Recent Publications (2020-Current)

  1. El Seblani N, Welleford AS, Quintero JE, van Horne CG, Gerhardt GA. Invited review: Utilizing peripheral nerve regenerative elements to repair damage in the CNS. J Neurosci Methods. 2020 Apr 1;335:108623. doi: 10.1016/j.jneumeth.2020.108623 . Epub 2020 Feb 3. PMID: 320278903
  2. Welleford AS, Quintero JE, Seblani NE, Blalock E, Gunewardena S, Shapiro SM, Riordan SM, Huettl P, Guduru Z, Stanford JA, van Horne CG, Gerhardt GA. RNA Sequencing of Human Peripheral Nerve in Response to Injury: Distinctive Analysis of the Nerve Repair Pathways. Cell Transplant. 2020 Jan-Dec;29:963689720926157. doi: 10.1177/0963689720926157. PMID: 32425114
  3. Ledo A., Fernandes, E, Quintero JE, Gerhardt GA and Barbosa RM.  Electrochemical Evaluation of a Clinical Depth Recording Electrode for Monitoring Cerebral Tissue Oxygen. Micromachines 2020, 11(7), 632;  (June 2020) PMID: 32605324
  4. Gash DM, Gerhardt GA, Wagner R and Slevin JT.  GDNF clinical trials for Parkinson’s disease: A critical human dimension.  Cell & Tissue Res 2020,, (August 2020) PMID: 32830288
  5. Quintero JE, Zhang R, Pan Q, Xing Y, Hardy P, Fan X, Ai Y, Gash DM, Gerhardt GA, Grondin R, and Zhang Z. Surgical methodology and protocols for preventing implanted cerebral catheters frm becoming obstructed during and after neurosurgery.  J Neurosci Methods. 2021 Feb 1;349:109020. doi: 10.1016/j.jneumeth.2020.109020. Epub 2020 Dec 4.  PMID: 33285151
  6. Rogers DT, Pomer F, Kelley Z, Brown D, Lynn B, Gerhardt GA and Littleton J.  Target-directed evolution of novel modulators of the dopamine transporter in Lobelia cardinalis hairy root cultures.  J Biotechnology (accepted, October 2021). PMID: 27637316
  7. Gera G, Guduru Z, Yamasaki T, Gurwell JA, Chau MJ, Krotinger A, Schmitt FA, Slevin JT, Gerhardt GA, van Horne C and Quintero JE.  Gait and Balance Changes with Investigational Peripheral Nerve Cell Therapy during Deep Brain Stimulation in People with Parkinson’s Disease. Special Issue Balance Rehabilitation in Neurological Disorders, Brain Sciences doi: 10.3390/brainsci11040500, April 2021.  PMID: 33921079
  8. Chau MJ, Quintero JE, Guiliani A, Hines T, Samaan C, Seybold K, Stowe M, Hanlon D, Gerhardt G and van Horne C.  Implementing Telehealth in a Neurosurgery Department During the COVID-19 Pandemic. PLOS ONE. (in press, May 2021) PMID: 31429978
  9. Chau MJ, Quintero JE, Blalock E, Samaan C, Gerhardt G and van Horne C.  Transection injury differentially alters the proteome of the human sural nerve.  bioRxiv, doi: (in press; preprint available online) November 23, 2021.
  10. Chau M, Quintero J, Monje P, Voss S, Welleford A, Gerhardt G and van Horne C. Using a transection paradigm to enhance the repair mechanisms of an investigational human cell therapy.  Cell Transplantation (in press, March 2022).
  11. Sonne JW, Cass WA, Bradley L, Gerhardt GA and Gash DM.  Intranasal DNSP-11 enters the CNS and protects dopaminergic neurons from a 6-OHDA lesion model of Parkinson’s disease in Fischer 344 male rats.  IJMS (submitted, February 2022).

Publications (2019)

  1. Burmeister JJ, Price DA, Pomerleau F, Huettl P, Quintero JE and Gerahrdt GA. Challenges of Simultaneous Measurements of Brain Extracellular GABA and Glutamate In Vivo Using Enzyme-Coated Microelectrode Arrays. J Neurosci Methods. 2020 Jan 1;329:108435. doi: 10.1016/j.jneumeth.2019.108435. Epub 2019 Oct 7. PMID: 31600528 PMCID: PMC6924626
  2. af Bjerken S, Persson RS, Barkander A, Karalija N, Pelegrina-Hidalgo N, Gerhardt GA, Virel A and Stromberg I.  Noradrenaline is crucial for the substantia nigra dopamine cell maintenance.  Neurochem Int. 2019 Dec;131:104551. doi: 10.1016/j.neuint.2019.104551. Epub 2019 Sep 19. PMID: 31542295
  3. Butler CR, Boychuck JA, Pomerleau F, Alcala R, Huettl P, Ai Y, Jakobsson J, Whiteheart SW, Gerhardt GA, Smith BN and Slevin J.  Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics.  Epilepsy Res. 2020 Jan;159:106244. doi: 10.1016/j.eplepsyres.2019.106244. Epub 2019 Nov 26. PMID: 31816591 PMCID: PMC7451242

Publications (2018)

  1. Batten SR, Pomerleau F, Quintero J, Gerhardt GA and Beckman J.  The Role of Glutamate Signaling in Incentive Salience: Second-by-second Glutamate Recordings in Awake Sprague Dawley Rats.  J Neurochem. 2018 May;145(4):276-286. doi: 10.1111/jnc.14298. Epub 2018 May 15. 
  2. Ferreira R, Ledo A, Gerhardt GA, Laranjinha J, Barbosa R.  Simultaneous Measurements of Ascorbate and Glutamate In vivo in the Rat Brain Using Carbon Fiber Nanocomposite Sensors and Microbiosensor Arrays. Bioelectrochemistry. 2018 Jun;121:142-150. doi: 10.1016/j.bioelechem.2018.01.009. Epub 2018 Jan 31. 
  3. Stenslik MJ, Evans A, Pomerleau F, Weeks R, Huettl P, Foreman E,Turchan-Cholewo J, Andersen A, Cass WA, Zhang Z, Grondin RC, Gash DM, Gerhardt GA and Bradley LH.  Methodology and effects of repeated instranasal delivery of DNSP-11 in awke Rhesus macaques.  J Neurosci Methods. 2018 Jun 1;303:30-40. doi: 10.1016/j.jneumeth.2018.03.006. Epub 2018 Mar 31.
  4. van Horne CG, Quintero JE, Slevin JT, Anderson-Mooney A, Gurwell JA, Welleford BS, Lamm JR, Wagner RP and Gerhardt GA.  Peripheral nerve grafts implanted into the substantia nigra in patients with Parkinson’s disease during DBS surgery: one-year follow-up of safety, feasibility, and clinical outcome. J Neurosurg. 2018 Dec 1;129(6):1550-1561. doi: 10.3171/2017.8.JNS163222.
  5. Ledo A, Lourenco CF, Laranjinha J, Gerhardt GA and Barbosa RM.  Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential Amperometry.  Current Opinion Electrochemistry, Volume 112, December 2018, Pages 129-140.
  6. Miller EM, Quintero JE, Pomerleau F, Huettl P, Gerhardt GA and Glaser PEA.  Chronic Methylphenidate Alters Tonic and Phasic Glutamate Signaling in the Frontal Cortex of a Freely-Moving Rat Model of ADHD.  Neurochem Res. 2019 Jan;44(1):89-101. doi: 10.1007/s11064-018-2483-1. Epub 2018 Feb 3.
  7. Quintero JE, Ai Y, Andersen AH, Hardy P, Grondin R, Guduru Z, Gash DM, Gerhardt GA and Zhang Z.  Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques.  Neuroimage Clin. 2019;22:101724. doi: 10.1016/j.nicl.2019.101724. Epub 2019 Feb 18. PMCID: PMC6396014
  8. Grondin R, Littrell OM, Zhang Z, Ai Y, Huettl P, Pomerleau F, Quintero JE, Andersen AH, Stenslik MJ, Bradley LH, Lemmon J, O’Neill MJ, Gash DM and Gerhardt GA.  GDNF revisited: A novel mammalian cell-derived variant from GDNF increases dopamine turnover and improves brain biodistribution.  Neuropharmacology. 2019 Mar 15;147:28-36. doi: 10.1016/j.neuropharm.2018.05.014. Epub 2018 May 29.

