Alexander "Sasha" Rabchevsky, PhD
Connect
(859) 323-0267agrab@uky.edu
Positions
- Professor of Physiology
College Unit(s)
Other Affiliation(s)
- SCOBIRC - Core Faculty
Biography and Education
Education
Alexander ‘Sasha’ Rabchevsky is a tenured SCoBIRC endowed Professor of Physiology at the University Kentucky in Lexington, KY and a faculty member of the Spinal Cord & Brain Injury Research Center (SCoBIRC). After graduating with a B.S. in Biology from Hampden-Sydney College, VA only a semester behind his original ’87 class, and working as a technician at the NIH, he was accepted into the University of Florida Neuroscience graduate program in 1990 and worked in the laboratory of Dr. Paul J. Reier. He defended his doctoral thesis in 1995 entitled, “Intraspinal transplantation of microglia: Studies of host cellular responses and effects on neuritic growth.” He then moved to France where he undertook a foreign postdoctoral fellowship at the University of Paris, XII in INSERM Unite 421, headed by Dr. Marc Peschanski, during which he studied neuroimmunology in the context of autoimmune disease animal models, employing novel transplantation techniques, as well as employing transgenic mice and molecular biology to study the role of TGF-alpha in astrogliosis.
Since 1997, Sasha has been based in Lexington, KY where he has been investigating multiple therapeutic approaches to treat experimental spinal cord injury (SCI). After conducting a second postdoctoral fellowship under the guidance of Dr. Stephen Scheff in the UK Department of Anatomy and Neurobiology, he obtained independent funding which helped launch his independent research program. His interests have focused on alleviating both hindlimb locomotor and/or autonomic dysfunction following SCI in rats employing pharmacological treatments and/or gene therapy to over-express certain growth factors near injury sites. HIs laboratory has conducted pioneering studies uniquely characterizing bioenergetic damage to mitochondria after contusion SCI in order to target their dysfunction. Specifically, pharmacological agents that maintain mitochondrial integrity have been administered at acute and more prolonged time points after injury, resulting in significantly reduced secondary tissue damage that is manifested in improved hindlimb functional recovery. In a parallel but novel line of investigations, his lab was funded to test whether directly transplanting healthy mitochondria isolated from exogenous sources into the contused rat spinal cord maintains cellular bioenergetics and promotes functional recovery.
Alternatively, Sasha’s research has gained him international recognition as a leading expert in autonomic pathophysiology following SCI. In particular, his work has helped to identify the abnormal neural circuitry which develops below the injury level that is associated with the development of a hypertensive condition termed autonomic dysreflexia; this syndrome occurs in the majority of SCI individuals, including him. To this end, he developed state-of-the-art telemetric monitoring of cardiophysiology before and after injury to report that commonly prescribed neuropathic pain medications (i.e., gabapentinoids) mitigate the incidence and severity of this secondary complication after SCI, along with muscle spasticity, both of which are triggered by noxious stimulation. With these proof-of-principle concepts, his work has led other investigators to test gabapentin in other animal models using novel viral vector advances to understand the influences of maladaptive intraspinal plasticity on the incidence and/or severity of AD. In yet another line of investigation, he employed novel intrathecal antisense oligonucleotides injections in attempts to attenuate muscular spasticity in a chronic SCI model; based on high impact reports that unregulated serotonergic receptor activity is the underlying cause of muscle spasticity in adult spinal rats. Utilizing the identical complete S2 transection SCI model, he injected designer oligonucleotides intrathecally to inactivate constitutively active 5HT2C receptors below the transected rat spinal cord. What his laboratory unexpectedly reported, however, was that the highly cited evidence for spinal cord 5HT2C receptor splicing does not occur following S2 spinal cord transections, and the antisense oligonucleotide experiments showed no significant changes in the manifestation of spasticity.
