Research Support

As a multidisciplinary collaborative, COCVD encourages the development of research infrastructure and shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease.

Attribution - Research Support Services and Equipment

It is imperative that all users of COBRE Core services and/or equipment, including radiotelemetry, EchoMRI, DEXA-IR, metabolism chambers, pathology services, MS or bioplex analytical services and the statistical analysis that Dr. Katherine Thompson provides, must cite the COBRE NIH grant using this language as an example:  

"Research reported in this [publication, release] was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30 GM127211.”

Appropriate Use and Handling of Equipment

Before utilizing research equipment on the fifth floor of the CT Wethington Building and other locations, please review this overview on the use and handling of equipment.

Equipment Calendars for Instrument Use

COCVD investigators and staff have access to read calendars available through the medical center's Microsoft SharePoint server. Please note that you must provide a valid user ID and password to enter this portion of the site.

To schedule instrument use of telemetry (BBSRB B016), please contact Ming Gong or Mark Schwarcz.

To schedule use of EchoMRI (BBSRB B014),  Visitech (BBSRB B015), Calorimetric cages (BioPharm B059D), and Cryostat and microscopes (CTW 551, 564, 599B) contact Wendy Katz.

Recent Publications

2022

Prakhya KS, Luo Y, Adkins J, Hu X, Wang QJ, Whiteheart SW. A sensitive and
adaptable method to measure platelet-fibrin clot contraction kinetics. Res Pract
Thromb Haemost. 2022 Jul 21;6(5):e12755. doi: 10.1002/rth2.12755. PMID:
35873218; PMCID: PMC9301529.

Bruno MEC, Mukherjee S, Powell WL, Mori SF, Wallace FK, Balasuriya BK, Su LC,
Stromberg AJ, Cohen DA, Starr ME. Accumulation of γδ T cells in visceral fat
with aging promotes chronic inflammation. Geroscience. 2022 Jun;44(3):1761-1778.
doi: 10.1007/s11357-022-00572-w. Epub 2022 Apr 28. PMID: 35477832; PMCID:
PMC9213615.

Ji A, Trumbauer AC, Noffsinger VP, Jeon H, Patrick AC, De Beer FC, Webb NR,
Tannock LR, Shridas P. Serum Amyloid A is not obligatory for high-fat, high-
sucrose, cholesterol-fed diet-induced obesity and its metabolic and inflammatory
complications. PLoS One. 2022 Apr 18;17(4):e0266688. doi:
10.1371/journal.pone.0266688. PMID: 35436297; PMCID: PMC9015120.

Radulescu A, Killian M, Kang Q, Yuan Q, Softic S. Dietary Counseling Aimed at
Reducing Sugar Intake Yields the Greatest Improvement in Management of Weight
and Metabolic Dysfunction in Children with Obesity. Nutrients. 2022 Apr
3;14(7):1500. doi: 10.3390/nu14071500. PMID: 35406113; PMCID: PMC9003198.

Van Hoose PM, Yang L, Kraemer M, Ubele M, Morris AJ, Smyth SS. Lipid
phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced
abdominal aortic aneurysm formation. Sci Rep. 2022 Apr 5;12(1):5664. doi:
10.1038/s41598-022-08422-7. PMID: 35383201; PMCID: PMC8983654.

Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ,
Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu
W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander
LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK,
Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ,
Evans RM, Zheng Y, Marson A. Obesity alters pathology and treatment response in
inflammatory disease. Nature. 2022 Apr;604(7905):337-342. doi:
10.1038/s41586-022-04536-0. Epub 2022 Mar 30. PMID: 35355021; PMCID: PMC9165753.

Shridas P, Ji A, Trumbauer AC, Noffsinger VP, Leung SW, Dugan AJ, Thatcher
SE, Cassis LA, de Beer FC, Webb NR, Tannock LR. Adipocyte-Derived Serum Amyloid
A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J
Mice. Arterioscler Thromb Vasc Biol. 2022 May;42(5):632-643. doi:
10.1161/ATVBAHA.121.317225. Epub 2022 Mar 28. PMID: 35344382; PMCID: PMC9050948.

Valenca SS, Dong BE, Gordon EM, Sun RC, Waters CM. ASK1 Regulates Bleomycin-
induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 May;66(5):484-496.
doi: 10.1165/rcmb.2021-0465OC. PMID: 35148253; PMCID: PMC9116360.

Gwag T, Ma E, Zhou C, Wang S. Anti-CD47 antibody treatment attenuates liver
inflammation and fibrosis in experimental non-alcoholic steatohepatitis models.
Liver Int. 2022 Apr;42(4):829-841. doi: 10.1111/liv.15182. Epub 2022 Feb 15.
PMID: 35129307; PMCID: PMC9101015.

Dudick K, Che C, Shoemaker R. Differential cardiac geometry during pregnancy
in lean versus obese mice. Rev Cardiovasc Med. 2022 Jan 20;23(1):40. doi:
10.31083/j.rcm2301040. PMID: 35092232.

