Our full departmental research profile can be found on Scholars@UK.
ABL1/2 and DDR1 Drive MEKi Resistance in NRAS-Mutant Melanomas by Stabilizing RAF/MYC/ETS1 and Promoting RAF Homodimerization
Lyon, A., Tripathi, R., Meeks, C., He, D., Wu, Y., Liu, J., Wang, C., Chen, J., Zhu, H., Mukherjee, S., Ganguly, S. & Plattner, R., Feb 2023, In: Cancers. 15, 3, 954.Research output: Contribution to journal › Article › peer-review
Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs
Arizaca Maquera, K. A., Welden, J. R., Margvelani, G., Miranda Sardón, S. C., Hart, S., Robil, N., Hernandez, A. G., de la Grange, P., Nelson, P. T. & Stamm, S., 2023, In: Frontiers in Molecular Neuroscience. 16, 1141079.Research output: Contribution to journal › Article › peer-review
A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin
Mitchell, R. J., Kriger, S. M., Fenton, A. D., Havrylyuk, D., Pandeya, A., Sun, Y., Smith, T., DeRouchey, J. E., Unrine, J. M., Oza, V., Blackburn, J. S., Wei, Y., Heidary, D. K. & Glazer, E. C., Feb 27 2023, In: RSC Chemical Biology. 4, 5, p. 344-353 10 p.Research output: Contribution to journal › Article › peer-review
Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content
Kipp, Z. A., Martinez, G. J., Bates, E. A., Maharramov, A. B., Flight, R. M., Moseley, H. N. B., Morris, A., Stec, D. E. & Hinds, T. D., Feb 2023, In: Metabolites. 13, 2, 215.Research output: Contribution to journal › Article › peer-review
Bridging the Biomarker Chasm With Interprofessional Molecular Tumor Boards
Kolesar, J. M., Arnold, S. M., Ueland, F. R. & Evers, B. M., Aug 1 2023, In: JCO Oncology Practice. 19, 8, p. 677-678 2 p.Research output: Contribution to journal › Letter › peer-review
Cervical spinal cord injury leads to injury and altered metabolism in the lungs
Huffman, E. E., Dong, B. E., Clarke, H. A., Young, L. E. A., Gentry, M. S., Allison, D., Sun, R. C., Waters, C. M. & Alilain, W. J., 2023, In: Brain Communications. 5, 2, fcad091.Research output: Contribution to journal › Article › peer-review
Chalcone Derivative CX258 Suppresses Colorectal Cancer via Inhibiting the TOP2A/Wnt/β-Catenin Signaling
Chen, X., Lv, X., Gao, L., Liu, J., Wang, W., Guo, L., Frasinyuk, M. S., Zhang, W., Watt, D., Liu, C. & Liu, X., Apr 2023, In: Cells. 12, 7, 1066.Research output: Contribution to journal › Article › peer-review
Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition
Maghsoud, Y., Vázquez-Montelongo, E. A., Yang, X., Liu, C., Jing, Z., Lee, J., Harger, M., Smith, A. K., Espinoza, M., Guo, H. F., Kurie, J. M., Dalby, K. N., Ren, P. & Cisneros, G. A., Feb 13 2023, In: Journal of Chemical Information and Modeling. 63, 3, p. 986-1001 16 p.Research output: Contribution to journal › Article › peer-review
Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3
Smith, C. N., Kihn, K., Williamson, Z. A., Chow, K. M., Hersh, L. B., Korotkov, K. V., Deredge, D. & Blackburn, J. S., May 2023, In: PLoS ONE. 18, 5 May, e0285964.Research output: Contribution to journal › Article › peer-review
Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis
Joshi, S., Smith, A. N., Prakhya, K. S., Alfar, H. R., Lykins, J., Zhang, M., Pokrovskaya, I., Aronova, M., Leapman, R. D., Storrie, B. & Whiteheart, S. W., Mar 2023, In: Journal of Visualized Experiments. 2023, 193, e64985.Research output: Contribution to journal › Article › peer-review
Genomic screening methodology not requiring barcoding: Single nucleotide polymorphism-based, mixed-cell screening (SMICS)
Zhang, Z., Chen, X., Zhang, W., Liu, J., Xie, Y., Zhang, S., Stromberg, A. J., Watt, D., Liu, X., Wang, C. & Liu, C., Sep 2023, In: Genomics. 115, 5, 110666.Research output: Contribution to journal › Article › peer-review
Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation
Li, C., Zhou, Y., Wei, R., Napier, D. L., Sengoku, T., Alstott, M. C., Liu, J., Wang, C., Zaytseva, Y. Y., Weiss, H. L., Wang, Q. & Evers, B. M., Jan 2023, In: CMGH. 15, 4, p. 931-947 17 p.Research output: Contribution to journal › Article › peer-review
