Our full departmental research profile can be found on Scholars@UK.
A Coaching-Based Training for Underrepresented Mentors in STEM
Tuck, M. E., Palomino, K. A., Bradley, J. A., Mohr-Schroeder, M. & Bradley, L. H., Mar 2025, In: Education Sciences. 15, 3Research output: Contribution to journal › Article › peer-review
Age-related differences in resting glutamate levels and glutamate uptake in the hippocampus and frontal cortex of C57BL/6 mice
Pomerleau, F., Sulkowski, B. A., Suhail, C., Quintero, J. E., Littrell, O. M., Murphy, M. P., Huettl, P. & Gerhardt, G. A., Jun 2025, In: Neurobiology of Aging. 150, p. 146-156 11 p.Research output: Contribution to journal › Article › peer-review
A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation
Gao, L., Liu, J., Zhang, R., Chen, X., Wang, M., Dong, Y., Frasinyuk, M. S., Zhang, W., Watt, D., Meng, W., Xue, J., Liu, C., Cheng, Y. & Liu, X., Mar 2025, In: Biochemical Pharmacology. 233, 116783.Research output: Contribution to journal › Article › peer-review
Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain
Dutta, A., Roy, R., Pandey, M., Chhetry, S., Phukan, B. C., Roy, A., Bhattacharya, P. & Borah, A., Mar 15 2025, In: Brain Research. 1851, 149493.Research output: Contribution to journal › Article › peer-review
Astrocyte involvement in metabolic regulation and disease
Naveed, M., Smedlund, K., Zhou, Q. G., Cai, W. & Hill, J. W., Mar 2025, In: Trends in Endocrinology and Metabolism. 36, 3, p. 219-234 16 p.Research output: Contribution to journal › Review article › peer-review
Cloning, expression, and characterization of collagen galactosyltransferases from human, sponge, and sea walnut
Kim, J. S., Chen, T., Zhang, B., Miller, T. M., Gilliam, M. E. & Guo, H., May 2025, In: Protein Expression and Purification. 229, 106685.Research output: Contribution to journal › Article › peer-review
Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward
Huang, Q., Lee, H. H., Volpe, B., Zhang, Q., Xue, C., Liu, B. C., Abuhasan, Y. R., Li, L., Yang, J. S., Egholm, J., Gutierrez-Vazquez, C., Li, A., Lee, A., Tang, S., Wong, C. W., Liu, T., Huang, Y., Ramos, R. L., Stout, R. F. & El Ouaamari, A. & 5 others, , Feb 2025, In: Molecular Psychiatry. 30, 2, p. 506-520 15 p., 33609.Research output: Contribution to journal › Article › peer-review
Early changes in inflammation-related proteins in the cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage
Braun, D. J., Hatton, K. W., Fraser, J. F., Flight, R. M., Moseley, H. N. B., Bailey, C. S., Morganti, J. M., Zhang, B., Ariyapala, I. S., Kim, T. K. & Van Eldik, L. J., Jun 2025, In: Journal of Stroke and Cerebrovascular Diseases. 34, 6, 108304.Research output: Contribution to journal › Article › peer-review
Electrochemical Observation and pH Dependence of All Three Expected Redox Couples in an Extremophilic Bifurcating Electron Transfer Flavoprotein with Fused Subunits
Das, D., El Housseini, W., Brachi, M., Minteer, S. D. & Miller, A. F., 2025, (Accepted/In press) In: JACS Au.Research output: Contribution to journal › Article › peer-review
Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer’s Disease Models
Bulgart, H. R., Lopez Perez, M. A. & Weisleder, N., Mar 2025, In: Biomolecules. 15, 3, 418.Research output: Contribution to journal › Article › peer-review
Epithelial-mesenchymal transition promotes metabolic reprogramming to suppress ferroptosis
Guo, W., Duan, Z., Wu, J. & Zhou, B. P., Jul 2025, In: Seminars in Cancer Biology. 112, p. 20-35 16 p.Research output: Contribution to journal › Review article › peer-review
Examining Geographic Disparity: Variation in Cancer Outcomes Within Appalachia
Burus, T., Hull, P. C., Lang Kuhs, K. A., Gao, T., Brainson, C. F. & Evers, B. M., Apr 1 2025, In: Journal of the American College of Surgeons. 240, 4, p. 425-436 12 p.Research output: Contribution to journal › Article › peer-review
