peer-review
Peripheral amylin modulation rebalances brain glycolysis and Tau-Ser214 phosphorylation via cAMP-PKA signaling
Davargaon, R. S., Verma, N., Kotiya, D., Leibold, N., Velmurugan, G. V., Coburn, H., Chen, K. C., Ruiz, D., Corces, V., Liu, H., Kachroo, P., Singh, P. K., Gentry, M. S., Despa, S. & Despa, F., Mar 20 2026, In: iScience. 29, 3, 115157.Research output: Contribution to journal › Article › peer-review
Platelet α-granule cargo packaging and endocytosis are important for normal mouse skin wound healing
Coenen, D. M., Alfar, H. R., Mohammadmoradi, S. & Whiteheart, S. W., Apr 14 2026, In: Blood advances. 10, 7, p. 2376-2394 19 p.Research output: Contribution to journal › Article › peer-review
Preoperative Glucagon-like Peptide-1 Therapy in Bariatric Surgery Patients with Morbid Obesity (PreMO): Rationale and Study Design for a Randomized Controlled Trial
Jain, V., McMullen, C. A., Kimbrough, J. I., Rockich, A. K., Davenport, D. L., Hawk, G. S., Nikolajczyk, B. S., Kern, P. A., Fisher, S. J., Steiner, J. P., Inabnet, W. B. & Starr, M. E., Mar 2026, In: Journal of Surgical Research. 319, p. 58-65 8 p.Research output: Contribution to journal › Article › peer-review
Protocol for stable isotope tracing of primary human peripheral blood mononuclear cells
Hart, S. N., Williams, H., Inabnet, W. B., Steiner, J. P., Jain, V., Kern, P. A., Wood, C. R., Nikolajczyk, B. S. & Johnson, L. A., Jun 19 2026, In: STAR Protocols. 7, 2, 104450.Research output: Contribution to journal › Article › peer-review
RNA-Micelles as Self-Assembling Structures for Efficient Co-Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis
Jin, K., Rychahou, P., Binzel, D. W., Evers, B. M. & Guo, P., Apr 27 2026, In: Advanced Functional Materials. 36, 34, e21863.Research output: Contribution to journal › Article › peer-review
Role of Rubicon in platelets: a promoter of thrombosis but not an autophagy repressor
Alfar, H. R., Driehaus, E. R., Smith, A. N., Coenen, D. M., Mahmood, D. F. D., Wood, J. P. & Whiteheart, S. W., Feb 24 2026, In: Blood advances. 10, 4, p. 1413-1425 13 p.Research output: Contribution to journal › Article › peer-review
Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation
Ocegueda, E., Chase, G., Niceforo, M., Javidan, A., Gugliuzza, L., Yu, J., Kang, R. Y., Lankowski, A., Stefanik, O., Leclerc, K., Valentine, Y., Drummond, M. J., Deeney, J. T., Modica-Napolitano, J. S., Proctor, E. A., Hasturk, H., Nikolajczyk, B. S. & Bharath, L. P., Apr 2026, In: Aging Cell. 25, 4, e70451.Research output: Contribution to journal › Article › peer-review
Signaling scaffold Shoc2 regulates lymphangiogenesis by suppressing mTORC1-mediated IFN responses
Wilson, P., Vishwakarma, V., Norcross, R., Khaire, K., Pham, V. N., Weinstein, B. M., Jung, H. M. & Galperin, E., 2026, (Accepted/In press) In: Cell Death and Differentiation.Research output: Contribution to journal › Article › peer-review
The platelet transcriptome after stem cell transplantation
Lin, L. I., Whiteheart, S. W. & Munker, R., Apr 2026, In: Clinical and Translational Discovery. 6, 2, e70121.Research output: Contribution to journal › Letter › peer-review
A Coaching-Based Training for Underrepresented Mentors in STEM