Publications (2017)

  1. Ledo A, Laurenco C, Laranjinha J, Brett C, Gerhardt G and Barbosa R.  Ceramic-based multi-site platinum microelectrode arrays: Morphological characteristics and electrochemical performance for extracellular oxygen measurements in brain tissue.  Anal Chem. 2017 Feb 7;89(3):1674-1683. doi: 10.1021/acs.analchem.6b03772. Epub 2017 Jan 25. 
  2. Hunsberger HC, Setti SE, Heslin TR, Quintero JE, Gerhardt GA and Reed MN.  Using enzyme-based biosensors to measure tonic and phasic glutamate in Alzheimer's mouse models.  J Vis Exp. 2017 May 3;(123). doi: 10.3791/55418.
  3. Geyer ED, Shetty PA, Suozzi CJ, Allen DZ, Benavidez PP, Liu J, Hollis CN, Gerhardt GA, Quintero JE, Burmeister JJ and Whitaker EE.  Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain.  J Vis Exp. 2018 May 12;(135). doi: 10.3791/57391.
  4. Thomas TC, Noel T, Jungsuwadee P, Butterfield DA, St. Clair DK, Vore M, Gerhardt GA. Acute Treatment with Doxorubicin Affects Glutamate Neurotransmission in the Mouse Frontal Cortex and Hippocampus. Brain Res. 2017 Jul 10. pii: S0006-8993(17)30293-7. doi: 10.1016/j.brainres.2017.07.003. [Epub ahead of print]
  5. Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA and Norris CM.  Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Ab-bearing mice.  Neuron J Neurosci. 2017 Jun 21;37(25):6132-6148. doi: 10.1523/JNEUROSCI.0877-17.2017. Epub 2017 May 30.
  6. Lourenco C, Ledo A, Gerhardt G, Laranjinha J and Barbosa R.  Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor array.  Sci Rep. 2017 Jul 28;7(1):6764. doi: 10.1038/s41598-017-07119-6.
  7. Batten SR, Matveeva EA, Whiteheart SW, Vanaman TC, Gerhardt GA and Slevin JT.  Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/Tomosyn-1 Gene.  Brain Behav. 2017 Aug 13;7(9):e00795. doi: 10.1002/brb3.795. eCollection 2017 Sep.
  8. Ledo A, Lourenco C, Laranjinha J, Gerhardt G, Barbosa R.  Combined in vivo Amperometric Oximetry and Electrophysiology in a Single Sensor – a Tool for Epilepsy Research.  Anal Chem. 2017 Nov 21;89(22):12383-12390. doi: 10.1021/acs.analchem.7b03452. Epub 2017 Nov 7.

Publications (2016)

  1. van Horne CG, Quintero JE, Gurwell JA, Wagner RP, Slevin JT, and Gerhardt GA.  Implantation of autologous peripheralnerve grafts into the substantia nigra of subjects with idiopathic Parkinson’s disease treated with bilateral STN DBS:  A report of safety and Feasibility.  J Neurosurg. 2017 Apr;126(4):1140-1147. doi: 10.3171/2016.2.JNS151988. Epub 2016 May 6
  2. Rossi PJ, Gunduz A, Judy J,…… Gerhardt GA...Okun MS. Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A review of Emerging Issues and Technologies.  Front Neurosci. 2016 Apr 6;10:119. eCollection 2016.  PMCID: PMC4821860
  3. Grondin RC, Ai Y, Hardy PA, Butt MT, Nelson BD, Lemmon J, Bumcrot D, Gash DM, Gerhardt GA and Zhang, Z.  Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: A pre-clinical safety study.  J Neurosurg. 2016 May 27:1-10. [Epub ahead of print]. 
  4. Brown DP, Rogers DT, Pomerleau F, Siripurapu KB, Kulshrestha M, Gerhardt GA and Littleton JM.  Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis.   Fitoterapia. 2016 Jun;111:109-23. doi: 10.1016/j.fitote.2016.04.013. Epub 2016 Apr 20 PMCID: PMC5299595
  5. Deadwyler SA, Hampson RE, Song D, Opris I, Gerhardt GA, Marmarelis VZ, Berger TW.  A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain.  Exp Neurol. 2017 Jan;287(Pt 4):452-460. doi: 10.1016/j.expneurol.2016.05.031. Epub 2016 May 24.
  6. Lourenco CF, Ledo A, Laranjinha J, Gerhardt GA and Barbosa RM.  Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain.  Sensors and Actuators B: Chemical 237 (2016) 298–307.
  7. Hunsberger HC, Weitzner DS, Rudy CC, Hickman JE, Libell EM, Speer RR, Setti SE, Gerhardt GA and Reed MN.  Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression. Supplemental review. World Biomedical Frontiers, ISSN:2328-0166, 2016-3-4/
  8. Deeb W, Giordano JJ, Rossi PJ, et al., Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank – A Review of Emerging Issues and Technologies.  Front Integr Neurosci. 2016 Nov 22;10:38. eCollection 2016.
  9. Brown, DP, Rogers DT, Gunjan SK, Gerhardt GA and Littleton JM.  Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells.  J Biotechnol. 2016 Nov 20;238:9-14. doi: 10.1016/j.jbiotec.2016.09.007. Epub 2016 Sep 13.

Publications (2015)

