Beth Garvy, PhD
Connect
Office: 859-323-5043 Lab: 859 257-0440bgarv0@email.uky.edu
Positions
- Professor
- Senior Associate Dean for Biomedical Education
College Unit(s)
Other Affiliation(s)
- MD/PhD Program Mentor
Biography and Education
Education
1981, University of South Florida, Tampa, FL, B.A., Biology and Science Education, 1985, The Ohio State University, Columbus, OH, M.A., Exercise Physiology 1991, Michigan State University, E. Lansing, MI, Ph.D., Biochemistry and Exercise Science 1993, Postdoctoral fellow, University of Miami School of Medicine, Miami, FL 1996, Research Associate, Trudeau Institute, Saranac Lake, NY
Research
Pneumocystis carinii is an opportunistic fungal pathogen that can cause pneumonia in immunosuppressed individuals including AIDS patients. It has been known for a number of years that an intact CD4 T cell compartment is critical for defense against P. carinii. The focus of our work has been to examine the immune response to P. carinii using a murine model of infection. These projects are being closed down and final papers written along two different lines:
1. How do the two identifiable life forms of P. carinii differentially interact with the lung immune system? The ascus form of the organisms has a thick cell wall containing beta glucans that can be recognized by glucan receptors such as dectin-1 on alveolar macrophages. The trophic form of the organisms lack a cell wall but make up 90% of the lung organism burden. We have found that the trophic forms inhibit inflammatory mediators produced by myeloid cells and we are now trying to determine the mechanisms responsible for this inhibition.
2. How do neonatal mice handle respiratory infection? It has long been known that infants are particularly susceptible to respiratory pathogens. We are using mouse models of P. carinii and influenza virus infection to examine neonatal immunity in the lungs.
Current research efforts are collaborative projects that address the overall question of how viral infection effects thrombotic events? My interest is in the monocyte/macrophage interactions with virus, platelets, and coagulation factors. Our research group is part of the RECOVER project that is a large NHLBI-funded clinical trial to understand long-COVID.
Educational efforts include funding of ABE (Alliance of Biomedical Educators) in the College of Medicine. The goal of ABE is to provide support for faculty interested in writing grants that fund education programs for trainees working on projects in the College of Medicine.
Note that my administrative position occupies most of my time and so I am no longer training students or post-docs in a laboratory setting.
Selected Publications
Sim MMS, Banerjee M, Myint T, Garvy BA, Whiteheart SW, Wood JP.J (2022) Total Plasma Protein S Is a Prothrombotic Marker in People Living With HIV. Acquir Immune Defic Syndr. Aug 1;90(4):463-471. PMID: 35616596
Kurkjian, C, B.S. Murphy, D.J. Feola, and B.A. Garvy. (2021) Alternatively activated macrophages regulate the neonatal immune response to Pneumocystis. J Fungi (Basel). Oct 2;7(10):827. PMID: 34682248
Haydar, D., R. Gonzalez, B.A. Garvy, S. Garneau-Tsodikova, N.T. Chandrika, T.J. Bocklage, D.J. Feola. (2021) Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia. Immunobiol. 226(1) 152034. PMID: 33278710
Banerjee, M., Y. Huang, S. Joshi, G.J. Popa, M.D. Mendenhall, Q.J. Wang, B.A. Garvy, T. Myint, S.W. Whiteheart. (2020) Platelets endocytose viral particles and are activated via TLR (Toll-like receptor) signaling. ATVB 40(7): 1635-1650, 2020. PMID: 32434410
Huaman, M.A., D. Henson, P.L. Rondan, E. Ticona, G. Miranda, R.J. Kryscio, R. Mugruza, E. Aranda, C. Ticona, S. Abarca, P. Heredia, A. Aguirree, T.R. Sterling, B.A. Garvy, C.J. Fichtenbaum. (2018) Latent tuberculosis infection is associated with increased unstimulated levels of Interferon-gamma in Lima, Peru. Plos Path.