Tuck, M. E., Palomino, K. A., Bradley, J. A., Mohr-Schroeder, M. & Bradley, L. H., Mar 2025, In: Education Sciences. 15, 3Research output: Contribution to journal › Article › peer-review
ACTC1 Variants Result in Isolated and Syndromic Cardiac Phenotypes
Zarate, Y. A., Abdelmoti, L., Oh, S., White, A., Starks, C., Au, M. G., Chen, J., Weaver, N. K., Korotkov, K. V. & Galperin, E., Dec 2025, In: Clinical Genetics. 108, 6, p. 713-719 7 p.Research output: Contribution to journal › Article › peer-review
ACTC1 Variants Result in Isolated and Syndromic Cardiac Phenotypes
Zarate, Y. A., Abdelmoti, L., Oh, S., White, A., Starks, C., Au, M. G., Chen, J., Weaver, N. K., Korotkov, K. V. & Galperin, E., May 27 2025, (E-pub ahead of print) In: Clinical Genetics.Research output: Contribution to journal › Article › peer-review
Age-related differences in resting glutamate levels and glutamate uptake in the hippocampus and frontal cortex of C57BL/6 mice
Pomerleau, F., Sulkowski, B. A., Suhail, C., Quintero, J. E., Littrell, O. M., Murphy, M. P., Huettl, P. & Gerhardt, G. A., Jun 2025, In: Neurobiology of Aging. 150, p. 146-156 11 p.Research output: Contribution to journal › Article › peer-review
A high-throughput workflow for assessing self-renewal using colony formation assays
Al-Hamaly, M. A. & Blackburn, J. S., Sep 2025, In: Stem Cell Research. 87, 103757.Research output: Contribution to journal › Article › peer-review
A hypothalamic circuit underlying the dynamic control of social homeostasis
Liu, D., Rahman, M., Johnson, A., Amo, R., Tsutsui-Kimura, I., Sullivan, Z. A., Pena, N., Talay, M., Logeman, B. L., Finkbeiner, S., Qian, L., Choi, S., Capo-Battaglia, A., Abdus-Saboor, I., Ginty, D. D., Uchida, N., Watabe-Uchida, M. & Dulac, C., Apr 24 2025, In: Nature. 640, 8060, p. 1000-1010 11 p.Research output: Contribution to journal › Article › peer-review
A molecular dynamic modeling and in silico analysis approach to three-dimensional structure of glutelin type-B 5-like proteins from proso millet: effects of temperature and electric field
Akharume, F., Singh, A., Korotkov, K. V. & Adedeji, A., 2025, In: Exploration of Foods and Foodomics. 3, 101088.Research output: Contribution to journal › Article › peer-review
A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation
Gao, L., Liu, J., Zhang, R., Chen, X., Wang, M., Dong, Y., Frasinyuk, M. S., Zhang, W., Watt, D., Meng, W., Xue, J., Liu, C., Cheng, Y. & Liu, X., Mar 2025, In: Biochemical Pharmacology. 233, 116783.Research output: Contribution to journal › Article › peer-review
APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition
Golden, L. R., Siano, D. S., Stephens, I. O., MacLean, S. M., Saito, K., Nolt, G. L., Funnell, J. L., Pallerla, A. V., Lee, S., Smith, C., Chen, J., Zhu, H., Voy, C., Whitus, C. M., Hernandez, G., Farmer, B. C., Pandya, K., Cowley, D. O., Macauley, S. L. & Gordon, S. M. & 2 others, , Dec 2025, In: Nature Neuroscience. 28, 12, p. 2461-2475 15 p.Research output: Contribution to journal › Article › peer-review
Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain
Dutta, A., Roy, R., Pandey, M., Chhetry, S., Phukan, B. C., Roy, A., Bhattacharya, P. & Borah, A., Mar 15 2025, In: Brain Research. 1851, 149493.Research output: Contribution to journal › Article › peer-review
Astrocyte involvement in metabolic regulation and disease
