Gang Chen, PhD
- Associate Professor
- Associate DGS of Nutritional Sciences Graduate Program
- Graduate Faculty in Nutritional Sciences
- Nutritional Sciences Graduate Faculty
- Pharmacology and Nutritional Sciences Primary Faculty
- Toxicology - Joint Faculty
Biography and Education
West Virginia University, Ph.D., 2005
There are two research directions in my laboratory. One direction is ethanol toxicity, in which we investigate the mechanism(s) for ethanol-induced damage to the developing central nervous system and consequent behavioral deficits targeting Fetal Alcohol Spectrum Disorders (FASDs) and the mechanism of ethanol-enhanced mammary tumorigenesis. The other direction is the mechanism underlying arsenic lung carcinogenesis . FASD and the cancers caused by environmental factors are severe public health problems. The ultimate goal for our research is to find strategies for the prevention and treatment of these diseases. The approach is to determine the molecular mechanisms underlying the diseases and identify the responsible targets (genes, proteins or signaling pathways) using pharmacological or genetic manipulation methods in cell culture and animal models.
- Wenhua Xu, Linqing Wu, Mei Xu, Jia Luo, and Gang Chen. Ethanol Exposure Up-regulates PD-L1/PD-1 Immune Checkpoint Pathway and Promotes Mammary Tumor Development. Front Oncol. 2022 Jun 8;12:874156.
- Hongsen Wang, Jiaqi Li, Wenhua Xu, Chunming Li, Kuaiying Wu, Gang Chen and Jiajun Cui. The mechanism underlying arsenic-induced PD-L1 upregulation in transformed BEAS-2B cells. Toxicol Appl Pharmacol. 2022 Jan 15; 435: 115845. (co-corresponding author)
- Wenhua Xu, Jiajun Cui, Linqing Wu, Caigu He and Gang Chen. The role of PD-1/PD-L1 checkpoint in arsenic lung tumorigenesis. Toxicol Appl Pharmacol. 2021 Jun 22; 426: 115633.
- Wenhua Xu; Hui Li; Caigu He, Jacqueline A. Frank; and Gang Chen. Early ethanol exposure inhibits the differentiation of hippocampal dentate gyrus granule cells in a mouse model of Fetal Alcohol Spectrum Disorders. Alcoholism: Clinical and Experimental Research. 2020 May;44(5):1112-1122.
- Wenhua Xu, Andrew Hawkey, Hui Li, Lu Dai, Howard H. Brim, Jacqueline A. Frank, Jia Luo, Susan Barron and Gang Chen. Early Postnatal Ethanol Exposure Causes Behavioral Deficits in Young Mice. Alcoholism: Clinical and Experimental Research. 2018 Apr;42(4):743-750.