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William O'Connor, MD

MS 137


  • Professor
  • Director - Autopsy Services
  • Director of Surgical Pathology Fellowship Program

College Unit(s)

Other Affiliation(s)
  • Diversity Departmental Ambassadors

Biography and Education


MD - National University of Ireland (1972)

AP Residency - Georgetown University (1975)

Selected Publications

Publications & Other Scholarly Work:

1     Dana Ionel DO, Fred Odago MD, A. E. Ene, MD, William N. O’Connor MD, Jessica D. Lee MD, Luther C. Pettigrew MD: Cerebral Air Embolism Complicating Atrio-esophageal Fistula in Williams Syndrome. Annals of Clinical and Translational Neurology

2     Roberto G. Aru, Jerald P. Wallace, Michael C. Bounds, Mary B. Sheppard, Akif K. Guney, William N. O'Connor, Sam C. Tyagi Spontaneous Rupture of Mesenteric Vasculature Associated with Fibromuscular Dysplasia in a 28-Year-Old Male Annals of Vascular Surgery, 2021-02-01, Volume 71, Pages 534.e13-534.e15,

3     Snigdha Nutalapati, Richard O'Neal, William O'Connor, Brett T. Comer, Gerhard C. Hildebrandt. Challenges in Medicine: The Odyssey of a Patient with Isolated IgG4-Related Eosinophilic Angiocentric Fibrosis Presenting as a Locally Destructive Sinonasal Mass Case Rep Rheumatol. 2021; 2021: 6668184. Published online 2021 Mar9. doi: 10.1155/2021/6668184

4     Zwischenberger, Brittany A.†Balasuriya, Beverly K.†Harris, Dwight D.†Nataraj, Nisha†Owen, Allison M.‡Bruno, Maria E. C.†Mukherjee, Sujata§Ortiz-Soriano, Victor|| O’Connor, William¶Ke, Chenlu#Stromberg, Arnold J.#Chang, Phillip K.†Neyra, Javier A.||Saito, Hiroshi‡Starr, Marlene E.§ Adipose-Derived Inflammatory and Coagulant Mediators in Patients With Sepsis Shock. May 2021, Volume 55 (5), p 596–606.

5     Rajagopalan N, Dennis D, and O’Connor W. Successful combined heart and kidney transplantation in patient with Fabry’s disease. A case report. Transplantation Proceedings XX, 1e3 (2019).

6     Tretter JT, Tran VH, Gray S, Ta H, Loomba RS, O’Connor W, Spicer DE, Cook AC, Anderson RH: Assessing the Criteria for Definition of Perimembranous Ventricular Septal Defects in Light of the Search for Consensus. Orphanet Journal of Rare Diseases 2019; April 3;14

7     Purushothaman K, Purushothaman M, Turnbull I, Adams D, Anyanwu A, Krishnan P, Kini A, Sharma S, O’Connor W, Moreno P: Association of altered collagen content and lysyl oxidase expression in degenerative mitral valve disease. Cardiovascular Pathology 29 :11-18, 2017.

8     Sudhakar P, Tobin S, O’Connor W, Kedar S: Neuro-Ophthalmic Presentation of Neuro-Sweet Disease. Neuro-Ophthalmology, DOI: 10.1080/01658107. 2017.1291687

9     Stewart RL, West D, Wang C, Weiss HL, Gal T, Durbin EB, O’Connor W, Chen M, O’Connor KL:  Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer Human Pathology 54 174-183. 2016.

10   Bennett G, Hager m, Cornea V, O’Connor W, Guglin M: Fulminant Necrotizing Eosinophilic Myocarditis: A case report and comprehensive review of the literature. The VAD Journal: 2016.

11   Purushothaman K, Krishnan P, Purushothaman M, Baber U, Tarricone A, Vasquez M, Wiley J, Kini A, Sharma S, O’Connor W, Moreno P: Increased Internal Elastic Lamellar Layer Disruption to Neointimal Cellular Proliferation and Type III Collagen Deposition in Human Peripheral Artery Restenosis. Am J Cardiol 2016; 117: 1173 - 1179.