  1. Hunsberger HC, Rudy CC, Batten SR, Gerhardt GA and Reed MN.  P301L Tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway.  J Neurochem. 2015 Jan;132(2):169-82. Epub 2014 Oct 31.  PMCID: PMC4302046
  2. Miller EM, Quintero JE, Pomerleau F, Huettl P, Gerhardt GA and Glaser PEA.  Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tool for ADHD research.  Special Issue: Models of Brain Disorders, J Neurosci Methods. 2015 252:75-9. [Epub ahead of print]  PMID:  25614383 [PubMed – in process]
  3. Andersen AH, Hardy PA, Forman E, Gerhardt GA, Gash DM, Grondin RC, and Zhang Z.  Pharmacologic MRI (phMRI) as a tool to differentiate Parkinson's disease-related from age-related changes in basal ganglia function. Neurobiol Aging. 2015 Feb;36(2):1174-82. Epub 2014 Oct 16. PMID: 25443764 [PubMed – in process]
  4. Opris I, Fuqua JL, Gerhardt GA, Hampson RE, Deadwyler SA.  Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation J Neurosci Methods. 2015 Apr 15;244:104-13. doi: 10.1016/j.jneumeth.2014.05.029. Epub 2014 Jun 2. PMCID: PMC4595476
  5. van Horne CG, Vaughan SW, Massari C, Bennett M, Asfahani WS, Quintero JE and Gerhardt GA.  Streamlining deep brain stimulation surgery by reversing the staging order.  J Neurosurg. 2015 May;122(5):1042-7. Epub 2015 Mar 6.  PMID: 25748305
  6. Hinzman JM, DiNapoli VA, Mahoney EJ, Gerhardt GA and Hartings JA.  Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.   Exp Neurol. 2015 May;267:243-53. doi: 10.1016/j.expneurol.2015.03.014. Epub 2015 Mar 24.  PMID:  25819105. [PubMed – in process]
  7. Opris I, Santos LM, Gerhardt GA, Song D, Berger TW, Hampson RE and Deadwyler S.  Distributed encoding of spatial and object categories in primate hippocampal microcircuits.  Front Syst Neurosci. 2015 May 29;9:79. doi: 10.3389/fnsys.2015.00079. eCollection 2015. PMCID:PMC4594006
  8. Stenslik MJ, Potts LF, Sonne JW, Cass WA, Turdhan-Cholewo J, Pomerleau F, Huettl P, Ai Y, Gash DM, Gerhardt GA, Bradley LH.  Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson’s disease.  J Neurosci Methods. 2015 Aug 15;251:120-9. doi: 10.1016/j.jneumeth.2015.05.006. Epub 2015 May 18. PMCID: PMC4500736   
  9. Hunsberger HC, Weitzner DS, Rudy CC, Hickman JE, Libell EM, Speer RR, Gerhardt GA and Reed MN.  Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression.  J Neurochem. 2015 Oct;135(2):381-94. doi: 10.1111/jnc.13230. Epub 2015 Aug 13. PMCID: PMC4302046
  10. Quintero JE, Slevin JT, Gurwell JA, Gerhardt GA, van Horne CG. (2015). Combining Deep Brain Stimulation With Neuroregenerative Therapy to Alter the Progression of Parkinson’s Disease: Is It Possible? (2015). Cell Transplantation 24 (4): 769-770.
  11. van Horne, C.G., Quintero, G., Gurwell, J., Gerhardt, G., Slevin, J.; Peripheral nerve grafts reduce medication requirements and reduce motor scores in Parkinson's disease patients with deep brain stimulation therapy [abstract]. Movement Disorders 2015; 30 Suppl 1 :624
  12. Womersley JS, Kellaway LA, Stein DJ, Gerhardt GA and Russell VA.  Effect of cocaine on striatal dopamine clearance in a rat model of developmental stress and attention-deficit/hyperactivity disorder.  Stress. 2016;19(1):78-82. doi: 10.3109/10253890.2015.1096925. Epub 2015 Oct 20. PMID:     26394534
  13. Hinzman JM, Gibson JL, Tackla RD, Costello MS, Burmeister JJ, Quintero JE, Gerhardt GA and Hartings JA.  Real-time monitoring of extracellular adenosine using enzyme-linked microelectrode arrays.  Biosens Bioelectron. 2015 Dec 15;74:512-7. doi: 10.1016/j.bios.2015.06.074. Epub 2015 Jul 7

Publications (2014)

  1. Quintero JE, Gurwell JA, Slevin JT, Gerhardt GA, van Horne CG. (2014). Implantation of Autologous Peripheral Nerve Grafts into the Substania Nigra of Subjects with Parkinson’s Disease Undergoing Deep Brain Stimulation Surgery (2014).  Cell Transplantation 23 (6): 781-782
  2. Nevalainen N, Bjerken S AF, Gerhardt GA and Stromberg I.  Serotonergic nerve fibers in L-dopa derived dopamine release and dyskinesia.  Neuroscience. Feb 28;260:73-86, 2014.  PMID:  24361918 (PMCID in progress).
  3. Fan XT, Zhao F, Ai Y, Andersen A, Hardy P, Ling F, Gerhardt GA, Zhang Z, and Quintero JE.  Cortical glutamate levels decrease in a non-human primate model of dopamine deficiency. Brain Res. Mar 13;1552:34-40, 2014  PMCID: PMC4005040
  4. Santos LM, Opris I, Hampson RE, Good D, Gerhardt GA and Deadwyler S.  Functional dynamics of primate cortico-striatal networks during volitional movements.  Frontiers Mar 10;8:27, 2014. PMCID:  PMC3947991
  5. Fuqua JL, Littrell OM, Lundblad M, Turchan-Cholewo J, Abdelmoti LG, Galperin E, Bradley LH, Cass WA, Gash DM and Gerhardt GA.  Dynamic changes in the dopamine neuron function after DNSP-11 Treatment: Effects in vivo and increased ERK ½ phosphorylation in vitro.  Peptides. 2014 Apr;54:1-8. PMCID: PMC3989369
  6. Miller EM, Pomerleau F, Huettl P, Gerhardt GA and Glaser PE.  Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Psychopharmacology (Berl). 2014 Aug;231(15):3019-29. doi: 10.1007/s00213-014-3479-4. Epub 2014 Feb 28. PMID: 24682500 (PMCID in progress).
  7. Stephens ML, William A, Deel ME, Bensalem-Owen M, Slevin J, Pomerleau F, Huettl P and Gerhardt GA.  Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure. Epilepsia. 2014 Nov;55(11):1817-25. doi: 10.1111/epi.12797. Epub 2014 Sep 29. PMID: 25266171

Publications (2013)

  1. Eriksson TM, Alvarsson A, Stan TL, Zhang X, Hascup KN, Hascup ER, Kehr J, Gerhardt GA, Warner-Schmidt J, Arango-Lievano M, Kaplitt MG, Ogren SO, Greengard P, Svenningsson P.  Bidirectional regulation of emotional memory by 5-HT(1B) receptors involves hippocampal p11. Mol Psychiatry. 2013 Oct;18(10):1096-105. doi: 10.1038/mp.2012.130. Epub 2012 Oct 2. PMCID: PMC3781317
  2. Opris I, Fuqua JL, Huettl PF, Gerhardt GA, Berger TW, Hampson RE and Deadwyler SA.  Closing the loop in primate prefrontal cortex: Inter-laminar processing.  Frontiers in Neural Circuits 6:88, 2012. [Epub 2012 Nov 22]. PMCID: PMC3504312
  3. Nevalainen N, Lundblad M, Gerhardt GA, and Stromberg I.  Striatal glutamate release in L-DOPA-induced dyskinetic animals.  PLoS ONE 8(2):e557-6, Feb. 4, 2013.  PMCID: PMC3563586
  4. Burmeister JJ, Davis VA, Quintero JE, Pomerleau F, Huettl P, Gerhardt GA.  Glutaraldehyde Cross-Linked Glutamate Oxidase Coated Microelectrode Arrays: Selectivity and Resting Levels of Glutamate in the CNS. ACS Chem Neurosci 4(5):721-8. May 15 2013 [Epub 2013 May 9]  PMCID: PMC3656760
  5. Littrell OM, Granholm AC, Gerhardt GA and Boger HA.  Cligal cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF. Pharmacol Biochem Behav. 2013 Mar;104:10-9. doi: 10.1016/j.pbb.2012.12.022. Epub 2013 Jan 2.  PMCID: PMC3638246   
  6. Opris I, Santos L, Gerhardt GA, Song D, Berger TW, Hampson RE and Deadwyler SA.  Prefrontal cortical microcircuits bind perception to executive contro.  Sci Rep. 2013;3:2285. doi: 10.1038/srep02285. PMCID: PMC3725477
  7. Hampson R, Song D, Opris I, Santos L, Shin D, Gerhardt GA, Marmarelis V, Berther T, and Deadwyler S.  Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task specific neural firing. J Neural Eng, Dec;10(6):066013, 2013. PMCID:  PMC3919468  (*
  8. Deadwyler SA, Berger TW, Sweat A, Song D, Chan RH, Opris I, Gerhardt GA, Marmarelis VZ, and Hampson RE.  Donor/Recipient Enhancement of Memory in Rat Hippocampus.  Front Syst Neurosci.  Dec 26;7:120, 2013. PMCID: PMC3872745
  9. Wyse J, Zinda K, Gerhardt GA, Huettl P, Gregory R and Grulke EA.  Patent Technology Landscapes for Assessing Intellectual Property in Academic Environments. les Nouvelles, Dec 2013.

