CNS-Met COBRE
About
The University of Kentucky Phase I Center of Research in central nervous system metabolism is supported by a $10.6 million, five-year award (P20 GM148326) from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.
The central nervous system (CNS) has a very high requirement for energy which results in high metabolism rates. As such, CNS metabolism and neuronal excitability are interdependent, and disruptions of CNS metabolism are implicated in numerous neurological disease states, including Alzheimer’s Disease, Parkinson’s disease, epilepsy, ischemia, and traumatic CNS injury, but the mechanisms and underlying connections between CNS metabolism and disease are not well-defined. The University of Kentucky College of Medicine has made significant investments over the past decade in investigators with strong metabolic and metabolomics expertise and instrumentation to support research efforts, which has greatly enhanced existing strongholds in neuroscience, cancer, cardiovascular, diabetes, and obesity research. The goal of our multidisciplinary Center of Biomedical Research Excellence (COBRE) focused on CNS Metabolism (CNS-Met) is a strategically designed, sustainable framework that promotes leading-edge research focused on the role of metabolic mediators of brain function and disease, with an emphasis on encouraging research excellence from Junior Research Project Leaders. To accomplish these goals, we will meet four specific aims: (1) develop a critical mass of funded investigators with research programs directly related to the COBRE’s unifying theme; (2) provide strong team-based mentoring combining basic and clinical expertise; (3) recruit new investigators to the COBRE in multidisciplinary areas of neurologic dysfunction through pilot project grant and recruitment of junior Research Project Leaders; and (4) create synergy among research projects via critical links to strong research centers and core facilities at UK, including existing COBREs. Overall, the CNS-Met will create a critical mass of scientists who are skilled and well-equipped to foster a sustainable research center focused on CNS metabolism.
Use the following sentence to cite the COBRE award in your COBRE work:
"Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM148326. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."
Rules for Foreign Co-Authorship of Publications
Recent Publications
Publications 1 – 9
1: Constantino NJ, Irmen RE, Lanning MJ, Turner SM, Ashley CC, Carroll CM, Neary
EM, Rubinow D, Snipes JA, Macauley SL. Early microglial response to amyloid
plaques drives sleep loss in Alzheimer's disease. Alzheimers Dement. 2026
Jun;22(6):e71579. doi: 10.1002/alz.71579. PMID: 42252510; PMCID: PMC13243238.
2: Chaudhary CL, Lages PC, Peña AM, Pinto AK, Radka CD, Tidgewell KJ. Synthesis
and Evaluation of Sulfobacin A and Analogues for Their Roles in Immunological
Recognition. ACS Med Chem Lett. 2026 May 4;17(5):1050-1056. doi:
10.1021/acsmedchemlett.5c00788. PMID: 42157810; PMCID: PMC13181453.
3: Laye CJ, Hubbard WB. Restoring mitochondrial health after blast-induced
traumatic brain injury: modifiable factors and therapeutic opportunities. NPJ
Metab Health Dis. 2026 May 13;4(1):18. doi: 10.1038/s44324-026-00111-7. PMID:
42129353; PMCID: PMC13172328.
4: Peña Rosado A, Pinto AK. Powassan virus. Trends Microbiol. 2026
May;34(5):578-579. doi: 10.1016/j.tim.2025.11.012. Epub 2025 Dec 13. PMID:
41391988; PMCID: PMC12871046.
5: Moallem EZ, Vekaria HJ, Macheda T, Hawkins MR, Roberts KN, Patel SP, Sullivan
PG, Bachstetter AD. Traumatic brain injury exacerbates mitochondrial dysfunction
in APP/PS1 knock-in mice through time-dependent pathways. Exp Neurol. 2026
Apr;398:115629. doi: 10.1016/j.expneurol.2025.115629. Epub 2025 Dec 30. PMID:
41478423; PMCID: PMC13042949.
6: Shade LMP, Qiao Q, Katsumata Y, Mukherjee S, Broome JG, Johnson LA, Ebbert
MTW, Nelson PT, Fardo DW. Reply to: a quantitative trait locus for reduced
microglial APOE expression associates with reduced cerebral amyloid angiopathy.
