Guan-Yu Xiao, PhD
Connect
859-323-1729Guan-Yu.Xiao@uky.edu
760 Press Avenue, HKRB Room 511. Lexington, KY 40536.
Positions
- Assistant Professor
College Unit(s)
Other Affiliation(s)
- Markey Cancer Center
Biography and Education
Education
Ph.D., Institute of Biotechnology, National Taiwan University
Postdoctoral Fellow, Department of Cell Biology, UT Southwestern Medical Center with Sandra L. Schmid, Ph.D.
Postdoctoral Fellow, Thoracic/Head and Neck Medical Oncology, UT MD Anderson Cancer Center with Jonathan M. Kurie, M.D.
Research
Systematically investigates the molecular mechanisms of membrane trafficking in driving cancer progression by multidisciplinary approaches to identify actionable targets for cancer therapy.
Selected Publications
- Xiao, GY, Tan, X, Rodriguez, BL, Gibbons, DL, Wang, S, Wu, C, Liu, X, Yu, J, Vasquez, ME, Tran, HT, Xu, J, Russell, WK, Haymaker, C, Lee, Y, Zhang, J, Solis, L, Wistuba, II, Kurie, JM. (2023) EMT activates exocytotic Rabs to coordinate invasion and immunosuppression in lung cancer. PNAS 120 (28): e2220276120. "This work demonstrates that the EMT-dependent metastasis, which was previously thought to be a cell-autonomous process, is also driven by a cell-non-autonomous mechanism. This discovery has significant implications for targeting secretory trafficking to prevent LUAD metastasis".
- Banerjee, P*, Xiao, GY*, Tan, X, Zheng, VJ, Shi, L, Rabassedas, MNB, Guo, HF, Liu, X, Yu, J, Diao, L, Wang, J, Russell, WK, Roszik, J, Creighton, CJ, Kurie, JM. (2021) The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells. Nature Communications 12(1): 6354. *Co-first author. "This work determines that EMT coordinates endocytic trafficking pathways via a transcriptional network to establish a polarity axis for lung cancer cell migration".
- Xiao, GY and Schmid, SL. (2020) FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking. PLoS Biology 18(7): e3000778. "This work elucidates that FCHSD2 functions as a key nexus in the outcome of oncogenic ERK1/2 signaling by controlling the trafficking and expression of EGFR and MET".
- Xiao, GY, Mohanakrishnan, A, Schmid, SL. (2018) ERK1/2-dependent activation of FCHSD2 drives cancer cell-selective regulation of clathrin-mediated endocytosis. PNAS 115(41): E9570-E9579. "This work discovers the cancer-specific adaptions that oncogenic signaling kinases manage endocytic vesicle trafficking to control center progression".