Image Useful Publications Center for Environmental and Systems Biochemistry Services Key Questions Useful Publications Examples of the use of stable isotope resolved metabolomics can be found in the publications listed below: Fan, T.WM., Lane, A.N., Higashi, R.M., Farag, M.A., Gao, H., Bousamra, M. & Miller, D.M. (2009) Altered Regulation of Metabolic Pathways in Human Lung Cancer Discerned by 13C Stable Isotope-Resolved Metabolomics (SIRM). Molecular Cancer. 8:41 Fan, T. W-M., Lane, A.N., Higashi, R.M., Yan, J. (2011) Stable Isotope Resolved Metabolomics of Lung Cancer in a SCID Mouse Model. Metabolomics 7, 257-269 Le, A., Lane, A.N., Hamaker, M., Bose, S., Barbi, J., Tsukamoto, T., Rojas, C.J., Slusher, B.S., Zhang, H., Zimmerman. L.J., Liebler, D.C., Slebos, R.J.C., Lorkiewicz, P.K., Higashi, R.M., Fan, T.W-M., and Dang, C.V. (2012) Myc induction of hypoxic glutamine metabolism and a glucose-independent TCA cycle in human B lymphocytes. Cell Metabolism. 15, 110-121 Yang, Y., Lane, A.N., Fan, T.W-M., Rickets, C., Wu, M., Boros, L., Linehan, W.M. (2013) Understanding How Fumarate Hydratase (FH) Null Cells Use its Central Carbon for Energy and Malignant Development PlosOne 8, e72179 Sellers, K., Fox, M.P., Bousamra, M., Slone, S., Higashi, R.M.,Miller, D.M., Wang, Y., Yan, J., Yuneva, M., Deshpande, R., Lane, A.N., Fan, T. W-M. (2015) Pyruvate carboxylase is upregulated in NSCLC. J Clin Invest. 125(2): 687-698 The review by Fan, T.W-M., Lorkiewicz, P., Sellers, K., Moseley, H.N.B., Higashi, R.M., Lane, A.N. (2012). Stable isotope-resolved metabolomics and applications to drug development. Pharmacology & Therapeutics. 133:366-391 is also a good background source of examples. Our Handbook of Metabolomics, The Handbook of Metabolomics Methods in Pharmacology and Toxicology, vol. 17, Humana Press 2012. DOI 10.1007/978-1-61779-618-0_4