"Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice"
Latha Muniappan1, Aida Javidan1, Weihua Jiang1, Shayan Mohammadmoradi 1, Jessica J.
Moorleghen1, Wendy S. Katz1, Anju Balakrishnan1, Deborah A. Howatt1 & Venkateswaran
Subramanian1,2
Adipose tissue macrophages have been proposed as a link between obesity and insulin resistance.
However, the mechanisms underlying these processes are not completely defined. Calpains are calciumdependent
neutral cysteine proteases that modulate cellular function and have been implicated in
Vizient Value-Based Care Education Panel: Choosing Wisely
2017 Vizient Health Innovation and Implementation Network (HIIN) Community Knowledge Network Education Series features CHSR Director, Mark Williams. This program continues the examination of an ongoing and crucial issue for healthcare providers and patients, reducing unnecessary utilization. Decreasing unnecessary utilization is not only important for cost-containment but also for patient safety, and it is a success factor for organizations moving into a value-based reimbursement environment.
Schwartz Memorial Lecture to address growing shortage of surgeons in America
Conference Room at Northwestern named for Mark Williams
UK College of Medicine recognized as member of ACGME Patient Safety Collaborative
The Accreditation Council for Graduate Medical Education (ACGME) selected the University of Kentucky College of Medicine as one of nine Pathway Leaders. These Pathway Leaders will serve as the inaugural members of the Patient Safety Collaborative – an effort focused on creating and testing a framework for residents and fellows to engage with their learning environments in promoting a culture of safety.
"Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development"
OBJECTIVE:
The upregulated expression of heparin binding EGF-like growth factor (HB-EGF) in the vessel and circulation is associated with risk of cardiovascular disease. In this study, we tested the effects of HB-EGF targeting using HB-EGF-specific antisense oligonucleotide (ASO) on the development of aortic aneurysm in a mouse aneurysm model.
NIH Publishes Revised Grants Policy Statement for FY18
On October 12, 2017, NIH announced the publication of the revised NIH Grants Policy Statement for FY18. The policy does not introduce any new material but it does contain modified requirements, clarified policies and updated statutes or regulations.
The full policy statement can be found by clicking here.
Predicting How Healthy Your Heart Will be Years Down the Road
Picture this: you're battling heart failure and meeting with your doctor to discuss treatment. Before prescribing anything, the doctor pulls up a virtual model of your heart on her computer and "treats" it with several drugs. A few moments later, she can see how your heart is doing five years down the road.
Your doctor chooses the treatment with the best long-term outcome, and you live a longer and healthier life.
Two University of Kentucky researchers are working to make this experience a reality for the 5.7 million adults in the U.S. with heart failure.
Sanders-Brown Markesbery Symposium Focuses on Why Some People Don't Get Alzheimer's or Dementia
Why do some people stay intellectually sharp into their 90s, while others have memory problems? Is there anything we can learn from their lifestyles that can help everyone age successfully?
These are among topics scheduled for the University of Kentucky Sanders-Brown Center on Aging's Markesbery Symposium on Nov. 3-4. Keynote speakers are:
Barnstable Brown Diabetes Center Announces Expansion to Turfland Thanks to Support from Annual Derby Eve Gala
University of Kentucky President Eli Capilouto, UK Executive Vice President for Health Affairs Dr. Mark F. Newman, Lexington Mayor Jim Gray, Dr. John Fowlkes, director of the Barnstable Brown Diabetes Center, and members of the Barnstable Brown family will participate in a ribbon-cutting ceremony for the newly expanded Barnstable Brown Diabetes Center at UK HealthCare’s Turfland location and celebration of the recent U.S. News and World Report National ranking placing the Barnstable Brown Center in the top 50 for endocrinology and diabetes care.
