Our full departmental research profile can be found on Scholars@UK.
A Coaching-Based Training for Underrepresented Mentors in STEM
Tuck, M. E., Palomino, K. A., Bradley, J. A., Mohr-Schroeder, M. & Bradley, L. H., Mar 2025, In: Education Sciences. 15, 3Research output: Contribution to journal › Article › peer-review
Age-related differences in resting glutamate levels and glutamate uptake in the hippocampus and frontal cortex of C57BL/6 mice
Pomerleau, F., Sulkowski, B. A., Suhail, C., Quintero, J. E., Littrell, O. M., Murphy, M., Huettl, P. & Gerhardt, G. A., Jun 2025, In: Neurobiology of Aging. 150, p. 146-156 11 p.Research output: Contribution to journal › Article › peer-review
Astrocyte involvement in metabolic regulation and disease
Naveed, M., Smedlund, K., Zhou, Q. G., Cai, W. & Hill, J. W., Mar 2025, In: Trends in Endocrinology and Metabolism. 36, 3, p. 219-234 16 p.Research output: Contribution to journal › Review article › peer-review
Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward
Huang, Q., Lee, H. H., Volpe, B., Zhang, Q., Xue, C., Liu, B. C., Abuhasan, Y. R., Li, L., Yang, J. S., Egholm, J., Gutierrez-Vazquez, C., Li, A., Lee, A., Tang, S., Wong, C. W., Liu, T., Huang, Y., Ramos, R. L., Stout, R. F. & El Ouaamari, A. & 5 others, , Feb 2025, In: Molecular Psychiatry. 30, 2, p. 506-520 15 p., 33609.Research output: Contribution to journal › Article › peer-review
Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer’s Disease Models
Bulgart, H. R., Lopez Perez, M. A. & Weisleder, N., Mar 2025, In: Biomolecules. 15, 3, 418.Research output: Contribution to journal › Article › peer-review
Epithelial-mesenchymal transition promotes metabolic reprogramming to suppress ferroptosis
Guo, W., Duan, Z., Wu, J. & Zhou, B. P., Jul 2025, In: Seminars in Cancer Biology. 112, p. 20-35 16 p.Research output: Contribution to journal › Review article › peer-review
Exploring Oxylipins in Host–Microbe Interactions and Their Impact on Infection and Immunity
Neff, R. J. & Radka, C. D., Mar 2025, In: Current Issues in Molecular Biology. 47, 3, 190.Research output: Contribution to journal › Review article › peer-review
GDP-mannose 4,6-dehydratase is a key driver of MYCN-amplified neuroblastoma core fucosylation and tumorigenesis
Zhu, B., Pitts, M. G., Buoncristiani, M. D., Bryant, L. T., Lopez-Nunez, O., Gurria, J. P., Shedlock, C., Ribas, R., Keohane, S., Liu, J., Wang, C., Gentry, M. S., Shelman, N. R., Allison, D. B., Evers, B. M., Sun, R. C. & Rellinger, E. J., 2025, (Accepted/In press) In: Oncogene. 100304.Research output: Contribution to journal › Article › peer-review
L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds
Imam, I. A., Al Adawi, S., Liu, X., Ellingson, S., Brainson, C. F., Moseley, H. N. B., Zinner, R., Zhang, S. & Shao, Q., Mar 2025, In: Proteins: Structure, Function and Bioinformatics. 93, 3, p. 673-683 11 p.Research output: Contribution to journal › Article › peer-review
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity
Devilée, L. A. C., Salama, A. B. M., Miller, J. M., Reid, J. D., Ou, Q., Baraka, N. M., Abou Farraj, K., Jamal, M., Nong, Y., Rosengart, T. K., Andres, D., Satin, J., Mohamed, T. M. A., Hudson, J. E. & Abouleisa, R. R. E., Dec 2025, In: npj Regenerative Medicine. 10, 1, 1.Research output: Contribution to journal › Article › peer-review
Predicting the Pathway Involvement of Compounds Annotated in the Reactome Knowledgebase
Huckvale, E. D. & Moseley, H. N. B., Mar 2025, In: Metabolites. 15, 3, 161.Research output: Contribution to journal › Article › peer-review
S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance
Ganguly, S., Burikhanov, R., Sviripa, V. M., Ellingson, S., Jiang, J., Gosser, C. M., Orren, D., Goellner, E. M., Shenoy, G. G., Rao, M., D’orazio, J., Brainson, C. F., Zhan, C. G., Spielmann, P. H., Watt, D. S. & Rangnekar, V. M., 2025, In: International Journal of Biological Sciences. 21, 2, p. 454-472 19 p.Research output: Contribution to journal › Article › peer-review
