Charles T. Lutz, MD, PhD

Publications & Other Scholarly Work:

1     Presnell, SR, Spear, HK Durham, Riddle, JT Applegate, A and Lutz, CT * 2020. Differential fuel requirements of human NK cells and human CD8 T cells: glutamine regulates glucose uptake in strongly activated CD8 T cells. Immunohorizons 4: 231-244 {32385048}

2     Reed, RG, Al-Attar, A, Presnell, SR, Lutz, CT, & Segerstrom, SC 2019. A longitudinal study of the stability, variability, and interdependencies among late-differentiated T and NK cell subsets in older adults. Exp Gerontol 121:46 {30885717}

3     Reed, RG, Presnell, SR, Al-Attar, A, Lutz, CT, & Segerstrom, SC 2019. Perceived stress, cytomegalovirus titers, and late-differentiated T and NK cells: Between- and within-person associations in a longitudinal study of older adults. Brain Behav Immun 80:266, {30885843}

4     Al-Attar, A., Presnell SR, Clasey JL, Long DE, Walton RG, Sexton M, Starr ME, Kern PA, Peterson CA, and Lutz, CT*. 2018. Human body composition and immunity: visceral adipose tissue produces IL-15 and muscle strength inversely correlates with NK cell function in elderly humans. Front Immunol 9:440. {29559978}

5     Al-Attar, A, Presnell SR, Peterson CA, Thomas DT, and Lutz, CT *. 2016. Data correlations between gender, cytomegalovirus infection and T cells, NK cells, and soluble immune mediators in elderly humans. Data in Brief. 8:536.  {27508213}

6     Al-Attar, A, Presnell SR, Peterson CA, Thomas DT, and Lutz, CT. 2016. The effect of sex on immune cells in healthy aging: elderly women have more robust natural killer lymphocytes than do elderly men. Mech. Ageing Dev. 156: 25. {27059724}

7     Hart, J, Lutz, CT*, Jennings, CD, May, JR, Nelson, K, Jacobs, and S, Hoopes, CW. 2015. Falsely incompatible B-cell flow cytometry crossmatch following pronase treatment:  a case report. Transplant Proc 47:831. {25891741}

8     Presnell SR, Al-Attar, A, Cichocki, F., Miller JS, and Lutz, CT*. 2015. Human NK Cell microRNA: Differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs. Genes Immun 16:89. {25410655}

9     Lutz, CT*. 2014. Human leukocyte antigen Bw4 and Bw6 epitopes recognized by antibodies and natural killer cells. Curr Opin Organ Transplant 19:436. {24977435}

10   Lutz, CT*, Al-Attar A, May JR, Jennings CD. 2014. Alloantibody to a Bw4 epitope in a Bw4+ B*27:05 patient. Transplantation 98:853. {24914571} (Subject of Editorial Comment by Gebel, H.M. Transplantation 98:817.)

11   Lutz, CT *, MacIvor D, Rayapati P, Jennings CD. 2014. Broadly reactive anti-HLA antibodies following a single unit transfusion with non-leukoreduced RBC. Am Surgeon 80:E97.

12   Presnell SR, Chan W-C, Zhang L and Lutz, CT *. 2013. IL-2/IL-15 activate the human clonally-restricted KIR3DL1 reverse promoter. Genes Immun 14:107. {23328843}

13   Segerstrom SC, Al-Attar A and Lutz, CT *. 2012. Psychosocial resources, aging, and natural killer cell terminal maturity, Psychology and Aging 27:892. {22708535}

14   Lutz, CT * and Quinn, LS. 2012. Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism. Aging 4: 535.

15   Presnell SR, Zhang L, Chlebowy CN, Al-Attar A, and Lutz, CT *. 2012. Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/IL-15-treated conditions. J Immunol 188: 4394. {22467658}

16   Cichocki, F., Felices M, McCullar V, Presnell SR, Al-Attar A, Lutz, CT, and Miller JS. 2011. Cutting Edge: MicroRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol 187: 6171. {22084432}

