Wang-Xia Wang, PhD

Publications & Other Scholarly Work:

1     Wang-Xia Wang, Springer, JE,  Hatton, KW (2021) MicroRNAs as Biomarkers for Predicting Complications following Aneurysmal Subarachnoid Hemorrhage. Int J Mol Sci. PMID: 34502401. DOI: 10.3390/ijms22179492 (Corresponding author)

2     Niedowicz, DM, Wang-Xia Wang, Price, DA, Nelson, PT (2021) Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and Compensatory Brain Changes. J. Thyroid Res. PMID: 34257897. doi.org/10.1155/2021/9960188

3     Wang-Xia Wang, Springer, JE, Xie, K, Fardo, DW, and Hatton, KW (2021) A Highly Predictive MicroRNA Panel for Determining Delayed Cerebral Vasospasm Risk Following Aneurysmal Subarachnoid Hemorrhage. Front. Mol. Biosci. 8:657258. doi: 10.3389/fmolb.2021.657258 (Co-corresponding author)

4     Bao WD, Pang P, Zhou CT, Hu F, Xiong W, Chen K, Wang J, Wang F, Xie D, Hu YZ, Han ZT, Zhang HH, Wang-Xia Wang,  Nelson PT,  Chen JZ, Lu Y, Man HY, Liu D, Zhu LQ (2021) Loss of ferroportin induces memory impairment by promotingferroptosis in Alzheimer’s disease. Cell Death Differ. 2021 Jan 4. doi: 10.1038/s41418-020-00685-9. PMID: 33398092.

5     Wang-Xia Wang, Prajapati, P, Vekaria, HJ, Spry, M, Cloud, AL, Sullivan, PG, and Springer, JE. (2021) Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery. Neural Regen Res. 2021 Mar;16(3):514-522. doi: 10.4103/1673-5374.293149. PMID: 32985480 (Co-corresponding author). Cited by: 2 (source: Google Scholar)

6     Wang-Xia Wang, Prajapati, P, Nelson, PT, and Springer, JE. (2020) The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs. Mol Neurobiol. DOI: 10.1007/s12035-020-01937-y. PMID: 32451872 (Corresponding author). Cited by: 5 (source: Google Scholar)

7     Yuriko Katsumata, David W Fardo, Adam D Bachstetter, Sergey C Artiushin, Wang-Xia Wang, Angela Wei, Lena J Brzezinski, Bela G Nelson, Qingwei Huang, Erin L Abner, Sonya Anderson, Indumati Patel, Benjamin C Shaw, Douglas A Price, Dana M Niedowicz, Donna W Wilcock, Gregory A Jicha, Janna H Neltner, Linda J Van Eldik , Steven Estus, Peter T Nelson (2020) Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene. J Neuropathol Exp Neurol. 79(1):3-21. doi: 10.1093/jnen/nlz116. PMID: 31748784. Cited by: 10 (source: Google Scholar)

8     Prajapati, P, Dalwadi, P, Gohel, D, Singh, K, Sripada, L, Bhatelia, K, Joshi, B, Roy, M, Wang-Xia Wang, Springer, JE, Singh, R, Singh, R. (2019) Enforced lysosomal biogenesis rescues erythromycin- and clindamycin-induced mitochondria-mediated cell death in human cells. Mol Cell Biochem. 2019 Jul 15. doi: 10.1007/s11010-019-03585-w. [Epub ahead of print]. PMID: 31309409. Cited by: 3 (source: Google Scholar)

9     Nelson, PT, Gala, Z, Wang-Xia Wang, Niedowicz, D, Artiushin, S,Wycoff, S, Wei, A, Jicha, G, Fardo, D (2019) TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels. Neurobiol Dis. 2019 Jan 22. pii: S0969-9961(18)30702-2. doi: 10.1016/j.nbd.2019.01.013. [Epub ahead of print]. PMID: 30682540. Cited by: 10 (source: Google Scholar)

10   Chornenkyy, Y., Wang-Xia Wang, Wei A., Nelson, PT (2018) Alzheimer's disease and Type 2 Diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline. Brain Pathol. 2018 Aug 14. doi: 10.1111/bpa.12655. [Epub ahead of print]. PMID: 30106209. Cited by: 55 (source: Google Scholar)

11   Wang-Xia Wang (2018) Micromanaging Memory. Biol Psychiatry. 2018 Mar 1;83(5):390-392. doi: 10.1016/j.biopsych.2017.12.013. PMID: 29420952 (Corresponding author)

12   Gal J, Chen J, Katsumata Y, Fardo DW, Wang-Xia Wang, Artiushin S, Price D, Anderson S, Patel E, Zhu H, Nelson PT (2018) Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons. J Neuropathol Exp Neurol. 2018 Jan 1;77(1):21-39. doi: 10.1093/jnen/nlx097. PMID: 29186589. Cited by: 12 (source: Google Scholar)