Research
Molecular Biological and Biochemical Therapies for Spinal Cord Injury
The major focuses of my laboratory are to alleviate both autonomic and/or hind limb locomotor dysfunction following complete transection or incomplete contusion spinal cord injury (SCI) in adult rats, respectively. In conjunction with precise surgical and histological approaches, as well as behavioral and physiological assessments, we have employed gene therapy with replication-defective recombinant viruses injected into injured spinal cords in order to over-express different growth factors or inhibitory molecules. Such site-specific genetic manipulation of endogenous cellular responses after injury has been used to identify processes contributing to undesirable autonomic pathophysiology. An equally important area of my research endeavor has been directed at the molecular biological and biochemical assessments of the temporal profile of mitochondrial dysfunction after contusion SCI in order to establish therapeutic windows for mitochondrial-targeted interventions for promoting tissue sparing and functional recovery.
Autonomic dysreflexia is a condition that develops after severe SCI at or above high thoracic (T6) levels which manifests as potentially life-threatening hypertension often triggered by painful stimulation of sensory fibers below the injury that sprout into injured spinal cords due to elevated nerve growth factor (NGF) expression, in particular. Using a rodent model of this pathophysiological condition, triggered by painful colorectal distension (CRD), we have identified the contributions of both primary afferent nociceptive fibers and ascending propriospinal pathway plasticity to the development of autonomic dysreflexia, monitored radio-telemetrically. We have also conducted translational pharmaceutical studies to test whether blocking glutamatergic neurotransmission with neuropathic pain medications (gabapentinoids) mitigates the incidence and severity of this insidious secondary complication after SCI, along with muscle spasticity, both of which are triggered by noxious stimuli. Alternatively, intrathecal delivery of novel designer oligonucleotides have been used in attempts to attenuate reported constitutive activation of 5HT2C receptors reported to underlie muscle spasticity in a complete S2 transection SCI model in adult rats. However, our highly collaborative investigations challenge, for the first time, this widely accepted theory based on our report that alternative splicing of this serotonergic receptor subtype does not occur; hence does not underlie spasticity.
Mitochondria are the powerhouse of all cells and they are extremely vulnerable to damage following trauma. After establishing the temporal, sequential pattern of compromised bioenergetics (damage) of mitochondria after acute contusion SCI, for the first time, we have compelling evidence that pharmacological agents (mitoceuticals) which target and maintain mitochondrial function are, indeed, neuroprotective after severe contusion SCI. In particular, when administered within an hour after SCI, mitoceuticals which maintain mitochondrial integrity help preserve the integrity of both synaptic and non-synaptic mitochondrial populations, assessed one and two days later. Such preservation is correlated with remarkable spinal cord tissue sparing and, more importantly, long-term behavioral recovery of hind limb locomotion. More recent experiments have tested whether supplementing healthy mitochondria isolated from exogenous sources into the contused rat spinal cord maintains bioenergetics and promotes functional recovery. In particular, we are comparatively assessing intraspinal transplantation of mitochondria derived from autologous muscle and cultured cells with less invasive intrathecal delivery approaches via hydrogels design to protect mitochondria extracellularly, with multiple acute outcome measures and long-term behavioral studies in order to generate robust pre-clinical data for this novel biologic therapeutic.
Selected Publications
Complete List: http://www.ncbi.nlm.nih.gov/pubmed/?term=Rabchevsky
Malik Raza N., Samejima S., Shackleton C., Miller T., Pedrocchi A.L.G., Rabchevsky A.G., Moritz C.T., Darrow D., Field-Fote E.C., Guanziroli E., Ambrosini E., Molteni F., Gad P., Mushahwar V. K., Sachdeva R. and Krassioukov A.V. (2024) REPORT-SCS: Minimum reporting standards for spinal cord stimulation studies in spinal cord injury. J. Neural Engineering 2024 Feb 7;21(1) DOI 10.1088/1741-2552/ad2290 PMID: 38271712