Flack KD, Anderson RE 3rd, McFee KF, Kryscio R, Rush CR. Exercise increases
attentional bias towards food cues in individuals classified as overweight to
obese. Physiol Behav. 2022 Apr 1;247:113711. doi: 10.1016/j.physbeh.2022.113711.
Epub 2022 Jan 20. PMID: 35066060; PMCID: PMC8845497.

Platt KM, Przybylowski J, Charnigo RJ, Ngo Tenlep SY, Reynolds LJ, Pearson
KJ. Effects of maternal controlled exercise on offspring adiposity and glucose
tolerance. J Dev Orig Health Dis. 2022 Aug;13(4):455-462. doi:
10.1017/S2040174421000489. Epub 2021 Sep 10. PMID: 34503602; PMCID: PMC8907328.

Lewis ED, Williams HC, Bruno MEC, Stromberg AJ, Saito H, Johnson LA, Starr
ME. Exploring the Obesity Paradox in A Murine Model of Sepsis: Improved Survival
Despite Increased Organ Injury in Obese Mice. Shock. 2022 Jan 1;57(1):151-159.
doi: 10.1097/SHK.0000000000001856. PMID: 34482320; PMCID: PMC8678195.

Meng Z, Hernandez R, Liu J, Gwag T, Lu W, Hsiai TK, Kaul M, Zhou T, Zhou C.
HIV Protein Tat Induces Macrophage Dysfunction and Atherosclerosis Development
in Low-Density Lipoprotein Receptor-Deficient Mice. Cardiovasc Drugs Ther. 2022
Apr;36(2):201-215. doi: 10.1007/s10557-021-07141-x. Epub 2021 Jan 18. PMID:
33459922; PMCID: PMC8286272.

2020

Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, Wang C, Zaytseva YY, Schwartz CE,
Lee EY, Mark Evers B, Morris AJ, Liu S, She QB. Spermine synthase and MYC
cooperate to maintain colorectal cancer cell survival by repressing Bim
expression. Nat Commun. 2020 Jun 26;11(1):3243. doi: 10.1038/s41467-020-17067-x.
PMID: 32591507; PMCID: PMC7320137.

Chalfant JM, Howatt DA, Tannock LR, Daugherty A, Pendergast JS. Circadian
disruption with constant light exposure exacerbates atherosclerosis in male
ApolipoproteinE-deficient mice. Sci Rep. 2020 Jun 18;10(1):9920. doi:
10.1038/s41598-020-66834-9. PMID: 32555251; PMCID: PMC7303111.

Davis KA, Peng H, Chelvarajan L, Abdel-Latif A, Berron BJ. Increased yield of
gelatin coated therapeutic cells through cholesterol insertion. J Biomed Mater
Res A. 2020 Jun 3. doi: 10.1002/jbm.a.37025. Epub ahead of print. PMID:
32491263.

Mahanes TM, Murphy MO, Ouyang A, Yiannikouris FB, Fleenor BS, Loria AS.
Maternal separation-induced increases in vascular stiffness are independent of
circulating angiotensinogen levels. J Appl Physiol (1985). 2020 Jul
1;129(1):58-65. doi: 10.1152/japplphysiol.00703.2019. Epub 2020 May 14. PMID:
32407243.

Ratajczak MZ, Bujko K, Cymer M, Thapa A, Adamiak M, Ratajczak J, Abdel-Latif
AK, Kucia M. The Nlrp3 inflammasome as a "rising star" in studies of normal and
malignant hematopoiesis. Leukemia. 2020 Jun;34(6):1512-1523. doi:
10.1038/s41375-020-0827-8. Epub 2020 Apr 20. PMID: 32313108; PMCID: PMC7266743.

Sui Y, Meng Z, Park SH, Lu W, Livelo C, Chen Q, Zhou T, Zhou C. Myeloid-
specific deficiency of pregnane X receptor decreases atherosclerosis in LDL
receptor-deficient mice. J Lipid Res. 2020 May;61(5):696-706. doi:
10.1194/jlr.RA119000122. Epub 2020 Mar 13. PMID: 32170024; PMCID: PMC7193955.

Martínez-Martínez AB, Torres-Perez E, Devanney N, Del Moral R, Johnson LA,
Arbones-Mainar JM. Beyond the CNS: The many peripheral roles of APOE. Neurobiol
Dis. 2020 May;138:104809. doi: 10.1016/j.nbd.2020.104809. Epub 2020 Feb 19.
PMID: 32087284; PMCID: PMC7195217.

Finlin BS, Memetimin H, Zhu B, Confides AL, Vekaria HJ, El Khouli RH, Johnson
ZR, Westgate PM, Chen J, Morris AJ, Sullivan PG, Dupont-Versteegden EE, Kern PA.
The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in
obese humans. J Clin Invest. 2020 May 1;130(5):2319-2331. doi:
10.1172/JCI134892. PMID: 31961829; PMCID: PMC7190997.