17   Lutz, CT *, Karapetyan A, Al-Attar A, Shelton BJ, Holt KJ, Tucker JH, and Presnell SR. 2011. Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. J Immunol 186:4590. {21402893}

18   Butler JE, Moore MB, Chan W-C, Presnell SR, Chalupny NJ, and Lutz, CT *.  2009. Proteasome regulation of ULBP1 transcription.  J. Immunol.  182: 6600. {19414815}

19   Binyamin L, Alpaugh RK, Hughes TL, Lutz, CT, Campbell KS, and Weiner LM.  2008.  Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy.  J. Immunol. 180:6392. {18424763}

20   McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Lutz, CT, Wagner JE, and Miller JS.  2008.  Mouse fetal and embryonic liver cells differentiate human umbilical cord blood (UCB) progenitors into CD56 negative NK cell precursors in the absence of IL-15.  Exp. Hematol. 36:598

21   Presnell SR, Zhang L, Ramilo CA, Chan W-C, and Lutz, CT *.  2006.  Functional redundancy of transcription factor binding sites in the killer cell immunoglobulin-like receptor (KIR) gene promoter.  Int. Immunol. 18:1221. {16818466}

22   Rayhill SC, Kirby PA, Voigt MD, La Brecque DR, Lutz, CT, Katz DA, Mitros FA, Kalil RS, Miller RA, Stolpen AH, Heisey D, Wu YM, and Schmidt WN. 2005. Positive serum cryoglobulin is associated with worse outcome after liver transplantation for chronic hepatitis C. Transplantation 80:448.

23   Chan W-C, Miller JS, Moore MB, and Lutz, CT*.  2005.  Epigenetic control of highly homologous killer Ig-like receptor gene alleles.  J. Immunol.  175: 5966-5974 {16237090}

24   Lutz, CT*, Moore MB, Bradley S, Shelton BJ, and Lutgendorf SK.  2005.  Reciprocal age related change in natural killer cell receptors for MHC class I.  Mech. Ageing Dev. 126: 722-731. {15888327}

25   Lutgendorf SK, Moore MB, Bradley S, Shelton BJ, and Lutz, CT.  2005.  Distress and expression of natural killer receptors on lymphocytes.  Brain Behav. Immun. 19:185. {15797305}

26   Chan W-C, Kurago ZB, Stewart A, Wilson MJ, Martin MP, Mace BE, Carrington M, Trowsdale J and Lutz, CT*.  2003.  DNA methylation maintains allele-specific KIR gene expression in human NK cells.  J. Exp. Med., 197:245. {12538663}

27   Moore MB, Kurago ZB, Fullenkamp CA and Lutz, CT*. 2003. Squamous cell carcinoma cells differentially stimulate NK cell effector functions: the role of IL-18.  Cancer Immunol Immunol Immunotherapy. 52:107. {12594574}

28   Reber AJ, Turnquist HR, Thomas HJ, Lutz, CT and Solheim JC.  Invariant chain can influence MHC class I assembly and surface expression. Immunogenetics 54:74, 2002. {12037599}

29   Shi Y and Lutz, CT *.  Interferon-g control of EBV-transformed B cells: a role for CD8+ T cells that poorly kill EBV-infected cells. Viral Immunol. 15:213, 2002. {11952143}

30   Turnquist HR, Thomas HJ, Prilliman KR, Lutz, CT, Hildebrand WH and Solheim JC.  HLA-B polymorphism affects interactions with multiple endoplasmic reticulum proteins. Eur. J. Immunol. 30:3021, 2000. {11069086}

31   Lutz, CT* and Kurago ZB.  HLA class I expression on squamous cell carcinoma cells regulates natural killer cell activity. Cancer Res: 59:5793, 1999. {10582701}

32   Chiu BC-H, Cerhan JR, Gapstur SM, Sellers TA, Zheng W, Lutz, CT, Wallace RB, Potter JD.  Alcohol consumption and non-Hodgkin lymphoma in a cohort of older women. Br J Cancer: 80 1476, 1999. {10424754}