Warner F.M., Tong B., McDougall J., Ginis K.M., Rabchevsky A.G., Cragg J.J., Kramer J.L.K. (2023) Perspectives on data sharing in persons with spinal cord injury Neurotrauma Reports 9;4(1):781-789. DOI: 10.1089/neur.2023.0035 PMID: 38028277, PMCID: PMC10659015
Michael F.M., Patel S.P., Bachstetter A.D. and Rabchevsky A.G. (2023) Proinflammatory and immunomodulatory gene and protein expression patterns in spinal cord and spleen following acute and chronic high thoracic injury. Journal of Inflammation Research 16: 3341–3349 PMID: 37576153, PMCID: PMC10423003
Velmurugan G.V., Hubbard W.B., Prajapati P., Vekaria H.J., Patel S.P., Rabchevsky A.G. and Sullivan P.G. (2023) LRP1 deficiency promotes mitostasis in response to oxidative stress: Implications for mitochondrial targeting after traumatic brain injury. Cells 12, 1445. https://doi.org/10.3390/cells12101445
Patel S.P., Michael F.M., Gollihue J.L., Hubbard W.B., Sullivan P.G. and Rabchevsky A.G. (2023) Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma. Mitochondrion 68: 10-14. Epub 2022 Nov 9 PMID: 36371072 PMCID: PMC9805511
Michael F.M. and Rabchevsky A.G. (2023) Spinal interneurons and autonomic dysreflexia after injury. In: Spinal Interneurons: Plasticity after spinal cord injury. Zholudeva L. and Lane M. (Eds.), Elsevier, Chapter 11, pp 297-310. https://doi.org/10.1016/B978-0-12-819260-3.00001-9
Patel S.P., Michael F.M., Khan M.A., Duggan B., Wyse S., Darby D., Chaudhuri K., Pham J., Gollihue J., DeRouchey J.E., Sullivan P.G., Dziubla T.D. and Rabchevsky A.G. (2022) Erodible thermogelling hydrogels for localized mitochondrial transplantation to the spinal cord. Mitochondrion 64:145–155. Epub 2022 April 6 DOI: 10.1016/j.mito.2022.04.002 PMCID: PMC9154311
Hart S.H., Patel S.P., Michael F.M., Stoilov P., Leow C.J., Hernandez A., Jolly A., de la Grange P., Rabchevsky A.G., Stamm S. (2022) Rat spinal cord injury associated with spasticity leads to widespread changes in the regulation of retained introns. Neurotrauma Reports 3(1): 105-121. Epub 2022 Mar 4 DOI: 10.1089/neur.2021.0042 PMCID: PMC8985541
Morse L.R., Field-Fote E.C., Contreras-Vidal J., Noble-Haeusslein L.J., Rodreick M., SCI 2020 Working Group, Shields R.K., Sofroniew M., Wudlick R. and Zanca J.M. (2021) Meeting proceedings for SCI 2020: Launching a decade of disruption in spinal cord injury research. Journal of Neurotrauma 38(9):1251-1266. Epub 2021 Feb 3 DOI: 10.1089/neu.2020.7174 PMID: 33353467
Bourbeau D., Bolon A., Chernesky J., Creasey G., Fertig B., French J., Jeji T., Kaiser A., Kouznetsov R., Rabchevsky A.G., Gallo Santacruz, B., Sun J., Thor K.B., Wheeler T. and Wierbicky J. (2020) Needs, priorities, and attitudes of individuals with spinal cord injury toward nerve stimulation devices for bladder and bowel function. Spinal Cord 1-11. Epub 2020 Sept 7 PMID: 32895475 PMCID: PMC7642195
Rabchevsky A.G., Michael, F.M. and Patel S.P. (2020) Mitochondria focused neurotherapeutics for spinal cord injury. Special Issue “Mitochondria and Neurodegenerative Diseases,” Experimental Neurology 1-9. Epub 2020 Apr 27 DOI: 10.1016/j.expneurol.2020.113332 PMID: 32353464 PMCID: PMC9164988
Eldahan K.C., Williams H.C., Cox D.H., Gollihue J.L., Patel S.P. and Rabchevsky A.G. (2020) Paradoxical effects of continuous high dose gabapentin treatment on autonomic dysreflexia after complete spinal cord injury. Experimental Neurology 209: 59-70. Epub 2019 Oct 31 PMID: 31678138, PMCID: PMC9204647
Michael F.M., Patel S.P. and Rabchevsky A.G. (2019) Intraspinal plasticity associated with development of autonomic dysreflexia after complete spinal cord injury. Frontiers in Cellular Neuroscience 13: 505-115. Epub 2019 Nov 8 PMID: 31780900, PMCID: PMC6856770
Owen A.M., Patel S.P., Smith J.D., Belasuriya B.K., Mori S.F, Hawk G.S., Stromberg A.J., Kuriyama N., Kaneki M., Rabchevsky A.G., Butterfield T.A., Esser K.A., Peterson C.A., Starr M.E. and Saito H. (2019) Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model. eLife v. 8, e49920, p. 1-25. Epub 2019 Oct 19 PMID: 31793435, PMCID: PMC6890461
Patel S.P. and Rabchevsky A.G. (2019) Application of the Infinity Horizon spinal cord contusion injury model. Animal Models of Acute Neurological Injuries, 2nd edition, Humana Press; Chen J., Xu Z.C., Xu X.-M. and Zhang J.H. (Eds.) pp. 1-7.