Publications (2012)

  1. Hinzman JM, Thomas TC, Quintero JE, Gerhardt GA and Lifshitz J.  Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury.  J Neurotrauma. 2012 Apr 10;29(6):1197-208. doi: 10.1089/neu.2011.2261. Epub 2012 Apr 10. PMCID: PMC3325551.
  2. Matveeva EA, Price DA, Whiteheart SW, Vanaman TC, Gerhardt GA and Slevin J.  Reduction of VAMP2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy.  Neurosci Jan 27; 202:77-86, 2012.  PMCID: PMC3277846.
  3. Matveeva EA, Davis VA, Whiteheart SW, Vanaman TC, Gerhardt GA and Slevin JT.  Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release.  Epilepsia. 2012 Jan;53(1):157-67. doi: 10.1111/j.1528-1167.2011.03345.x. Epub 2011 Dec 9 PMCID: PMC3375214
  4. Kim BJ, Gutierrez CA, Gerhardt GA and Meng E.  Parylene-based Electrochemical-MEMS Force Sensor Array for Assessing Neural Probe Insertion Mechanics.  25th International Conference IEEE Micro Electro Mechanical Systems (MEMS) Conference Proceedings, pp. 124-127, 2012.
  5. Hampson RE, Song D, Chan RHM, Sweatt AJ, Riley R, Gerhardt GA, Shin DC, Marmarelis VZ, Berger TW, Deadwyler SA.  A nonlinear model for hippocampal cognitive prosthesis:  Memory facilitation by hippocampal ensemble stimulation.  IEEE Trans Neural Syst Rehabil Eng. 2012 Mar;20(2):184-97. doi: 10.1109/TNSRE.2012.2189163.  PMCID: PMC3397311.
  6. Onifer SM, Quintero JE and Gerhardt GA.  Cutaneous and electrically evoked glutamate signaling in the adult rat somatosensory system.  J Neurosci Meth 208:146-154, 2012.  [PubMed – in process]
  7. Hampson RE, Song D, Chan RH, Sweatt AJ, Riley MR, Goonawardena AV, Marmarelis VZ, Gerhardt GA, Berger TW and Deadwyler SA.  Closing the loop for memory prosthesis: detecting the role of hippocampal neural ensembles using nonlinear models.  IEEE Trans Neural Syst Rehabil Eng. Jul;20(4):510-25, 2012. Epub 2012 Apr 6. PMCID: PMC3395725
  8. Hascup ER, Hascup KN, Pomerleau F, Huettl P, Hajos-Korcsok E, Kehr J and Gerhardt GA.  An allosteric modulator of metabotropic glutamate receptors (mGluR2) inhibits restraint stress-induced phasic glutamate release in rat prefrontal cortex.  J Neurochem. Aug;122(3):619-27, 2012. PMCID:    PMC3970435
  9. Miller EM, Pomerleau F, Huettl P, Russell VA, Gerhardt GA and Glaser PEA.  The Spontaneously Hypertensive and Wistar Kyoto Rat Models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens. Neuropharmacology. 2012 Dec;63(8):1327-34. doi: 10.1016/j.neuropharm.2012.08.020. Epub 2012 Sep 1. PMCID: PMC3485688
  10. Berger T, Song D, Chan R, Shin D, Marmarelis V, Hampson R, Sweatt A, Heck C, Liu C, Wills J, Granacki J, Gerhardt G, Deadwyler S.  Role of the hippocampus in memory formation: restorative encoding memory integration neural device as a cognitive neural prosthesis.  IEEE Pulse. 2012 Sep-Oct;3(5):17-22. doi: 10.1109/MPUL.2012.2205775.  PMID:  23014702 [PMCID – In Progress]
  11. Opris I, Hampson RE, Gerhardt GA, Berger TW, Deadwyler SA.  Columnar Processing in Primate pFC: Evidence for Executive Control Microcircuits.  J Cogn Neurosci. 2012 Dec;24(12):2334-47. doi: 10.1162/jocn_a_00307. Epub 2012 Sep 27. PMCID: PMC3754813
  12. *Hampson RE, Gerhardt GA, Marmarelis V, Song D, Opris I, Santos, Berger TW and Deadwyler SA.  Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specif neural firing. J Neural Eng. 2012 Oct;9(5):056012. Epub 2012 Sep 13. PMCID: PMC3505670 (*Journal of Neural Engineering Award for 10,000 downloads.  (
  13. Littrell OM, Fuqua JL, Richardson AD, Turchan-Cholewo J, Hascup ER, Huettl P, Pomerleau F, Bradley LH, Gash DM, Gerhardt GA.  A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function. Neuropeptides. 2013 Feb;47(1):43-9. doi: 10.1016/j.npep.2012.08.004. Epub 2012 Sep 13. PMCID: PMC3558608

Publications (2011)