13   Nelson PT, Wang-Xia Wang, Janse SA, Thompson KL (2018) MicroRNA expression patterns in human anterior cingulate and motor cortex: A study of dementia with Lewy bodies cases and controls. Brain Res. 2018 Jan 1;1678:374-383. doi: 10.1016/j.brainres.2017.11.009. Epub 2017 Nov 13. PMID: 29146111. Cited by: 16 (source: Google Scholar)

14   Wang-Xia Wang, Sullivan PG, Springer JE. (2017) Mitochondria and microRNA crosstalk in traumatic brain injury. Prog Neuropsychopharmacol Biol Psychiatry. 73:104-108. Cited by: 19 (source: Google Scholar) (Co-corresponding author)

15   Wang-Xia Wang, Fardo DW, Jicha GA, Nelson PT. A customized quantitative PCR microRNA panel provides a technically robust context for studying neurodegenerative disease biomarkers and indicates a high correlation between cerebrospinal fluid and choroid plexus microRNA expression. Mol Neurobiol., (2016) doi:10.1007/s12035-016-0316-2. PMID: 27900678. Cited by: 14 (source: Google Scholar) (Co-corresponding author)

16   Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang-Xia Wang, Kim C, Nelson PT, Springer W, Kim J. (2016) miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol Neurodegener. 11(1):55. PMID: 27456084. Cited by: 66 (source: Google Scholar)

17   Nelson, P.T., Katsumata, Y., Nho, K.;Artiushin, S.C., Jicha, G.A., Wang-Xia Wang, Abner, E.L., Saykin, A.J., Kukull, W.A., Alzheimer's Disease Neuroimaging Initiative, (A.D.N.I.)., Fardo, D.W. Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging. Acta neuropathologica. 132, 6 (2016): 841-858. Cited by: 24 (source: Google Scholar)

18   Nelson PT, Wang-Xia Wang, Wilfred BR, Wei A, Dimayuga J, Huang Q, Ighodaro E, Artiushin S, Fardo DW. (2015) Novel human ABCC9/SUR2 brain-expressed transcripts and an eQTL relevant to hippocampal sclerosis of aging. J Neurochem. 134(6):1026-39. Cited by: 21 (source: Google Scholar)

19   Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang-Xia Wang, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET. (2016) "New old pathologies": Ad, part, and cerebral age-related TDP-43 with sclerosis (CARTS). J Neuropathol Exp Neurol. 75(6):482-98. Cited by: 121 (source: Google Scholar)

20   Wang-Xia Wang, Springer JE (2015) Role of mitochondria in regulating microRNA activity and its relevance to the central nervous system. Neural Regen Res. 10(7):1026-8. Cited by: 17 (source: Google Scholar)

21   Nelson PT, Jicha GA, Wang-Xia Wang, Ighodaro E, Artiushin S, Nichols CG, Fardo DW. (2015) ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target. Ageing Res Rev. 24(Pt B):111-25. Cited by: 53 (source: Google Scholar)

22   Wang-Xia Wang, Visavadiya NP, Pandya JD, Nelson PT, Sullivan PG, Springer JE. Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury. (2015) Exp Neurol. 265:84-93. PMID: 25562527. Cited by: 92 (source: Google Scholar)

23   Nelson PT, Wang-Xia Wang, Partch AB, Monsell SE, Valladares O, Ellingson SR, Wilfred BR, Naj AC, Wang LS, Kukull WA, Fardo DW. (2014) Reassessment of Risk Genotypes (GRN, TMEM106B, and ABCC9 Variants) Associated with Hippocampal Sclerosis of Aging Pathology. J Neuropathol Exp Neurol. 74(1):75-84. Cited by: 38 (source: Google Scholar)

24   Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang-Xia Wang, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, Crane PK, Valladares O, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Scheff SW, Sonnen JA, Haines JL, Pericak-Vance MA, Mayeux R, Farrer LA, Van Eldik LJ, Horbinski C, Green RC, Gearing M, Poon LW, Kramer PL, Woltjer RL, Montine TJ, Partch AB, Rajic AJ, Richmire K, Monsell SE; Alzheimer’ Disease Genetic Consortium, Schellenberg GD, Fardo DW. (2014) ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 127(6):825-43. Cited by: 58 (source: Google Scholar)

25   Wang-Xia Wang, Danaher RJ, Miller CS, Berger JR, Nubia VG, Wilfred BS, Neltner JH, Norris CM, Nelson, PT (2014) Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells. Genomics Proteomics Bioinformatics. 12(1):19-30. PMID: 24480177. Cited by: 52 (source: Google Scholar)