Scholpa N.E., Williams H., Wang W., Corum D., Narang A., Tomlinson S., Sullivan P.G., Rabchevsky A.G. and Schnellmann R.G. (2019) Pharmacological stimulation of mitochondrial biogenesis using the FDA-approved β2-adrenoreceptor agonist formoterol for the treatment of spinal cord injury. Journal of Neurotrauma 36:962-972. PMID: 30280980, PMCID: PMC6484358
Gollihue J.L., Patel S.P., Mashburn C., Eldahan K.C., Cox D.H., Donahue R.R., Taylor B.K., Sullivan P.G. and Rabchevsky A.G. (2018) Effects of mitochondrial transplantation on bioenergetics, cellular incorporation and functional recovery after spinal cord injury. Journal of Neurotrauma 35:842–853. Epub 2017 Dec 15 PMID: 29205090, PMCID: PMC6053898
Eldahan K.C., Cox DH, Gollihue, J.L., Patel S.P. and Rabchevsky A.G. (2018) Rapamycin exacerbates cardiovascular dysfunction after complete high-thoracic spinal cord injury. Journal of Neurotrauma 35:842–853. Epub 2017 Dec 15 PMID: 29205090, PMCID: PMC5863090
Eldahan K.C. and Rabchevsky A.G. (2018) Autonomic dysreflexia after spinal cord injury: Systemic pathophysiology and methods of management. Special Issue “Spinal cord injury (SCI) and the autonomic nervous system,” Autonomic Neuroscience: Basic and Clinical, 209: 59-70. Epub 2017 May 8 PMID: 28506502, PMID: PMC5677594
Gollihue J.L., Patel S.P. and Rabchevsky A.G. (2018) Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma. Neural Regeneration Research 13(2):194-197. Epub 2017 Dec 7 PMID: 29557359, PMCID: PMC5879881
Rabchevsky A.G., Patel S.P. and Sullivan P.G. (2017) Targeting mitoNEET with pioglitazone for therapeutic neuroprotection after spinal cord injury. Neural Regeneration Research 12(11): 1807-1808. Epub 2017 Oct 19 PMID: 29239323 PMCID: PMC5745831
Stamm S., Gruber S.B., Rabchevsky A.G. and Emeson R.B. (2017) The activity of the serotonin receptor 2C is regulated by alternative splicing. Human Genetics 136(9):1079-1091. Epub 2017 June 29 PMID: 28664341 PMCID: PMC5873585
Gollihue J.L., Patel S.P., Mashburn C., Eldahan K.C., Sullivan P.G. and Rabchevsky A.G. (2017) Optimization of mitochondrial isolation techniques for intraspinal transplantation procedures. Journal of Neuroscience Methods 287: 1–12. Epub 2017 May 26 PMID: 28554833 DOI: 10.1016/j.jneumeth.2017.05.023
Gollihue J.L. and Rabchevsky A.G. (2017) Prospects for therapeutic mitochondrial transplantation. Mitochondrion 35: 70-79. PMID: 28533168 DOI: 10.1016/j.mito.2017.05.007
Patel S.P.*, Cox D.H.*, Gollihue J.L., Bailey W.M., Geldenhuys W.J., Gensel J.C., Sullivan P.G. and Rabchevsky A.G. (2017) Pioglitazone treatment following spinal cord injury maintains acute mitochondrial integrity and increases chronic tissue sparing and functional recovery. Experimental Neurology 293 74-82. Epub 2017 March 30 PMID: 28365473, PMCID: PMC5473659 *authors contributed equally
Zhang Z., Shen M., Gresch P., Ghamari-Langroudi M., Rabchevsky A.G., Emeson R. and Stamm S. (2016) Oligonucleotide-induced alternative splicing of serotonin 2C receptor reduces food intake. EMBO Molecular Medicine 8(8): 878–894. Epub 2016 June 9 PMID: 27406820, PMCID: PMC4967942
Rau K.K., Hill C.E., Harrison B.J., Venkat G., Koenig H.M., Cook S.B., Rabchevsky A.G., Taylor B.K., Hai T. and Petruska J.C. (2016) Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons. Experimental Neurology S0014-4886(16)30159-5. Epub June 2 PMID: 27264359, PMCID: PMC4992590