Williams HC, Farmer BC, Piron MA, Walsh AE, Bruntz RC, Gentry MS, Sun RC,
Johnson LA. APOE alters glucose flux through central carbon pathways in
astrocytes. Neurobiol Dis. 2020 Mar;136:104742. doi: 10.1016/j.nbd.2020.104742.
Epub 2020 Jan 11. PMID: 31931141; PMCID: PMC7044721.

Johnson LA. APOE at the BBB: Pericyte-Derived Apolipoprotein E4 Diminishes
Endothelial Cell Barrier Function. Arterioscler Thromb Vasc Biol. 2020
Jan;40(1):14-16. doi: 10.1161/ATVBAHA.119.313627. Epub 2019 Dec 23. PMID:
31869265; PMCID: PMC7001796.

Lifsey HC, Kaur R, Thompson BH, Bennett L, Temel RE, Graf GA. Stigmasterol
stimulates transintestinal cholesterol excretion independent of liver X receptor
activation in the small intestine. J Nutr Biochem. 2020 Feb;76:108263. doi:
10.1016/j.jnutbio.2019.108263. Epub 2019 Nov 9. PMID: 31759199; PMCID:
PMC7199294.

El-Helw M, Chelvarajan L, Abo-Aly M, Soliman M, Milburn G, Conger AL,
Campbell K, Ratajczak MZ, Abdel-Latif A. Identification of Human Very Small
Embryonic like Stem Cells (VSELS) in Human Heart Tissue Among Young and Old
Individuals. Stem Cell Rev Rep. 2020 Feb;16(1):181-185. doi:
10.1007/s12015-019-09923-1. PMID: 31758373; PMCID: PMC7027381.

Deng P, Hoffman JB, Petriello MC, Wang CY, Li XS, Kraemer MP, Morris AJ,
Hennig B. Dietary inulin decreases circulating ceramides by suppressing neutral
sphingomyelinase expression and activity in mice. J Lipid Res. 2020
Jan;61(1):45-53. doi: 10.1194/jlr.RA119000346. Epub 2019 Oct 11. PMID: 31604806;
PMCID: PMC6939596.

2019

Che C, Dudick K, Shoemaker R. Cardiac hypertrophy with obesity is augmented
after pregnancy in C57BL/6 mice. Biol Sex Differ. 2019 Dec 16;10(1):59. doi:
10.1186/s13293-019-0269-z. PMID: 31842996; PMCID: PMC6916003.

Dalmasso C, Leachman JR, Ensor CM, Yiannikouris FB, Giani JF, Cassis LA,
Loria AS. Female Mice Exposed to Postnatal Neglect Display Angiotensin II-
Dependent Obesity-Induced Hypertension. J Am Heart Assoc. 2019 Dec
3;8(23):e012309. doi: 10.1161/JAHA.119.012309. Epub 2019 Nov 22. PMID: 31752639;
PMCID: PMC6912962.

Omotola O, Legan S, Slade E, Adekunle A, Pendergast JS. Estradiol regulates
daily rhythms underlying diet-induced obesity in female mice. Am J Physiol
Endocrinol Metab. 2019 Dec 1;317(6):E1172-E1181. doi:
10.1152/ajpendo.00365.2019. Epub 2019 Nov 5. PMID: 31689145; PMCID: PMC6957379.

Strattan E, Palaniyandi S, Kumari R, Du J, Hakim N, Huang T, Kesler MV,
Jennings CD, Sturgill JL, Hildebrandt GC. Mast Cells Are Mediators of Fibrosis
and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease. Front
Immunol. 2019 Oct 18;10:2470. doi: 10.3389/fimmu.2019.02470. PMID: 31681336;
PMCID: PMC6813249.

Zein AA, Kaur R, Hussein TOK, Graf GA, Lee JY. ABCG5/G8: a structural view
to pathophysiology of the hepatobiliary cholesterol secretion. Biochem Soc
Trans. 2019 Oct 31;47(5):1259-1268. doi: 10.1042/BST20190130. PMID: 31654053;
PMCID: PMC6824678.

Mueller PA, Yang L, Ubele M, Mao G, Brandon J, Vandra J, Nichols TC,
Escalante-Alcalde D, Morris AJ, Smyth SS. Coronary Artery Disease Risk-
Associated <i>Plpp3</i> Gene and Its Product Lipid Phosphate Phosphatase 3
Regulate Experimental Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019
Nov;39(11):2261-2272. doi: 10.1161/ATVBAHA.119.313056. Epub 2019 Sep 19. PMID:
31533471; PMCID: PMC6812632.

Shoemaker R, Tannock LR, Su W, Gong M, Gurley SB, Thatcher SE, Yiannikouris
F, Ensor CM, Cassis LA. Adipocyte deficiency of ACE2 increases systolic blood
pressures of obese female C57BL/6 mice. Biol Sex Differ. 2019 Sep 4;10(1):45.
doi: 10.1186/s13293-019-0260-8. PMID: 31484552; PMCID: PMC6727421.