Nat Genet. 2026 Feb;58(2):273-274. doi: 10.1038/s41588-025-02473-y. Epub 2026
Jan 26. PMID: 41588233; PMCID: PMC13068160.
7: Velmurugan GV, Vekaria HJ, Patel SP, Sullivan PG, Hubbard WB. Astrocytic
mitochondrial transfer to brain endothelial cells and pericytes <i>in vivo</i>
increases with aging. J Cereb Blood Flow Metab. 2026 Feb;46(2):418-429. doi:
10.1177/0271678X241306054. Epub 2024 Dec 12. PMID: 39668588; PMCID: PMC11638933.
8: Johnson LA, Saito K, Pallerla AV, Funnell JL, Ezzo AR, Song CM, Harrison DA,
Norton NJ, Moore LC, Van Eldik LJ, Fardo DW, Cooper GE, Morganti JM. Clonal
expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA. Nat Commun.
2026 Jan 30;17(1):2180. doi: 10.1038/s41467-026-68921-3. PMID: 41617706; PMCID:
PMC12960807.
9: Kaur S, Baur AM, Condrey JA, Gal DP, Patel SP, Gensel JC. In Vivo Telemetry
to Record Long-Term Cardiovascular Parameters, Temperature, and Activity in
Spinal Cord Injury Rat Models. J Vis Exp. 2026 Jan 2;(227):10.3791/69714. doi:
10.3791/69714. PMID: 41553925; PMCID: PMC13091495.
Publications 1 – 9
1: Constantino NJ, Irmen RE, Lanning MJ, Turner SM, Ashley CC, Carroll CM, Neary
EM, Rubinow D, Snipes JA, Macauley SL. Early microglial response to amyloid
plaques drives sleep loss in Alzheimer's disease. Alzheimers Dement. 2026
Jun;22(6):e71579. doi: 10.1002/alz.71579. PMID: 42252510; PMCID: PMC13243238.
2: Chaudhary CL, Lages PC, Peña AM, Pinto AK, Radka CD, Tidgewell KJ. Synthesis
and Evaluation of Sulfobacin A and Analogues for Their Roles in Immunological
Recognition. ACS Med Chem Lett. 2026 May 4;17(5):1050-1056. doi:
10.1021/acsmedchemlett.5c00788. PMID: 42157810; PMCID: PMC13181453.
3: Laye CJ, Hubbard WB. Restoring mitochondrial health after blast-induced
traumatic brain injury: modifiable factors and therapeutic opportunities. NPJ
Metab Health Dis. 2026 May 13;4(1):18. doi: 10.1038/s44324-026-00111-7. PMID:
42129353; PMCID: PMC13172328.
4: Peña Rosado A, Pinto AK. Powassan virus. Trends Microbiol. 2026
May;34(5):578-579. doi: 10.1016/j.tim.2025.11.012. Epub 2025 Dec 13. PMID:
41391988; PMCID: PMC12871046.
5: Moallem EZ, Vekaria HJ, Macheda T, Hawkins MR, Roberts KN, Patel SP, Sullivan
PG, Bachstetter AD. Traumatic brain injury exacerbates mitochondrial dysfunction
in APP/PS1 knock-in mice through time-dependent pathways. Exp Neurol. 2026
Apr;398:115629. doi: 10.1016/j.expneurol.2025.115629. Epub 2025 Dec 30. PMID:
41478423; PMCID: PMC13042949.
6: Shade LMP, Qiao Q, Katsumata Y, Mukherjee S, Broome JG, Johnson LA, Ebbert
MTW, Nelson PT, Fardo DW. Reply to: a quantitative trait locus for reduced
microglial APOE expression associates with reduced cerebral amyloid angiopathy.
Nat Genet. 2026 Feb;58(2):273-274. doi: 10.1038/s41588-025-02473-y. Epub 2026
Jan 26. PMID: 41588233; PMCID: PMC13068160.