Evans, H.M. and B.A. Garvy. (2017) The trophic life cycle stage of Pneumocystis species induces protective adaptive responses without inflammation-mediated progression to pneumonia. Med. Mycol. Myx145; doi: 10.1093/mmy/myx145.
Huaman, M.A., E. Ticona, G. Miranda, R.J. Kryscio, R. Mugruza, E. Aranda, P. Rondan, D. Henson, C. Ticona, T.R. Sterling, C.J. Fichtenbaum, and B.A. Garvy (2017) The relationship between latent tuberculosis infection and acute myocardial infarction. Clin. Infect. Dis. [Epub ahead of print] PMID: 2869328
Evans, H.M., A. Simpson, S. Shen, A.J. Stromberg, C.L. Pickett, and B.A. Garvy. (2017) The trophic life cycle stage of the opportunistic fungal pathogen Pneumocystis murina hinders the ability of dendritic cells to stimulate CD4+ T cell responses. Infect. Immun., 85(10): e00396-17. PMID:28694293
Huaman, M.A., R.J. Kriscyo, C.J. Fichtenbaum, D. Henson, E. Salt, T.R. Sterling, and B.A. Garvy. (2017) Tuberculosis and one-year risk of acute myocardial infarction: A propensity score-matched analysis. Epidemiol. Infect. 145(7):1363-1367. PMID: 28202093.
Deckman, J.M., C.J. Kurkjian, J.P. McGillis, T.J. Cory, S.E. Birket, L.M. Schutzman, B.S. Murphy, B.A. Garvy, and D.J. Feola (2017) Pneumocystis infection reprograms the activation state of pulmonary macrophages. Immunobiology, 222(2): 188-197. PMID: 27720434.
Evans, H., G.L. Bryant, and B.A. Garvy (2016) The life cycle states of Pneumocystis murina have opposing effects on the immune response to this opportunistic, fungal pathogen Infect Immun, 84(11): 3195-3205. PMID: 27572330.
Opata, M.M., M.L. Hollifield, F.E. Lund, T.D. Randall, R. Dunn, B.A. Garvy, and D.J. Feola (2015) B lymphocytes are required during the early priming of CD4+ T cells for clearance of Pneumocystis infection in mice. J. Immunol. 195: 195(2):611-620. PMID: 26041535
Hu, Y., Y-T. Lee, SmM. Kaech, B. Garvy, and L.S. Cauley (2015) Smad4 promotes differentiation of effector and circulating memory CD8 T cells, but is dispensable for tissue resident memory CD8 T cells. J. Immunol. 194:2407-2414. PMID: 25637015
Opata, M.M., Y. Zhan, M. Hollifield, and B.A. Garvy. (2013) B cell production of TNF in response to Pneumocystis infection in mice. Infect. Immun. 81(11):4252-4260.
Breslow-Decker, J., C. Mattingly, S.E. Birket, S Hoskins, T.N. Ho, B.A. Garvy, and D.J. Feola. (2013) Linezolid Decreases Susceptibility to Secondary Bacterial Pneumonia Post-Influenza Infection in Mice Through its Effects on Interferon-γ. J Immunol. 191(4):1792-1799. PMID: 23833238
C. Kurkjian, M. Hollifield, J.L. Lines, A. Rogoskly, K.M. Empey, M.H. Qureshi, S.A. Brown, and B.A. Garvy (2012) Alveolar macrophages in neonatal mice are inherently unresponsive to Pneumocystis infection. Infect Immun, 80(8):2835-2846. PMID: 22665378
Fallah M.P., Chelvarajan R.L., Garvy B.A., and S. Bondada. (2011) Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors. Mech Ageing Dev. 132:274-286. PMID: 21645538
Lines J.L., Hoskins S., Hollifield M., Cauley L.S., and B.A. Garvy. (2010) The migration of T cells in response to influenza virus is altered in neonatal mice. J Immunol. 185(5):2980-8.
