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Plants put up a natural defense system against bacteria and disease through bioactive chemical constituents called flavonoids.

While humans have turned to plants and herbs for medicinal purposes throughout history, researchers are now learning how to harness the chemopreventive properties of flavonoids to prevent human disease. Medical research suggests flavonoids can prevent the development of steroid-responsive cancers, but not all flavonoids serve the same beneficial function.

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For University of Kentucky Vice President for Research Lisa Cassis the drive to conduct meaningful research is personal.

 “You don’t go into it for the money, you go into it because you want to help people,” Cassis said.

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Analia Loria, assistant professor of pharmacology and nutritional sciences at the University of Kentucky, will be a featured presenter at the First Physiology and Gender Conference organized by the American Physiological Society this week.

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Doctors commonly recommend patients increase their intake of calcium as a means of combating osteoporosis for aging bones. But calcium also plays an essential role in the neurological functioning of the brain, where it must be tightly regulated and not rise to excessive levels. A signaling molecule, calcium enables learning, cognition and the retention of memories.

Doctor of Philosophy: Junting Ai, China; Kate Townsend Creasy, Richmond, VA; Paulina Renee Davis, Temecula, CA; Leann Sara Fiore, Tulsa, OK; Sang Hee Lee, South Korea; Kristen Platt, Flemingsburg, KY; Robin Camille Shoemaker, Farmington, NM; Joel Christopher Thompson, Lexington, KY; Congqing Wu, Lexington, KY

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The University of Kentucky’s fifth annual Barnstable Brown Obesity and Diabetes Research Day was held on May 20 at the Albert B. Chandler Hospital Pavilion A.

Since 2011, the event has focused on current findings in obesity and diabetes research and features presentations by nationally prominent physician-scientists as well as the work of regional researchers and UK students, postdoctoral fellows and faculty chosen from abstract submissions.

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Two researchers from the Sanders-Brown Center on Aging have received a multi-million dollar grant renewal to unlock the mysteries of Alzheimer's disease (AD) and brain aging with the help of people with Down syndrome (DS).

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"Drug Interactions in Breast Cancer" project has the potential to help scientists understand why the drug tamoxifen may not work as a therapy for breast cancer in some patients. Hollie Swanson, professor in the Department of Pharmacology and Nutritional Sciences, and Ok-Kyong Park-Sarge, associate professor in the Department of Physiology, worked with 10 STEMCats students on the project.
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Dr. John Fowlkes took the helm as new director of the University of Kentucky's Barnstable Brown Diabetes and Obesity Center earlier this year with a vision to build upon the center's past work and develop a robust and comprehensive adult and pediatric center providing research, education and patient care for the thousands of Kentuckians diagnosed with diabetes. But the Texas native who has spent the last decade at the University of Arkansas Children's Hospital, has found himself in familiar territory. Fowlkes, who succeeds Dr.
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On Friday, February 6, 2015 the Department of Pharmacology and Nutritional Sciences hosted the University of Kentucky’s inaugural “Wear Red Day” symposium to raise awareness for cardiovascular research in women. The event was a part of the annual “National Wear Red Day” sponsored by the American Heart Association (AHA) that takes place on the first Friday of February.
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Registration is now available for the fifth annual Barnstable Brown Obesity & Diabetes Research Day set for May 20, 2015, at the University of Kentucky Albert B. Chandler Hospital Pavilion A. The event is sponsored by the Barnstable Brown Kentucky Diabetes and Obesity Center, Center of Research in Obesity and Cardiovascular Disease and the Nutrition and Oxidative Stress Training. Researchers from the University of Kentucky and other regional institutes will share their current findings and ongoing research about the alarming rise in obesity and diabetes rates.
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Shuxia Wang, MD, Ph.D., has received NIH RO1 funding for a project titled "Thrombospondin1 in obesity associated inflammation and insulin resistance." The project will be supported by $1,204,651 grant for the period of August 2014 to May 2018. In addition, Dr. Wang recently received a competitive score for an R03 award to study interventions that may reduce acute kidney injury in the elderly. Dr. Wang joined the University of Kentucky faculty in 2005, and has served extensively in the areas of research, graduate training, and education. Dr.

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Changcheng Zhou, PhD, assistant professor of Pharmacology and Nutritional Sciences, has received funding for an NIH R21 grant: "Mechanisms of atherogenic effects of bisphenol A," for the period April 1, 2014 - March 31, 2016. Dr. Zhou joined the faculty of University of Kentucky in 2010. He also holds an adjunct faculty position at Rockefeller University, NY. The main focus of Dr. Zhou’s laboratory is to investigate the molecular mechanisms of atherosclerosis and metabolic disorders.

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Dr. Michael Kilgore, PhD, received recognition as a “Teacher Who Made a Difference” at the 16th Annual Teachers Who Made a Difference awards ceremony on April 26, 2014. More than 150 teachers’ names were put forward, including teachers from across the Commonwealth of Kentucky as well as teachers from Illinois, Indiana, Louisiana, New York, North Carolina, Tennessee and Ohio. The program, hosted by the University of Kentucky College of Education, was begun in 1998 to recognize educators who made a positive impact on the lives of their students. Congratulations Dr. Kilgore.
Four students seeking their master's degrees and five students doctoral programs competed last week in an event designed to prepare them for presenting research. The "Three Minute Thesis" event, hosted by the UK Graduate School and the Graduate Student Congress, is a research communication initiative requiring graduate students to speak succinctly and engagingly about their current research to a nonspecialist audience. It provides students with the opportunity to practice presenting their work, and to receive feedback from a panel of judges.
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The University of Kentucky Board of Trustees Saturday adopted a sweeping statement of principles, directing President Eli Capilouto to focus on the "most pressing" needs of Kentucky by determining how best to grow UK's research enterprise through strategic investments in facilities and talent. "The challenges are overwhelming, but we can be up to the task of making a difference," Capilouto said. "These are not easy issues, but they must be our issues.
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The University of Kentucky Center for Health Services Research (CHSR), which serves as a connector, catalyst and creator at UK and UK HealthCare, announces the launch of its new website and seeks membership applicants for its efforts in applying research to optimize health care delivery. The CHSR is focused on creating, testing, and scaling next-generation health services research solutions to improve the efficiency and effectiveness of health delivery within Kentucky and beyond.

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The Department of Pharmacology and Nutritional Sciences is pleased to announce that Associate Professors Florin and Sanda Despa recently received tenure, and Dr. Kevin Pearson was promoted to the positon of associate professor with tenure. Before coming to the University of Kentucky in 2013, Florin and Sanda Despa had appointments at the University of California, Davis. Florin earned his Ph.D. from the Institute of Physics in Bucharest, Romania and did post-doctoral studies in the Department of Chemistry at the University of Chicago. He was an assistant professor of research at U.C.

The Journal of the American Heart Association (JAHA) has accepted an article by authors Sanda Despa, Savita Sharma, Todd R. Harris, Hua Dong, Ning Li, Nipavan Chiamvimonvat, Heinrich Taegtmeyer, Kenneth B. Margulies, Bruce D. Hammock, and Florin Despa. JAHA plans to publish their work, "Cardioprotection by controlling hyperamylinemia in a 'humanized' diabetic rat model," as soon as possible.