Exploring Oxylipins in Host–Microbe Interactions and Their Impact on Infection and Immunity
Neff, R. J. & Radka, C. D., Mar 2025, In: Current Issues in Molecular Biology. 47, 3, 190.Research output: Contribution to journal › Review article › peer-review
GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis
Zhu, B., Pitts, M. G., Buoncristiani, M. D., Bryant, L. T., Lopez-Nunez, O., Gurria, J. P., Shedlock, C., Ribas, R., Keohane, S., Liu, J., Wang, C., Gentry, M. S., Shelman, N. R., Allison, D. B., Evers, B. M., Sun, R. C. & Rellinger, E. J., May 23 2025, In: Oncogene. 44, 18, p. 1272-1283 12 p., 100304.Research output: Contribution to journal › Article › peer-review
Glycogen drives tumour initiation and progression in lung adenocarcinoma
Clarke, H. A., Hawkinson, T. R., Shedlock, C. J., Medina, T., Ribas, R. A., Wu, L., Liu, Z., Ma, X., Xia, Y., Huang, Y., He, X., Chang, J. E., Young, L. E. A., Juras, J. A., Buoncristiani, M. D., James, A. N., Rushin, A., Merritt, M. E., Mestas, A. & Lamb, J. F. & 11 others, , 2025, (Accepted/In press) In: Nature Metabolism. e44235.Research output: Contribution to journal › Article › peer-review
Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci
Rahman, M. M., Zamakhaeva, S., Rush, J. S., Chaton, C. T., Kenner, C. W., Hla, Y. M., Tsui, H.-C. T., Uversky, V. N., Winkler, M. E., Korotkov, K. V. & Korotkova, N., Apr 29 2025, In: Nature Communications. 16, 1, p. 4011Research output: Contribution to journal › Article › peer-review
Interactions between daily sleep-wake rhythms, γ-secretase, and amyloid-β peptide pathology point to complex underlying relationships
Turton, S. M., Padgett, S., Maisel, M. T., Johnson, C. E., Buzinova, V. A., Barth, S. E., Kohler, K., Spearman, H. M., Macheda, T., Manauis, E. C., Guo, L. Z., Whitlock, H. R., Bachstetter, A. D., Sunderam, S., O'Hara, B. F., Duncan, M. & Murphy, M., Aug 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 6, 167840.Research output: Contribution to journal › Article › peer-review
L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer
Xiao, J., Wang, J., Li, J., Xiao, J., Liu, C. C., Tan, L., Tu, Y., Yang, R., Pei, Y., Wang, M., Wong, J., Zhou, B. P., Li, J. & Feng, J., Dec 2025, In: Nature Communications. 16, 1, 231.Research output: Contribution to journal › Article › peer-review
L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds
Imam, I. A., Al Adawi, S., Liu, X., Ellingson, S., Brainson, C. F., Moseley, H. N. B., Zinner, R., Zhang, S. & Shao, Q., Mar 2025, In: Proteins: Structure, Function and Bioinformatics. 93, 3, p. 673-683 11 p.Research output: Contribution to journal › Article › peer-review
Lysyl hydroxylase 2 glucosylates collagen VI to drive lung cancer progression
Wang, S., Guo, H., Fukushima, R., Terajima, M., Liu, M., Xiao, G. Y., Koudelková, L., Wu, C., Liu, X., Yu, J., Burris, E., Xu, J., Schiavinato, A., Russell, W. K., Yamauchi, M., Tan, X. & Kurie, J. M., Apr 1 2025, In: Journal of Clinical Investigation. 135, 7, e189197.Research output: Contribution to journal › Article › peer-review
Membrane Filtration of Nanoscale Biomaterials: Model System and Membrane Performance Evaluation for AAV2 Viral Vector Clarification and Recovery
Leach, M., Edmonds, K., Ingram, E., Dutch, R., Wickramasinghe, R., Chwatko, M. & Bhattacharyya, D., Feb 2025, In: Nanomaterials. 15, 4, 310.Research output: Contribution to journal › Article › peer-review
miR-27a-3p regulates intestinal cell proliferation and differentiation through Wnt/β-catenin signalling
Li, C., Zhou, Y., Jiang, Y., Yin, Z., Weiss, H. L., Wang, Q. & Evers, B. M., Feb 2025, In: Cell Proliferation. 58, 2, e13757.Research output: Contribution to journal › Article › peer-review
