Recent Publications

Our full departmental research profile can be found on Scholars@UK.

ABL1/2 and DDR1 Drive MEKi Resistance in NRAS-Mutant Melanomas by Stabilizing RAF/MYC/ETS1 and Promoting RAF Homodimerization

Lyon, A., Tripathi, R., Meeks, C., He, D., Wu, Y., Liu, J., Wang, C., Chen, J., Zhu, H., Mukherjee, S., Ganguly, S. & Plattner, R., Feb 2023, In: Cancers. 15, 3, 954.

Research output: Contribution to journal › Article › peer-review

Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs

Arizaca Maquera, K. A., Welden, J. R., Margvelani, G., Miranda Sardón, S. C., Hart, S., Robil, N., Hernandez, A. G., de la Grange, P., Nelson, P. T. & Stamm, S., 2023, In: Frontiers in Molecular Neuroscience. 16, 1141079.

Research output: Contribution to journal › Article › peer-review

A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin

Mitchell, R. J., Kriger, S. M., Fenton, A. D., Havrylyuk, D., Pandeya, A., Sun, Y., Smith, T., DeRouchey, J. E., Unrine, J. M., Oza, V., Blackburn, J. S., Wei, Y., Heidary, D. K. & Glazer, E. C., Feb 27 2023, In: RSC Chemical Biology. 4, 5, p. 344-353 10 p.

Research output: Contribution to journal › Article › peer-review

Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content

Kipp, Z. A., Martinez, G. J., Bates, E. A., Maharramov, A. B., Flight, R. M., Moseley, H. N. B., Morris, A., Stec, D. E. & Hinds, T. D., Feb 2023, In: Metabolites. 13, 2, 215.

Research output: Contribution to journal › Article › peer-review

Bridging the Biomarker Chasm With Interprofessional Molecular Tumor Boards

Kolesar, J. M., Arnold, S. M., Ueland, F. R. & Evers, B. M., Aug 1 2023, In: JCO Oncology Practice. 19, 8, p. 677-678 2 p.

Research output: Contribution to journal › Letter › peer-review

Cervical spinal cord injury leads to injury and altered metabolism in the lungs

Huffman, E. E., Dong, B. E., Clarke, H. A., Young, L. E. A., Gentry, M. S., Allison, D., Sun, R. C., Waters, C. M. & Alilain, W. J., 2023, In: Brain Communications. 5, 2, fcad091.

Research output: Contribution to journal › Article › peer-review

Chalcone Derivative CX258 Suppresses Colorectal Cancer via Inhibiting the TOP2A/Wnt/β-Catenin Signaling

Chen, X., Lv, X., Gao, L., Liu, J., Wang, W., Guo, L., Frasinyuk, M. S., Zhang, W., Watt, D., Liu, C. & Liu, X., Apr 2023, In: Cells. 12, 7, 1066.

Research output: Contribution to journal › Article › peer-review

Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition

Maghsoud, Y., Vázquez-Montelongo, E. A., Yang, X., Liu, C., Jing, Z., Lee, J., Harger, M., Smith, A. K., Espinoza, M., Guo, H. F., Kurie, J. M., Dalby, K. N., Ren, P. & Cisneros, G. A., Feb 13 2023, In: Journal of Chemical Information and Modeling. 63, 3, p. 986-1001 16 p.

Research output: Contribution to journal › Article › peer-review

Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3

Smith, C. N., Kihn, K., Williamson, Z. A., Chow, K. M., Hersh, L. B., Korotkov, K. V., Deredge, D. & Blackburn, J. S., May 2023, In: PLoS ONE. 18, 5 May, e0285964.

Research output: Contribution to journal › Article › peer-review

Ferric Chloride-Induced Arterial Thrombosis and Sample Collection for 3D Electron Microscopy Analysis

Joshi, S., Smith, A. N., Prakhya, K. S., Alfar, H. R., Lykins, J., Zhang, M., Pokrovskaya, I., Aronova, M., Leapman, R. D., Storrie, B. & Whiteheart, S. W., Mar 2023, In: Journal of Visualized Experiments. 2023, 193, e64985.

