Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways. RNF145 expression is induced in response to LXR activation and high-cholesterol diet feeding. Transduction of RNF145 into mouse liver inhibits the expression of genes involved in cholesterol biosynthesis and reduces plasma cholesterol levels.

2017-12-08

Even though there is an increasing shortage of surgeons in several key specialties across the United States, the need for general surgeons in urban and rural areas has reached crisis levels, according to Dr. David Richardson, Vice Chair of the Department of Surgery at the University of Louisville and a past president of the American College of Surgeons (ACS). Richardson delivered this news as the special guest lecturer at the fourth annual Richard W. Schwartz, MD Memorial Lecture and Surgical Symposium on Thursday afternoon, November 16^th.

The University of Kentucky Center of Excellence in Rural Health (UK CERH) is providing funding and technical assistance for three student groups involved in the Healthalachia Innovation Project.  Healthalachia encourages student teams to identify a community problem they want to address, and then review local data, trends, and research to develop a strategic plan of action with key stakeholders. 

With NIH’s implementation of the F-RPPR and I-RPPR, a new section, Section I – Outcomes, has been added.

Congratulations to Dr. Brittany Smalls on being selected for a career development opportunity with the 2018 National Research Mentoring Network Proposal Preparation Program (NRMN-P3). The NRMN-P3 is one of four intensive grant writing training programs that is committed to delivering relevant and thorough coaching on the grant writing and submission processes to scientists from all backgrounds, with the ultimate goal of increasing the number of individuals from currently underrepresented backgrounds successfully obtaining NIH grants.

Congratulations to Lu Dai who successfully defended her Ph.D. Congratulations Dr. Dai! And congratulations to Dr. Gang Chen for his excellent mentorship and Lu’s committee members for their guidance through her training.

Congratulations to Joe Abisambra for being awarded the Early Career Research Award by Future Science OA. Please follow the links below to learn more about Dr. Abisambra's achievement.

Meet the FS Early Career Research Award winner Joe Abisambra

Q&A with Award Winner Joe Abisambra

NIH is offering a new funding opportunity from the National Institute on Drug Abuse (NIDA) which may be highly relevant to entrepreneurial researchers at University Of Kentucky.  

Does reducing the use of cocaine, but not abstaining from the substance entirely, produce health benefits? There's currently little research available that answers that question.