  1. Michaelis EK, Wang X, Pal R, Bao X, Hascup KN, Wang Y, Wang WT, Hui D, Agbas A, Choi IY, Belousov A, Gerhardt GA.  Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: Increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression.  Neurochem Int. Sep;59(4):473-81, 2011. Epub 2011 Mar 17 PMCID: PMC3152645
  2. Quintero JE, Dooley DJ, Pomerleau F, Huettl P and Gerhardt GA.  Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices:  Role of Voltage-Sensitive Ca2+ _2_-1 Subunit.  J Pharmacol Exp Ther. Jul;338(1):240-5, 2011. Epub 2011 Apr 4. PMCID: PMC3126634
  3. Hascup KN, Hascup ER, Stephens ML, Glaser PEA, Yoshitake T, Mathe AA, Gerhardt GA and Kehr J. Resting glutamate levels and rapid glutamate transients in the prefrontal cortex of the Flinders Sensitive Line Rat: A genetic rodent model of depression.  Neuropsychopharm 36(8):1769-77, 2011 [Apr 27 Epub ahead of print]  PMCID: PMC3138656 
  4. Harvey BK, Airavaara MT, Hinzman JH, Simons EM, Chiocco MC, Howard DB, Shen H, Gerhardt GA, Hoffer BJ, and Wang Y.  Targeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in rat model of stroke.  PLoS One.;6(8):e22135, 2011. Epub 2011 Aug 10. PMCID: PMC3154194
  5. Kelps KA, Turchan-Cholewo J, Hascup ER, Taylor TL, Gash DM, Gerhardt GA, Bradley LH.  Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence.  Neuropeptides Jun;45(3):213-8, 2011. PMCID: PMC3091812
  6. Talauliker PM, Price DA, Burmeister JJ, Nagarid S, Quintero JE, Pomerleau F, Huettl P, Hastings JT and Gerhardt GA.  Ceramic-based microelectrode arrays: recording surface characteristics and topographical analysis.  J Neurosci Meth Jun 15;198(2):222-9, 2011.  PMCID: PMC3108255
  7. Hascup KN, Bao X, Hascup ER, Hui D, Xu W, Pomerleau F, Huettl p, Michaelis ML, Michaelis EK and Gerhardt GA.  Differential levels of glutamate dehydrogenase 1 (GLUD1) in BALB/c and C57BL/6 mice and the effects of over-expression of Glud1 Gene on Glutamate Release in Striatum.  ASN Neuro, Apr 21;3(2), 2011.  PMCID: PMC3086280
  8. Nevalainen N, Af Bjerken S, Lundblad M, Gerhardt GA, Stromberg I.  Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia.  J Neurochem 118(1):12-23, 2011.  PMCID: PMC3112269
  9. Lockrow J, Boger H, Gerhardt GA, Bachman D and Granholm A-C.  A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model.  J Alzheimers Dis. Jan 1;23(3):471-89, 2011.  PMID: 21098982 [PubMed – in process]
  10. Quintero, JE, Pomerleau F, Huettl P, Johnson KW, Offord J, and Gerhardt GA.  Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: Basic characterization and drug pharmacology.  Brain Res. Jul 15;1401:1-9, 2011. Epub 2011 May 18. PMCID: PMC3197737  [Available on 2012/7/15]
  11. Santos RM, Lourenco CF, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J, Barbosa RM.  Evidence for a pathway that facilitates nitric oxide diffusion in the brain.  Neurochem Int. Aug;59(1):90-6, 2011. Epub 2011 Jun 6] PMID: 21672575
  12. Morris JK, Bomhoff GL, Gorres BK, Davis VA, Kim J, Lee PP, Brooks WM, Gerhardt GA, Geiger PC, Stanford JA.  Insulin resistance impairs nigrostriatal dopamine function.  Exp Neurol. Sep;231(1):171-80, 2011. [Epub 2011 Jun 15]  PMCID: PMC3169014   [Available on 2012/9/1]
  13. Mattinson CE, Burmeister JJ, Quintero JE, Pomerleau F, Huettl P, and Gerhardt GA.  Tonic and phasic release of glutamate and acetylcholine neurotransmission in sub-regions of the rat prefrontal cortex using enzyme-based microelectrode arrays.  J Neurosci Methods. Nov 15;202(2):199-208, 2011. [Epub 2011 Aug 27]  PMCID: PMC3607211
  14. Womersley JS, Hsieh JH, Kellaway LA, Gerhardt GA and Russell VA.  Maternal separation affects dopamine transporter function in the Spontaneously Hypertensive Rat: An in vivo electrochemical study.  Behav Brain Funct. Dec 1;7:49, 2011 PMCID: PMC3285054   
  15. Thomas TC, Hinzman JM, Gerhardt GA and Lifshitz J. Hypersensitive glutamate signaling correlates with the development of late-onset behavioral morbidity in diffuse brain-injured circuitry.  J Neurotrauma. Jan 20;29(2):187-200, 2012. [Epub 2011 Dec 1].  PMCID:  PMC3261793  [Available on 2013/1/20]
  16. van Bregt D, Thomas TC, Hinzman JM, Cao T, Gerhardt GA, Pauly JR and Lifshitz J.  Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.  Mar 11, 2011.  Exp Neurol. Mar;234(1):8-19, 2012.  Epub 2011 Dec 9.  PMCID:  PMC3294202    [Available on 2013/3/1]
  17. Hampson RE, Marmaralis V, Shin DC, Gerhardt GA, Song D, Chan RH, Sweatt AJ, Granacki J, Berger TW and Deadwyler SA.  Restorative encoding memory integrative neural device: “REMIND”.  Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3338-41. doi: 10.1109/IEMBS.2011.6090905 PMID: 22255054 [PubMed – in process].

Publications (2010)

  1. Lourenco CF, Santos R, Barbosa RM, Gerhardt GA, Cadenas E and Laranjinha J.  In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus.  Hippocampus Feb. 18, 2010 [Epub ahead of print].  PMID: 20169537
  2. Hinzman J, Thomas T, Burmeister JJ, Quintero J, Huettl P Pomerleau F, Gerhardt GA and Lifshitz J. Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: An enzyme-based microelectrode array study.  J Neurotrauma.  27(5):889-99, 2010 (Mar 16. [Epub ahead of print]) PMC2943939 [Available on 2011/5/1]
  3. Bradley LH, Fuqua J, Richard A, Turchan-Cholewo J, Ai, Y, Kelps KA, Glass JD, He X, Zhang Z, Grondin R, Littrell OM, Huettl P, Pomerleau F, Gash DM and Gerhardt GA.  Dopamine neuron stimulating actions of a GDNF propeptide.  PLoS One Biology 5(3):e9752, 2010. PMCID: PMC2841203
  4. Opris I, Hampson RE, Stanford TR, Gerhardt GA and Deadwyler SA.  Neural activity in frontal cortical layers during sensorimotor processing in a behavioral task.  J Cog Neurosci, Jun;23(6):1507-21, 2011. PMCID: PMC3110724
  5. Santos RM, Lourenco CF, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J, and Barbosa RM.  Brain nitric oxide inactivation is governed by the vasculature.  Antioxid Redox Signal. 2011 Mar 15;14(6):1011-21. Epub 2010 Dec 28.  PMID: 20712398
  6. Miller EM, Gerhardt GA and Glaser PEA.  Is ADHD linked to a dopamine signaling deficit?  Featured Review Cell Sci Rev Vol 7 No 2 2010.
  7. Hascup ER, Hascup KN, Stephens M, Pomerleau F, Huettl P, Gratton A and Gerhardt GA.  Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex.  J. Neurochem 115(6):1608-20, 2010. PMCID: PMC2996468
  8. Littrell OM, Pomerleau F, Huettl P, Surgener S, McGinty JF, Middaugh LD, Granholm A-C, Gerhardt GA and Boger HA.  Enhanced Dopamine Transporter Activity in Middle-Aged GDNF Heterozygous Mice.  Neurobiol Aging. Feb;33(2):427.e1-14, 2012 PMCID: PMC3117013
  9. Gerhardt GA.  Intra-operative Chemical Diagnostics in the Brain for Glutamate and GABA using Enzyme-based Microelectrode Arrays.  Chinese J of Pain Med, Vol. 16, 2010.
  10. Zhao F, Fan X, Grondin R, Edwards R, Forman E, Moorehead J, Gerhardt GA, Wang X and Zhang Z.  Improved methods for electroacupuncture and electromyographic recordings in normal parkinsonian rhesus monkeys.  JNM, 192:199-206, 2010. PMCID: PMC2942968

Publications (2009)

