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Xu Xiao, PhD

(/ʃuː ʃaʊ/)

Connect

(859) 323 7064
xxi240@uky.edu
741 South Limestone Street

Positions

  • Assistant Professor

College Unit(s)

Other Affiliation(s)
  • CVRC - Core Faculty
  • Physiology - Joint Faculty

Biography and Education

Education

2011-2017: Ph.D, Shanghai Institute of Biochemistry and Cell Biology (SIBCB), Chinese Academy of Sciences (CAS), Shanghai, China.

2017-2023. Postdoctoral Fellow, Department of Pathology and Lab Medicine, University of California, Los Angeles.

Research

Lipids provide the structural framework of membranes that enclose the cell and its organelles. Precise spatial and temporal localization of lipids is essential for maintaining organelle homeostasis and overall organism health. My research focus on identifying novel intracellular lipid transport pathways, understanding their cellular functions, and developing strategies to modulate intracellular lipid homeostasis for disease prevention and treatment.

Selected Publications

  1. Xiao X, Kennelly JP, Feng AC, Cheng L, Romartinez-Alonso B, Bedard A, Gao Y, Cui L, Young SG, Schwabe JW, Tontonoz P. Aster-B-dependent estradiol synthesis protects female mice from diet-induced obesity. J Clin Invest. 2024 Jan 4;134(4):e173002. https://doi.org/10.1172/JCI173002; PMID: 38175723; PMCID: PMC10866650.
  2. Xiao X, Kennelly JP, Ferrari A, Clifford B, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee SM, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, Vallim TA, Tontonoz P. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat. Metab. 2023. 5, 165–181. https://doi.org/10.1038/s42255-022-00722-6; PMID: 36646756; PMCID: PMC9995220.
  3. Xiao X, Kim Y, Romartinez-Alonso B, Sirvydis K, Ory DS, Schwabe JWR, Jung ME, Tontonoz P. Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2). https://doi.org/10.1073/pnas.2024149118; PMID: 33376205; PMCID: PMC7812747.
  4. Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL, Yin L, Qi W, Wong CC, Zhao Y, Li BL, Qiu WW, Song BL. Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. Mol Cell. 2017 Apr 6;66(1):154-162.e10. https://doi.org/10.1016/j.molcel.2017.02.015; PMID: 28344083.
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