7: Velmurugan GV, Vekaria HJ, Patel SP, Sullivan PG, Hubbard WB. Astrocytic
mitochondrial transfer to brain endothelial cells and pericytes <i>in vivo</i>
increases with aging. J Cereb Blood Flow Metab. 2026 Feb;46(2):418-429. doi:
10.1177/0271678X241306054. Epub 2024 Dec 12. PMID: 39668588; PMCID: PMC11638933.
8: Johnson LA, Saito K, Pallerla AV, Funnell JL, Ezzo AR, Song CM, Harrison DA,
Norton NJ, Moore LC, Van Eldik LJ, Fardo DW, Cooper GE, Morganti JM. Clonal
expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA. Nat Commun.
2026 Jan 30;17(1):2180. doi: 10.1038/s41467-026-68921-3. PMID: 41617706; PMCID:
PMC12960807.
9: Kaur S, Baur AM, Condrey JA, Gal DP, Patel SP, Gensel JC. In Vivo Telemetry
to Record Long-Term Cardiovascular Parameters, Temperature, and Activity in
Spinal Cord Injury Rat Models. J Vis Exp. 2026 Jan 2;(227):10.3791/69714. doi:
10.3791/69714. PMID: 41553925; PMCID: PMC13091495.
Publications 10 – 18
10: Irmen RE, Turner SM, Snipes JA, Schloss KH, Wang X, Williams HC, Velmurugan
GV, Hunt JB Jr, Li J, Sullivan PG, Lee DC, Bauer AQ, Johnson LA, Macauley SL.
Tau pathology reprograms glucose metabolism to support cortical
hyperexcitability, excitatory/inhibitory imbalance, and sleep loss. NPJ Dement.
2026;2(1):6. doi: 10.1038/s44400-025-00054-8. Epub 2026 Jan 23. PMID: 41586259;
PMCID: PMC12830363.
11: Nolt GL, Golden LR, Thorpe SP, Funnell JL, Stephens IO, Hernandez G, MacLean
SM, Lucido CC, Brock CR, Pallerla AV, Adreon DR, Williams HC, Morganti JM,
Johnson LA. Microglia-derived APOE2 improves remyelination even in the presence
of endogenous APOE4. J Neuroinflammation. 2025 Dec 11;23(1):18. doi:
10.1186/s12974-025-03639-5. PMID: 41382275; PMCID: PMC12802005.
12: Kemna RE, Kueck PJ, Blankenship A, John CS, Johnson CN, Green ZD, Mayfield
H, Yoksh L, Johnson L, Thyfault JP, Mahnken JD, Miller BF, Morris JK. Acute
effects of lactate infusion on metabolism, AD biomarkers, and cognition: The
LEAN study. Alzheimers Dement. 2025 Dec;21(12):e70984. doi: 10.1002/alz.70984.
PMID: 41376120; PMCID: PMC12696042.
13: Golden LR, Siano DS, Stephens IO, MacLean SM, Saito K, Nolt GL, Funnell JL,
Pallerla AV, Lee S, Smith C, Chen J, Zhu H, Voy C, Whitus CM, Hernandez G,
Farmer BC, Pandya K, Cowley DO, Macauley SL, Gordon SM, Morganti JM, Johnson LA.
APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related
metabolic signatures, neuropathology and cognition. Nat Neurosci. 2025
Dec;28(12):2461-2475. doi: 10.1038/s41593-025-02094-y. Epub 2025 Nov 11. PMID:
41219507; PMCID: PMC12672373.
14: LaMontia-Hankin E, Wollner CJ, Stone ET, Peña Rosado A, Pflugheber J, Zalla
A, Nieto S, Pinto AK, Brien JD, Richner JM. mRNA-LNP Vaccines Encoding for
Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADE.
bioRxiv [Preprint]. 2025 Nov 20:2025.07.21.665855. doi:
10.1101/2025.07.21.665855. PMID: 41332583; PMCID: PMC12667845.
