Vivek K Pandey, PhD
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Scientist III
Contact
About Vivek K Pandey, PhD
I am a Scientist in the Department of Physical Medicine and Rehabilitation at the University of Kentucky, with expertise in translational neuro-metabolic research. My research focuses on autonomic dysfunction following spinal cord injury, with particular emphasis on how co-existing diabetes modifies neural and metabolic outcomes, using both human clinical studies and mechanistic rodent models. I am involved in clinically focused research on Hereditary Spastic Paraplegia (HSP), a group of motor neurodegenerative disorders, contributing to efforts aimed at improving understanding of disease mechanisms and functional outcomes. Previously at the University of Kentucky, I examined the impact of diabetes on cardiac remodeling, neurodegeneration, and aging. I earned my Ph.D. in Biological Sciences from AcSIR (CSIR-IITR), with doctoral training in endoplasmic reticulum stress, metabolic disease, and molecular mechanisms of cell death, and I bring prior industry experience in preclinical biosimilar evaluation for anti-diabetic and anti-cancer therapeutics.
Research
Funded Grants (As PI/Co-I)
- Project title: Noninvasive Neuromodulation to Enhance Glucose Homeostasis in Individuals with Spinal Cord Injury and Diabetes Role: Co-Investigator (PI- Dr. Rahul Sachdeva). Funded By: DRC-pilot and feasibility grants. Duration: April 2026 - March 2027
- Project title: Noninvasive Spinal Cord Neuromodulation to Enhance Motor Function in Individuals with Hereditary Spastic Paraplegia. Role: Co-Investigator (PI- Dr. Rahul Sachdeva). Funded By: The Spastic Paraplegia Foundation. Duration: November 2025 -November 2027.
- Project title: Phlorizin, an apple ingredient, supplementation prevents diabetic heart failure. Role: Principal Investigator. Funded By: Saha Foundation Fund for the study of the Association of Food and Cardiovascular Health. Duration: 2025
Selected Publications
- Pandey VK, Law M, Shamatutu C, Martin KC, Taunk M, Gad P, Nightingale TE, Dymock ZR, Krassioukov AV, Sachdeva R. Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review. Journal of NeuroEngineering and Rehabilitation. 2026 Jun 12.
- Velmurugan S, Pandey VK, Verma N, Kotiya D, Despa F, Despa S. Cardiac remodelling, recognition memory deficits and accelerated ageing in a rat model of gestational diabetes. Diabetologia. 2025 Jul;68(7):1574-84.
- Pandey VK, Mathur A, Khan MF, Kakkar P. Endoplasmic reticulum stress induces degradation of glucose transporter proteins during hyperglycemic hepatotoxicity: Role of PERK-eIF2α-ATF4 axis. European Journal of Pharmacology. 2022 Jul 5;926:175012.
- Verma N, Srodulski S, Velmurugan S, Hoskins A, Pandey VK, Despa F, Despa S. Gestational diabetes triggers postpartum cardiac hypertrophy via activation of calcineurin/NFAT signaling. Scientific reports. 2021 Oct 22;11(1):20926.
- Pandey VK, Mathur A, Kakkar P. Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes. Life sciences. 2019 Jan 1;216:246-58.
Selected Publications
- Pandey VK, Law M, Shamatutu C, Martin KC, Taunk M, Gad P, Nightingale TE, Dymock ZR, Krassioukov AV, Sachdeva R. Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review. Journal of NeuroEngineering and Rehabilitation. 2026 Jun 12.
- Velmurugan S, Pandey VK, Verma N, Kotiya D, Despa F, Despa S. Cardiac remodelling, recognition memory deficits and accelerated ageing in a rat model of gestational diabetes. Diabetologia. 2025 Jul;68(7):1574-84.
- Pandey VK, Mathur A, Khan MF, Kakkar P. Endoplasmic reticulum stress induces degradation of glucose transporter proteins during hyperglycemic hepatotoxicity: Role of PERK-eIF2α-ATF4 axis. European Journal of Pharmacology. 2022 Jul 5;926:175012.
- Verma N, Srodulski S, Velmurugan S, Hoskins A, Pandey VK, Despa F, Despa S. Gestational diabetes triggers postpartum cardiac hypertrophy via activation of calcineurin/NFAT signaling. Scientific reports. 2021 Oct 22;11(1):20926.
- Pandey VK, Mathur A, Kakkar P. Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes. Life sciences. 2019 Jan 1;216:246-58.
Education
Ph.D. (Biological Sciences)