12   Seratnahaei A, Bailey A, Hensley P, O’Connor W, Smith M: Infective endocarditis complicated by mitral valve aneurysm: pathologic and echocardiographic correlations. Echocardiography 2015; 32: 1417-1422.

13   VanDerPloeg D, Strong WR, Krohmer S, O’Connor W, Martin J: Congenital bronchial artery to pulmonary artery fistula presenting as hemoptysis. Ann Thorac Surg 2015; 99:e19-20

14   Rateri D, Davis FR, Balakrishnan A, Howatt D, Moorleghen JJ, OConnor WN, Charnigo R, Cassis LA, Daugherty A: Angiotensin II induces region-specific medial disruption during evolution of Ascending Aortic Aneurysms. Am J Pathol 184 (9) 2586-2595, 2014.

15   Chau, D. F., Srour, H., Rolf, C. M., O'Connor, W. N., Cumbermack, K. M., Bezold, L. I., Kozik, D. J., Plunkett, M., Murphy, J. T., Hessel, E. A. (2013). Death by late-presenting Bochdalek hernia in infant soon after congenital cardiac repair.  World Journal of Pediatric Congenital Heart Surgery, 4(2), 213-6, 2013

16   Martin JT, O’Connor WN, Ramaiah C: Isolated necrotizing aortitis presenting Incidental Thoracoabdominal Aortic Aneurysm – a case report.  Int J Angiology 20(1) 59-62, 2011

17   Purushothaman KR, Purushothaman M, Muntner P, Lento PA, O’Connor WN, Sharma SK, Fuster V, Moreno PR. Inflammation, neovascularization and intraplaque hemorrhage are associated with increased collagen content: implications for plaque progression in diabetic atherosclerosis. Vascular Medicine 2011; 16:103-108.

18   Lin AE, Alexander ME, Colan SD, Kerr B, Rauen KA, Noonan JA, Baffa J, Hopkins E, Sol-Church K, Limongelli G, Diglio MC, Marino B, Innes AM, Aoki Y, Silberbach M, Delrue MA, White SM, Hamilton RM, O’Connor W, et al: Clinical, Pathological and Molecular Analyses of Cardiovascular Abnormalities in Costello Syndrome – A Ras/MAPK Pathway Syndrome. Am J Med Genetics 2011; 155:486-507.

19   Ramos JM, Davis GD, O’CONNOR WN.  Cor Pulmonale Secondary to Multiple Pulmonary Thromboemboli in a Patient with Klippel-Trenaunay Syndrome.  Am J of Forensic Med Pathol

20   Ohebsion J, O’CONNOR WN, Attili AK, Diaz-Guzman E.  A Thirty Year Old Man with Facial Flushing and a Mediastinal Mass.  Chest 2010;138:746-49.

21   Echeverri D, Purushothaman KR, Kilpatrick D, O’CONNOR WN, Moreno PR: Plaque stabilization by bare metal and drug-eluting stents in an experimental model of thin cap fibroatheroma. (Portuguese) Rev Bras Cardiol Invas. 2008; 16(2); 170-177.

22   Moreno PR, Purushothaman, KR, Fuster V, Echeverri D, Truszczynska H, Sharma SK, Badimon JJ, O’CONNOR WN:  Neovascularization is increased in ruptured atherosclerotic lesions of human aorta: Implications for plaque vulnerability.  Circulation 2004; 110: 2032-38.

23   Moreno PR, Purushothaman, KR, Fuster V, O’CONNOR WN:  Intimomedial Interface Damage and Adventitial Inflammation is Increased Beneath Disrupted Atherosclerosis in the Aorta: Implications for Plaque Vulnerability. Circulation 105:2504-2511, 2002.

24   Moreno PR; Lodder RA, Purushothaman KR, Charash WE, O’CONNOR WN, Muller JE:  Detection of Lipid Pool, Thin Fibrous Cap, and Inflammatory Cells in Human Aortic Atherosclerotic Plaques by Near-Infrared Spectroscopy. Circulation 105:923-927, 2002.