33   Lutz, CT*, Browne GA, and Petzold CR.  Methylcholanthrene causes increased thymic apoptosis.  Toxicology: 128:151, 1998. {9710156} 

34   Shi Y, Smith KD, and Lutz, CT*.  TAP-independent MHC class I peptide antigen presentation to alloreactive CTL is enhanced by target cell incubation at subphysiological temperature.  J. Immunol. 160:4305, 1998. {9574533}

35   Lutz, CT*, Foster PA, Noll WW, Voelkerding KV, Press RD, and Kirschbaum NE.  Multicenter evaluation of PCR methods for the detection of factor V Leiden (R506Q) genotypes. Clin Chem, 44:1356, 1998. {9625070}

36   Kurago ZB, Lutz, CT*, Smith KD, and Colonna M.  NK cell natural cytotoxicity and IFN-g production are not always coordinately regulated:  Engagement of DX9 KIR+ NK cells by HLA-B7 variants and target cells. J. Immunol. 160:1573, 1998. {9469412}

37   Lutz, CT*.  DNA-Based Assay Formats for Detecting Thrombosis Factor V Genotypes. J Clin Ligand Assay 20:235-244, 1997. 

38   Smith KD, Kurago ZB, and Lutz, CT*.  Conformational changes in MHC class I molecules: Antibody, T cell receptor and NK cell recognition in a HLA-B7 model system.  Immunol Research 16:243, 1997. {9379075}

39   Shi Y, Smith KD, Kurilla MG, and Lutz, CT*.  Cytotoxic CD8+ T cells recognize Epstein-Barr virus antigen but poorly kill autologous EBV-infected B lymphoblasts:  Immunodominance is elicited by a peptide epitope that is presented at low levels in vitro.  J. Immunol. 159:1844, 1997. {9257848}

40   Smith KD, Huczko E, Engelhard VH, Li Y-Y, and Lutz, CT*.  Alloreactive cytotoxic T lymphocytes focus on specific MHC-bound peptides. Transplantation: 64:351, 1997. {9256200}

41   Cerhan JR, Wallace RB, Folsom AR, Potter JD, Sellers TA, Zheng W, and Lutz, CT. Medical history risk factors for the development of non-Hodgkin lymphoma in older women. J Natl Cancer Inst: 89:314, 1997 {9048836}

42   Smith KD and Lutz, CT*.  Alloreactive T cell recognition of MHC class I molecules.  The T cell receptor interacts with limited regions of the MHC class I long a-helices. J Immunol: 158:2805, 1997. {9058816}

43   Voelkerding KV, Huber S, Strobl F, Wu LA, Sabatini LM, Anderson M, and Lutz, CT.  Resistance to activated protein C: Comparison of three different PCR methods for detection of FV R506Q. Mol Diagn 1:297, 1996. {2341305}

44   Vigna JL, Smith KD and Lutz, CT*.  Invariant chain associates preferentially with HLA class I/b2-microglobulin heterodimers in an allele-specific manner, and association is influenced by peptide binding groove residues.  J. Immunol. 157:4503, 1996. {8906828}

45   Smith KD, Mace BE, Valenzuela A, Vigna JL, McCutcheon JA, Barbosa JA, Huczko E, Engelhard VH, and Lutz, CT*.  Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies.  J Immunol 157:2470, 1996. {8805647}

46   Li Y-Y, Smith KD, Shi Y and Lutz, CT*.  Alloreactive anti-HLA-B7 cytolytic T cell use restricted TCR genes.  Transplantation  62:954, 1996. {8878390}

47   Zarling AL, Smith KD, Lutz, CT, Lee DR.  Corrected Cw3 genomic sequence tentatively identifies it as Cw*0304.  Immunogenetics, 44:82, 1996. {8613148}

48   Smith KD and Lutz, CT*.  Peptide dependent expression of HLA-B7 on antigen processing deficient T2 cells.  J. Immunol. 156:3755, 1996. {8621911}

