Hsin-Sheng Yang
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Professor
Contact
Research
Dr. Yang's lab studies protein translational control of genes involved in tumor invasion and metastasis. Currently, we focus on investigating how Pdcd4 (Programed cell death 4), a novel tumor suppressor and a translation inhibitor, impacts on protein translation particularly the genes critical for tumor invasion and metastasis. Therefore, our research interests include:
- Elucidation of the signaling pathways impinged upon tumor invasion and metastasis
- Identification and characterization of novel factors involved in protein translation initiation
- Development and identification of novel agents or approaches for cancer therapeutics
Selected Publications
- Wang Q., J. Zhu, Y. Zhang, Z. Sun, X. Guo, X. Wang, E. Lee, V. Bakthavatchalu, Q. Yang, and H.-S. Yang. (2013). Down-regulation of Pdcd4 leads to epithelial to mesenchymal transition and promotes metastasis in nude mice. Eur. J. Cancer 49, 1761-1770. PMID: 23312883
- Wang Q., Y. Zhang, and H.-S. Yang. (2012). Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc. Biochim. Biophys. Acta 1823, 1807-1814. PMID:22801218
- Guo, X., W. Li, Q. Wang, and H.-S. Yang. (2011). AKT activation by Pdcd4 knockdown upregulates cyclin D1 expression and promotes cell proliferation. Genes & Cancer 2, 818-828. PMCID: PMC3278903
- Wang, Q., Z. Sun, H. Allgayer, and H.-S. Yang. (2010). Down-regulation of E-cadherin is an essential event in activating β-catenin-dependent transcription and expression of its target genes in Pdcd4 knock-down cells. Oncogene 29, 128-138. PMCID: PMC2920641
- Loh, P. G., H.-S. Yang, M. Walsh, Q. Wang, X. Wang, Z. Cheng, D. Liu, and H. Song. (2009).Structural basis for translational inhibition by the tumor suppressor Pdcd4. EMBO J. 28, 274-285.
- Wang, Q., Z. Sun, and H.-S. Yang. (2008). Down-regulation of tumor suppressor Pdcd4 promotes invasion and activates both b-catenin/Tcf and AP-1 dependent transcription in colon carcinoma cells. Oncogene 27, 1527-1535.
Selected Publications
- Wang Q., J. Zhu, Y. Zhang, Z. Sun, X. Guo, X. Wang, E. Lee, V. Bakthavatchalu, Q. Yang, and H.-S. Yang. (2013). Down-regulation of Pdcd4 leads to epithelial to mesenchymal transition and promotes metastasis in nude mice. Eur. J. Cancer 49, 1761-1770. PMID: 23312883
- Wang Q., Y. Zhang, and H.-S. Yang. (2012). Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc. Biochim. Biophys. Acta 1823, 1807-1814. PMID:22801218
- Guo, X., W. Li, Q. Wang, and H.-S. Yang. (2011). AKT activation by Pdcd4 knockdown upregulates cyclin D1 expression and promotes cell proliferation. Genes & Cancer 2, 818-828. PMCID: PMC3278903
- Wang, Q., Z. Sun, H. Allgayer, and H.-S. Yang. (2010). Down-regulation of E-cadherin is an essential event in activating β-catenin-dependent transcription and expression of its target genes in Pdcd4 knock-down cells. Oncogene 29, 128-138. PMCID: PMC2920641
- Loh, P. G., H.-S. Yang, M. Walsh, Q. Wang, X. Wang, Z. Cheng, D. Liu, and H. Song. (2009).Structural basis for translational inhibition by the tumor suppressor Pdcd4. EMBO J. 28, 274-285.
- Wang, Q., Z. Sun, and H.-S. Yang. (2008). Down-regulation of tumor suppressor Pdcd4 promotes invasion and activates both b-catenin/Tcf and AP-1 dependent transcription in colon carcinoma cells. Oncogene 27, 1527-1535.
Education
B.S., Tamkang University, Taiwan M.S. Tamkang University, Taiwan Ph.D. Arizona State University