Microbes and society focuses on the impact, good and bad, of microbes on humanity and civilization. The course explores the beneficial effects of microbes on the environment, agriculture, industry, biotechnology, and medicine. In addition, the course describes how microbes and microbial diseases have influenced the history and evolution of humans. The course also explores the negative impact of microbes as pathogens and emerging infectious agents on civilization. Host pathogen interactions including how microbes cause infectious diseases and how the host immune response clears infections and protects the host against re-infection with the same microbe are also covered in the course.

This course will cover topics of critical importance for understanding modern bacterial genetics. The course content will include the study of DNA elements including the chromosome, plasmids and bacteriophage, gene expression at the transcriptional, translational and post-translational levels, methods of genetic analysis, transposition, recombination, and the genetics of antibiotic resistance. Incorporated into these topics will be problem solving exercises, discussions of new directions in bacterial genetics, and selected readings in recent applications of bacterial genetics to pathogenesis, development and spread of antibiotic resistance, disease therapy or the study of the human microbiota. Prereq: BIO 208 or BIO 308 or equivalent or consent of instructor

MI 482 will introduce students to the physical, chemical, and biological properties of viruses. The key elements of the viral life cycle will be examined in molecular detail for representative viruses, and critical aspects of host-pathogen interactions will be discussed.
Prereq: BIO 304 and biochemistry or equivalent strongly recommended, or consent of the instructor.

Crosslisted with: BIO 482

A survey of theories and mechanisms of immunity, including: nature of antigens and antibodies, antigen-antibody reactions, immunocompetent cells, immunogenetics, allergic reactions, tumor immunology, and transplantation immunology. Prerequisites: BCH 401G (may be taken concurrently) and BIO 208 or BIO 308 or consent of instructor. (Same as BIO 494G.)

This course will examine the pathogenic mechanisms used by bacteria to cause human disease. Bacterial virulence factors and host susceptibility factors will be discussed, with an emphasis on understanding the techniques that can be used to identify these traits in newly emerging pathogens. Prerequisites: BIO 308, BIO 315, BCH 401 recommended. Or permission of instructor. (Same as BIO 495G.)

Immunotherapy, the application of immunologic principles to the clinic, often called “Bench to Bedside”, has led to significant objective clinical responses and prolonged time to tumor progression or recurrence in a subset of cancer patients. The current class will discuss basic immunologic principles and show how they apply to the tumor setting. In addition, the class will demonstrate how immunologic mechanisms can be exploited in the treatment of cancer. The semester will be divided into three stages including:

1. A concise review of basic immunology concepts preparing the student for applying those concepts to the tumor setting,
2. A detailed examination of the tumor microenvironment, tumor derived immunosuppression and the effector function of both soluble and cellular mechanisms against tumors of varying stages.
3. A broad overview of immunotherapy including regulatory issues pertaining to reagent development and delivery as well as an in depth review of all of the different approaches utilized to treat cancer since 1980. The course will be lecture based utilizing current and historic literature as well as the Course Directors extensive experience in the field. Prereq: MI 494G or MI 685

Physical, chemical, and biological properties of viruses. Modes of replication and control of gene product formation displayed by representative plant, animal, and bacterial viruses. Prerequisites: BIO 304 and biochemistry or equivalent strongly recommended, or consent of instructor. (Same as BIO 582.)

An introduction to the concepts of clinical microbiology through a survey of the microbial diseases of man using an organ system approach. Prerequisites: BIO 208 and 209, BIO 476G recommended, CHE 230 or 236, or consent of instructor. (Same as PAT 598.)

An introductory graduate-level course on mechanisms associated with DNA structure, replication, recombination and repair, chromatin, transcriptional control, mRNA processing, and protein synthesis. Aspects of contemporary genetics, genomics and bioinformatics will also be included. Techniques in genetic engineering and recombinant DNA that are critical to molecular biology research will be covered. Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents.

An introductory graduate level course that is focused on a number of topics related to cell biology including cell types and cell architecture/organization, membrane structure, cytoskeleton, nucleus, and mitochondria. Aspects of development, cell division, cell cycle, and apoptosis will also be discussed with an emphasis on signaling pathways controlling these processes. Prerequisites: CHE 105 and 107, CHE 230 and 232, BIO 150 and 152, or equivalents.

An introductory graduate level course that considers the function of the mammalian organism from a perspective ranging from cells to organs, with an emphasis on physiological communication between organ systems. The course is organized into 3 sections that include: (a) overview of basic physiological mechanisms maintaining homeostasis and mechanisms of endocrine communication via the bloodstream, (b) mechanisms of cell to cell communication by the immune system, and (c) mechanisms of neural communication. Prerequisites: IBS 601 and IBS 602.