49   Smith KD, Epperson DF, and Lutz, CT*.  Alloreactive cytotoxic T-lymphocytes-defined HLA-B7 subtypes differ in peptide antigen presentation.  Immunogenetics 43:27, 1995. {8537119}

50   Greiner TC, Raffeld M, Lutz C, Dick F, and Jaffe ES.  Analysis of T cell receptor-g gene rearrangements by denaturing gradient gel electrophoresis of GC-clamped polymerase chain reaction products:  Correlation with tumor-specific sequences.  Amer J Path 146:46, 1995. {7856738}

51   McCutcheon JA, Gumperz J, Smith KD, Lutz, CT, and Parham P.  Low HLA-C expression at cell surfaces correlates with increased turnover of mRNA.  J. Exp. Med. 181:2085, 1995. {776000}

52   Kurago ZB, Smith KD and Lutz, CT*.  Natural killer cell recognition of MHC class I:  NK cells are sensitive to peptide binding groove and surface a-helical mutations that affect T cells.  J. Immunol. 154:2631, 1995.

53   Lutz, CT*, Smith KD, Greazel NS, Mace BE, Jensen DA, McCutcheon JA, and Goeken NE.  Bw4-reactive and Bw6-reactive antibodies recognize multiple distinct HLA structures that partially overlap in the a-1 helix.  J. Immunol. 153:4099, 1994. {7523516}

54   Hardarson S, Anderson ME and Lutz, CT*.  Epstein-Barr virus is present in many types of benign and malignant lymphoid lesions. Diagn Mol Path 3:22-31, 1994. {8162252}

55   Lutz, CT*.  Primary and secondary science teaching from an advanced education perspective.  Chataqua Notes 10:4-10, 1994.

56   DeVito LD, Mason BP, Jankowska-Gan E, Hogan KT, Guo J-W, Lutz, CT, Sollinger HW and Burlingham WJ.  Epitope fine specificity of human anti-HLA-A2 antibodies.  Identification of four epitopes including a hapenlike epitope on HLA-A2 at lysine 127.  Hum Immunol 37:165, 1993.

57   Smith KD, Valenzuela A, Vigna JL, Aalbers K and Lutz, CT*.  Unwanted mutations in PCR mutagenesis:  avoiding the predictable.  PCR Methods and Applications 2:253-257, 1993.

58   McCutcheon JA, Smith KD, Valenzuela A, Aalbers K and Lutz, CT*.  HLA-B* 0702 antibody epitopes are affected indirectly by distant antigen residues.  Hum Immunol 36:69-75, 1993. {7681814}

59   DeVito LD, Hogan KT, Mason BP, Lutz, CT, Sollinger HW and Burlingham WJ.  Epitope fine specificity of human anti-HLA-A2 antibodies.  Trans Proc 25:189-190, 1993. {7679810}

60   McCutcheon JA and Lutz, CT*.  Mutagenesis around residue 176 on HLA-B* 0702 characterizes multiple distinct epitopes for anti-HLA antibodies.  Hum Immunol 35:125-131, 1992. {1283748}

61   Gulley ML, Raphael M, Lutz, CT, Ross DW and Raab-Traub N.  Epstein-Barr virus integration in human lymphomas and in lymphoid cell lines.  Cancer 70:185-191, 1992. {1318776}

62   Cai J, Humphries C, Lutz C and Tucker PW.  Analysis of VH251 gene mutation in chronic lymphocytic leukemia (CLL) and normal B-cell subsets.  Ann NY Acad Sci 651:384-392, 1992. {1599132}

63   Laszewski MJ, Belding PJ, Fedderson RM, Lutz, CT, Goeken JA, Kemp JD and Dick FR.   Clonal immunoglobulin gene rearrangement in the infarcted lymph node syndrome.  Am J Clin Pathol 96:116-120, 1991. {2069129}

64   Lutz, CT*, Cornell SH and Goeken JA.  Cerebrospinal fluid b-2 microglobulin: Establishment of a reference interval with two commercial assays.  Clin Chem 37:104-107, 1991. {1988188}