Research output: Contribution to journal › Article › peer-review

Genomic screening methodology not requiring barcoding: Single nucleotide polymorphism-based, mixed-cell screening (SMICS)

Zhang, Z., Chen, X., Zhang, W., Liu, J., Xie, Y., Zhang, S., Stromberg, A. J., Watt, D., Liu, X., Wang, C. & Liu, C., Sep 2023, In: Genomics. 115, 5, 110666.

Research output: Contribution to journal › Article › peer-review

Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and Differentiation

Li, C., Zhou, Y., Wei, R., Napier, D. L., Sengoku, T., Alstott, M. C., Liu, J., Wang, C., Zaytseva, Y. Y., Weiss, H. L., Wang, Q. & Evers, B. M., Jan 2023, In: CMGH. 15, 4, p. 931-947 17 p.

Research output: Contribution to journal › Article › peer-review

Impact of the Affordable Care Act on Providing Equitable Healthcare Access for IBD in the Kentucky Appalachian Region

Castle, J. T., Levy, B. E., Mangino, A. A., McDonald, H. G., McAtee, E. E., Patel, J. A., Evers, B. M. & Bhakta, A. S., Sep 1 2023, In: Diseases of the Colon and Rectum. 66, 9, p. 1273-1281 9 p.

Research output: Contribution to journal › Article › peer-review

Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy

Geddes, J. W., Bondada, V., Croall, D. E., Rodgers, D. W. & Gal, J., Aug 2023, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1869, 6, 166747.

Research output: Contribution to journal › Article › peer-review

In memory of Dr. Susan S. Smyth, MD/Ph.D

Whiteheart, S. W., Dec 1 2023, In: Platelets. 34, 1, p. 2183050 1 p.

Research output: Contribution to journal › Article › peer-review

In situ microwave fixation provides an instantaneous snapshot of the brain metabolome

Juras, J. A., Webb, M. B., Young, L. E. A., Markussen, K. H., Hawkinson, T. R., Buoncristiani, M. D., Bolton, K. E., Coburn, P. T., Williams, M. I., Sun, L. P. Y., Sanders, W. C., Bruntz, R. C., Conroy, L. R., Wang, C., Gentry, M. S., Smith, B. N. & Sun, R. C., Apr 24 2023, In: Cell Reports Methods. 3, 4, 100455.

Research output: Contribution to journal › Article › peer-review

kegg_pull: a software package for the RESTful access and pulling from the Kyoto Encyclopedia of Gene and Genomes

Huckvale, E. & Moseley, H. N. B., Dec 2023, In: BMC Bioinformatics. 24, 1, 78.

Research output: Contribution to journal › Article › peer-review

Liver transplantation for biliary cysts: perioperative and long-term outcomes

Orozco, G., Shah, M. B., Gupta, M., Marti, F., Mei, X., Ancheta, A., Desai, S., Cavnar, M., Evers, B. M., Zwischenberger, J. & Gedaly, R., Aug 2023, In: HPB. 25, 8, p. 954-961 8 p.

Research output: Contribution to journal › Article › peer-review

NF-<bold>κ</bold>B represses retinoic acid receptor–mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia

Song, H., Ye, X., Liao, Y., Zhang, S., Xu, D., Zhong, S., Jing, B., Wang, T., Sun, B., Xu, J., Guo, W., Li, K., Hu, M., Kuang, Y., Ling, J., Zhang, T., Wu, Y., Du, J., Yao, F., Chin, Y. E., & 3 othersWang, Q., Zhou, B. P. & Deng, J., Jan 10 2023, In: JCI insight. 8, 1, e153976.

Research output: Contribution to journal › Article › peer-review

Noncovalent interactions that tune the reactivities of the flavins in bifurcating electron transferring flavoprotein

González-Viegas, M., Kar, R. K., Miller, A. F. & Mroginski, M. A., Jun 2023, In: Journal of Biological Chemistry. 299, 6, 104762.

