Lesley Golden in the lab

I’m a fourth-year graduate student in the department of physiology in Dr. Lance Johnson’s lab. Our lab studies the different isoforms of Apolipoprotein E (ApoE) and their role in Alzheimer’s disease. ApoE4 is the greatest genetic risk factor for late-onset Alzheimer’s disease, but ApoE2 decreases an individual’s risk.

Nick Devanney in the lab

The Johnson lab studies the strongest genetic risk factor for Alzheimer’s disease (AD), apolipoprotein E (APOE). The E4 allele of APOE is carried by more than 25% of the population. A single copy of E4 increases Alzheimer’s risk 3-4 fold compared to the more common E3 allele.

Sanders-Brown team gathered on the stairs.

LEXINGTON, Ky. (Sept. 2, 2022) — A team of researchers at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) has been awarded a $20.5 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH).

Elizabeth Rhodus

As an occupational therapist, Elizabeth Rhodus, PhD, has worked closely with older Kentuckians facing Alzheimer’s disease and related dementias (ADRD). She also has witnessed firsthand how poor health, limited resources, and high poverty rates have served as barriers to proper prevention and treatment.

SBCoA director Linda J. Van Eldik, PhD, on March 14, 2019.

LEXINGTON, Ky. (Aug. 19, 2022) — Linda J. Van Eldik, PhD, director of the University of Kentucky Sanders-Brown Center on Aging, is part of a $1.5 million grant to help further research into a possible treatment for Alzheimer’s disease.

Peter Nelson has dedicated his life, and the past 15 years at the University of Kentucky, to developing research that helps combat neurological diseases.

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LEXINGTON, Ky. (July 25, 2022) — Today, the UK College of Medicine, UK HealthCare, and community leaders celebrated the full opening of the Sanders-Brown Memory Clinic at Turfland. The new, larger clinic replaces the former Sanders-Brown facilities along North Broadway in Lexington.

David Fardo is a 2022-23 University Research Professor.

LEXINGTON, Ky. (July 22, 2022) — David Fardo, PhD, a professor of biostatisticsand the inaugural Stephen W. Wyatt Endowed Professor in the University of Kentucky College of Public Health, is one of 14 University Research Professors for 2022-23.

UK College of Social Work's Allison Gibson, PhD, is working to address a lack of information and services for people with a diagnosis of mild cognitive impairment, which often leads to dementia and Alzheimer's disease.

LEXINGTON, Ky. (July 21, 2022) — In her work with the University of Kentucky Sanders-Brown Center on Aging, UK College of Social Work Associate Professor Allison Gibson, PhD, has noticed an array of responses when people receive a diagnosis of mild cognitive impairment (MCI).

Mark Ebbert and his research assistants on Aug. 5, 2021.

LEXINGTON, Ky. (June 29, 2022) — A recent publication from researchers at the University of Kentucky explains the importance of identifying and understanding how differences between tissues and cells alter gene expression without changing the underlying genetic code.

Woman talking to her grandmother, working at a computer.

LEXINGTON, Ky. (June 23, 2022) — A researcher at the University of Kentucky’s Sanders-Brown Center on Aging is one of several experts in the field who recently discussed the use of two popular screening tests for dementia and Alzheimer’s disease. Frederick A. Schmitt, PhD.

UK researchers Erhard Bieberich and Simone Crivelli have identified new therapeutic targets for Alzheimer’s disease.

LEXINGTON, Ky. (June 15, 2022) — A new University of Kentucky College of Medicine study has identified potential targets to develop a therapy that could prevent Alzheimer’s disease. 

Man sitting with a nurse and his wife.
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Dementia Friendly Lexington began when a group of concerned community members, including caregivers, persons living with dementia, and representatives from several organizations began to discuss ways Lexington could be more dementia friendly.

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LEXINGTON, Ky. (May 2, 2022) — Are you caring for someone with dementia? We invite you to participate in a research study that offers the Harmony at H.O.M.E. (Help Online Modifying the Environment) telehealth program at the University of Kentucky. The program provides training and tools for care partners to assess and modify the home to promote activity engagement and behavior regulation for the person with dementia. This study is led by researchers within UK’s Sanders-Brown Center on Aging.

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LEXINGTON, Ky. (April 19, 2022) — Two undergraduates have been selected as the first recipients of the University of Kentucky’s new Beckman Scholars Program, titled Scholars United by Chemistry: Cultivating Excellence through Science Stewardship (SUCCESS).

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The motivation driving the work of Pete Nelson, M.D., Ph.D., is personal. His grandmother, Sylvia Becker, died with Alzheimer's disease, and he says his mother then grew terrified of developing the disease.

“It gives me purpose in life to attack that,” Nelson said. As an experimental neuropathologist at the University of Kentucky’s Sanders-Brown Center on Aging, he is guided by that motivation. “It is most every researcher’s dream to help identify and classify a disease, and then to go on and help beat it.”

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LEXINGTON, Ky. (March 10, 2022) — The University of Kentucky’s Sanders-Brown Center on Aging has been around for nearly half a century. In that time, they have built an international reputation for best-in-class research into a disease that kills more people every year than breast and prostate cancer combined – Alzheimer’s disease. There are several components to the ongoing research at Sanders-Brown, one is exploring ways to detect Alzheimer’s earlier in a person’s life.

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LEXINGTON, Ky. (March 10, 2022) - University of Kentucky Women’s Basketball Coach Kyra Elzy is passionate about Alzheimer’s disease research because of her close relationships with her grandmother, Mary Elzy, and her college basketball coach.

As a four-year letter winner at Tennessee, Elzy was a member of two national championship teams in 1997 and 1998 and a national runner-up squad in 2000, all under the legendary Pat Summitt. Her beloved coach died in 2016 at the age of 64 following a battle with Alzheimer’s disease.

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LEXINGTON, Ky. (March 1, 2022) — A researcher with the University of Kentucky's Sanders-Brown Center on Aging is part of a team who worked to identify genetic variants more accurately in genomic regions known to be involved in disease. In the fields of molecular biology and genetics, a genome is all genetic information for an organism. The basis of the study was that the repetitive nature and complexity of some medically relevant genes pose a challenge to accurately analyze in a clinical setting.