Serglycin controls megakaryocyte retention of platelet factor 4 and influences megakaryocyte fate in bone marrow
Lykins, J., Becker, I. C., Camacho, V., Alfar, H. R., Park, J. W., Italiano, J. & Whiteheart, S. W., Jan 14 2025, In: Blood advances. 9, 1, p. 15-28 14 p.Research output: Contribution to journal › Article › peer-review
Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide
Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., Dec 2025, In: Nature Communications. 16, 1, 954.Research output: Contribution to journal › Article › peer-review
Structure and mechanism of biosynthesis of Streptococcus mutans cell wall polysaccharide
Rush, J. S., Zamakhaeva, S., Murner, N. R., Deng, P., Morris, A. J., Kenner, C. W., Black, I., Heiss, C., Azadi, P., Korotkov, K. V., Widmalm, G. & Korotkova, N., Jan 22 2025, In: Nature Communications. 16, 1, p. 954Research output: Contribution to journal › Article › peer-review
Translation of circular RNAs
Margvelani, G., Maquera, K. A. A., Welden, J. R., Rodgers, D. W. & Stamm, S., Jan 13 2025, In: Nucleic Acids Research. 53, 1, gkae1167.Research output: Contribution to journal › Article › peer-review
A cautionary tale about properly vetting datasets used in supervised learning predicting metabolic pathway involvement
Huckvale, E. D. & Moseley, H. N. B., May 2024, In: PLoS ONE. 19, 5 MAY, e0299583.Research output: Contribution to journal › Article › peer-review
A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial–mesenchymal plasticity.
Rea, M., Kimmerer, G., Mittendorf, S., Xiong, X., Green, M., Chandler, D., Saintilnord, W., Blackburn, J., Gao, T. & Fondufe-Mittendorf, Y. N., Apr 15 2024, In: Environmental Pollution. 347, 123586.Research output: Contribution to journal › Article › peer-review
AI is a viable alternative to high throughput screening: a 318-target study
Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H. & Ng, H. L. & 667 others, , Dec 2024, In: Scientific Reports. 14, 1, 7526.Research output: Contribution to journal › Article › peer-review
Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression
Zhang, H., Sun, X., Li, Z., Liu, T., Zhang, F., Meng, X., Li, K., Xu, J., He, W., Jing, B., Wang, T., Ni, N., Sun, B., Yao, F., Wu, Y., Wang, Q., Du, J., Chin, E. Y., Zhou, B. P. & Jiang, P. & 2 others, , May 2024, In: Genes and Diseases. 11, 3, 100999.Research output: Contribution to journal › Article › peer-review
A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer
Mani, R., Martin, C. G., Balu, K. E., Wang, Q., Rychahou, P., Izumi, T., Evers, B. M. & Suzuki, Y., Jan 2024, In: Cells. 13, 2, 111.Research output: Contribution to journal › Article › peer-review
A Probabilistic Approach to Estimate the Temporal Order of Pathway Mutations Accounting for Intra-Tumor Heterogeneity
Wang, M., Xie, Y., Liu, J., Li, A., Chen, L., Stromberg, A., Arnold, S. M., Liu, C. & Wang, C., Jul 2024, In: Cancers. 16, 13, 2488.Research output: Contribution to journal › Article › peer-review
A single hydrogen bond that tunes flavin redox reactivity and activates it for modification
Das, D. & Miller, A. F., Apr 24 2024, In: Chemical Science. 15, 20, p. 7610-7622 13 p.Research output: Contribution to journal › Article › peer-review
Atypical Mycobacterium abscessus BlaRI Ortholog Mediates Regulation of Energy Metabolism but Not β-Lactam Resistance
Bonefont, L. E., Davenport, H. C., Chaton, C. T., Korotkov, K. V. & Rohde, K. H., Sep 22 2024, (E-pub ahead of print) In: Molecular Microbiology.Research output: Contribution to journal › Article › peer-review
A unique inflammaging profile generated by T cells from people with obesity is metformin resistant
SantaCruz-Calvo, S., Saraswat, S., Kalantar, G. H., Zukowski, E., Marszalkowski, H., Javidan, A., Gholamrezaeinejad, F., Bharath, L. P., Kern, P. A., Zhang, X. D. & Nikolajczyk, B. S., 2024, (Accepted/In press) In: GeroScience.Research output: Contribution to journal › Article › peer-review
Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1
Melikishvili, M., Fried, M. G. & Fondufe-Mittendorf, Y. N., Dec 2024, In: Scientific Reports. 14, 1, 7530.Research output: Contribution to journal › Article › peer-review
Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)
The Atomwise AIMS Program, Dec 2024, In: Scientific Reports. 14, 1, 21579.Research output: Contribution to journal › Comment/debate
Correction to: NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer (Molecular Cancer, (2024), 23, 1, (188), 10.1186/s12943-024-02102-y)
Ngule, C., Shi, R., Ren, X., Jia, H., Oyelami, F., Li, D., Park, Y., Kim, J., Hemati, H., Zhang, Y., Xiong, X., Shinkle, A., Vanderford, N. L., Bachert, S., Zhou, B. P., Wang, J., Song, J., Liu, X. & Yang, J., Dec 2024, In: Molecular Cancer. 23, 1, 220.Research output: Contribution to journal › Comment/debate
Creating an Integrated Coaching Culture in Higher Education
Bradley, J. A., Tuck, M. E., Reynolds, M. A. & Bradley, L. H., 2024, In: Journal of appreciative education. 11, p. 15-24 10 p.Research output: Contribution to journal › Article › peer-review
Cryo-EM reconstruction of oleate hydratase bound to a phospholipid membrane bilayer
Oldham, M. L., Zuhaib Qayyum, M., Kalathur, R. C., Rock, C. O. & Radka, C. D., Sep 2024, In: Journal of Structural Biology. 216, 3, 108116.Research output: Contribution to journal › Article › peer-review
Differential processing of VesB by two rhomboid proteases in Vibrio cholerae.
Roberts, C. S., Shannon, A. B., Korotkov, K. V. & Sandkvist, M., Sep 11 2024, In: mBio. 15, 9, p. e0127024Research output: Contribution to journal › Article › peer-review
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort
RECOVER-Adult Cohort, Sep 2024, In: Annals of Internal Medicine. 177, 9, p. 1209-1221 13 p.Research output: Contribution to journal › Article › peer-review
Disorder regulates homeostasis of extracytoplasmic proteins in streptococci
Rahman, M. M., Zamakhaeva, S., Rush, J. S., Chaton, C. T., Kenner, C. W., Hla, Y. M., Tsui, H.-C. T., Winkler, M. E., Korotkov, K. V. & Korotkova, N., May 8 2024, In: bioRxiv.Research output: Contribution to journal › Article
Dissecting the biophysical mechanisms of oleate hydratase association with membranes
Lathram, W. A., Neff, R. J., Zalla, A. N., Brien, J. D., Subramanian, V. & Radka, C. D., 2024, In: Frontiers in Molecular Biosciences. 11, 1504373.Research output: Contribution to journal › Article › peer-review
EcoHIV-Infected Mice Show No Signs of Platelet Activation
Alfar, H. R., Nthenge-Ngumbau, D. N., Saatman, K. E. & Whiteheart, S. W., Jan 2024, In: Viruses. 16, 1, 55.Research output: Contribution to journal › Article › peer-review
Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
Zhang, Y., Fong, K. W., Mao, F., Wang, R., Allison, D. B., Napier, D., He, D., Liu, J., Zhang, Y., Chen, J., Kong, Y., Li, C., Li, G., Liu, J., Li, Z., Zhu, H., Wang, C. & Liu, X., Jul 23 2024, In: Cell Reports. 43, 7, 114431.Research output: Contribution to journal › Article › peer-review
Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
Rockhold, J. D., Marszalkowski, H., Sannella, M., Gibney, K., Murphy, L., Zukowski, E., Kalantar, G. H., SantaCruz-Calvo, S., Hart, S. N., Kuhn, M. K., Yu, J., Stefanik, O., Chase, G., Proctor, E. A., Hasturk, H., Nikolajczyk, B. S. & Bharath, L. P., Dec 2024, In: GeroScience. 46, 6, p. 5681-5699 19 p.Research output: Contribution to journal › Article › peer-review
Examination of respiratory syncytial virus fusion protein proteolytic processing and roles of the P27 domain
Neal, H. E., Barrett, C. T., Edmonds, K., Moncman, C. L. & Dutch, R. E., Dec 2024, In: Journal of Virology. 98, 12Research output: Contribution to journal › Article › peer-review
Examining Phosphatases Through Immunofluorescent Microscopy