26   Nelson PT, Smith CD, Abner EL, Wilfred BJ, Wang-Xia Wang, Neltner JH, Baker M, Fardo DW, Kryscio RJ, Scheff SW, Jicha GA, Jellinger KA, Van Eldik LJ, Schmitt FA. (2013) Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease. Acta Neuropathol. 126(2):161-77. Cited by: 143 (source: Google Scholar)

27   Hébert, SS, Wang-Xia Wang, Zhu, Q, Nelson, PT. (2013) A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J Alzheimers Dis. 35(2):335-348. PMID: 23403535. Cited by: 114 (source: Google Scholar)

28   Nelson PT, Wang-Xia Wang, Mao G, Wilfred B; Xie K, Jennings M, Gao Z, and Wang X (2011) Specific sequence determinants of miR-15/107 microRNA gene group targets. Nucleic Acids Res.  39: 8163-72. Cited by: 55 (source: Google Scholar)

29   Wang-Xia Wang, Huang Q, Hu Y, Stromberg AJ, Nelson PT. (2011)  Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter.  Acta Neuropathol. 121: 193-205. Cited by: 309 (source: Google Scholar)

30   Wang-Xia Wang, Kyprianou N, Wang X, Nelson PT. (2010) Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group. Cancer Res. 70: 9137-9142. Cited by: 48 (source: Google Scholar)

31   Finnerty JR*, Wang-Xia Wang*, Hébert SS, Wilfred BR, Mao G, Nelson PT. (2010) The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases.  J Mol Biol. 402: 491-509. Cited by: 358 (source: Google Scholar)

32   Nelson PT, Kiriakidou M, Mourelatos Z, Tan GS, Jennings M, Xie K, and Wang-Xia Wang.  (2010) High-throughput experimental studies to identify miRNA targets directly, with special focus on the mammalian brain.  Brain Research 1338: 122-130. Cited by: 18 (source: Google Scholar)

33   Wang-Xia Wang, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, Stromberg AJ, Huang Q, Saatman KE, and Nelson PT. (2010) MiR-107 regulates Granulin/Progranulin with implications for traumatic brain injury and neurodegenerative disease. Am Journal of Pathology 177: 334-345. Cited by: 182 (source: Google Scholar)

34   Wang-Xia Wang, Wilfred BR, Xie K, Jennings M, Hu Y, Stromberg AJ, and Nelson PT.  (2010) Individual microRNAs (miRNAs) display distinct mRNA targeting “rules”.  RNA Biology 7: 373-380. Cited by: 67 (source: Google Scholar)

35   Peter T. Nelson and Wang-Xia Wang.  (2010) MiR-107 is reduced in Alzheimer brain neocortex: validation study.  Journal of Alzheimers Disease 21: 75-79. Cited by: 212 (source: Google Scholar)

36   Wang-Xia Wang, Bernard R. Wilfred, Yanling Hu, Arnold J. Stromberg, and Peter T. Nelson (2010) Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes. RNA. 16: 394-404. Cited by: 120 (source: Google Scholar)

37   Xiaoyun Jia, Wang-Xia Wang, Ligang Ren, Qi-Jun Chen, Venugopal Mendu, Benjamin Willcut, Randy Dinkins, Xiaoqing Tang, and Guiliang Tang (2009) Differential and dynamic regulation of miR398 and its targets in response to ABA and salt stress in Populus tremula and Arabidopsis thaliana. Plant Molecular Biology 71: 51-59. Cited by: 229 (source: Google Scholar)

38   Peter T. Nelson, Charles D. Smith, Erin A. Abner, Frederick A. Schmitt, Stephen W. Scheff, Gregory J. Davis, Jeffrey N. Keller, Gregory A. Jicha, Daron Davis, Wang-Xia Wang, Adria Hartman, Douglas G. Katz, and William R. Markesbery (2009) Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta. 1792(5): 454–469. PMCID: PMC2834412. Cited by: 177 (source: Google Scholar)

39   Peter T. Nelson, Wang-Xia Wang, Bernard R. Wilfred, Guiliang Tang (2008) Technical variables in high-throughput miRNA expression profiling: Much work remains to be done. Biochim Biophys Acta. 2008 Apr 7; [Epub ahead of print]. Cited by: 94 (source: Google Scholar)

40   Wang-Xia Wang, Bernard W. Rajeev, Donald A. Baldwin, R. Benjamin Isett, Na Ren, Arnold Stromberg, and Peter T. Nelson (2008) Focus on RNA isolation: Obtaining RNA for microRNA (miRNA) expression profiling analyses of neural tissue. Biochim Biophys Acta, Feb 13; [Epub ahead of print]. Cited by: 78 (source: Google Scholar)