15: Bailey CS, Gant JC, Frazier HN, Morganti JM, Coleman MC, Davis VA, J Vekaria
H, G Sullivan P, Norris CM, Van Eldik LJ, Braun DJ. Early loss of astrocyte p38α
MAPK reduces hippocampal neuroinflammation, enhances synaptic strength, and
increases non-synaptic mitochondrial uncoupling in female mice during non-
pathological aging. Geroscience. 2025 Nov 14. doi: 10.1007/s11357-025-01948-4.
Epub ahead of print. PMID: 41239109.
16: Stephens IO, Johnson LA. Knockout of Perilipin-2 in Microglia Alters Lipid
Droplet Accumulation and Response to Alzheimer's Disease Stimuli. Cells. 2025
Nov 13;14(22):1783. doi: 10.3390/cells14221783. PMID: 41294836; PMCID:
PMC12651832.
17: Yassine HN, Hugo C, O'Donovan B, Stephens IO, Johnson LA, Cole G, Tcw J,
Johansson J, Kisler K, Chiba-Falek O. APOE-Targeted Therapeutics for Alzheimer's
Disease. J Neurosci. 2025 Nov 12;45(46):e1388252025. doi:
10.1523/JNEUROSCI.1388-25.2025. PMID: 41224653; PMCID: PMC12614056.
18: Constantino NJ, Ashley CC, Macauley SL. The Energetic Collapse of the
Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks. J
Neurochem. 2025 Nov;169(11):e70294. doi: 10.1111/jnc.70294. PMID: 41231438;
PMCID: PMC12614295.
Publications 10 – 18
10: Irmen RE, Turner SM, Snipes JA, Schloss KH, Wang X, Williams HC, Velmurugan
GV, Hunt JB Jr, Li J, Sullivan PG, Lee DC, Bauer AQ, Johnson LA, Macauley SL.
Tau pathology reprograms glucose metabolism to support cortical
hyperexcitability, excitatory/inhibitory imbalance, and sleep loss. NPJ Dement.
2026;2(1):6. doi: 10.1038/s44400-025-00054-8. Epub 2026 Jan 23. PMID: 41586259;
PMCID: PMC12830363.
11: Nolt GL, Golden LR, Thorpe SP, Funnell JL, Stephens IO, Hernandez G, MacLean
SM, Lucido CC, Brock CR, Pallerla AV, Adreon DR, Williams HC, Morganti JM,
Johnson LA. Microglia-derived APOE2 improves remyelination even in the presence
of endogenous APOE4. J Neuroinflammation. 2025 Dec 11;23(1):18. doi:
10.1186/s12974-025-03639-5. PMID: 41382275; PMCID: PMC12802005.
12: Kemna RE, Kueck PJ, Blankenship A, John CS, Johnson CN, Green ZD, Mayfield
H, Yoksh L, Johnson L, Thyfault JP, Mahnken JD, Miller BF, Morris JK. Acute
effects of lactate infusion on metabolism, AD biomarkers, and cognition: The
LEAN study. Alzheimers Dement. 2025 Dec;21(12):e70984. doi: 10.1002/alz.70984.
PMID: 41376120; PMCID: PMC12696042.
13: Golden LR, Siano DS, Stephens IO, MacLean SM, Saito K, Nolt GL, Funnell JL,
Pallerla AV, Lee S, Smith C, Chen J, Zhu H, Voy C, Whitus CM, Hernandez G,
Farmer BC, Pandya K, Cowley DO, Macauley SL, Gordon SM, Morganti JM, Johnson LA.
APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related
metabolic signatures, neuropathology and cognition. Nat Neurosci. 2025
Dec;28(12):2461-2475. doi: 10.1038/s41593-025-02094-y. Epub 2025 Nov 11. PMID:
41219507; PMCID: PMC12672373.
14: LaMontia-Hankin E, Wollner CJ, Stone ET, Peña Rosado A, Pflugheber J, Zalla
A, Nieto S, Pinto AK, Brien JD, Richner JM. mRNA-LNP Vaccines Encoding for
Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADE.
bioRxiv [Preprint]. 2025 Nov 20:2025.07.21.665855. doi:
10.1101/2025.07.21.665855. PMID: 41332583; PMCID: PMC12667845.