  1. Lundblad M, af Bjerkén S, Cenci MA, Pomerleau F, Gerhardt GA and Strömberg I.  Chronic intermittent L-DOPA treatment induces changes in dopamine release.  J Neurochem 108(4):998-1008, 2009. PMID: 19196428
  2. Stephens ML, Quintero JE, Pomerleau F, Huettl P and Gerhardt GA.  Age-related changes in glutamate release in the CA3 and dentate gyrus of the rat hippocampus.  Neurobiol Aging, May;32(5):811-20, 2011. Epub ahead of print June 15, 2009].  PMCID: PMC3407977
  3. Hascup ER, Bjerkén SA, Hascup KN, Pomerleau F, Huettl P, Strömberg I and Gerhardt GA.  Histological studies of the effects of chronic implantation of ceramic-based microelectrode arrays microdialysis probes in rat prefrontal cortex.  Brain Res Jul 2 Sep 29;1291:12-20, 2009.  NIHMS139988, PMC2980830
  4. Berger TW, Gerhardt GA, Liker MA and Soussou W.  The Impact of Neurotechnology on Rehabilitation, In: IEEE Reviews in Biomedical Engineering, Jose C. Principe, (Ed), Vol. 1, pp. 157-197, 2008.
  5.  Konradsson-Geuken A, Gash CR, Alexander K, Pomerleau F, Huettl P, Gerhardt GA and Bruno JP.  Second-by-second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats.  Synapse 63(12):1069-1082, 2009.  PMCID: PMC2759414
  6.  Bao X, Pal R, Hascup K, Wang Y, Wang W-T, Xu W, Hui D, Agbas A, Wang X, Michaelis M, Choi I-Y, Belousov A, Gerhardt GA and Michaelis E.  Transgenic Expression of Glutamate Dehydrogenase 1 (Glud1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability J Neurosc 4:29(44):13929-44, 2009.  PMCID: PMC2811066
  7. Stephens, ML, Pomerleau F, Huettl P, Gerhardt GA and Zhang Z.  Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype.  J Neuro Meth, 185(2):264:72, 2010. Epub 2009 Oct 20.   PMCID: PMC2815042, NIHMS153577
  8. Stromberg I, Bickford P and Gerhardt GA.  Grafted dopamine neurons: morphology, neurochemistry and electrophysiology.  Prog Neurobiol. 2010 Feb 9; 90(2):190-7. Epub 2009 Oct 21. Review PMID: 19853009
  9. Salvatore MF, Gerhardt GA and Stanford JA.  Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system. Exp. Neurology, 219(1):197-207, 2009. Epub 2009 May 19.  NIHMS141429  PMCID: PMC6700751

Publications (2008)

  1. Gash DM, Rutland K, Hudson JL, Sullivan PG, Bing G, Cass WA, Pandya JD, Liu M, Choi D-Y, Hunter RL, Gerhardt GA, Smith CD, Slevin JT and Prince TS.  Trichloroethylene: Parkinsonism and Complex I Mitochondrial Neurotoxicity.  Ann Neurol Feb; 63(2):184-92, 2008. PMID: 18157908
  2. Hascup KN, Hascup ER, Pomerleau F, Huettl P, and Gerhardt GA.  Second-by-second measures of l-glutamate in the prefrontal cortex and striatum of freely moving mice.  JPET Feb; 324(2):725-31, 2008. (Epub 2007 Nov 16) PMID: 18024788
  3. Xin T. Ai Y, Gerhardt GA, Gash and Zhang Z.  Globus pallidus plays a critical role in neurotrophic factor induced functional improvements in hemiparkinsonian monkeys.  Biochem Biophys Res Comm Biochem Biophys Res Commun. Jun 6;370(3):434-9, 2008. (Epub 2008 Mar 31) PMCID: PMC2682325
  4. Luan L, Ding F, Ai Y, Andersen A, Hardy P, Forman E, Gerhardt GA, Gash DM, Grondin R and Zhang Z.  Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys.  Cell Transplantation, 17(4):417-25, 2008. [Epub ahead of print] PMCID: PMC2605704
  5. Grondin R, Zhang Z, Ai Y, Ding F, Walton AA, Surgener SP, Gerhardt GA and Gash DM.  Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys.  Cell Transplantation 17(4):373-81, 2008. PMCID: PMC2680490
  6. Ding F, Luan L, Ai Y, Walton A, Gerhardt GA, Gash DM, Grondin R and Zhang Z.  Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkeys.  Exp Neuron 212(2):431-9, 2008. [Epub ahead of print] PMCID: PMC2527750
  7. Barbosa RM, Lourenco CF, Santos RM, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J. Chapter 20 in vivo real-time measurement of nitric oxide in anesthetized rat brain. Methods Enzymol 441:351-67, 2008. PMID: 18554545
  8. Santos RM, Lourenco CF, Piedade AP, Andrews R, Pomerleau F, Huettl P, Gerhardt GA, Laranjinha J and Barbosa RM.  A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue.  Biosens Bioelectron 24(4), 704-709, 2008.  PMID: 18657966
  9. Zaman V, Boger HA, Granholm A-C, Rohrer B, Moore A, Buhusi M, Gerhardt GA, Hoffer BJ and Middaugh LD.  The nigrostriatal dopamine system of aging GFRa-1 heterozygous mice: neurochemistry, morphology and behavior.  Eur J Neurosci 28(8):1557-68, 2008.  PMC2704551, NIHMS105188
  10. Berger TW, Gerhardt GA, Liker MA, and Soussou W.  The Impact of Neurotechnology on Rehabilitation. Clinical Application Review. IEEE Reviews in Biomedical Engineering, Vol 1, 157-197, 2008.
  11. Thomas TC, Grandy DK, Gerhardt GA and Glaser PE.  Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum. Neuropsychopharmacology 34(2):436-45, 2009. [Epub 2008 Jun 4]  PMID: 18536704

Publications (2007)

  1. Chronic second-by-second measures of L-glutamate in the CNS of freely moving rats. Rutherford EC, Pomerleau F, Huettl P, Stromberg I and Gerhardt GA. J Neurochem (in press), Feb. 2007.
  2. Validation studies of the human motor activities panel for Hand/Arm Performance. Smith CD, Walton A, Slevin JT, Gerhardt GA, Umberger G, Smoot K, Schulze E and Gash DM. J Neurosci Meth (in press), 2007.
  3. Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats. Stanford JA, Salvatore MF, Joyce BM, Zhang H, Gash DM and Gerhardt GA. Neurobio Aging 28:156-165, 2007.
  4. Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys. Cass, WA, Grondin R, Andersen AH, Zhang Z, Hardy PA, Hussey-Andersen LK, Rayens WS, Gerhardt GA and Gash DM. Neurobiology of Aging 28(2):258-71, 2007.
  5. Ceramic-based multisite microelectrode arrays for simultaneous measures of choline and acetylcholine in CNS. Burmeister JJ, Pomerleau F, Huettl P, Gash CR, Werner CE, Bruno JP and Gerhardt GA.    Biosens Bioelectron Apr 15;23(9):1382-9. 2008. (Epub 2007 Dec 23) PMID: 18243683

Publications (2006)

  1. Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers. Joyce BM, Glaser P, and Gerhardt G. Psychopharmacology Oct 10, 2006; [Epub ahead of print]
  2. Second-by-second measurement of acetylcholine release in prefrontal cortex. Bruno JP, Gash C, Martin B, Zmarowski A, Pomerleau F, Burmeister J, Huettl P and Gerhardt GA. Eur J Neurosci. 24(10):2749-57, 2006.
  3. Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques. Zhang Z, Andersen AH, Ai Y, Loveland A, Hardy PA, Gerhardt GA and Gash DM. Neuroimage 33(2):636-43, 2006.
  4. Reduced Plasma Membrane Surface Expression of GLAST Mediates Decreased Glutamate Regulation in the Aged Striatum. Nickell JR, Salvatore MF, Pomerleau F, Apparsundaram S and Gerhardt GA. Neurobiology of Aging (in press) [Epub ahead of print] Sep 5 2006.
  5. Point source concentration of GDNF may explain failure of Phase II clinical trial. Salvatore MF, Ai Y, Fischer B, Zhang AM, Grondin RC, Zhang Z, Gerhardt GA and Gash DM. Exp Neurol 202(2):497-505, 2006.
  6. Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal. Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, and Young AB. Neurosurg Focus 20(5):E1, 2006.
  7. Reply: GDNF poses troubling questions for doctors, drug maker. Slevin JT, Gerhardt GA, Smith CD, Gash DM, and Young AB. Ann Neurol. 59(6):989-990, 2006.
  8. MRI Volumetric and intensity analysis of the cerebellum in Parkinson’s disease patients infused with glial-derived neurotrophic factor (GDNF). Chebrolu H, Slevin JT, Gash DM, Gerhardt GA, Young BA and Smith CD. Exp Neurol 198(2):450-6, 2006.
  9. Microelectrode array studies of basal and potassium-evoked release of L-glutamate in the anesthetized rat brain. Day BK, Pomerleau F, Burmeister J, Huettl PF, and Gerhardt GA. J Neurochem Mar;96(6):1626-35, 2006.
  10. GDNF in treatment of Parkinson's disease: response to editorial. Penn R, Dalvi A, Slevin J, Young B, Gash D, Gerhardt GA, Hutchinson M. The Lancet Neurology, 5(3): 202-203, 2006.
  11. Towards a neuroscience of attention-deficit/hyperactivity disorder: Fractionating the phenotype. Castellanos FX, Glaser PEA and Gerhardt GA. J Neurosci Methods. Feb 15;151(1):1-4, 2006.
  12. Does dopamine neurotransmission occur in the cerebellar vermis? Cerebellar neurotransmission in attention-deficit/hyperactivity disorder. Glaser PEA, Surgener SP, Grondin R, Gash CR, Palmer M, Castellanos FX and Gerhardt GA. 2006 J Neurosci Methods Feb 15;151(1):62-67, 2006.
  13. Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice. Fernandez E, Koek W, Ran Q, Gerhardt GA, France CP and Strong R. Alcohol Clin Exp Res 30(10):1650-8, 2006.