Patel S.P.*, Smith T.D.*, VanRooyen J.L., Powell D., Cox D.H., Sullivan P.G. and Rabchevsky A.G. (2016) Serial diffusion tensor imaging in vivo predicts long-term functional recovery and histopathology in rats following different severities of spinal cord injury. Journal of Neurotrauma 33: 917–928. PMID: 26650623, PMID: 26650623, PMCID: PMC4876527 *authors contributed equally
Visavadiya N.P.*, Patel S.P.*, VanRooyen J.L., Sullivan P.G. and Rabchevsky A.G. (2016) Cellular and subcellular oxidative stress parameters following severe spinal cord injury. Redox Biology 8: 59-67. PMID: 26760911 *authors contributed equally
Kwon B.K., Streijger F., Hill C.E., Anderson A.J., Bacon M., Beattie M.S., Blesch A., Bradbury E.J., Brown A., Bresnahan J.C., Case C.C., Colburn R.W., David S., Fawcett J.W., Ferguson A.R., Fischer I., Floyd C.L., Gensel J.C., Houle J.D., Jakeman L.B., Jeffery N.D., Jones L.A., Kleitman N., Kocsis J., Lu P., Magnuson D.S., Marsala M., Moore S.W., Mothe A.J., Oudega M., Plant G.W., Rabchevsky A.S., Schwab J.M., Silver J., Steward O., Xu X.M., Guest J.D., Tetzlaff W. (2015) Large animal and primate models of spinal cord injury for the testing of novel therapies. Experimental Neurology 269:154-168. PMID: 25902036
Hou S.P. and Rabchevsky A.G. (2014) Autonomic consequences of spinal cord injury. Comprehensive Physiology 4: 1419-1453. Epub 2014 Oct 8 PMID: 25428850 DOI: 10.1002/cphy.c130045
*Patel S.P., Sullivan P.G., Pandy J.D., Goldstein G.A., VanRooyen J.L., Yonutas H.M., Eldahan K.C., Morehouse J., Magnuson D.S.K. and Rabchevsky A.G. (2014) N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Experimental Neurology 257: 95-105. PMID: 24805071 *sister article to the next citation
*Pandya J.D., Readnower R.D., Patel S.P., Yonutas H.M., Pauly J.R., Goldstein G.A., Rabchevsky A.G. and Sullivan P.G. (2014) N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Experimental Neurology 257: 106-113. PMID: 24792639 *Highlighted sister article
Nielson J.L., Guandique C.F., Liu A.W., Muraru V., Burke D.A., Lash A.T., Kline R.H. IV, Moseanko R., Hawbecker S., Strand S.C., Zdunowski S., Irvine K.A., Brock J.H., Rosenzweig E.S., Nout Y.S., Gensel J.C., Anderson K.D., Magnuson D.S.K., Whittemore S.R., McTigue D.M., Popovich P.G., Rabchevsky A.G., Steward O., Courtine G., Edgerton V.R., Tuszynski M.H., Beattie M.S., Bresnahan J.C. and Ferguson A.R. (2014) Development of a database for translational spinal cord injury research. Journal of Neurotrauma 31: 1789-1799 PMID: 25077610
Zhang Y., Guan Z., Reader B., Shawler T., Mandrekar-Colucci S., Huang K., Weil Z., Bratasz A., Wells J., Powell N., Sheridan J., Whitacre C., Rabchevsky A.G., Nash M. and Popovich P. (2013) Autonomic dysreflexia causes chronic immune suppression after spinal cord injury. Journal of Neuroscience 33:12970 –12981. PMID: 23926252
Petruska J.C., Hubscher C.H. and Rabchevsky A.G. (2013) Challenges and opportunities of sensory plasticity after SCI. Frontiers in Physiology 4: 231-234. PMID: 23986722
Rabchevsky A.G., Patel S.P., Lyttle T.S., Eldahan K.C., O’Dell C.R., Zhang Y., Popovich P.G., Kitzman P.H., and Donohue, K.D. (2012) Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury. Frontiers in Physiology 3: 329-350. PMID: 22934077