15: Bailey CS, Gant JC, Frazier HN, Morganti JM, Coleman MC, Davis VA, J Vekaria
H, G Sullivan P, Norris CM, Van Eldik LJ, Braun DJ. Early loss of astrocyte p38α
MAPK reduces hippocampal neuroinflammation, enhances synaptic strength, and
increases non-synaptic mitochondrial uncoupling in female mice during non-
pathological aging. Geroscience. 2025 Nov 14. doi: 10.1007/s11357-025-01948-4.
Epub ahead of print. PMID: 41239109.
16: Stephens IO, Johnson LA. Knockout of Perilipin-2 in Microglia Alters Lipid
Droplet Accumulation and Response to Alzheimer's Disease Stimuli. Cells. 2025
Nov 13;14(22):1783. doi: 10.3390/cells14221783. PMID: 41294836; PMCID:
PMC12651832.
17: Yassine HN, Hugo C, O'Donovan B, Stephens IO, Johnson LA, Cole G, Tcw J,
Johansson J, Kisler K, Chiba-Falek O. APOE-Targeted Therapeutics for Alzheimer's
Disease. J Neurosci. 2025 Nov 12;45(46):e1388252025. doi:
10.1523/JNEUROSCI.1388-25.2025. PMID: 41224653; PMCID: PMC12614056.
18: Constantino NJ, Ashley CC, Macauley SL. The Energetic Collapse of the
Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks. J
Neurochem. 2025 Nov;169(11):e70294. doi: 10.1111/jnc.70294. PMID: 41231438;
PMCID: PMC12614295.
Publications 19 – 27
19: Jagielo-Miller J, Bailey C, Patel S, Prajapati P, Leibold C, Sullivan P,
Prendergast M. Mechanical Distention of Organotypic Hippocampal Slice Culture
Membranes for High-Throughput <i>In Vitro</i> Modeling of Traumatic Brain
Injury. Neurotrauma Rep. 2025 Oct 27;6(1):982-990. doi:
10.1177/2689288X251389788. PMID: 41340827; PMCID: PMC12670678.
20: Aryee E, Aloysius A, Saxena S, Vekaria H, Sullivan PG, Seifert AW. Active
mitochondria in healthy spiny mouse fibroblasts resemble megamitochondria and
remain resilient across lifespan. bioRxiv [Preprint]. 2025 Oct
4:2025.10.02.680123. doi: 10.1101/2025.10.02.680123. PMID: 41256523; PMCID:
PMC12621865.
21: Moallem EZ, Vekaria HJ, Macheda T, Hawkins MR, Roberts KN, Patel SP,
Sullivan PG, Bachstetter AD. Traumatic brain injury exacerbates mitochondrial
dysfunction in APP/PS1 knock-in mice through time-dependent pathways. bioRxiv
[Preprint]. 2025 Oct 2:2025.10.01.679790. doi: 10.1101/2025.10.01.679790. Update
in: Exp Neurol. 2026 Apr;398:115629. doi: 10.1016/j.expneurol.2025.115629. PMID:
41256457; PMCID: PMC12621809.
22: Velmurugan GV, Prajapati S, Tran S, Miller C, Burke B, Hubbard WB. Sex-
dependent blood-brain barrier alterations following repeated mild blast
traumatic brain injury at varying inter-injury intervals. Exp Neurol. 2025
Oct;392:115325. doi: 10.1016/j.expneurol.2025.115325. Epub 2025 May 30. PMID:
40451452; PMCID: PMC12302826.
23: Friday CM, Stephens IO, Smith CT, Lee S, Satish D, Devanney NA, Cohen S,
Morganti JM, Gordon SM, Johnson LA. APOE4 reshapes the lipid droplet proteome
and modulates microglial inflammatory responses. Neurobiol Dis. 2025
Aug;212:106983. doi: 10.1016/j.nbd.2025.106983. Epub 2025 May 30. PMID:
40451545; PMCID: PMC12187248.