Naveed, M., Smedlund, K., Zhou, Q. G., Cai, W. & Hill, J. W., Mar 2025, In: Trends in Endocrinology and Metabolism. 36, 3, p. 219-234 16 p.Research output: Contribution to journal › Review article › peer-review
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
SantaCruz-Calvo, S., Saraswat, S., Kalantar, G. H., Zukowski, E., Marszalkowski, H., Javidan, A., Gholamrezaeinejad, F., Bharath, L. P., Kern, P. A., Zhang, X. D. & Nikolajczyk, B. S., Jun 2025, In: GeroScience. 47, 3, p. 3725-3739 15 p.Research output: Contribution to journal › Article › peer-review
Bacterial interactions with platelets: defining key themes
Alfar, H. R. & Whiteheart, S. W., 2025, In: Frontiers in Immunology. 16, 1610289.Research output: Contribution to journal › Review article › peer-review
Biological Plausibility Between Long-COVID and Periodontal Disease Development or Progression
Andriankaja, O. M., Whiteheart, S. & Mattos, M. B. D. A., Dec 2025, In: Biomedicines. 13, 12, 3023.Research output: Contribution to journal › Review article › peer-review
Cancer-associated fibroblast secreted DKK1 promotes the immunosuppressive tumor microenvironment and colorectal cancer resistance to chemotherapy
Yin, Z., Zhou, Y., Zhu, X., Goettl, R. A., Wang, C., Weiss, H. L., Evers, B. M. & Wang, Q., Dec 1 2025, In: Cancer Letters. 634, 218060.Research output: Contribution to journal › Article › peer-review
Cardiac Troponin: Fragments of the Future?
McGrath, S., Alaour, B., Kampourakis, T. & Marber, M., May 2025, In: JACC: Advances. 4, 5, 101695.Research output: Contribution to journal › Review article › peer-review
Challenges and opportunities in training cancer researchers
Keith, B., Welch, D. R., Agarwal, N., Blair, C., Chukwudozie, I. B., Shevde, L. A., Boise, L. H., Burnstein, K. L., Antalis, T. M., O’Connor, K. L., Dalal, S. N., Ellis, S. & Nakshatri, H., Feb 2025, In: Nature Cancer. 6, 2, p. 223-225 3 p.Research output: Contribution to journal › Comment/debate
Chronic Sleep Fragmentation Differentially Affects Alzheimer’s Disease Pathology in Male and Female APPSAA Knock-in Mice
Hawkins, M. R., Whitlock, H. R., Johnson, C. E., Macheda, T., Cox, M. K. F., Lapid, M. G., Roberts, K. N., Hash, H. M., Drinkard, E. G., Sunderam, S., O’Hara, B. F., Murphy, M. P., Duncan, M. J. & Bachstetter, A. D., 2025, In: Journal of Inflammation Research. 18, p. 14325-14341 17 p.Research output: Contribution to journal › Article › peer-review
Circular RNAs from the MAPT and TARDBP genes: Novel players in neurodegeneration?
Bagheri, N., Margvelani, G., Chiang, T. W., Nelson, P. T., Chuang, T. J. & Stamm, S., Oct 2025, In: Neurochemistry International. 189, 106019.Research output: Contribution to journal › Review article › peer-review
Cloning, expression, and characterization of collagen galactosyltransferases from human, sponge, and sea walnut
Kim, J. S., Chen, T., Zhang, B., Miller, T. M., Gilliam, M. E. & Guo, H., May 2025, In: Protein Expression and Purification. 229, 106685.Research output: Contribution to journal › Article › peer-review
Clot formation: Novel regulators, drugs, and targets
Wood, J. P. & Khasawneh, F. T., Oct 2025, In: Journal of Pharmacology and Experimental Therapeutics. 392, 10, 103707.Research output: Contribution to journal › Editorial
Commentary: is trogocytosis relevant for chimeric antigen receptor-T cells?
