Down syndrome is the most commonly diagnosed chromosomal condition in the United States. Each year, approximately 6,000 babies are born with Down syndrome, meaning it affects about one in every 700 births. This genetic condition results from the presence of an extra copy of chromosome 21, known as trisomy 21, which impacts physical and cognitive development to varying degrees.
World Down Syndrome Day, observed annually on March 21, is dedicated to raising awareness and advocating for the rights, inclusion, and overall well-being of individuals with Down syndrome. The date—3/21—was chosen to symbolize the triplication of the 21st chromosome, which causes Down syndrome. Across the globe, people recognize this day by engaging in various awareness campaigns, educational events, and community activities that promote understanding and acceptance.
One widely embraced tradition is wearing mismatched socks, a playful and symbolic way to spark conversations about Down syndrome. The mismatched socks serve as a visual representation of chromosomal differences while reinforcing the powerful message that "we are more alike than different." By participating in this initiative, individuals can show solidarity and help spread awareness in a simple yet impactful way.
Physicians and researchers across the College of Medicine and UK HealthCare are encouraging folks to join in the celebration by wearing mismatched socks on March 21. Participation is entirely voluntary, and individuals should ensure their sock choices align with their department’s uniform policies. Those who take part are invited to share photos of their socks by submitting them to healthdisparities@uky.edu by 3:00 PM on March 21. Submitted photos will be featured in a social media spotlight, highlighting the collective effort to spread awareness and celebrate World Down Syndrome Day together.
At the University of Kentucky, researchers are actively working to deepen the understanding of Down syndrome and its associated health concerns. Frederick Schmitt, PhD, a professor of neurology at the UK College of Medicine and a researcher at the UK Sanders-Brown Center on Aging, has been studying Down syndrome for over 40 years. His recent research explores the connection between Down syndrome and Alzheimer’s disease, providing valuable insights into how the condition may impact aging and cognitive health. You can read more about that research in a 2024 interview here.