25   Dishop MK, O’CONNOR WN, Abraham S, Cottrill CM:  Primary Cardiac Lipoblastoma. Pediatr Dev Pathol 4(3):276-280, 2001.

26   Leonelli F, Pisano E, Requarth J, Potenza D, Tomassoni G, O’CONNOR W, Natale A:  Frequency of superior vena cava syndrome following radiofrequency modification of the sinus node and its management. Am J Cardiol 85:771-774, 2000.

27   Cottrill HM, O’CONNOR WN:  The Autopsy in the 21st Century:  Time for Reconsideration. J Kentucky Med A 98:110-114, 2000.

28   Leonelli FM, Natale A, O’CONNOR W:  Human histopathologic findings following radiofrequency ablation of the Tricuspid-Inferior vena cava isthmus. J Cardiovasc Electophysiol 10:599-602, 1999.

29   Cottrill CM, Ho SY, O’CONNOR W:  Embryological development of equine heart. World Equine Vet Review.  Vol 3(1):28-33, 1998.

30   Skinker DM, Cottrill CC, O’CONNOR W.  Right ventricular biopsy findings of hypertrophic cardiomyopathy in a patient with Noonan syndrome. Cardiology in the Young.  8:256-259, 1998.

31   Cottrill CM, Ho SY, O’CONNOR W:  Embryological development of equine heart. Equine Vet J Suppl 24:14-18, 1997.

32   Chien S, Maley R, Oeltgen P, O’CONNOR W, Wu G, Zhang F, Salley R:  Canine lung transplantation after more than 24 hours of normothermic preservation. J Heart Lung Transplant 16:340-51, 1997

33   Noonan J, O’CONNOR W: (By invitation 6/95) Noonan syndrome: A clinical description emphasizing the cardiac findings. Acta Pediatrica Japonica 38:76-83, 1996

34   Schneider D, Cottrill C, O’CONNOR W, Salley R:  Right ventricular outflow muscle in Tetralogy of Fallot: Histologic and immunohistochemical monoclonal antibody analysis. Cardiovascular Pathology 5:121-131, 1996.

35   Cottrill CM, O’CONNOR W:  A cardiac tale of flies, fish, birds and beasts. Proceedings of the International Society of Veterinary Perinatology, Cambridge United Kingdom, July 1995.

36   Winters J, O’CONNOR W, Geil J:  Immunohistology, Cytogenetics and Molecular studies of small round cell tumors of childhood. Annals of Clinical and Laboratory Science 25:66-78, 1995.

37   Zhang Z, Proffitt G, Salley RK, Diana JN, Zhang F, Wu G, O’CONNOR WN, Chien S:  Autoperfused heart-lung preparation:  one reason for unsuccessful lung preservation. Acta Biomed Ateneo Parmense 65(3-4):115-131, 1994.

38   Chien S, Zhang F, Zhang Z, Wu G, Proffitt G, O’CONNOR WN, Salley RK:  Two-day preservation of the lungs by normothermic perfusion. Acta Biomed Ateneo Parmense 65(3-4):165-169, 1994.

39   Murphy GF, Miller SD, Kenady DE, O’CONNOR WN, Wood DP, McRoberts WF, Gee WF:  Familial paraganglioma. Urology 44(4):273-277, 1994.

40   Hunsaker JC, O’CONNOR WN, Lie JT:  Is spontaneous dissection of the coronary artery with eosinophilia a limited from of Churg-Strauss syndrome? Arch Pathol Lab Med 118(9):863-864, 1994.

41   Bummer PM, Baughn JA, Sanders LP, Tarrence KR, O’CONNOR W, Olson JW, and Gillespie MN:  Surfactant disposition in monocrotaline-induced pneumotoxicity. Toxicol 90:53-62, 1994.

