Cancer research at the Department of Toxicology and Cancer Biology involves multiple laboratories with various focus areas. They include chemical carcinogenesis, metal carcinogenesis, tumor suppressor genes, gene regulation during carcinogenesis, redox-mediated mechanisms of tumor suppression, reactive oxygen species and cancer, cell signaling in cancer biology, environmental risk factors in cancer, and cancer prevention. Molecular, cellular, genomic, transgenic, and proteomic techniques are used in these studies, addressing important problems in the biology and therapy of lung, colon, prostate, skin cancers and leukemia. Experimental systems from cell culture to animal models to patient specimens are used for basic and translational cancer research. These research activities yield knowledge for better understanding of cancer biology and aim at improving cancer therapy and cancer prevention.