My name is James Overly, and I am junior biology and neuroscience student. I have been in the lab of Daniel Lee, MD, at the Sanders-Brown Center on Aging for 2 years, where we study Alzheimer’s disease and other tauopathies. Under Dr. Lee’s mentorship, my focus on Alzheimer's disease and related tauopathies brought me towards the study of polyamine metabolism and the polyamine stress response (PSR). This work investigates the role of polyamines, aliphatic polycations essential for various physiological functions, particularly under conditions of stress.