42   Gillespie MN, Hartsfield CL, O’CONNOR W, Cohen DA:  Pulmonary hypertension in a murine model of the acquired immunodeficiency syndrome. Am J. Respir Crit Care Med 150:194-199, 1994.

43   Farrell T, Cottrill C, O’CONNOR W, Boucher L, Noonan J:  Dissecting aneurysm of the pulmonary artery - an unusual complication of congenital heart disease. Cardiology in the Young 4:131-135, 1994.

44   Hunsaker J, O’CONNOR W, Lie J:  Spontaneous coronary arterial dissection and isolated eosinophilic coronary arteritis: sudden cardiac death in a limited form of Churg-Strauss syndrome. Mayo Clinic Proceedings 67:761-766, 1992.

45   Cottrill C, O’CONNOR W, Fitz R, Gillespie M:  Pulmonary vascular remodeling in rats with unilaterally banded lobar pulmonary veins. Cardiology in the Young 2:121-128, 1992.

46   Winters J, O’CONNOR W, Broughton R, Noonan J:  Bordetella bronchiseptica pneumonia in a patient with Down Syndrome: a case report and review. Pediatrics 89(6):7-10, 1992.

47   O’CONNOR W, Cottrill C, Marion M, Noonan J:  Defective regional myocardial development and vascularization in one variant of tricuspid atresia: clinical and necropsy findings in three cases. Cardiology in the Young 2:42-52, 1992.

48   Damm D, O’CONNOR W, White D, Drummond J, Morrow L, Kenady D:  Intraoral sebaceous carcinoma. Oral Surgery, Oral Medicine, and Oral Pathology 72:709-711, 1991.

49   Barton J, Hiett A, O’CONNOR W, Nissen S, Greene J:  Endomyocardial ultrastructural findings in preeclampsia. American Journal of Obstetrics and Gynecology, 165:389-391, 1991.

50   Endean E, Kispert J, Martin K, and O’CONNOR W:  Intimal hyperplasia is reduced by ornithine decarboxylase inhibition. Journal of Surgical Research, 50:634-637, 1991.

51   Shih W, Cottrill C, Coupal T, O’CONNOR W, Kung H, Ryo U:  Iodine-123-HIPDM lung imaging in pulmonary vein-banded pulmonary hypertension. Journal of Nuclear Medicine 31:668-673, 1990.

52   Grines C, Booth D, Nissen S, Gurley J, Bennett K, O’CONNOR W, DeMaria A:  Mechanisms of acute myocardial infarction in patients with prior coronary artery bypass grafting and therapeutic implications. American Journal of Cardiology 65:1292-1296, 1990.

53   Toursarkissian B, O’CONNOR W, Dillon M:  Mediastinal epithelioid hemangioendothelioma. Annals of Thoracic Surgery 49:680-685, 1990.

54   Chien S, Diana J, Oeltgen P, Todd E, O’CONNOR W, Chitwood R:  Eighteen to thirty-seven hours’ preservation of major organs using a new autoperfusion multiorgan preparation. Ann Thorac Surg 47:860-867, 1989.

55   Shih W, Flueck J, O’CONNOR W, Domstad P:  Extensive extraosseous localization of bone imaging agent in a patient with renal failure and rhabdomyolysis accompanied by combined hypercalcemia and hyperphosphatemia. Clinical Nuclear Medicine 14:163-167, 1989.

56   Chien S, Diana J, Todd E, O’CONNOR W, Marion T, Smith K:  New autoperfusion preparation for long term organ preservation. Circulation 78(Supp III):58-65, 1988.

57   Wisenbaugh T, O’CONNOR W:  Right ventricular hypertrophy long after reversal of severe pressure overload in the cat. American Journal of Physiology (Heart & Circulatory Physiology 23) 254:H1099-H1104, 1988.

58   O’CONNOR W, Stahr G, Cottrill C, Todd E, Noonan J:  Ventriculocoronary connections in hypoplastic right heart syndrome - autopsy serial section study of six cases. Journal of the American College of Cardiology 11:1061-1972, 1988.

