July 6, 2020

The Department had seven publications listed in PubMed for the month of June 2020.

1: Garcia EG, Veloso A, Oliveira ML, Allen JR, Loontiens S, Brunson D, Do D, Yan C, Morris R, Iyer S, Garcia SP, Iftimia N, Van Loocke W, Matthijssens F, McCarthy K, Barata JT, Speleman F, Taghon T, Gutierrez A, Van Vlierberghe P, Haas W, Blackburn JS, Langenau DM. PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis. Leukemia. 2020 Jun 30. doi: 10.1038/s41375-020-0937-3. Epub ahead of print. PMID: 32606318.

July 1, 2020
A University of Kentucky College of Medicine researcher has been awarded $1.9 million to continue research examining molecular pathogenesis of Noonan-like syndrome. Emilia Galperin, Ph.D., professor in the Department of Molecular & Cellular Biochemistry, was awarded a prestigious R35 Maximizing Investigator’s Research Award Grant from the National Institute of General Medical Sciences that will fund her lab’s research over the next five years. Normal human cell growth is controlled by complex signaling pathways, and errors in these signal transmissions can have serious consequences inclu
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June 19, 2020

LEXINGTON, Ky. (June 18, 2020) — Alpacas Big Boy, Blue Eyes and Emperor may hold the key to combating COVID-19. Their antibodies could offer a defense against SARS-CoV-2, the virus that causes the disease.

University of Kentucky College of Medicine researchers are using the special antibodies made by alpacas, called nanobodies, to help understand the novel coronavirus and potentially develop a treatment that could protect people from being infected. 

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June 12, 2020

LEXINGTON, Ky. (June 12, 2020) — In the wake of the COVID-19 pandemic, University of Kentucky experts quickly mobilized and pivoted their research to unite in the fight against the novel coronavirus.

UK researchers across many disciplines are addressing COVID-19’s medical challenges and beyond — including developing new personal protective equipment (PPE) materials, designing testing and diagnostic equipment, and examining the wider societal, economic and legal implications of the pandemic.

June 5, 2020

The Department had four publications listed in PubMed for the month of May 2020.

1: Banerjee M, Huang Y, Joshi S, Popa GJ, Mendenhall MD, Wang QJ, Garvy BA, Myint T, Whiteheart SW. Platelets Endocytose Viral Particles and Are Activated via TLR (Toll-Like Receptor) Signaling. Arterioscler Thromb Vasc Biol. 2020 May 21:ATVBAHA120314180. doi: 10.1161/ATVBAHA.120.314180. Epub ahead of print. PMID: 32434410.

May 26, 2020

LEXINGTON, Ky. (May 22, 2020) — University of Kentucky College of Medicine scientist Matthew Gentry is one of 20 recipients of a prestigious R35 grant from the National Institute of Neurological Disorders (NINDS) for his research on energy metabolism in the brain.

May 5, 2020

The Department had ten publications listed in PubMed for the month of April 2020.

1: Han R, Hensley PJ, Li J, Zhang Y, Stark TW, Heller A, Qian H, Shi J, Liu Z, Huang JA, Jin T, Wei X, Zhou BP, Wu Y, Kyprianou N, Chen J, Yang XH. Integrin-associated CD151 is a suppressor of prostate cancer progression. Am J Transl Res. 2020 Apr 15;12(4):1428-1442. eCollection 2020. PubMed PMID: 32355552; PubMed Central PMCID: PMC7191174.

April 30, 2020
University of Kentucky College of Medicine researcher Sidney Whiteheart has been awarded a prestigious Outstanding Investigator Award from the National Heart, Blood and Lung Institute (NHBLI) for his research on how platelets function in hemostasis and during immune responses. The $6.6 million grant will fund the Molecular & Cellular Biochemistry professor’s research over the next seven years. The study, which Whiteheart is leading in collaboration with researchers from Beth Israel Deaconess Medical Center, University of Arkansas for Medical Sciences, and the University of Pennsylvania,
April 6, 2020

The Department had nine publications listed in PubMed for the month of March 2020.

1: Jin H, Moseley HNB. Robust Moiety Model Selection Using Mass Spectrometry Measured Isotopologues. Metabolites. 2020 Mar 21;10(3). pii: E118. doi: 10.3390/metabo10030118. PubMed PMID: 32245221.