Research output: Contribution to journal › Article › peer-review

Opioid Use After Colorectal Resection: Identifying Preoperative Risk Factors for Postoperative Use

Levy, B. E., Castle, J. T., Ebbitt, L. M., Kennon, C., McAtee, E., Davenport, D. L., Evers, B. M. & Bhakta, A., Mar 2023, In: Journal of Surgical Research. 283, p. 296-304 9 p.

Research output: Contribution to journal › Article › peer-review

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence

Xiao, M., Wu, C. H., Meek, G., Kelly, B., Castillo, D. B., Young, L. E. A., Martire, S., Dhungel, S., McCauley, E., Saha, P., Dube, A. L., Gentry, M. S., Banaszynski, L. A., Sun, R. C. & Kikani, C. K., Apr 2023, In: eLife. 12, e81717.

Research output: Contribution to journal › Article › peer-review

Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors

Chen, F., Byrd, A. L., Liu, J., Flight, R. M., DuCote, T. J., Naughton, K. J., Song, X., Edgin, A. R., Lukyanchuk, A., Dixon, D. T., Gosser, C. M., Esoe, D. P., Jayswal, R. D., Orkin, S. H., Moseley, H. N. B., Wang, C. & Brainson, C. F., Dec 2023, In: Nature Communications. 14, 1, 336.

Research output: Contribution to journal › Article › peer-review

Predictors and outcomes of acute pulmonary embolism in COVID-19; insights from US National COVID cohort collaborative

Gul, M. H., Htun, Z. M., de Jesus Perez, V., Suleman, M., Arshad, S., Imran, M., Vyasabattu, M., Wood, J. P., Anstead, M. & Morris, P. E., Dec 2023, In: Respiratory Research. 24, 1, 59.

Research output: Contribution to journal › Article › peer-review

Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity

Hepowit, N. L., Blalock, E., Lee, S., Bretland, K. M., MacGurn, J. A. & Dickson, R. C., 2023, In: Aging. 15, 2, p. 472-491 20 p.

Research output: Contribution to journal › Article › peer-review

Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis

Conroy, L. R., Clarke, H. A., Allison, D. B., Valenca, S. S., Sun, Q., Hawkinson, T. R., Young, L. E. A., Ferreira, J. E., Hammonds, A. V., Dunne, J. B., McDonald, R. J., Absher, K. J., Dong, B. E., Bruntz, R. C., Markussen, K. H., Juras, J. A., Alilain, W. J., Liu, J., Gentry, M. S., Angel, P. M., & 2 othersWaters, C. M. & Sun, R. C., Dec 2023, In: Nature Communications. 14, 1, 2759.

Research output: Contribution to journal › Article › peer-review

Specific Residues in the C-Terminal Domain of the Human Metapneumovirus Phosphoprotein Are Indispensable for Formation of Viral Replication Centers and Regulation of the Function of the Viral Polymerase Complex

Thompson, R. E., Edmonds, K. & Dutch, R. E., May 2023, In: Journal of Virology. 97, 5

Research output: Contribution to journal › Article › peer-review

Structure-function analysis of the dual functioning mycobacterial virulence factors EspE and EspF

Prest, R. J., Korotkov, K. V. & Champion, P. A., Feb 10 2023, In: Biophysical Journal. 122, 3S1, p. 41a

Research output: Contribution to journal › Article › peer-review

Structure of puromycin-sensitive aminopeptidase and polyglutamine binding

Madabushi, S., Martin Chow, K., Song, E. S., Goswami, A., Hersh, L. B. & Rodgers, D. W., Jul 2023, In: PLoS ONE. 18, 7 July, e0287086.

Research output: Contribution to journal › Article › peer-review

Targeting receptor tyrosine kinases in ovarian cancer: Genomic dysregulation, clinical evaluation of inhibitors, and potential for combinatorial therapies

Wei, Y., Erfani, S., Schweer, D., de Gouvea, R., Qadir, J., Shi, J., Cheng, K., Wu, D., Craven, R., Wu, Y., Olivier, T., Baldwin, L. A., Zhou, B., Zhou, Y., Zhao, W., Yang, B. B., Ueland, F. R. & Yang, X. H., Mar 16 2023, In: Molecular Therapy - Oncolytics. 28, p. 293-306 14 p.