24: Irmen RE, Turner SM, Snipes JA, Williams HC, Viswanathan VG, Hunt JB, Li J,
Sullivan PG, Lee DC, Johnson LA, Macauley SL. Tau pathology reprograms glucose
metabolism to support glutamatergic activity and excitatory imbalance. bioRxiv
[Preprint]. 2025 Jul 31:2025.07.25.666872. doi: 10.1101/2025.07.25.666872.
Update in: NPJ Dement. 2026;2(1):6. doi: 10.1038/s44400-025-00054-8. PMID:
40766533; PMCID: PMC12324325.
25: Maeda N, Taylor LS, Nassar-Guifarro M, Monawar MS, Dunn SM, Devanney NA, Li
F, Johnson LA, Kayashima Y. Genomic and cellular context-dependent expression of
the human ELMO1 gene transcript variants. Gene. 2025 Jun 20;954:149438. doi:
10.1016/j.gene.2025.149438. Epub 2025 Mar 25. PMID: 40147730; PMCID:
PMC12147996.
26: Vekaria HJ, Shelley SJ, Messmer SJ, Kunjadia PD, McLouth CJ, Sullivan PG,
Fraser JF, Pennypacker KR, Pandya CD. Sex- and Tissue-Specific Effects of
Leukemia Inhibitory Factor on Mitochondrial Bioenergetics Following Ischemic
Stroke. Biomolecules. 2025 May 20;15(5):738. doi: 10.3390/biom15050738. PMID:
40427631; PMCID: PMC12109232.
27: Ostrakhovitch EA, Song ES, Stegemann JE, McLeod M, Yamasaki TR. Effect of
hydrogen sulfide on alpha-synuclein aggregation and cell viability. Sci Rep.
2025 May 4;15(1):15597. doi: 10.1038/s41598-025-99794-z. PMID: 40320462; PMCID:
PMC12050307.
Publications 19 – 27
19: Jagielo-Miller J, Bailey C, Patel S, Prajapati P, Leibold C, Sullivan P,
Prendergast M. Mechanical Distention of Organotypic Hippocampal Slice Culture
Membranes for High-Throughput <i>In Vitro</i> Modeling of Traumatic Brain
Injury. Neurotrauma Rep. 2025 Oct 27;6(1):982-990. doi:
10.1177/2689288X251389788. PMID: 41340827; PMCID: PMC12670678.
20: Aryee E, Aloysius A, Saxena S, Vekaria H, Sullivan PG, Seifert AW. Active
mitochondria in healthy spiny mouse fibroblasts resemble megamitochondria and
remain resilient across lifespan. bioRxiv [Preprint]. 2025 Oct
4:2025.10.02.680123. doi: 10.1101/2025.10.02.680123. PMID: 41256523; PMCID:
PMC12621865.
21: Moallem EZ, Vekaria HJ, Macheda T, Hawkins MR, Roberts KN, Patel SP,
Sullivan PG, Bachstetter AD. Traumatic brain injury exacerbates mitochondrial
dysfunction in APP/PS1 knock-in mice through time-dependent pathways. bioRxiv
[Preprint]. 2025 Oct 2:2025.10.01.679790. doi: 10.1101/2025.10.01.679790. Update
in: Exp Neurol. 2026 Apr;398:115629. doi: 10.1016/j.expneurol.2025.115629. PMID:
41256457; PMCID: PMC12621809.
22: Velmurugan GV, Prajapati S, Tran S, Miller C, Burke B, Hubbard WB. Sex-
dependent blood-brain barrier alterations following repeated mild blast
traumatic brain injury at varying inter-injury intervals. Exp Neurol. 2025
Oct;392:115325. doi: 10.1016/j.expneurol.2025.115325. Epub 2025 May 30. PMID:
40451452; PMCID: PMC12302826.