Patel S.P., Sullivan P.G., Lyttle T.S., Magnuson D.S.K. and Rabchevsky A.G. (2012) Acetyl-l-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery. Neuroscience 210: 296–307. PMID: 22445934
Rabchevsky A.G., Patel S.P. and Springer J.E. (2011) Pharmacological interventions for spinal cord injury: Where do we stand? How might we step forward? Pharmacology & Therapeutics 132: 15–29. PMID: 21605594
Rabchevsky A.G. and Kitzman P.H. (2011) Latest approaches for the treatment of spasticity and autonomic dysreflexia in chronic spinal cord injury. Neurotherapeutics 8(2): 274-82. PMID: 21384222
Rabchevsky A.G., Patel S.P., Duale H., Lyttle T.S., O’Dell C.R. and Kitzman P.H. (2011) Gabapentin for spasticity & autonomic dysreflexia after severe spinal cord injury. Spinal Cord 49: 99–105. PMID: 20514053
Patel S.P., Sullivan P.G., Lyttle T.S. and Rabchevsky A.G. (2010) Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. Journal of Neurochemistry 114(1): 291-301. PMID: 20438613
Duale H., Lyttle T.S., Smith B.N. and Rabchevsky A.G. (2010) Noxious colorectal distention in spinalized rats further reduces pseudorabies virus labeling of sympathetic neurons. Journal of Neurotrauma 27: 1369-1378. PMID: 20528165
Derbenev A.V., Duale H., Rabchevsky A.G. and Smith B.N. (2010) Electrophysiological characteristics of identified kidney-related neurons in adult rat spinal cord slices. Neuroscience Letters 474(3): 168-172. Epub 2010 Mar 18. PMID: 20303390, PMCID: PMC2863015
Patel S.P., Pandya J.D., Sullivan P.G. and Rabchevsky A.G. (2009) Effects of mitochondrial uncoupling agent, 2,4-dinitrophenol, or nitroxide antioxidant, tempol, on mitochondrial integrity following acute contusion spinal cord injury. Journal of Neuroscience Research 87(1):130-140. PMID: 18709657
Duale H., Hou S.P., Derbenev A.V., Smith B.N. and Rabchevsky A.G. (2009) Spinal cord injury reduces the efficacy of pseudorabies virus labeling of sympathetic preganglionic neurons. Journal of Neuropathology and Experimental Neurology 68(2): 168-178. Epub 2009 Jan 20 PMID: 19151624, PMCID: PMC2748969
Hou S.P., Duale H., Cameron A.A., Abshire S.M., Lyttle T.S. and Rabchevsky A.G. (2008) Plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transection. Journal of Comparative Neurology 509(4): 382-399. Epub 2008 June 3 PMID: 18512692, PMCID: PMC2536612
Sullivan P.G., Krishnamurthy S., Patel S.P., Pandya J.D. and Rabchevsky A.G. (2007) Temporal characterization of mitochondrial bioenergetics after spinal cord injury. Journal of Neurotrauma 24(6): 991-999. Epub 2007 Jun 30 DOI: 10.1089/neu.2006.0242 PMID: 17600515
Rabchevsky A.G. (2006) Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury. Progress in Brain Research 152: Autonomic Dysfunction after Spinal Cord Injury. Weaver L.C. & Polosa C. (Eds.), Elsevier B.V. pp. 265-274. Epub 2005 Oct 4 PMID: 16198706, PMCID: PMC3529572
Cameron A.A., Smith G.M., Randall D.C., Brown D.R. and Rabchevsky A.G. (2006) Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia. Journal of Neuroscience 26(11): 2923-2932. Epub 2006 Mar 17 PMID: 16540569, PMCID: PMC3535471
Hynds D.L., Rangappa N., Ter Beest J., Snow D.M. and Rabchevsky A.G. (2004) Microglia enhance dorsal root ganglion outgrowth in Schwann cell cultures. Glia 46(2): 218-223. Epub 2004 Mar 26 PMID: 15042588