59   Chien S, Todd E, Diana J, and O’CONNOR W:  A simple technique for multiorgan preservation. The Journal of Thoracic and Cardiovascular Surgery 95:55-61, 1988.

60   Kasarskis E, O’CONNOR W, Earle G:  Embolic stroke from cardiac papillary fibroelastomas. Stroke 19:1171-1173, 1988.

61   Gillespie M, Moore C, Wright C, O’CONNOR W:  Salutary effects of prostaglandin E in perfused rat lungs injured with hydrogen peroxide. The Journal of Pharmacology and Experimental Therapeutics 241(1):1-5, 1987.

62   Cottrill C, Cudd T, O’CONNOR W, Rantanen N:  Persistence of fetal circulatory pathways in a newborn foal. Equine Veterinary Journal 19(3):252-255, 1987.

63   Johnson G, O’CONNOR W, Verble S, Cottrill C, Noonan J:  Ventricular septal defect with mobile tricuspid valve pouch mimicking Tetralogy of Fallot. Pediatric Cardiology 7:53-56, 1986.

64   Harrison M, Smith M, O’CONNOR W, DeMaria A:  Post-operative valve ring aneurysm formation, coronary arteritis and myocardial infarction in systemic lupus erythematosus. American Heart Journal 112:414-417, 1986.

65   Gillespie M, Olson J, Reinsel C, O’CONNOR W, Altiere R:  Vascular hyperresponsiveness in perfused lungs from monocrotaline-treated rats. American Journal of Physiology (Heart & Circulatory Physiology 20) 251:H109-H114, 1986.

66   Gillespie M, Owasoyo J, Kiritsy-Roy J, O’CONNOR W, VanLoon G:  Exaggerated nicotine-induced norepinephrine release from atherosclerotic rabbit hearts. Toxicology 37:147-157, 1985.

67   Gillespie M, Dyer K, Olson J, O’CONNOR W, Altiere R:  Alpha-Difluoromethylornithine, an inhibitor of polyamine synthesis, attenuates monocrotaline-induced pulmonary vascular hyperresponsiveness in isolated perfused rat lungs. Research Communications in Chemical Pathology and Pharmacology 50:365-378, 1985.

68   Cottrill C, Davis D, McMillen M, O’CONNOR W, Noonan J, Todd E:  Anomalous left coronary artery from the pulmonary artery.  Significance of associated intracardiac defects. J Amer Coll Cardiol 6:237-242, 1985.

69   O’CONNOR W, Davis J, Geissler R, Cottrill C, Noonan J, Todd E:  Supravalvular aortic stenosis:  Clinical and pathologic observations in six patients. Arch Pathol Lab Med 109:179-185, 1985.

70   Litsey S, Noonan J, O’CONNOR W, Cottrill C, Mitchell B:  Maternal connective tissue disease and congenital heart block: demonstration of immunoglobulin in cardiac tissue. New England Journal of Medicine 312:98-100, 1985.

71   Simon M, Mitchell B, O’CONNOR W, Noonan J, Davis C, Wyatt R:  Glomerulonephritis, pulmonary hemorrhage and coagulopathy associated with Hemophilus para-influenzae endocarditis. Pediatric Infectious Disease 4:183-188, 1985.

72   Wisenbaugh T, Allen P, Cooper G, O’CONNOR W, Mezaros L, Streter F, Bahinski A,    Houser S, Spann J:  Hypertrophy without contractile dysfunction after reversal of pressure overload in the cat. Am Jour Physiol (Heart & Circulatory Physiology) 247:H146-H154, 1984.

73   Christy C, Noonan J, and O’CONNOR W:  Discrete sub-aortic stenosis following Tetralogy of Fallot repair. British Heart Journal 49:510-512, 1983.

74   O’CONNOR W, Hamann S, Hanley H:  Reconstruction of the microscopic transmural edge of experimentally infarcted canine myocardium. British Journal of Experimental Pathology 64:81-86, 1983.