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity
Devilée, L. A. C., Salama, A. B. M., Miller, J. M., Reid, J. D., Ou, Q., Baraka, N. M., Abou Farraj, K., Jamal, M., Nong, Y., Rosengart, T. K., Andres, D., Satin, J., Mohamed, T. M. A., Hudson, J. E. & Abouleisa, R. R. E., Dec 2025, In: npj Regenerative Medicine. 10, 1, 1.Research output: Contribution to journal › Article › peer-review
Predicting the Pathway Involvement of Compounds Annotated in the Reactome Knowledgebase
Huckvale, E. D. & Moseley, H. N. B., Mar 2025, In: Metabolites. 15, 3, 161.Research output: Contribution to journal › Article › peer-review
S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance
Ganguly, S., Burikhanov, R., Sviripa, V. M., Ellingson, S., Jiang, J., Gosser, C. M., Orren, D., Goellner, E. M., Shenoy, G. G., Rao, M., D’orazio, J., Brainson, C. F., Zhan, C. G., Spielmann, P. H., Watt, D. S. & Rangnekar, V. M., 2025, In: International Journal of Biological Sciences. 21, 2, p. 454-472 19 p.Research output: Contribution to journal › Article › peer-review
Serglycin controls megakaryocyte retention of platelet factor 4 and influences megakaryocyte fate in bone marrow
Lykins, J., Becker, I. C., Camacho, V., Alfar, H. R., Park, J. W., Italiano, J. & Whiteheart, S. W., Jan 14 2025, In: Blood advances. 9, 1, p. 15-28 14 p.Research output: Contribution to journal › Article › peer-review
Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide
Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., Jan 22 2025, In: Nature Communications. 16, 1, p. 954Research output: Contribution to journal › Article › peer-review
Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide
Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., Dec 2025, In: Nature Communications. 16, 1, 954.Research output: Contribution to journal › Article › peer-review
Survival Disparity and the Unique Genomic and Microbiome Profiles of Colon Cancer in Appalachian Kentucky
McDonald, H. G., Reagan, A. M., Faisal, A. S. M., Goettl, R., Wang, C., Hoyd, R., Spakowicz, D., Evers, B. M., Kim, J. & Bhakta, A. S., Apr 1 2025, In: Journal of the American College of Surgeons. 240, 4, p. 612-624 13 p.Research output: Contribution to journal › Article › peer-review
The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia
Al-Hamaly, M. A., Winter, E. & Blackburn, J. S., 2025, In: Cancer Biology and Therapy. 26, 1, 2460252.Research output: Contribution to journal › Article › peer-review
The PACT Network: PRL, ARL, CNNM, and TRPM Proteins in Magnesium Transport and Disease
Jolly, J. T. & Blackburn, J. S., Feb 2025, In: International Journal of Molecular Sciences. 26, 4, 1528.Research output: Contribution to journal › Review article › peer-review
The Role of Race/Ethnicity on the Association between Neighborhood Deprivation and Breast Cancer Outcomes among Kentucky Patients with Breast Cancer (2010–2022)
Walker, B., Pollard, E., Howard, S. P., Jones, V. M., O’Connor, K. L., Durbin, E. B., Hull, P. C., Jones, S. R., Adegboyega, A., Wang, X., Owen, W. A. B., Szabunio, M. M., Williams, L. B. & Moore, J. X., Apr 1 2025, In: Cancer Epidemiology Biomarkers and Prevention. 34, 4, p. 474-482 9 p.Research output: Contribution to journal › Article › peer-review
Translation of circular RNAs
Margvelani, G., Maquera, K. A. A., Welden, J. R., Rodgers, D. W. & Stamm, S., Jan 13 2025, In: Nucleic Acids Research. 53, 1, gkae1167.Research output: Contribution to journal › Article › peer-review
A cautionary tale about properly vetting datasets used in supervised learning predicting metabolic pathway involvement
Huckvale, E. D. & Moseley, H. N. B., May 2024, In: PLoS ONE. 19, 5 MAY, e0299583.Research output: Contribution to journal › Article › peer-review
A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial–mesenchymal plasticity.