Toolabi, B., Whiteheart, S. W. & Munker, R., Jun 1 2025, In: Oncologist. 30, 6, oyaf150.Research output: Contribution to journal › Comment/debate
Cyclometalated Gold(III)-Mediated Cysteine Arylation: A Bioorthogonal Platform for Covalent Targeting of Intrinsically Disordered Proteins
Munugoda, U., Gilpatrick, S. T., Das, D., Parkin, S., Miller, A. F. & Awuah, S. G., Dec 8 2025, In: Angewandte Chemie - International Edition. 64, 50, e202516331.Research output: Contribution to journal › Article › peer-review
Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward
Huang, Q., Lee, H. H., Volpe, B., Zhang, Q., Xue, C., Liu, B. C., Abuhasan, Y. R., Li, L., Yang, J. S., Egholm, J., Gutierrez-Vazquez, C., Li, A., Lee, A., Tang, S., Wong, C. W., Liu, T., Huang, Y., Ramos, R. L., Stout, R. F. & El Ouaamari, A. & 5 others, , Feb 2025, In: Molecular Psychiatry. 30, 2, p. 506-520 15 p., 33609.Research output: Contribution to journal › Article › peer-review
Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase
Lin, J., He, R., Qu, Z., Dong, J., Krabill, A. D., Wu, L., Bai, Y., Conroy, L. R., Bruntz, R. C., Miao, Y., Jassim, B. A., Babalola, B., Nguele Meke, F. G. B., Sun, R., Gentry, M. S. & Zhang, Z. Y., May 8 2025, In: Journal of Medicinal Chemistry. 68, 9, p. 9220-9240 21 p.Research output: Contribution to journal › Article › peer-review
Discovery of glycerol phosphate and an immunogenic glycan motif in rhamnose-rich polysaccharides of Streptococcus uberis
Shi, Y., Widmalm, G., Korotkova, N., Molenaar, A., Holmes, M. A., McDougall, S., Bijlsma, J. J. E., van Sorge, N. M. & Benedictus, L., Jul 7 2025, In: Veterinary Research. 56, 1, p. 139 1 p.Research output: Contribution to journal › Article › peer-review
Dynamics of amylopectin granule accumulation during the course of chronic Toxoplasma infection is linked to intra-cyst bradyzoite replication
Tripathi, A., Donkin, R. W., Miracle, J. S., Murphy, R. D., Gentry, M. S., Patwardhan, A. & Sinai, A. P., Jul 2025, In: mSphere. 10, 7Research output: Contribution to journal › Article › peer-review
Early changes in inflammation-related proteins in the cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage
Braun, D. J., Hatton, K. W., Fraser, J. F., Flight, R. M., Moseley, H. N. B., Bailey, C. S., Morganti, J. M., Zhang, B., Ariyapala, I. S., Kim, T. K. & Van Eldik, L. J., Jun 2025, In: Journal of Stroke and Cerebrovascular Diseases. 34, 6, 108304.Research output: Contribution to journal › Article › peer-review
Electrochemical Observation and pH Dependence of All Three Expected Redox Couples in an Extremophilic Bifurcating Electron Transfer Flavoprotein with Fused Subunits
Das, D., El Housseini, W., Brachi, M., Minteer, S. D. & Miller, A. F., Apr 28 2025, In: JACS Au. 5, 4, p. 1689-1706 18 p.Research output: Contribution to journal › Article › peer-review
Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer’s Disease Models
Bulgart, H. R., Lopez Perez, M. A. & Weisleder, N., Mar 2025, In: Biomolecules. 15, 3, 418.Research output: Contribution to journal › Article › peer-review
Epithelial-mesenchymal transition promotes metabolic reprogramming to suppress ferroptosis
Guo, W., Duan, Z., Wu, J. & Zhou, B. P., Jul 2025, In: Seminars in Cancer Biology. 112, p. 20-35 16 p.Research output: Contribution to journal › Review article › peer-review