Research output: Contribution to journal › Review article › peer-review

The metabolomics workbench file status website: a metadata repository promoting FAIR principles of metabolomics data

Powell, C. D. & Moseley, H. N. B., Dec 2023, In: BMC Bioinformatics. 24, 1, 299.

Research output: Contribution to journal › Article › peer-review

Triarylphosphine-Coordinated Bipyridyl Ru(II) Complexes Induce Mitochondrial Dysfunction

Mitchell, R. J., Gowda, A. S., Olivelli, A. G., Huckaba, A. J., Parkin, S., Unrine, J., Oza, V., Blackburn, J., Ladipo, F., Heidary, D. K. & Glazer, E., 2023, (Accepted/In press) In: Inorganic Chemistry.

Research output: Contribution to journal › Article › peer-review

Virology under the Microscope-a Call for Rational Discourse

Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 othersCameron, C., Campos, S., Caposio, P., Chan, G., Cliffe, A., Coffin, J., Collins, K., Damania, B., Daugherty, M., Debbink, K., DeCaprio, J., Dermody, T., Dikeakos, J., DiMaio, D., Dinglasan, R., Duprex, W. P., Dutch, R., Elde, N., Emerman, M., Enquist, L., Fane, B., Fernandez-Sesma, A., Flenniken, M., Frappier, L., Frieman, M., Frueh, K., Gack, M., Gaglia, M., Gallagher, T., Galloway, D., García-Sastre, A., Geballe, A., Glaunsinger, B., Goff, S., Greninger, A., Hancock, M., Harris, E., Heaton, N., Heise, M., Heldwein, E., Hogue, B., Horner, S., Hutchinson, E., Hyser, J., Jackson, W., Kalejta, R., Kamil, J., Karst, S., Kirchhoff, F., Knipe, D., Kowalik, T., Lagunoff, M., Laimins, L., Langlois, R., Lauring, A., Lee, B., Leib, D., Liu, S. L., Longnecker, R., Lopez, C., Luftig, M., Lund, J., Manicassamy, B., McFadden, G., McIntosh, M., Mehle, A., Miller, W. A., Mohr, I., Moody, C., Moorman, N., Moscona, A., Mounce, B., Munger, J., Münger, K., Murphy, E., Naghavi, M., Nelson, J., Neufeldt, C., Nikolich, J., O'Connor, C., Ono, A., Orenstein, W., Ornelles, D., Ou, J. H., Parker, J., Parrish, C., Pekosz, A., Pellett, P., Pfeiffer, J., Plemper, R., Polyak, S., Purdy, J., Pyeon, D., Quinones-Mateu, M., Renne, R., Rice, C., Schoggins, J., Roller, R., Russell, C., Sandri-Goldin, R., Sapp, M., Schang, L., Schmid, S., Schultz-Cherry, S., Semler, B., Shenk, T., Silvestri, G., Simon, V., Smith, G., Smith, J., Spindler, K., Stanifer, M., Subbarao, K., Sundquist, W., Suthar, M., Sutton, T., Tai, A., Tarakanova, V., tenOever, B., Tibbetts, S., Tompkins, S., Toth, Z., van Doorslaer, K., Vignuzzi, M., Wallace, N., Walsh, D., Weekes, M., Weinberg, J., Weitzman, M., Weller, S., Whelan, S., White, E., Williams, B., Wobus, C., Wong, S. & Yurochko, A., Apr 20 2023, In: mSphere. 8, 2, p. e0003423

Research output: Contribution to journal › Article › peer-review

Virology under the Microscope-a Call for Rational Discourse

Research output: Contribution to journal › Review article › peer-review

Virology under the Microscope—a Call for Rational Discourse

Research output: Contribution to journal › Review article › peer-review

Zebrafish Cancer Avatars: A Translational Platform for Analyzing Tumor Heterogeneity and Predicting Patient Outcomes

Al-Hamaly, M. A., Turner, L. T., Rivera-Martinez, A., Rodriguez, A. & Blackburn, J. S., Feb 2023, In: International Journal of Molecular Sciences. 24, 3, 2288.