Smith, C. N. & Blackburn, J. S., 2024, Methods in Molecular Biology. p. 111-122 12 p. (Methods in Molecular Biology; vol. 2743).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Exposure to Lead in Drinking Water Causes Cognitive Impairment via an Alzheimer’s Disease Gene-Dependent Mechanism in Adult Mice
Kohler, K., Macheda, T., Hobbs, M. M., Maisel, M. T., Rodriguez, A., Farris, L., Wessel, C. R., Infantino, C., Niedowicz, D. M., Helman, A. M., Beckett, T. L., Unrine, J. M. & Murphy, M. P., Aug 20 2024, In: Journal of Alzheimer's Disease. 100, s1, p. S291-S304Research output: Contribution to journal › Article › peer-review
Extended conformations of bifurcating electron transfer flavoprotein constitute up to half the population, possibly mediating conformational change
Khan, S. A., Hicks, A., Leite, W. C., Byrnes, J., Gorai, B., Mroginski, M. A., O'Neill, H. & Miller, A. F., Oct 23 2024, In: Chemical Science. 15, 45, p. 18796-18817 22 p.Research output: Contribution to journal › Article › peer-review
Fasting and Glucose Metabolism Differentially Impact Peripheral Inflammation in Human Type 2 Diabetes
Kalantar, G. H., Saraswat, S., SantaCruz-Calvo, S., Gholamrezaeinejad, F., Javidan, A., Agrawal, M., Liu, R., Kern, P., Zhang, X. & Nikolajczyk, B. S., May 7 2024, In: Nutrients. 16, 10Research output: Contribution to journal › Article › peer-review
Fish Oil Supplement Mitigates Muscle Injury In Vivo and In Vitro: A Preliminary Report †
Russ, D. W., Sehested, C., Banford, K. & Weisleder, N. L., Oct 2024, In: Nutrients. 16, 20, 3511.Research output: Contribution to journal › Article › peer-review
Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota
Mercado-Evans, V., Mejia, M. E., Zulk, J. J., Ottinger, S., Hameed, Z. A., Serchejian, C., Marunde, M. G., Robertson, C. M., Ballard, M. B., Ruano, S. H., Korotkova, N., Flores, A. R., Pennington, K. A. & Patras, K. A., Dec 2024, In: Nature Communications. 15, 1Research output: Contribution to journal › Article › peer-review
Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
Huang, K., Li, Z., He, X., Dai, J., Huang, B., Shi, Y., Fan, D., Zhang, Z., Liu, Y., Li, N., Zhang, Z., Peng, J., Liu, C., Zeng, R., Cen, Z., Wang, T., Yang, W., Cen, M., Li, J. & Yuan, S. & 40 others, , Mar 5 2024, In: Cell Metabolism. 36, 3, p. 598-616.e9Research output: Contribution to journal › Article › peer-review
Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining
Al-Hamaly, M. A., Chernyavskaya, Y. & Blackburn, J. S., Jul 2024, In: Journal of Visualized Experiments. 2024, 209, e67059.Research output: Contribution to journal › Article › peer-review
Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
Shi, H., Mirzaei, N., Koronyo, Y., Davis, M. R., Robinson, E., Braun, G. M., Jallow, O., Rentsendorj, A., Ramanujan, V. K., Fert-Bober, J., Kramerov, A. A., Ljubimov, A. V., Schneider, L. S., Tourtellotte, W. G., Hawes, D., Schneider, J. A., Black, K. L., Kayed, R., Selenica, M. L. B. & Lee, D. C. & 2 others, , Dec 2024, In: Acta Neuropathologica. 148, 1, 3.Research output: Contribution to journal › Article › peer-review
InChI isotopologue and isotopomer specifications
Moseley, H. N. B., Rocca-Serra, P., Salek, R. M., Arita, M. & Schymanski, E. L., Dec 2024, In: Journal of Cheminformatics. 16, 1, 54.Research output: Contribution to journal › Article › peer-review
Independent evolution of oleate hydratase clades in Bacillales reflects molecular convergence
Neff, R. J., Lages, P. C., Donworth, S. K., Brien, J. D. & Radka, C. D., 2024, In: Frontiers in Molecular Biosciences. 11, 1485485.Research output: Contribution to journal › Article › peer-review
Influence of FTDP-17 mutants on circular tau RNAs
Margvelani, G., Welden, J. R., Maquera, A. A., Van Eyk, J. E., Murray, C., Miranda Sardon, S. C. & Stamm, S., Apr 2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 4, 167036.Research output: Contribution to journal › Article › peer-review