23: Friday CM, Stephens IO, Smith CT, Lee S, Satish D, Devanney NA, Cohen S,
Morganti JM, Gordon SM, Johnson LA. APOE4 reshapes the lipid droplet proteome
and modulates microglial inflammatory responses. Neurobiol Dis. 2025
Aug;212:106983. doi: 10.1016/j.nbd.2025.106983. Epub 2025 May 30. PMID:
40451545; PMCID: PMC12187248.
24: Irmen RE, Turner SM, Snipes JA, Williams HC, Viswanathan VG, Hunt JB, Li J,
Sullivan PG, Lee DC, Johnson LA, Macauley SL. Tau pathology reprograms glucose
metabolism to support glutamatergic activity and excitatory imbalance. bioRxiv
[Preprint]. 2025 Jul 31:2025.07.25.666872. doi: 10.1101/2025.07.25.666872.
Update in: NPJ Dement. 2026;2(1):6. doi: 10.1038/s44400-025-00054-8. PMID:
40766533; PMCID: PMC12324325.
25: Maeda N, Taylor LS, Nassar-Guifarro M, Monawar MS, Dunn SM, Devanney NA, Li
F, Johnson LA, Kayashima Y. Genomic and cellular context-dependent expression of
the human ELMO1 gene transcript variants. Gene. 2025 Jun 20;954:149438. doi:
10.1016/j.gene.2025.149438. Epub 2025 Mar 25. PMID: 40147730; PMCID:
PMC12147996.
26: Vekaria HJ, Shelley SJ, Messmer SJ, Kunjadia PD, McLouth CJ, Sullivan PG,
Fraser JF, Pennypacker KR, Pandya CD. Sex- and Tissue-Specific Effects of
Leukemia Inhibitory Factor on Mitochondrial Bioenergetics Following Ischemic
Stroke. Biomolecules. 2025 May 20;15(5):738. doi: 10.3390/biom15050738. PMID:
40427631; PMCID: PMC12109232.
27: Ostrakhovitch EA, Song ES, Stegemann JE, McLeod M, Yamasaki TR. Effect of
hydrogen sulfide on alpha-synuclein aggregation and cell viability. Sci Rep.
2025 May 4;15(1):15597. doi: 10.1038/s41598-025-99794-z. PMID: 40320462; PMCID:
PMC12050307.
Publications 28 – 36
28: Ostrakhovitch EA, Ono K, Yamasaki TR. Metabolomics in Parkinson's Disease
and Correlation with Disease State. Metabolites. 2025 Mar 18;15(3):208. doi:
10.3390/metabo15030208. PMID: 40137172; PMCID: PMC11944848.
29: Constantino NJ, Carroll CM, Williams HC, Vekaria HJ, Yuede CM, Saito K,
Sheehan PW, Snipes JA, Raichle ME, Musiek ES, Sullivan PG, Morganti JM, Johnson
LA, Macauley SL. ATP-sensitive potassium channels alter glycolytic flux to
modulate cortical activity and sleep. Proc Natl Acad Sci U S A. 2025 Feb
25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. Epub 2025 Feb 18. PMID:
39964713; PMCID: PMC11874466.
30: Geerling E, Stone ET, Carpenter D, Dickson AM, Brien JD, Pinto AK. Metabolic
syndrome enhances SARS-CoV-2 disease severity and reduces mRNA vaccine efficacy
in a mouse model. bioRxiv [Preprint]. 2025 Jan 15:2025.01.15.633120. doi:
10.1101/2025.01.15.633120. PMID: 41030984; PMCID: PMC12478387.
31: Friday CM, Stephens IO, Smith CT, Lee S, Satish D, Devanney NA, Cohen S,
Morganti JM, Gordon SM, Johnson LA. <i>APOE4</i> alters the lipid droplet
proteome and modulates droplet dynamics. bioRxiv [Preprint]. 2024 Dec
20:2024.12.16.628710. doi: 10.1101/2024.12.16.628710. Update in: Neurobiol Dis.
2025 Aug;212:106983. doi: 10.1016/j.nbd.2025.106983. PMID: 39763832; PMCID:
PMC11702569.