Publications (2005)

  1. Concentration dynamics of nitric oxide in rat hippocampal sub regions evoked by stimulation of the NMDA glutamate receptor. Ledo A, Barbosa RM, Gerhardt GA, Cadenas E and Laranjinha J. PNAS 102(48):17483-8, 2005.
  2. Restoring lost cognitive function. Berger TA, Ahuja A, Courellis SH, Deadwyler SA, Erinjinppurath G, Gerhardt GA, Gholmieh G, Granacki JJ, Hampson R, Hsaio MC, LaCoss J, Marmarelis VZ, Nasiatka P, Srinivasan V, Song D, Tanguay AR and Wills J. IEEE Eng Med Biol Mag 24(5): 30-44, 2005.
  3. Trophic factor distribution predicts functional recovery in parkinsonian monkeys. Gash DM, Zhang Z, Ai Y, Grondin R, Coffey R, and Gerhardt GA. Ann Neurol 58(2):224-33, 2005.
  4. Neurochemical investigations of dopamine neural systems in iron-regulatory protein 2 (IRP-2) knockout mice. Salvatore MF, Fisher B, Surgener SP, Gerhardt GA, and Roualut T. Mol Brain Res 139:341-347, 2005.
  5. Electrochemical measurement of endogenously-produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes. Ferreira NR, Ledo A, Frade JG, Gerhardt GA, Laranjinha J, and Barbosa RM. Analytica Chimica Acta 535 (1-2):1-7, 2005.
  6. Improvement of bilateral motor functions in patients with Parkinson’s disease through the unilateral intraputamenal infusion of glial cell line-derived neurotrophic factor. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, and Young AB. J Neurosurg 102(2):216-222, 2005.
  7. Research on Parkinson’s disease. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, and Young AB. J Neurosurg 102(2):401, 2005.
  8. Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core. Glaser PEA, Currier TD, Joyce BM, Castellanos FX and Gerhardt GA. Psychopharmacology 178(2-3):250-8, 2005.
  9. Electrochemical measurement of endogenously-produced nitric oxide in brain slices using nafion/o-phenylenediamine modified carbon fiber microelectrodes. Ferreira NR, Ledo A, Frade JG, Gerhardt GA, Laranjinha J, and Barbosa RM. Analytica Chimica Acta (in press), 2005.
  10. In vivo electrochemical studies of d-amphetamine and d,l-amphetamine-induced dopamine release in the rat striatum and nucleus accumbens core. Glaser PEA, Currier TD, Joyce BM, Castellanos FX and Gerhardt GA. Psychopharmacology (in press), 2005.
  11. Transport mechanisms governing serotonin clearance in vivo revealed by high speed chronoamperometry. Daws LC, Montanez S, Owens WA, Gould GG, Frazer A, Toney GM and Gerhardt GA. J Neurosci Meth (in press), 2005.
  12. L-lactate measures in brain tissue with ceramic-based multisite microelectrodes. Burmeister JJ, Palmer M and Gerhardt GA. Biosensors and Bioelectronics 20:1772-1779, 2005.

Publications (2004)

  1. Aged related changes in the dynamics of potassium-evoked l-glutamate release in the striatum of Fischer 344 rats. Nickell J, Pomerleau F, Allen J and Gerhardt GA. J Neural Transm. 112(1):87-96, 2004.
  2. Amperometric measurement of extracellular choline: A method for the detection of rapid changes in cholinergic transmission. Parikh V, Sarter M, Bruno JP, Pomerleau F, Huettl P, and Gerhardt GA. Eur J Neurosci. 20(6):1545-54., 2004.
  3. Ceramic-based multisite electrode arrays for chronic single-neuron recording. Moxon, K.A., Leiser S., Gerhardt GA and Chapin J.K. IEEE Transaction on Biomedical Engineering 51(4):647-656, 2004.

Publications (2003)

  1. Real time in vivo measures of l-glutamate in the rat central nervous system using ceramic-based multisite microelectrode arrays. Pomerleau F, Day BK, Huettl P, Burmeister JJ, and Gerhardt GA. Ann NY Acad Sci. 1003:454-457, 2003.
  2. Ceramic-based multisite microelectrode arrays for in vivo electrochemical recordings of glutamate and other neurochemicals. Burmeister JJ and Gerhardt GA. Trends Analyt Chem 22(9):503-508, 2003.
  3. Chloral hydrate and ethanol, but not urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of freely-moving rats. Sabeti J, Gerhardt GA and Zahniser NR. Neurosci Lett 343(1):9-12, 2003.
  4. Ceramic-based multisite microelectrode array for rapid choline measures in brain tissue. Burmeister JJ, Palmer MR and Gerhardt GA. Analytica Chimica Acta 481:65-74, 2003.

Publications (2002)

  1. Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region in vivo. Montanez, S., Daws, LC, Gould, GG, Gerhardt GA and Frazer, A. Brain Res 955(1-2):236-44, 2002.
  2. Quantitative analysis of striatal clearance of exogenous dopamine, recorded by chronoamperometry in the freely-moving rat. Sabeti J, Adams CE, Gerhardt GA, and Zahniser, NR. J Neurosci Meth 121(1):41-52, 2002.
  3. Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS. Burmeister, JJ, Pomerleau F, Palmer M, Day BK, Huettl P and Gerhardt GA. J Neurosci Meth 119(2):163-171, 2002.

Publications (2001)

  1. Effects of recording media composition on the response of Nafion-coated carbon fiber microelectrodes measured using high-speed chronoamperometry. Gerhardt GA and Hoffman, A.F. J. Neurosci. Meth. 109(1):13-21, 2001.
  2. Self-referencing ceramic-based multisite microelectrodes for the detection and elimination of interferents from the measurement of L-glutamate and other Analytes. Burmeister, J.J. and Gerhardt GA. Anal. Chem., 73(5):1037-1042, 2001.

