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Jian Fu


1095 V A Drive


  • Professor

College Unit(s)

Biography and Education


2001, Ph.D., University of Alabama at Birmingham


*Inflammation and innate immunity *Critical Care Medicine *Lung, kidney and vascular inflammation, injury and repair *Epigenetic regulation of lung inflammation and carcinogenesis by environmental factors *Nanotoxicology; Nanoparticles for drug delivery

Selected Publications

Liu L., Zhou X., Shetty S., Hou G., Wang QY, Fu J. HDAC6 inhibition blocks inflammatory signaling and caspase-1 activation in LPS-induced acute lung injury. Toxicology and Applied Pharmacology 370:178-183, 2019. Nagaraja MR, Tiwari N, Shetty SK, Marudamuthu AS, Fan L, Ostrom RS, Fu J., Gopu V, Radhakrishnan V, Idell S, Shetty S.p53 Expression in Lung Fibroblasts Is Linked to Mitigation of Fibrotic Lung Remodeling. American Journal of Pathology 2018 Oct;188(10):2207-2222 Puthusseri B, Marudamuthu A, Tiwari N, Fu J., Idell S, Shetty S. Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells. American Journal of Physiology- Lung Cellular and Molecular Physiology 312(6):L783-L796, 2017. Shetty SK, Tiwari N., Marudamuthu A, Puthusseri B., Bhandary Y., Fu, J., Levin J., Idell S., and Shetty S. p53 and microRNA-34a feedback promotes lung epithelial injury and pulmonary fibrosis. American Journal of Pathology 187(5):1016-1034, 2017 Yu J., Ma Z., Shetty S., Ma M., Fu J. Selective HDAC6 inhibition prevents TNF-α-induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema. American Journal of Physiology- Lung Cellular and Molecular Physiology, 311(1):L39-47, 2016 Tiwari N, Marudamuthu AS, Tsukasaki Y, Ikebe M, Fu J, Shetty S. p53- and PAI-1-mediated induction of C-X-C chemokines and CXCR2: Importance in Pulmonary Inflammation due to Cigarette Smoke exposure. American Journal of Physiology- Lung Cellular and Molecular Physiology 310(6):L496- 506, 2016 Dong C., Li B., Li Z., Shetty S., Fu J. Dasatinib-loaded albumin nanoparticles possess diminished endothelial cell barrier disruption and retain potent anti-leukemia cell activity. Oncotarget, 7(31):49699-49709, 2016. Yu J., Ma M., Ma Z., Fu J. HDAC6 inhibition prevents TNF-α-induced caspase 3 activation in lung endothelial cell and maintains cell-cell junctions. Oncotarget, 7(34):54714- 54722, 2016 Marudamuthu AS., Shetty SK, Bhandary Y., Karandashova S., Thompson M., Sathish V., Florova G., Hogan1 T., Pabelick C., Prakash YS., Tsukasaki Y., Fu J., Ikebe M., Idell S., Shetty S. Plasminogen activator inhibitor-1 suppresses pro-fibrotic responses in fibroblasts from fibrotic lungs. Journal of Biological Chemistry 290(15):9428-41, 2015 Gao R., Chen J., Hu Y., Shetty S., Ma Z., Fu J. Sirt1 restrains lung inflammasome activation in a murine model of sepsis. American Journal of Physiology- Lung Cellular and Molecular Physiology 308(8):L847-53, 2015 Marudamuthu AS., Bhandary YP., Shetty SK., Fu J., Sathish V., Prakash YS and Shetty S. Role of the urokinase-fibrinolytic system in epithelial mesenchymal transition during lung injury. American Journal of Pathology 185(1):55-68, 2015. Gao R., Ma Z., Chen J., Ma M., Yu J., Li Z., Shetty S., Fu J. Deletion of Src family kinase Lyn aggravates endotoxin-induced lung inflammation. American Journal of Physiology- Lung Cellular and Molecular Physiology 309(11):L1376-81, 2015 Bhandary YP., Marudamuthu AS., Shetty SK., Midde KK, Ji HL, Shams H., Idell S., Fu J., Shetty S. Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury. PLoS One 10(5):e0123187, 2015. Bhandary Y., Shetty SK, Marudamuthu A., Fu J., Pinson B., Levin J., Shetty S. Role of p53–fibrinolytic system cross-talk in the regulation of quartz-induced lung injury. Toxicology and Applied Pharmacology 283(2):92-98, 2015. Khisamutdinov EF., Li H., Jasinski DL., Chen J., Fu J., Guo P. Enhancing immunomodulation on innate immunity by shape transition among RNA triangle, square and pentagon nanovehicles. Nucleic Acids Research 42(15):9996-10004, 2014. Han J, Zhang G, Welch EJ, Liang Y, Fu J., Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood 122(25):4140- 9, 2013. Bhandary YP, Shetty SK, Marudamuthu A, Ji HL, Neuenschwander P, Boggaram V, Morris GF, Fu J., Idell S, Shetty S. Regulation of Lung Injury and Fibrosis by p53-Mediated Changes in Urokinase and Plasminogen Activator Inhibitor-1. American Journal of Pathology 183(1):131-43, 2013. Wu Z., Liu M., Liang M., Fu J. Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure. Blood 119(10):2422-29, 2012. Shetty SK., Marudamuthu AS., Abernathy D., Shetty R., Fu J., Idell S., Bhandary Y., Ji H., Liu MC., Shetty S. Posttranscriptional regulation of urokinase expression by lung epithelial cells. Biochemistry 51(1):205-13, 2012. Wu Z., Sawamura T., Kurdowska AK., Ji HL., Idell S., Fu J. LOX-1 deletion improves neutrophil function, enhances bacterial clearance and reduces lung injury in a murine polymicrobial sepsis model. Infection and Immunity 79(7):2865-2870, 2011. Yasuda S., Yasuda T., Liu MY., Shetty S., Idell S., Boggaram V., Suiko M., Sakakibara Y., Fu J., Liu MC. Sulfation of Chlorotyrosine and Nitrotyrosine by Human Lung Endothelial and Epithelial Cells: Role of the Human SULT1A3. Toxicology and Applied Pharmacology 251(2): 104–109, 2011. Zhang P., Cheng L., Liang M., Liu MC. Fu J. Blockade of LOX-1 prevents endotoxin-induced lung inflammation and injury in mice. Journal of Innate Immunity 1(4):358-365, 2009. Han D., Nie H., Gu X., Nayak R., Su X., Fu J., Chang Y., Rao V., Ji H. K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport. Respiratory Research 11:65, 2010. Low B., Liang M., Fu J. p38 Mitogen-Activated Protein Kinase Mediates Sidestream Cigarette Smoke-Induced Endothelial Permeability. Journal of Pharmacological Sciences 104(3): 225-231, 2007. Gao XP., Zhu XD., Fu J., Liu QH., Frey RS., Malik AB. Blockade of Class IA Phosphoinositide 3- Kinase in Neutrophils Prevents NADPH Oxidase Activation- and Adhesion- Dependent Inflammation. Journal of Biological Chemistry 282(9):6116-25, 2007. Ge X., Low B., Liang M., Fu J. Angiotensin II directly triggers endothelial exocytosis via PKC- dependent PKD2 Activation. Journal of Pharmacological Sciences 105(2): 168-176, 2007.