Alan Daugherty, PhD, DSc, FAHA
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859-323-3512Positions
- Chair, Physiology
- Director, Saha Cardiovascular Research Center
- Gill Foundation Chair in Preventive Cardiology
College Unit(s)
Other Affiliation(s)
- MD/PhD Program Mentor
- CVRC - Core Faculty
- Nutritional Sciences Graduate Faculty
Biography and Education
Biography
Alan Daugherty completed a BSc in Pharmacology at Sunderland Polytechnic and received his PhD and DSc in Pharmacology from the University of Bath. He moved to Washington University in St. Louis for fellowship training and was subsequently appointed to the faculty. In 1997, he moved to the University of Kentucky in Lexington, Kentucky. Dr. Daugherty is the Gill Foundation Professor of Preventive Cardiology, Director of the Saha Cardiovascular Research Center and the Saha Aorta Center, and Chair of the Department of Physiology. Dr. Daugherty has been highly committed to the cardiovascular research community. This have included many roles in the American Heart Association, including a 10-year term as Editor-in-Chief of Arteriosclerosis, Thrombosis, and Vascular Biology. He has also served for many years as a grant reviewer for the British Heart Foundation. Dr. Daugherty’s research focuses on mechanisms leading to vascular pathologies; particularly atherosclerosis and aortopathies. This has predominantly emphasized the role of the renin angiotensin system with particular interest in angiotensinogen inhibition.
Education
- Sunderland Polytechnic, UK, B.Sc. (Hons), 1978, Pharmacology
- University of Bath, UK, Ph.D., 1982, Pharmacology
- University of Bath, UK, Fellow, 1981-1982, Cardiol. Physiol.
- Washington University, St. Louis, MO, Fellow, 1982-1985, Atherosclerosis
- University of Bath, UK, D.Sc., 2002, Pharmacology
Research
Focus of the laboratory
The Daugherty lab is primarily focused on the role of the renin angiotensin system on the development of several vascular pathologies, including atherosclerosis and aortic diseases.
Current ongoing projects in the lab
- Role of cell specific activation by angiotensin II to promote atherosclerosis and aortic diseases.
- Role of fibroblasts in atherosclerosis and aortic diseases.
- Role of fibrillin-1 and elastin in maintain the integrity of the vasculature.
- Role of LRP1 in the heterogeneity of aortic aneurysms, dissections, and tortuosity.
Selected Publications
Dr. Daugherty has over 440 publications with over 33,000 citations. To see the complete list of publications, follow the links below.