Pradoldej (Bob) Sompol, PhD
Connect
(895) 323-8991pradoldej.sompol@uky.edu
Positions
- Assistant Professor
College Unit(s)
Other Affiliation(s)
- Pharmacology and Nutritional Sciences Center Affiliated Faculty
Research
We aim to investigate different aspect of reactive astrocytes in the brain of age-related neurodegenerative disorder like Alzheimer’s disease (AD). We used high-quality postmortem human brain samples to examine oxidative stress, cell signaling, vascular lesion, and AD hallmarks. We use cutting-edge intravital imaging techniques to investigate the function and interaction of brain cells (neuron and astrocytes) and cerebrovasculatures. We develop our own protocol to generate a novel mixed AD and vascular pathology at a single capillary level. This is a model of vascular oxidative stress that shows impair of neurovascular coupling function and degeneration of perivascular cells. We investigate molecular mechanism and cell signaling that involve in both degeneration and regeneration of these cells. Furthermore, we use electrophysiology techniques to measure basal synaptic transmission and synaptic plasticity as well as animal behavior to characterize our animal models.
Selected Publications
1. Sompol P, Gollihue, JL, Kraner SD, Artiushin IA, Cloyd RA, Chishti EA, Koren SA, Nation GK, Abisambra JF, Huzian O, Nagy LI, Jr3 LH, Puskas LG and Norris CM (2021) Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology. Aging Cell, Jul;20(7):e13416
2. Fu X, Sompol P, Brandon JA, Norris CM, Wilkop T, Johnson LA, Richards CI (2020) In Vivo Single-Molecule Detection of Nanoparticles for Multiphoton Fluorescence Correlation Spectroscopy to Quantify Cerebral Blood Flow. Nano Lett. 12;20(8):6135-6141
3. Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM (2017) Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Abeta-Bearing Mice. J Neurosci 37:6132-6148.
4. Furman JL*, Sompol P*, Kraner SD, Pleiss MM, Putman EJ, Dunkerson J, Mohmmad Abdul H, Roberts KN, Scheff SW, Norris CM (2016) Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury. J Neurosci 36:1502-1515. (*contributed equally)
5. Sompol P, Ittarat W, Tangpong J, Chen Y, Doubinskaia I, Batinic-Haberle I, Abdul HM, Butterfield DA, St Clair DK (2008) A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury. Neuroscience 153, 120-130. PMID: 18353561
6. Sompol P, Xu Y, Ittarat W, Daosukho C, St Clair D (2006) NF-kappaB-associated MnSOD induction protects against beta-amyloid-induced neuronal apoptosis. J Mol Neurosci 29:279-288.
7. Jang SW, Liu X, Pradoldej S, Tosini G, Chang Q, Iuvone PM, Ye K (2010) N-acetylserotonin activates TrkB receptor in a circadian rhythm. Proc Natl Acad Sci U S A 107:3876-3881.
8. Sompol P, Liu X, Baba K, Paul KN, Tosini G, Iuvone PM, Ye K (2011) N-acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice. Proc Natl Acad Sci U S A 108:8844-8849.
9. Shen J, Ghai K, Sompol P, Liu X, Cao X, Iuvone PM, Ye K (2012) N-acetyl serotonin derivatives as potent neuroprotectants for retinas. Proc Natl Acad Sci U S A 109:3540-3545.
10. Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K (2010) A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem 53:8274-8286.
Full publication: https://www.ncbi.nlm.nih.gov/myncbi/pradoldej.sompol.1/bibliography/pub…