Impact of the Affordable Care Act on Providing Equitable Healthcare Access for IBD in the Kentucky Appalachian Region
Castle, J. T., Levy, B. E., Mangino, A. A., McDonald, H. G., McAtee, E. E., Patel, J. A., Evers, B. M. & Bhakta, A. S., Sep 1 2023, In: Diseases of the Colon and Rectum. 66, 9, p. 1273-1281 9 p.Research output: Contribution to journal › Article › peer-review
Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy
Geddes, J. W., Bondada, V., Croall, D. E., Rodgers, D. W. & Gal, J., Aug 2023, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1869, 6, 166747.Research output: Contribution to journal › Article › peer-review
In memory of Dr. Susan S. Smyth, MD/Ph.D
Whiteheart, S. W., Dec 1 2023, In: Platelets. 34, 1, p. 2183050 1 p.Research output: Contribution to journal › Article › peer-review
In situ microwave fixation provides an instantaneous snapshot of the brain metabolome
Juras, J. A., Webb, M. B., Young, L. E. A., Markussen, K. H., Hawkinson, T. R., Buoncristiani, M. D., Bolton, K. E., Coburn, P. T., Williams, M. I., Sun, L. P. Y., Sanders, W. C., Bruntz, R. C., Conroy, L. R., Wang, C., Gentry, M. S., Smith, B. N. & Sun, R. C., Apr 24 2023, In: Cell Reports Methods. 3, 4, 100455.Research output: Contribution to journal › Article › peer-review
kegg_pull: a software package for the RESTful access and pulling from the Kyoto Encyclopedia of Gene and Genomes
Huckvale, E. & Moseley, H. N. B., Dec 2023, In: BMC Bioinformatics. 24, 1, 78.Research output: Contribution to journal › Article › peer-review
Liver transplantation for biliary cysts: perioperative and long-term outcomes
Orozco, G., Shah, M. B., Gupta, M., Marti, F., Mei, X., Ancheta, A., Desai, S., Cavnar, M., Evers, B. M., Zwischenberger, J. & Gedaly, R., Aug 2023, In: HPB. 25, 8, p. 954-961 8 p.Research output: Contribution to journal › Article › peer-review
NF-<bold>κ</bold>B represses retinoic acid receptor–mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia
Song, H., Ye, X., Liao, Y., Zhang, S., Xu, D., Zhong, S., Jing, B., Wang, T., Sun, B., Xu, J., Guo, W., Li, K., Hu, M., Kuang, Y., Ling, J., Zhang, T., Wu, Y., Du, J., Yao, F., Chin, Y. E., & 3 others , Jan 10 2023, In: JCI insight. 8, 1, e153976.Research output: Contribution to journal › Article › peer-review
Noncovalent interactions that tune the reactivities of the flavins in bifurcating electron transferring flavoprotein
González-Viegas, M., Kar, R. K., Miller, A. F. & Mroginski, M. A., Jun 2023, In: Journal of Biological Chemistry. 299, 6, 104762.Research output: Contribution to journal › Article › peer-review
Opioid Use After Colorectal Resection: Identifying Preoperative Risk Factors for Postoperative Use
Levy, B. E., Castle, J. T., Ebbitt, L. M., Kennon, C., McAtee, E., Davenport, D. L., Evers, B. M. & Bhakta, A., Mar 2023, In: Journal of Surgical Research. 283, p. 296-304 9 p.Research output: Contribution to journal › Article › peer-review
PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence
Xiao, M., Wu, C. H., Meek, G., Kelly, B., Castillo, D. B., Young, L. E. A., Martire, S., Dhungel, S., McCauley, E., Saha, P., Dube, A. L., Gentry, M. S., Banaszynski, L. A., Sun, R. C. & Kikani, C. K., Apr 2023, In: eLife. 12, e81717.Research output: Contribution to journal › Article › peer-review
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors
Chen, F., Byrd, A. L., Liu, J., Flight, R. M., DuCote, T. J., Naughton, K. J., Song, X., Edgin, A. R., Lukyanchuk, A., Dixon, D. T., Gosser, C. M., Esoe, D. P., Jayswal, R. D., Orkin, S. H., Moseley, H. N. B., Wang, C. & Brainson, C. F., Dec 2023, In: Nature Communications. 14, 1, 336.Research output: Contribution to journal › Article › peer-review
Predictors and outcomes of acute pulmonary embolism in COVID-19; insights from US National COVID cohort collaborative
Gul, M. H., Htun, Z. M., de Jesus Perez, V., Suleman, M., Arshad, S., Imran, M., Vyasabattu, M., Wood, J. P., Anstead, M. & Morris, P. E., Dec 2023, In: Respiratory Research. 24, 1, 59.Research output: Contribution to journal › Article › peer-review
Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity
Hepowit, N. L., Blalock, E., Lee, S., Bretland, K. M., MacGurn, J. A. & Dickson, R. C., 2023, In: Aging. 15, 2, p. 472-491 20 p.Research output: Contribution to journal › Article › peer-review
Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis
Conroy, L. R., Clarke, H. A., Allison, D. B., Valenca, S. S., Sun, Q., Hawkinson, T. R., Young, L. E. A., Ferreira, J. E., Hammonds, A. V., Dunne, J. B., McDonald, R. J., Absher, K. J., Dong, B. E., Bruntz, R. C., Markussen, K. H., Juras, J. A., Alilain, W. J., Liu, J., Gentry, M. S., Angel, P. M., & 2 others , Dec 2023, In: Nature Communications. 14, 1, 2759.Research output: Contribution to journal › Article › peer-review
Specific Residues in the C-Terminal Domain of the Human Metapneumovirus Phosphoprotein Are Indispensable for Formation of Viral Replication Centers and Regulation of the Function of the Viral Polymerase Complex
Thompson, R. E., Edmonds, K. & Dutch, R. E., May 2023, In: Journal of Virology. 97, 5Research output: Contribution to journal › Article › peer-review
Structure-function analysis of the dual functioning mycobacterial virulence factors EspE and EspF
Prest, R. J., Korotkov, K. V. & Champion, P. A., Feb 10 2023, In: Biophysical Journal. 122, 3S1, p. 41aResearch output: Contribution to journal › Article › peer-review
Structure of puromycin-sensitive aminopeptidase and polyglutamine binding
Madabushi, S., Martin Chow, K., Song, E. S., Goswami, A., Hersh, L. B. & Rodgers, D. W., Jul 2023, In: PLoS ONE. 18, 7 July, e0287086.Research output: Contribution to journal › Article › peer-review
Targeting receptor tyrosine kinases in ovarian cancer: Genomic dysregulation, clinical evaluation of inhibitors, and potential for combinatorial therapies
Wei, Y., Erfani, S., Schweer, D., de Gouvea, R., Qadir, J., Shi, J., Cheng, K., Wu, D., Craven, R., Wu, Y., Olivier, T., Baldwin, L. A., Zhou, B., Zhou, Y., Zhao, W., Yang, B. B., Ueland, F. R. & Yang, X. H., Mar 16 2023, In: Molecular Therapy - Oncolytics. 28, p. 293-306 14 p.Research output: Contribution to journal › Review article › peer-review
The metabolomics workbench file status website: a metadata repository promoting FAIR principles of metabolomics data
Powell, C. D. & Moseley, H. N. B., Dec 2023, In: BMC Bioinformatics. 24, 1, 299.Research output: Contribution to journal › Article › peer-review
Triarylphosphine-Coordinated Bipyridyl Ru(II) Complexes Induce Mitochondrial Dysfunction
Mitchell, R. J., Gowda, A. S., Olivelli, A. G., Huckaba, A. J., Parkin, S., Unrine, J., Oza, V., Blackburn, J., Ladipo, F., Heidary, D. K. & Glazer, E., 2023, (Accepted/In press) In: Inorganic Chemistry.Research output: Contribution to journal › Article › peer-review
Virology under the Microscope-a Call for Rational Discourse
Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 others , Apr 20 2023, In: mSphere. 8, 2, p. e0003423Research output: Contribution to journal › Article › peer-review
Virology under the Microscope-a Call for Rational Discourse
Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 others , Jan 2023, In: mBio. 14, 1Research output: Contribution to journal › Review article › peer-review
Virology under the Microscope—a Call for Rational Discourse
Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 others , Feb 2023, In: Journal of Virology. 97, 2Research output: Contribution to journal › Review article › peer-review
Zebrafish Cancer Avatars: A Translational Platform for Analyzing Tumor Heterogeneity and Predicting Patient Outcomes
Al-Hamaly, M. A., Turner, L. T., Rivera-Martinez, A., Rodriguez, A. & Blackburn, J. S., Feb 2023, In: International Journal of Molecular Sciences. 24, 3, 2288.Research output: Contribution to journal › Review article › peer-review
Academic Tracker: Software for tracking and reporting publications associated with authors and grants
Thompson, P. T., Powell, C. D. & Moseley, H. N. B., Nov 2022, In: PLoS ONE. 17, 11 November, e0277834.Research output: Contribution to journal › Article › peer-review
Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice
Loon, A., Zamudio, F., Sanneh, A., Brown, B., Smeltzer, S., Brownlow, M. L., Quadri, Z., Peters, M., Weeber, E., Nash, K., Lee, D. C., Gordon, M. N., Morgan, D. & Selenica, M. L. B., Feb 2022, In: GeroScience. 44, 1, p. 173-194 22 p.Research output: Contribution to journal › Article › peer-review
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer
Xiong, X., Hasani, S., Young, L. E. A., Rivas, D. R., Skaggs, A. T., Martinez, R., Wang, C., Weiss, H. L., Gentry, M. S., Sun, R. C. & Gao, T., Oct 2022, In: Cell Death and Differentiation. 29, 10, p. 1913-1927 15 p.Research output: Contribution to journal › Article › peer-review
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities
SantaCruz-Calvo, S., Bharath, L., Pugh, G., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B. & Nikolajczyk, B. S., Jan 2022, In: Nature Reviews Endocrinology. 18, 1, p. 23-42 20 p.Research output: Contribution to journal › Review article › peer-review
Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes
Mills, R., Vogler, R. J., Bernard, M., Concolino, J., Hersh, L. B., Wei, Y., Hastings, J. T., Dziubla, T., Baldridge, K. C. & Bhattacharyya, D., Dec 2022, In: Communications Materials. 3, 1, 34.Research output: Contribution to journal › Article › peer-review
Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor
Ostrakhovitch, E. A., Song, E. S., Macedo, J. K. A., Gentry, M. S., Quintero, J. E., van Horne, C. & Yamasaki, T. R., Jan 19 2022, In: Neuroscience Letters. 769, 136428.Research output: Contribution to journal › Article › peer-review
Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells
Gedaly, R., Cornea, V., Turcios, L., Edmisson, J. S., Harris, D. D., Watt, D., Chapelin, F., Khurana, A., Mei, X., Liu, C., Taylor, I., Gonzalez-Valdivieso, J., Mitchel, H., Ruffing, A., Chishti, A., Orozco, G., Zwischenberger, J., Evers, B. M. & Marti, F., Dec 2022, In: Scientific Reports. 12, 1, 19112.Research output: Contribution to journal › Article › peer-review
Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele
Gal, J., Katsumata, Y., Zhu, H., Srinivasan, S., Chen, J., Johnson, L. A., Wang, W. X., Golden, L. R., Wilcock, D. M., Jicha, G. A., Cykowski, M. D. & Nelson, P. T., Mar 2022, In: American Journal of Pathology. 192, 3, p. 564-578 15 p.Research output: Contribution to journal › Article › peer-review
A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics
Prakhya, K. S., Luo, Y., Adkins, J., Hu, X., Wang, Q. J. & Whiteheart, S., Jul 1 2022, In: Research and Practice in Thrombosis and Haemostasis. 6, 5Research output: Contribution to journal › Article › peer-review
A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics
Prakhya, K. S., Luo, Y., Adkins, J., Hu, X., Wang, Q. J. & Whiteheart, S. W., Jul 2022, In: Research and Practice in Thrombosis and Haemostasis. 6, 5, e12755.Research output: Contribution to journal › Article › peer-review
ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis
Valenca, S. S., Dong, B. E., Gordon, E. M., Sun, R. C. & Waters, C. M., May 2022, In: American Journal of Respiratory Cell and Molecular Biology. 66, 5, p. 484-496 13 p.Research output: Contribution to journal › Article › peer-review
Biliverdin regulates NR2E3 and zebrafish retinal photoreceptor development
Lee, Y-S., Connor, B., Titialii-Torres, K. F., Rockenhaus, A., Passamonte, S. & Morris, A., 2022, In: Scientific Reports. 12, 1, p. 7310Research output: Contribution to journal › Article › peer-review
Characterization of Smoothened Phosphorylation and Activation
Jia, J., Han, Y., Cho, Y. S. & Jiang, J., 2022, Methods in Molecular Biology. p. 121-137 17 p. (Methods in Molecular Biology; vol. 2374).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's Disease
Duncan, M. J., Guerriero, L. E., Kohler, K., Beechem, L. E., Gillis, B. D., Salisbury, F., Wessel, C., Wang, J., Sunderam, S., Bachstetter, A. D., O'Hara, B. F. & Murphy, M. P., Jan 15 2022, In: Neuroscience. 481, p. 111-122 12 p.Research output: Contribution to journal › Article › peer-review