Sullivan P.G., Rabchevsky A.G., Keller J.N., Lovell M.A., Sodhi A., Hart R.P. and Scheff S.W. (2004) Intrinsic differences in isolated brain and spinal cord mitochondria: Implication for therapeutic interventions. Journal of Comparative Neurology 474(4): 524-534. Epub 2004 Jun 3 DOI: 10.1002/cne.20130 PMID: 15174070
Rabchevsky A.G., Sullivan P.G., Fugaccia I. and Scheff S.W. (2003) Creatine diet supplement for spinal cord injury in rats: influences on functional recovery and tissue sparing. Journal of Neurotrauma 20(7): 659-669. Epub 2003 Aug 12 PMID: 12908927
Scheff S.W., Rabchevsky A.G., Fugaccia I., Main J.A. and Lumpp J.E. (2003) Experimental modeling of spinal cord injury: characterization a force-defined injury device. Journal of Neurotrauma 20(2): 179-193. Epub 2003 Apr 5 PMID: 12675971
Rabchevsky A.G., Fugaccia I., Sullivan P.G., Blades D.A. and Scheff S.W. (2002) Efficacy of methylprednisolone therapy for the injured rat spinal cord. Journal of Neuroscience Research 68(1): 7-18. Epub 2002 Apr 5. PMID: 11933044
Rabchevsky A.G., Fugaccia I., Sullivan P.G. and Scheff S.W. (2001) Cyclosporin A (CsA) treatment following spinal cord injury to the rat: behavioral effects and stereological assessment of tissue sparing. Journal of Neurotrauma 18(5): 513-22. Epub 2001 Jun 8 PMID: 11393254
Zhang P., Abraham V.S., Kraft K.R., Rabchevsky A.G., Scheff S.W. and Swain J.A. (2000) Hyperthermic preconditioning protects against spinal cord ischemic injury. Annals Thoracic Surgery 70(5): 1490-1495. Epub 2000 Nov 28 PMID: 11093475
Rabchevsky A.G., Fugaccia I. Fletcher-Turner A., Blades D.A., Mattson M.P. and Scheff S.W. (2000) Basic fibroblast growth factor (bFGF) enhances functional recovery following severe spinal cord injury to the rat. Experimental Neurology 164(2): 280-291. Epub 2000 Aug 1 PMID: 10915567
Sullivan P.G., Rabchevsky A.G., Hicks M.R.R., Gibson T., Fletcher-Turner A. and Scheff S.W. (2000) Dose response curve and optimal dosing regimen of cyclosporin A after traumatic brain injury in rats. Neuroscience 101(2): 289-295. Epub 2000 Nov 14 PMID: 11074152
Rabchevsky A.G., Fugaccia I. Fletcher-Turner A., Blades D.A., Mattson M.P. and Scheff S.W. (1999) Basic fibroblast growth factor (bFGF) enhances tissue sparing and functional recovery following moderate spinal cord injury. Journal of Neurotrauma 16(9): 817-830. Epub 1999 Nov 16 PMID: 10521141
Sullivan P.G., Bruce-Keller A.J., Rabchevsky A.G., Christakos S., St. Clair D.K., Mattson M.P. and Scheff S.W. (1999) Exacerbation of damage and altered NF-kappa B activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. Journal of Neuroscience 19(15): 6248-6256. Epub 1999 Jul 22 PMID: 10414954 PMCID: PMC6782813
Rabchevsky A.G., Weinitz J.M., Coulpier M., Fages C., Tinel M. and Junier M.P. (1998) A role for transforming growth factor alpha as an inducer of astrogliosis. Journal of Neuroscience 18(24): 10541-10552. Epub 1998 Dec 16 PMID: 9852591 PMCID: PMC6793335
Rabchevsky A.G., Degos J.D. and Dreyfus P.A. (1999) Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis. Brain Research 832(1-2): 84-96. Epub 1999 Jun 22 PMID: 10375654
Rabchevsky A.G. and Streit W.J. (1997) Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth. Journal of Neuroscience Research 47(1): 34-48. Epub 1997 Jan 1 PMID: 8981236