Earlier Publications (1997-2000)

  1. Receptor-Mediated Regulation of Serotonin Clearance in Rat Hippocampus in vivoa. Daws, L.C., Gould, G.G., Teicher, S.D., Gerhardt GA, and Frazer, A. 5-HT1B J. Neurochem. 75(5):2113-2122, 2000.
  2. Ceramic-Based Multisite Microelectrodes for Electrochemical Recordings. Burmeister, J.J., Moxon, K., and Gerhardt GA. Anal. Chem., 72(1):187-192, 2000.
  3. In vivo microdialysis studies of age-related alterations in potassium-evoked overflow of dopamine in the dorsal striatum of Fischer 344 rats. Stanford, J.A., Giardina, K., and Gerhardt GA. Int. J. Develop. Neurosci. (18)4-5:411-416, 2000.
  4. Differences in the pharmacological properties of dopamine release between the substantia nigra and striatum: an in vivo electrochemical study. Hoffman, A.F. and Gerhardt GA. JPET, 289:455-463, 1999.
  5. In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors. Zahniser, N.R., Larson, G.A., and Gerhardt GA. JPET, 289:266-277, 1999.
  6. Methodology for coupling local application of dopamine and other chemicals with rapid in vivo electrochemical recordings in freely moving rats. Gerhardt GA, Ksir, C., Pivik, C., Dickinson, S.D., Sabeti, J., and Zahniser, N.R. J. Neurosci. Meth., 87:67-76, 1999.
  7. Age-related changes in the capacity, rate and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: An in vivo electrochemical study. Hebert, M.A. and Gerhardt GA. JPET, 288:879-887, 1999.
  8. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices. Hoffman, A.F., Lupica, C.R., and Gerhardt GA. J. Pharmacol. Exp. Therapeut., 287:487-496, 1998.
  9. In vivo electrochemical studies of dopamine clearance in subregions of rat nucleus accumbens: differential properties of the core and shell. David, D., Zahniser, N.R., Hoffer, B.J., and Gerhardt GA. Exp. Neurol., 153:277-286, 1998.
  10. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. Daws, L.C., Toney, G.M., Gerhardt GA, and Frazer, A. JPET, 286:967-976, 1998.
  11. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-OHDA lesions. Hoffman, A.F. and Gerhardt GA. J. Neurochem., 70:179-189, 1998.
  12. In vivo electrochemical measurements of serotonin clearance in rat striatum: effects of neonatal 6-hydroxydopamine-induced serotonin hyperinnervation and serotonin uptake inhibitors. Luthman, J., Friedemann, M.N., Hoffer, B.J., and Gerhardt GA. J. Neural Tran., 104:379-397, 1997.
  13. Effects of ethanol on striatal dopamine overflow and clearance: An in vivo electrochemical study. Wang, Y., Palmer, M.R., Cline, E.J., and Gerhardt GA. Alcohol, 14:593-601, 1997.
  14. In vivo chronoamperometric measurements of exogenously applied serotonin in the rat dentate gyrus. Daws, L.C., Toney, G.M., Davis, D.J., Gerhardt GA, and Frazer, A. J. Neurosci. Meth., 78:139-150, 1997.
  15. In vivo microdialysis studies of somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF. Hoffman, A.F., van Horne, C.G., Eken, S., Hoffer, B.J. and Gerhardt G. Exp. Neurology, 147:130-141, 1997.

Earlier Publications (1989-1996)

  1. Functional effects of GDNF in normal rat striatum: Presynaptic studies using in vivo electrochemisitry and microdialysis. Hebert, M.A., van Horne, C.G., Hoffer, B.J., and Gerhardt GA. J. Pharmacol. Exp. Therapeut., 279:1181-1190, 1996.
  2. o-Phenylenediamine modified carbon fiber electrodes for the detection of nitric oxide. Friedemann, M.N., Robinson, S.W. and Gerhardt GA. Analytical Chem., 68:2621-2628, 1996.
  3. Fabrication and characterization of sputtered-carbon microelectrode arrays. Sreenivas, G., Ang, S.S., Fritsch-Faules, I., Gerhardt G, and Woodward, D.J. Analytical Chemistry, 68:1858-1864, 1996.
  4. In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat. Friedemann, M.N. and Gerhardt GA.. Exp. Neurol., 138:53-63, 1996.
  5. In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys. Gerhardt GA, Cass, W.A., Hudson, J., Henson, M., Zhang, Z., Ovadia, A., Ketonen, E., Hoffer, B.J., and Gash, D.M. J. Neurochem., 66:579-588, 1996.
  6. In vivo assessment of dopamine uptake in rat medial prefrontal cortex: Comparison with dorsal striatum and nucleus accumbens. Cass, W.A. and Gerhardt GA.. J. Neurochem., 65:201-207, 1995.
  7. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo. Hudson, J., Granholm, A-C., Gerhardt GA, Henry, M.A., Hoffman, A., Biddle, P., Leela, N.S., Mackerlova, L., Lile, J.D., Collins, F., and Hoffer, B.J. Brain Res. Bull., 36:425-432, 1995.
  8. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Hoffer, B.J., Hoffman, A., Bowenkamp, K., Huettl, P., Hudson, J., Martin, D., Line, L-F. and Gerhardt GA.. Neurosci. Lett. 182:107-111, 1994.
  9. Direct in vivo evidence that D2 dopamine receptors can modulate dopamine uptake. Cass, W.A. and Gerhardt GA.. Neurosci. Lett., 176:259-263, 1994.
  10. In vivo electrochemical measurements of exogenous dopamine clearance in normal and neonatal 6-hydroxydopamine-treated rat striatum. Luthman, J., Friedemann, M.N., Hoffer, B.J. and Gerhardt GA.. Exp. Neurol., 122:273-282, 1993.
  11. In vivo electrochemical measurements and electrophysiological studies of rat striatum following neonatal 6-hydroxydopamine treatment. Luthman, J., Friedemann, M., Bickford, P., Olson, L., Hoffer, B.J. and Gerhardt GA.. Neuroscience 52:677-687, 1993.
  12. Age-induced changes in single locus coeruleus brain transplants grown in oculo: An in vivo electrochemical study. Gerhardt GA, Palmer, M.R. and Granholm, A-Ch. Neurobiology of Aging 12:487-494, 1991.
  13. Electrically-evoked release of norepinephrine in the rat cerebellum: An in vivo electrochemical and electrophysiological study. Bickford-Wimer, P., Pang, K., Rose, G.M. and Gerhardt GA.. Brain Res. 558:305-311, 1991.
  14. Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS. van Horne, C., Bement, B., Hoffer, B.J. and Gerhardt GA.. Neuroscience Lett., 120:249-252, 1990.
  15. The effects of cholecystokinin (CCK-8) on dopamine containing nerve terminals in the caudate nucleus and nucleus accumbens of the anesthetized rat: An in vivo -electrochemical study. Gerhardt GA, Friedemann, M., Brodie, M.S., Vickroy, T.W., Gratton, A.P., Hoffer, B.J. and Rose, G.M. Brain Res., 499: 157-163, 1989.
  16. High resolution spatio-temporal analysis of chemical signals using microelectrochemical electrodes. Moore, P.A., Gerhardt GA, and Atema, J. Chem. Senses, 14 (6): 829-840, 1989.
  17. Direct determination of unconjugated HVA in human plasma filtrates by HPLC coupled with dual-electrode coulometric electrochemical detection. Gerhardt GA, Drebing, C.J., Stephen, C. and Freedman, R. Biomed. Chromatog., 3(3): 105-109, 1989.
  18. In vivo electrochemical studies of the effects of N-methyl-D-aspartate (NMDA) on dopamine nerve terminals in the neostriatum of the anesthetized rat. Friedemann, M. and Gerhardt GA.. Proc. West Pharmacol. Soc. 32: 143-147, 1989.