Feola D.J., Garvy B.A., Cory T.J., Birket S.E., Hoy H., Hayes Jr. D., and B.S. Murphy. (2010) Azithromycin alters macrophage phenotype and pulmonary compartmentalization during lung infection with Pseudomonas. Antimicrob Agents Chemother. 54(6):2437-47. PDF
Oakley O.R., Garvy B.A., Humphreys S., Qureshi M.H., and C. Pomeroy. (2008) Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus. Clin Exp Immunol. 151(1):155-64. PDF
Murphy B.S., Wulff C.R., Garvy B.A., and S.C. Straley. (2007) Yersinia pestis YadC: a novel vaccine candidate against plague. Adv Exp Med Biol. 603:400-14.
Feola D.J., Garvy B.A., Rapp R.P., and A.C. Thornton. (2007) Blunted humoral response to influenza vaccination in patients exposed to zidovudine plus trimethoprim-sulfamethoxazole. Pharmacotherapy. 27(7):937-47.
Hollifield, M., W.J.S. deVilliers, and B.A. Garvy. (2007) Scavenger receptor A dampens induction of inflammation in response to the fungal pathogen Pneumocystis carinii. Infect. Immun. 75:3999-4005. PDF
Empey, K.M., M. Hollifield, and B.A. Garvy. (2007) LPS stimulates alveolar macrophages resulting in reduced Pneumocystis lung burden in infant mice. Infect. Immun. 75: 3382-3393. PDF
Lund, F.E., M. Hollifield, K. Schuer, T.D. Randall, and B.A. Garvy. (2006) B cells are required for priming of CD4 cells in response to Pneumocystis lung infection. J. Immunol., 176. PDF
Feola, D.J. and B.A. Garvy (2006) Combination exposure to zidovudine plus sulfamethoxazole-trimethoprim diminishes B lymphocyte immune responses to Pneumocystis murina infection in normal mice. Clin. Vaccine Immunol., 13:193-201.
Feola, D.J. and B.A. Garvy. (2005) Zidovudine plus sulfamethoxazole- trimethoprim adversely affects B lymphocyte maturation in bone marrow of normal mice. Int. Immunopharmacol., 5:1881-1894.
Qureshi, M.H., K.M. Empey, and B.A. Garvy. (2005) Modulation of proinflammatory responses to Pneumocystis carinii f. sp. muris in neonatal mice by granulocyte-macrophage colony-stimulating factor and IL-4: role of APCs. J. Immunol. 174,441.
Empey, K. M., M. Hollifield, K. Schuer, F. Gigliotti, and B.A. Garvy. (2004) Passive immunization of neonatal mice against Pneumocystis carinii f. sp. muris enhances control of infection without stimulating inflammation. Infect. Immun. 72,6211.
Lund, F.E., K. Schuer, M. Hollifield, T.D. Randall and B.A. Garvy. (2003) Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P. carinii-specific antibody. J. Immunol. 171, 1423. PDF
Qureshi, M.H., A.G. Harmsen, and B.A. Garvy. (2003) IL-10 Modulates Host Responses and Lung Damage Induced by Pneumocystis carinii Infection. J. Immunol. 170, 1002. PDF
Partida-Sanchez, S., D. Cockayne, S. Monard, E.L. Jacobson, B. Garvy, K. Kusser, M. Howard, A. Harmsen, T.D. Randall, and F.E. Lund (2001) Cyclic ADP-ribose production by CD38 controls extracellular calcium influx and chemtaxis in neutrophils and is required for bacterial clearance in vivo. Nature Med. 7,1209. PDF
Qureshi, M.H. and B.A. Garvy (2001) Neonatal T cells in an adult lung environment are competent to resolve Pneumocystis carinii pneumonia. J. Immunol. 166, 5704. PDF
Garvy, B.A. and M.H. Qureshi (2000) Delayed inflammatory response to Pneumocystis carinii infection in neonatal mice is due to an inadequate lung environment. J. Immunol. 165, 6480. PDF