Weekly seminar devoted to the presentation and discussion of classic and new research. May be repeated. Two semesters required as part of IBS curriculum. Prerequisites: Admission to IBS curriculum (non-IBS students may not register for this course).

Individualized laboratory and research experience under the supervision of a faculty member. May be repeated to a maximum of two credit hours. Two semesters required as part of IBS curriculum. Prerequisites: Admission to IBS curriculum and consent of instructor (non-IBS students may not register for this course).

Biology of cancer will be discussed at the molecular, cellular, and organismic level. Emphasis will be placed on cellular signaling, genomic instability, apoptosis, and cell cycle pathways unique to cancer cells that affect tumor cell behavior and its interactions with the host immune system. The biology of hematopoitic cells will also be included. Clinicians active in treatment and research of various types of cancer will be invited to participate in the lectures. Prerequisites: IBS 601, IBS 602, and/or IBS 603 (or comparable course in biochemistry, molecular biology, or cell biology) or otherwise by consent of course director. (Same as MED/PHA/TOX 616.)

An introductory level graduate course surveying current trends in immunology including the organization of the immune system, cells important for immunity and inflammation; types of immune responses, cellular immunology, molecular immunology, self-nonself discrimination, vaccines, and immune mediated diseases. Prerequisites: BCH 401G, or BCH 501 or 502, IBS 501, or equivalent or consent of the course director. (Same as BIO 685.)

MI 704 is targeted to pre-qualifying second-year graduate students pursuing a PhD, but may also be of value for post-qualifying graduate students and postdoctoral trainees. The primary objective is to help students improve their writing and critical thinking skills, structured around the development of an NIH National Research Service Award (NRSA) F31 Individual Fellowship. Students will become familiar with the NIH structure and resources, the different sections of an NRSA grant application, and the process of grant submission at UK. This will be done through in-class lectures and the writing/editing of NRSA fellowship components, including in-class time for writing and editing.

This course will deal with controversial and evolving areas of immunology. Lectures in a given topic will be accompanied by student discussion of contemporary literature. Prerequisites: MI 685 or equivalent or consent of instructor. (Same as BIO 707.)

This class focuses on grant writing. Prerequisites: Consent of instructor.

Molecular basis of structure and function in unicellular microbes. Molecular genetic and structural approaches to the analysis of bacterial architecture growth, division, and differentiation. Prerequisites: (to reflect appropriate IBS course). (Same as BIO 720 and OBI 720).

Mechanisms of Microbial Pathogenesis is designed to cover major pathogenic mechanisms of bacteria, protozoa, fungi, and viruses. Since it is impossible to include every possible pathogen, we instead focus on selected pathogens that illustrate particular lifestyles and pathogenic strategies. Emphasis is given to covering host mechanisms that combat the different weapons and lifestyles of the disease causing microbes. Students will gain an understanding of the interplay between pathogen and host and appreciate the myriad ways in which microbes have learned to subvert host pathways and evade the immune system. The course starts with an introduction to pathogenic concepts and immune responses, and then proceeds to the selected pathogens, including Listeria, Chlamydia, Mycobacterium, Toxoplasma, Ebola, Influenza, and HIV. The course is a mixture of lecture and discussion. Students will read current literature, assigned by their instructors, and participate in classroom discussions of the papers. Prerequisites: MI 720 or MI 495G.

Half-time to full-time work on thesis. May be repeated to a maximum of six semesters. Prerequisites: All course work toward the degree must be completed.

Half-time to full-time work on dissertation. May be repeated to a maximum of six semesters. Prerequisites: Registration for two full-time semesters of 769 residence credit following the successful completion of the qualifying exams. (Same as MB 749.)

Residency credit for dissertation research after the qualifying examination. Students may register for this course in the semester of the qualifying examination. A minimum of two semesters are required as well as continuous enrollment (Fall and Spring) until the dissertation is completed and defended.

May be repeated to a maximum of 12 hours. (Same as MB 768.)

May be repeated indefinitely. (Same as MB 769.)

Review of current literature in microbiology; presentation of papers on work in progress in the department or on assigned topics; reports on meetings of national and international scientific and professional societies and symposia. Required of all graduate students. Two hours per week. May be repeated nine times for a maximum of 10 credits. (Same as BIO 772.)

May be repeated to a maximum of 24 credits. Prerequisites: Consent of instructor. (Same as BIO 798.)

The course provides basic concepts of immunology and bacterial, viral, fungal and protozoal biology. It focuses on mechanisms of human immunity, immunologically mediated disease, and pathogenesis in infectious disease. The material covered includes relevant pathology associated with both immunologic and infectious diseases, and a summary of infectious diseases from a clinical perspective. Prereq: Enrolled in the DMD curriculum. (Same as OBI 828.)