Rea, M., Kimmerer, G., Mittendorf, S., Xiong, X., Green, M., Chandler, D., Saintilnord, W., Blackburn, J., Gao, T. & Fondufe-Mittendorf, Y. N., Apr 15 2024, In: Environmental Pollution. 347, 123586.Research output: Contribution to journal › Article › peer-review
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H. & Ng, H. L. & 667 others, , Dec 2024, In: Scientific Reports. 14, 1, 7526.Research output: Contribution to journal › Article › peer-review
Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression
Zhang, H., Sun, X., Li, Z., Liu, T., Zhang, F., Meng, X., Li, K., Xu, J., He, W., Jing, B., Wang, T., Ni, N., Sun, B., Yao, F., Wu, Y., Wang, Q., Du, J., Chin, E. Y., Zhou, B. P. & Jiang, P. & 2 others, , May 2024, In: Genes and Diseases. 11, 3, 100999.Research output: Contribution to journal › Article › peer-review
A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer
Mani, R., Martin, C. G., Balu, K. E., Wang, Q., Rychahou, P., Izumi, T., Evers, B. M. & Suzuki, Y., Jan 2024, In: Cells. 13, 2, 111.Research output: Contribution to journal › Article › peer-review
A Probabilistic Approach to Estimate the Temporal Order of Pathway Mutations Accounting for Intra-Tumor Heterogeneity
Wang, M., Xie, Y., Liu, J., Li, A., Chen, L., Stromberg, A., Arnold, S. M., Liu, C. & Wang, C., Jul 2024, In: Cancers. 16, 13, 2488.Research output: Contribution to journal › Article › peer-review
A single hydrogen bond that tunes flavin redox reactivity and activates it for modification
Das, D. & Miller, A. F., Apr 24 2024, In: Chemical Science. 15, 20, p. 7610-7622 13 p.Research output: Contribution to journal › Article › peer-review
Atypical Mycobacterium abscessus BlaRI Ortholog Mediates Regulation of Energy Metabolism but Not β-Lactam Resistance
Bonefont, L. E., Davenport, H. C., Chaton, C. T., Korotkov, K. V. & Rohde, K. H., Sep 22 2024, (E-pub ahead of print) In: Molecular Microbiology.Research output: Contribution to journal › Article › peer-review
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
SantaCruz-Calvo, S., Saraswat, S., Kalantar, G. H., Zukowski, E., Marszalkowski, H., Javidan, A., Gholamrezaeinejad, F., Bharath, L. P., Kern, P. A., Zhang, X. D. & Nikolajczyk, B. S., 2024, (Accepted/In press) In: GeroScience.Research output: Contribution to journal › Article › peer-review
Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1
Melikishvili, M., Fried, M. G. & Fondufe-Mittendorf, Y. N., Dec 2024, In: Scientific Reports. 14, 1, 7530.Research output: Contribution to journal › Article › peer-review
Correction to: NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer (Molecular Cancer, (2024), 23, 1, (188), 10.1186/s12943-024-02102-y)
Ngule, C., Shi, R., Ren, X., Jia, H., Oyelami, F., Li, D., Park, Y., Kim, J., Hemati, H., Zhang, Y., Xiong, X., Shinkle, A., Vanderford, N. L., Bachert, S., Zhou, B. P., Wang, J., Song, J., Liu, X. & Yang, J., Dec 2024, In: Molecular Cancer. 23, 1, 220.Research output: Contribution to journal › Comment/debate
Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
The Atomwise AIMS Program, Dec 2024, In: Scientific Reports. 14, 1, 21579.Research output: Contribution to journal › Comment/debate
Creating an Integrated Coaching Culture in Higher Education
Bradley, J. A., Tuck, M. E., Reynolds, M. A. & Bradley, L. H., 2024, In: Journal of appreciative education. 11, p. 15-24 10 p.Research output: Contribution to journal › Article › peer-review
Cryo-EM reconstruction of oleate hydratase bound to a phospholipid membrane bilayer
Oldham, M. L., Zuhaib Qayyum, M., Kalathur, R. C., Rock, C. O. & Radka, C. D., Sep 2024, In: Journal of Structural Biology. 216, 3, 108116.Research output: Contribution to journal › Article › peer-review
Differential processing of VesB by two rhomboid proteases in Vibrio cholerae.
Roberts, C. S., Shannon, A. B., Korotkov, K. V. & Sandkvist, M., Sep 11 2024, In: mBio. 15, 9, p. e0127024Research output: Contribution to journal › Article › peer-review
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort
RECOVER-Adult Cohort, Sep 2024, In: Annals of Internal Medicine. 177, 9, p. 1209-1221 13 p.Research output: Contribution to journal › Article › peer-review
Disorder regulates homeostasis of extracytoplasmic proteins in streptococci
Rahman, M. M., Zamakhaeva, S., Rush, J. S., Chaton, C. T., Kenner, C. W., Hla, Y. M., Tsui, H.-C. T., Winkler, M. E., Korotkov, K. V. & Korotkova, N., May 8 2024, In: bioRxiv.Research output: Contribution to journal › Article