75   Toedebusch W, Hagihara P, van Nagell J, and O’CONNOR W:  Adenocarcinoma of the colon associated with benign appendiceal neoplasm. Southern Medical Journal 75:893, 1982.

76   Mattingly W, O’CONNOR W, Zeok J, Todd E:  Thrombotic catastrophe in the patient with multiple Bjork-Shiley prostheses. The Annals of Thoracic Surgery 33:253-256, 1983.

77   Sampath R, O’CONNOR W, Noonan J, Todd E:  Management of ascending aortic aneurysm complicating coarctation of the aorta. The Annals of Thoracic Surgery 34:125-131, 1982.

78   O’CONNOR W, Valle S:  A combination Verhoeff’s elastic and Masson’s trichrome stain for routine histology. Stain Technology 57:207-210, 1982.

79   O’CONNOR W, Cash J, Cottrill C, Johnson G, and Noonan J:  Ventriculocoronary connections in hypoplastic left hearts:  An autopsy microscopic study. Circulation 66:1078-1086, 1982.

80   Mattingly W, O’CONNOR W, Zeok J, Todd E:  General surgical manifestations of Bjork-Shiley prosthetic dysfunction. The American Surgeon 48:207-210, 1982.

81   Powell D, Bivins B, Bell R, O’CONNOR W, Sachatello C, Griffen W:  Endocarditis:  Increasingly a surgical disease. The American Surgeon 48:5-10, 1982.

82   O’CONNOR W, Cottrill C, Johnson G, Noonan J, Todd E:  Pulmonary atresia with intact ventricular septum and ventriculocoronary communications:  Surgical significance. Circulation 65:805-809, 1982.

83   Cornish A, Hanley H, O’CONNOR W, Slack J, Patrick T, and Cole J:  Limitations of post-extrasystolic potentiation in identifying ischemic though viable myocardium. American Journal of Physiology (Heart & Circulatory Physiology) 241:H654-H661, 1981.

84   Noonan J, Kikoshis S, Cottrill C, O’CONNOR W, Haugh R, and Johnson G:  Congenital Heart Disease, butterfly vertebrae, and extrahepatic biliary atresia:  a variant of arteriohepatic dysplasia? The Journal of Pediatrics 99:(3)436-439, 1981.

85   Slack J, Landon J, Cole J, Hanley H, and O’CONNOR W:  Limitations of post-extrasystolic potentiation in assessing regional myocardial viability in man. Catheterization and Cardiovascular Diagnosis 6:373-386, 1980.

86   McComb R, Stahmann F, O’CONNOR W, and Todd E:  Structure-related thrombosis involving a porcine xenograft valve. The Annals of Thoracic Surgery 27(2):191-194, 1979.

87   McComb R, Markesbery W, and O’CONNOR W:  Fetal neonatal nemaline myopathy with multiple congenital anomalies. The Journal of Pediatrics 94(1):47-51, 1979.

88   O’CONNOR W, Challa V, Nelson O, and Gottlieb S:  Extracranial metastases of glioblastoma multiforme:  Report of a case confirmed by electron microscopy. Surgical Neurology 8(5):347-381, 1977.

Book & Book Chapters:

1     Applied Laboratory Medicine.  Tietz N, (Editor) with Conn R, Pruden E.  W. B. Saunders Co., Philadelphia, Pennsylvania (1992)

2     Cardiac & Cardiovascular Diseases:

Case 1.  Child with Heart Murmur and Cyanosis.  O’CONNOR W, and Cottrill C.  p. 7-10.

Case 2.  Woman with Angina Pectoris.  O’CONNOR W, Smith M, Porter W.  p. 11-14.

3     Ischemic Heart Disease.  Falk E, Shah PK, deFeyter, PJ. (Editors). Myocardial        Ischemia: Morbid Demand. 6.1 Cardiac Hypertrophy. pp 74.  Purushothaman KR, O’CONNOR W, Echeverri D, and Moreno PR.   Blackwell Publishing, Inc., United Kingdom, March, 2007.