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Ann M. Stowe, PhD, FAHA



  • Professor
  • Chair of TRAC
  • Faculty Council, At-large member
  • University Senator, College of Medicine

College Unit(s)

Other Affiliation(s)
  • Neuroscience - Joint Faculty
  • SCOBIRC - Faculty Associates
  • Sanders-Brown Center on Aging


My overarching hypothesis is that the immune system – driven by an autoreactivity to CNS-derived antigens – plays a fundamental role in neuronal plasticity within the CNS. B cells, T cells, and natural killer (NK) T cells comprise the adaptive component of the immune system, with their interactions initiated by antigen recognition. In stroke, I hypothesize that long-term plasticity requires T and B cell responses within the parenchyma, derived from lymphocyte populations sensitized to CNS antigens in the periphery. My preliminary data show that CD4 and CD8 T cells, as well as B cells, mediate long-term functional recovery and, depending on the responding lymphocyte subset, can directly support neuronal plasticity. Although I use preclinical studies to investigate the mechanisms by which autoimmune responses affect post-stroke plasticity (e.g., protection from excitotoxicity, dendritic pruning), it is critical to concomitantly confirm and characterize these cells in humans. My clinical studies into the role of neuroinflammation during brain injury and repair has expanded beyond the field of ischemic stroke to also include subjects with amnestic mild cognitive impairment and pediatric patients on ventilator and hemodynamic support who experience stroke. The combination of preclinical and clinical studies reflects both my own training, which included a clinical postdoctoral fellowship, and my ongoing scientific philosophy that translational research will hasten the collective understanding of functional recovery during and following brain injury.

Selected Publications

  1. Ortega, SB*, Torres, VO*, Latchney, SE, Whoolery, CW, Noorbhai, IZ, Poinsatte, K, Selvaraj, UM, Benson, MA, Meeuwissen, AJM, Plautz, EJ, Kong, X, Ramirez, DM, Ajay, AD, Meeks, JP, Goldberg, MP, Monson, NL, Eisch, AJ, and Stowe, AM (2020). B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice. Proc Natl Acad Sci, 117(9):4983-4993 (2018 IF:9.6) *equal contribution
  2. Selvaraj, UM, Ujas, TA, Kong, X, Kumas, A, Plautz, EJ, Zhang, S, Xing, C, Sudduth, TL, Wilcock, DM, Turchan-Cholewo, J, Goldberg, MP, and Stowe, AM (2021). Delayed diapedesis of CD8 T cells contributes to long-term pathology after ischemic stroke in male mice. Brain Behav Immun, 95: 502-513. PMID: 33964435
  3. Shaw, BC, Maglinger, GB, Ujas, TA, Rupareliya, C, Fraser, JF, Grupke, S, Kesler, M, Gelderblom, M, Pennypacker, KR, Turchan-Cholewo, J, and Stowe, AM (2022). Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy. J Cereb Blood Flow Metab, 42(2): 280-291. PMID: 34250820
  4. Yanev, P, van Tilborg, GA, van der Toorn, A, Kong, X, Stowe, AM, Dijkhuizen, RM (2022). Prolonged release of VEGF and Ang1 from intralesionally implanted hydrogel promotes perilesional vascularization and functional recovery after experimental ischemic stroke. J Cereb Blood Flow Metab, 42(6):1033-1048. PMID: 34986707
  5. Lutshumba, J, Wilcock, DM, Monson NL, and Stowe, AM (2023). Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias. Neurobiol Dis, online ahead of print. PMID: 37330146
  6. Karamyan, V and Stowe, AM (Co-Editors) Methods in Molecular Biology: Neural Repair, Springer Publishing, 2023