Research output: Contribution to journal › Review article › peer-review

Academic Tracker: Software for tracking and reporting publications associated with authors and grants

Thompson, P. T., Powell, C. D. & Moseley, H. N. B., Nov 2022, In: PLoS ONE. 17, 11 November, e0277834.

Research output: Contribution to journal › Article › peer-review

Accumulation of C-terminal cleaved tau is distinctly associated with cognitive deficits, synaptic plasticity impairment, and neurodegeneration in aged mice

Loon, A., Zamudio, F., Sanneh, A., Brown, B., Smeltzer, S., Brownlow, M. L., Quadri, Z., Peters, M., Weeber, E., Nash, K., Lee, D. C., Gordon, M. N., Morgan, D. & Selenica, M. L. B., Feb 2022, In: GeroScience. 44, 1, p. 173-194 22 p.

Research output: Contribution to journal › Article › peer-review

Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer

Xiong, X., Hasani, S., Young, L. E. A., Rivas, D. R., Skaggs, A. T., Martinez, R., Wang, C., Weiss, H. L., Gentry, M. S., Sun, R. C. & Gao, T., Oct 2022, In: Cell Death and Differentiation. 29, 10, p. 1913-1927 15 p.

Research output: Contribution to journal › Article › peer-review

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities

SantaCruz-Calvo, S., Bharath, L., Pugh, G., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B. & Nikolajczyk, B. S., Jan 2022, In: Nature Reviews Endocrinology. 18, 1, p. 23-42 20 p.

Research output: Contribution to journal › Review article › peer-review

Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes

Mills, R., Vogler, R. J., Bernard, M., Concolino, J., Hersh, L. B., Wei, Y., Hastings, J. T., Dziubla, T., Baldridge, K. C. & Bhattacharyya, D., Dec 2022, In: Communications Materials. 3, 1, 34.

Research output: Contribution to journal › Article › peer-review

Analysis of circulating metabolites to differentiate Parkinson's disease and essential tremor

Ostrakhovitch, E. A., Song, E. S., Macedo, J. K. A., Gentry, M. S., Quintero, J. E., van Horne, C. & Yamasaki, T. R., Jan 19 2022, In: Neuroscience Letters. 769, 136428.

Research output: Contribution to journal › Article › peer-review

Anti-neoplastic sulfonamides alter the metabolic homeostasis and disrupt the suppressor activity of regulatory T cells

Gedaly, R., Cornea, V., Turcios, L., Edmisson, J. S., Harris, D. D., Watt, D., Chapelin, F., Khurana, A., Mei, X., Liu, C., Taylor, I., Gonzalez-Valdivieso, J., Mitchel, H., Ruffing, A., Chishti, A., Orozco, G., Zwischenberger, J., Evers, B. M. & Marti, F., Dec 2022, In: Scientific Reports. 12, 1, 19112.

Research output: Contribution to journal › Article › peer-review

Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele

Gal, J., Katsumata, Y., Zhu, H., Srinivasan, S., Chen, J., Johnson, L. A., Wang, W. X., Golden, L. R., Wilcock, D. M., Jicha, G. A., Cykowski, M. D. & Nelson, P. T., Mar 2022, In: American Journal of Pathology. 192, 3, p. 564-578 15 p.

Research output: Contribution to journal › Article › peer-review

Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's Disease

Duncan, M. J., Guerriero, L. E., Kohler, K., Beechem, L. E., Gillis, B. D., Salisbury, F., Wessel, C., Wang, J., Sunderam, S., Bachstetter, A. D., O'Hara, B. F. & Murphy, M. P., Jan 15 2022, In: Neuroscience. 481, p. 111-122 12 p.

Research output: Contribution to journal › Article › peer-review