2: Welden JR, Pawluchin A, van Doorn J, Stamm S. Use of Alu Element Containing Minigenes to Analyze Circular RNAs. J Vis Exp. 2020 Mar 10;(157). doi: 10.3791/59760. PubMed PMID: 32225139.

March 23, 2020

Here are the various links and things I've been sending out while we're all the doing the work from home thing:

Work and career:

March 5, 2020

The Department had ten publications listed in PubMed for the month of February 2020.

1: Abeysinghe R, Hinderer EW, Moseley HNB, Cui L. SSIF: Subsumption-based Sub-term Inference Framework to Audit Gene Ontology. Bioinformatics. 2020 Feb 17. pii: btaa106. doi: 10.1093/bioinformatics/btaa106. [Epub ahead of print] PubMed PMID: 32065617.

February 5, 2020

The Department started the year with twelve publications listed in PubMed for the month of January 2020.

1: Wei M, Haney MG, Rivas DR, Blackburn JS. Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo. Oncogenesis. 2020 Jan 30;9(1):6. doi: 10.1038/s41389-020-0192-5. PubMed PMID: 32001668; PubMed Central PMCID: PMC6992623.

January 10, 2020

Researchers at the University of Kentucky’s College of Medicine have found that a class of antibiotics called aminoglycosides could be a promising treatment for frontotemporal dementia.

Results of their proof of concept study, which was a collaborative effort between UK’s Department of Molecular and Cellular Biochemistry and the University of California San Francisco’s Department of Pathology, were recently published in the journal, Human Molecular Genetics.

January 6, 2020

Happy New Year all! I hope this is a good one for everyone.

January 6, 2020

The Department finished the year with nine publications listed in PubMed for the month of December 2019.

1: Chaton CT, Rodriguez ES, Reed RW, Li J, Kenner CW, Korotkov KV. Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site. Sci Rep. 2019 Dec 30;9(1):20267. doi: 10.1038/s41598-019-56722-2. PubMed PMID: 31889085.

December 5, 2019

In November the Department had seven new publications listed in PubMed.

1: Li H, Li J, Han R, Deng X, Shi J, Huang H, Hamad N, McCaughley A, Liu J, Wang C, Chen K, Wei D, Qiang J, Thatcher S, Wu Y, Liu C, Thibault O, Wei X, Chen S, Qian H, Zhou BP, Xu P, Yang XH. Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling. Neoplasia. 2019 Nov 26;21(12):1151-1163. doi: 10.1016/j.neo.2019.08.005. [Epub ahead of print] PubMed PMID: 31783316.

November 7, 2019

In October the Department had eight new publications listed in PubMed.

1: Burggraaf MJ, Speer A, Meijers AS, Ummels R, van der Sar AM, Korotkov KV, Bitter W, Kuijl C. Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease. MBio. 2019 Oct 29;10(5). pii: e01951-19. doi: 10.1128/mBio.01951-19. PubMed PMID: 31662454.

November 5, 2019

And now for something a little different... Instead of suggesting something to read this month I'm going to suggest something to listen to (thanks for Bobby Murphy for this idea!). There are a lot of podcasts out there, including a lot that are science-based. One that looks particularly interesting comes from the BBC and is called "The Life Scientific". A different scientist is interviewed in each episode, providing insight into different fields, the different paths people take, and a variety of careers.

October 7, 2019

In September the Department had ten new publications listed in PubMed.

1: Zhang J, Liu Y, Jiang K, Jia J. Hedgehog signaling promotes lipolysis in adipose tissue through directly regulating Bmm/ATGL lipase. Dev Biol. 2019 Sep 21. pii: S0012-1606(19)30338-0. doi: 10.1016/j.ydbio.2019.09.009. [Epub ahead of print] PubMed PMID: 31550483.

2: Kim JT, Li C, Weiss HL, Zhou Y, Liu C, Wang Q, Evers BM. Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells. Cells. 2019 Sep 19;8(9). pii: E1106. doi: 10.3390/cells8091106. PubMed PMID:31546785.

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September 19, 2019

Decades of research and treatment advances have helped extend the lives of many people living with HIV, but while these patients live longer, their risk of developing dangerous blood clots increases as much as tenfold. Blood clots – also known as thrombi – can wreak havoc on the body, causing events such as debilitating strokes and heart attacks.