Yuan Wen, PhD-MD

First or Senior Author Publications (*Co-First or *Co-Senior Author)

Burke BI, Ismaeel A, Long DE, Depa LA, Coburn PT, Goh J, Saliu TP, Walton BJ, Vechetti IJ, Valentino TR, Mobley CB, Memetimin H, Wang D, Finlin BS, Kern PA, Peterson CA, McCarthy JJ* and Wen Y*. Extracellular Vesicle miR-1 Delivery from Skeletal Muscle to Adipose Tissue Modifies Lipolytic Pathways in Response to Resistance Exercise in Humans. JCI Insight. 2024

Chambers TL, Dimet-Wiley A, Keeble AR, Haghani A, Lo WJ, Kang G, Brooke R, Horvath S, Fry CS, Watowich SJ, Wen Y* and Murach KA*. Methylome-Proteome Integration After Late-Life Voluntary Exercise Training Reveals Regulation and Target Information for Improved Skeletal Muscle Health. J Physiol. 2024

Ismaeel A*, Thomas NT*, McCashland M, Vechetti IJ, Edman S, Lanner JT, Figueiredo VC, Fry CS, McCarthy JJ, Wen Y*, Murach KA*, von Walden F*. Coordinated Regulation of Myonuclear DNA Methylation, mRNA, and miRNA Levels Associates With the Metabolic Response to Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy in Female Mice. Function. 2024

Ismaeel A, Goh J, Mobley CB, Murach KA, Brett JO, de Morrée A, Rando TA, Peterson CA, Wen Y*, and McCarthy JJ*. Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus. Stem Cells. 2024.

Wen Y, Latham CM, Moore AN, Thomas NT, Lancaster BD, Reeves KA, Keeble AR, Fry CS, Johnson DL, Thompson KL, Noehren B, Fry JL. Vitamin D status associates with skeletal muscle loss after anterior cruciate ligament reconstruction. JCI Insight. 2023.

Ismaeel A*, Valentino TR*, Burke B, Goh J, Saliu TP, Albathi F, Owen A, McCarthy JJ*, Wen Y*. Acetate and succinate benefit host muscle energetics as exercise-associated post-biotics. Physiol Rep. 2023

Wen Y, Vechetti IJ, Leng D, Alimov AP, Valentino RV, Zhang XD, McCarthy JJ, Peterson CA. Early transcriptomic signatures and biomarkers of renal damage due to prolonged exposure to embedded metal. Cell Biology and Toxicology: 1-20, 2023

Viggars MR*, Wen Y*, Peterson CA, Jarvis JC. Automated cross-sectional analysis of trained, severely atrophied and recovering rat skeletal muscles using MyoVision 2.0. J Appl Physiol (1985). 2022.

Murach KA, Dungan CM, von Walden F, Wen Y. Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling. Am J Physiol Cell Physiol. 2022

Murach KA*, Dimet-Wiley AL*, Wen Y*, Brightwell CR, Latham CM, Dungan CM, Fry CS, Watowich SJ. Late-life exercise mitigates skeletal muscle epigenetic aging. Aging Cell. 2021:e13527.

Wen Y*, Englund DA*, Peck BD, Murach KA, McCarthy JJ, and Peterson CA. Myonuclear transcriptional dynamics in response to exercise following satellite cell depletion. iScience 24: 102838, 2021.

Wen Y, Dungan CM, Mobley CB, Valentino T, von Walden F, and Murach KA. Nucleus Type-Specific DNA Methylomics Reveals Epigenetic “Memory” of Prior Adaptation in Skeletal Muscle. Function 2: 2021.