65   Lutz, CT*, Jensen DA, Schiffenbauer J, Didier DK, Schwartz BD and Davis CS.  Multiple mechanisms produce diversity of HLA-C alleles.  Hum Immunol 28:27-31, 1990. {2341305}

66   Kamat D, Laszewski MJ, Kemp JD, Goeken JA, Lutz, CT, Platz CE and Dick FR.  The diagnostic utility of immunophenotyping and immunogenotyping in the pathologic evaluation of lymphoid proliferations.  Mod Pathol 3:105-112, 1990. {2183210}

67   Lutz, CT*, Galles ME, Kemp JD, Goeken JA and Dick FR.  Kappa immunoglobulin light chain gene rearrangement in a T-lineage chronic lymphocytic leukemia.  Am J Clin Pathol 93:702-705, 1990. {2109525}

68   Lutz, CT and Davie JM.  Genetics and primary structure of Vk gene segments encoding antibody to streptococcal group A carbohydrate.  J Immunol 140:641-645, 1988. {3121751}

69   Lutz, CT, Hollifield WC, Seed B, Davie JM and Huang HV.  Syrinx 2A:  An improved l phage vector designed for screening DNA libraries by recombination in vivo.   Proc Natl Acad Sci USA 84:4379-4383, 1987. {3102673}

70   Lutz, CT, Bartholow TL, Greenspan NS, Fulton RJ, Monafo WJ, Perlmutter RM, Huang HV and Davie JM.  Molecular dissection of the murine antibody response to streptococcal group A carbohydrate.  J Exp Med 165:531-545, 1987. {3102673}

71   Davie JM, Seiden MV, Greenspan NS, Lutz, CT, Bartholow TL and Clevinger BL. Structural correlates of idiotypes.  Ann Rev Immunol 4:147-165, 1986.

72   Lutz, CT, Bell CE, Wedner HJ and Krogstad DJ.  Allergy testing of multiple patients should no longer be performed with a common syringe.  N Engl J Med 310:1335-1337, 1984.

73   Lutz, CT and McDonald JM.  Serology of hepatitis B infection.  Barnes Hospital Division of Laboratory Medicine Newsletter, 1983.

74   Glasebrook AL, Sarmiento M, Loken MR, Dialynas DP, Quintans J, Eisenberg L, Lutz, CT, Wilde D and Fitch FW.  Murine T lymphocyte clones with distinct immunological functions.  Immunol Rev 54:219-266, 1981.

75   Lutz, CT*.  The generation of cytolytic activity in mixed leukocyte cultures.  Cortisone resistant thymocytes are deficient in helper T lymphocytes.  J Immunol 127:1156-1163, 1981. {6455469}

76   Lutz, CT, Glasebrook AL and Fitch FW.  Enumeration of alloreactive helper T lymphocytes which cooperate with cytolytic T lymphocytes.  Eur J Immunol 11:726-734, 1981.

77   Lutz, CT, Glasebrook AL and Fitch FW.  Alloreactive cloned T cell lines.  IV.   Interaction of alloantigen and T cell growth factors (TCGF) to stimulate cloned cytolytic T lymphocytes.  J Immunol 127:391-392, 1981.

78   Lutz, CT, Glasebrook AL and Fitch FW.  Alloreactive cloned T cell lines.  III.   Accessory cell requirements for the growth of cloned cytolytic T lymphocytes.  J Immunol 126:1404-1408, 1981. {6970775}

79   Lutz, CT and Fitch FW.  Accessory cell requirements for the generation of cytolytic T lymphocytes.  J Immunol 122:2598-2604, 1979. {109533}

Book and Book Chapters

1     Greenspan N, Seiden M, Clevinger B, Nahm M, Lutz, CT, Bartholow T, Heuckeroth R, Fine S and Davie JM.  Idiotypes and anti-idiotypes.  In: Immunity to Cancer.   A Reif and M Mitchell, editors.  Academic Press, NY, 1985.

2     Lutz, CT.  Cellular cooperation involved in the generation of cytolytic T lymphocytes.  Ph.D. Dissertation, University of Chicago, 1981.