41   Wang-Xia Wang*, Bernard R. Wilfred* et al, and Peter T. Nelson (2008) The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of BACE1. J. Neurosci, 28, 1213-1223. Cited by: 826 (source: Google Scholar)

42   Peter T. Nelson, Wang-Xia Wang, and Bernard R. Wilfred (2008) microRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol, 18:130-138. Cited by: 354 (source: Google Scholar)

43   Bernard R. Wilfred, Wang-Xia Wang, Peter T. Nelson (2007) Energizing miRNA research: A review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol. Genet. Metabolism, 91, 209-217. Cited by: 376 (source: Google Scholar)

44   Xiaoqing Tang, Jozsef Gal, Xun Zhuang, Wang-Xia Wang, Haining Zhu, and Guiliang Tang (2007) A simple array platform for microRNA analysis and its application in mouse tissues. RNA, 13, 1803-1822. Cited by: 153 (source: Google Scholar)

45   Wangxia Wang*, Or Dgani*, Sharon Grayer Wolf, Arie Altman and Oded Shoseyov (2006) Aspen SP1, an exceptional thermal, protease and detergent resistant self-assembled nano-particle. Biotech. Bioeng. 95, 161-168. Cited by: 38 (source: Google Scholar)

46   Parameswaran Ramakrishnan, Wangxia Wang, David Wallach (2004) Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Immunity. 21, 477-489. Cited by: 300 (source: Google Scholar)

47   Dgany O, Gonzalez A, Sofer O, Wangxia Wang, Zolotnitsky G, Wolf A, Shoham Y, Altman A, Wolf SG, Shoseyov O, Almog O. (2004) The structural basis of the thermostability of SP1, a novel plant (Populus tremula) boiling stable protein. J Biol Chem. 279, 51516-51523. Cited by: 82 (source: Google Scholar)

48   Wangxia Wang, Basia Vinocur, Oded Shoseyov and Arie Altman (2004) Role of plant heat-shock proteins and molecular chaperones in the abiotic stress response. Trends Plant Sci., 9, 244-252. Cited by: 2518 (source: Google Scholar)

49   Wangxia Wang*, Or Dgani*, Orly Dym, Arie Altman, Oded Shoseyov and Orna Almog (2003) Crystallization and preliminary X-ray crystallographic analysis of SP1, a novel chaperone-like protein. Acta Crystallogr. D Biol. Crystallogr., 59, 512-514. Cited by: 22 (source: Google Scholar)

50   Wangxia Wang, Basia Vinocur, Oded Shoseyov and Arie Altman (2003) Plant responses to drought, salinity and extreme temperatures: towards genetic engineering for stress tolerance. Planta, 218, 1-14. Cited by: 3827 (source: Google Scholar)

51   Wangxia Wang, Tal Barak, Basia Vinocur, Oded Shoseyov and Arie Altman (2003) Abiotic resistance and chaperones: possible physiological role of SP1, a stable and stabilizing protein from Populus. Acta Hort., In: Vasil IK (ed) Plant biotechnology 2000 and beyond. Kluwer, Dordrecht, pp 439-443. Cited by: 57 (source: Google Scholar)

52   Wangxia Wang, Dan Pelah, Tal Alergand, Oded Shoseyov and Arie Altman (2002) Characterization of SP1, a stress-responsive, boiling-soluble, homo-oligomeric protein from Aspen (Populus tremula L.). Plant Physiol., 130, 865-875. Cited by: 96 (source: Google Scholar)

53   Wangxia Wang, Basia Vinocur, Oded Shoseyov and Arie Altman (2001) Biotechnology of plant osmotic stress tolerance: physiological and molecular considerations. Acta Hort. 560, pp. 285-292. Cited by: 298 (source: Google Scholar)

Book and Book Chapters

1     Paresh Prajapatia*, Wang-Xia Wang*, Peter T. Nelson, and Joe E. Springer (2019) Methodology for Subcellular Fractionation and microRNA Examination of Mitochondria, Mitochondria Associated ER Membrane (MAM), ER, and Cytosol from Human Brain. In: Methods in Molecular Biology. DOI: 10.1007/978-1-0716-0138-9_11. PMID: 31667768 (Co-corresponding author). Cited by: 3 (source: Google Scholar)

2     Wang-Xia Wang, Peter T. Nelson, and Guiliang Tang. RNA Interference, mechanisms and proteins involved in. P1-10, in: Wiley Encyclopedia of Chemical Biology. John Wiley & Sons, Ltd: Chichester. (2008). Cited by: 2 (source: Google Scholar)

3     Wang-Xia Wang, Bobby Gaffney, Arthur G. Hunt and Guiliang Tang. Plant microRNAs and development. P1-8, In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. (2007). Cited by: 3 (source: Google Scholar)