32: Banadaki MD, Rummel NG, Backus S, Butterfield DA, St Clair DK, Campbell JM,
Zhong W, Mayer K, Berry SM, Chaiswing L. Extraction of redox extracellular
vesicles using exclusion-based sample preparation. Anal Bioanal Chem. 2024
Nov;416(28):6317-6331. doi: 10.1007/s00216-024-05518-z. Epub 2024 Sep 7. Erratum
in: Anal Bioanal Chem. 2024 Dec;416(29):7187-7188. doi:
10.1007/s00216-024-05568-3. PMID: 39243301; PMCID: PMC11807383.
33: Velmurugan GV, Vekaria HJ, Hartz AMS, Bauer B, Hubbard WB. Oxidative stress
alters mitochondrial homeostasis in isolated brain capillaries. Fluids Barriers
CNS. 2024 Oct 15;21(1):81. doi: 10.1186/s12987-024-00579-9. PMID: 39407313;
PMCID: PMC11476969.
34: Krizan I, Solingapuram Sai KK, Damuka N, Macauley SL, Maria Thurman B, Long
M, Kavanagh K. Exploratory Dual PET imaging of [<sup>18</sup>F]
fluorodeoxyglucose and [<sup>11</sup>C]acetoacetate in type 2 diabetic nonhuman
primates. Bioorg Med Chem Lett. 2024 Oct 1;111:129906. doi:
10.1016/j.bmcl.2024.129906. Epub 2024 Jul 25. PMID: 39059565; PMCID:
PMC11403582.
35: Mobilia M, Karakashian A, Neupane KR, Hage O, Whitus C, Carter A, Voy C,
Johnson LA, Graf GA, Gordon SM. Enhancement of high-density lipoprotein-
associated protease inhibitor activity prevents atherosclerosis progression.
Atherosclerosis. 2024 Sep;396:118544. doi:
10.1016/j.atherosclerosis.2024.118544. Epub 2024 Jul 16. PMID: 39126769; PMCID:
PMC11404725.
36: Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek
O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang
Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog
SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E,
Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS,
Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM,
Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M,
Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger
SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM. Advancements in APOE and
dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
Alzheimers Dement. 2024 Sep;20(9):6590-6605. doi: 10.1002/alz.13877. Epub 2024
Jul 19. PMID: 39031528; PMCID: PMC11497726.
Publications 28 – 36
28: Ostrakhovitch EA, Ono K, Yamasaki TR. Metabolomics in Parkinson's Disease
and Correlation with Disease State. Metabolites. 2025 Mar 18;15(3):208. doi:
10.3390/metabo15030208. PMID: 40137172; PMCID: PMC11944848.
29: Constantino NJ, Carroll CM, Williams HC, Vekaria HJ, Yuede CM, Saito K,
Sheehan PW, Snipes JA, Raichle ME, Musiek ES, Sullivan PG, Morganti JM, Johnson
LA, Macauley SL. ATP-sensitive potassium channels alter glycolytic flux to
modulate cortical activity and sleep. Proc Natl Acad Sci U S A. 2025 Feb
25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. Epub 2025 Feb 18. PMID:
39964713; PMCID: PMC11874466.
30: Geerling E, Stone ET, Carpenter D, Dickson AM, Brien JD, Pinto AK. Metabolic
syndrome enhances SARS-CoV-2 disease severity and reduces mRNA vaccine efficacy
in a mouse model. bioRxiv [Preprint]. 2025 Jan 15:2025.01.15.633120. doi:
10.1101/2025.01.15.633120. PMID: 41030984; PMCID: PMC12478387.
31: Friday CM, Stephens IO, Smith CT, Lee S, Satish D, Devanney NA, Cohen S,
Morganti JM, Gordon SM, Johnson LA. <i>APOE4</i> alters the lipid droplet
proteome and modulates droplet dynamics. bioRxiv [Preprint]. 2024 Dec
20:2024.12.16.628710. doi: 10.1101/2024.12.16.628710. Update in: Neurobiol Dis.
2025 Aug;212:106983. doi: 10.1016/j.nbd.2025.106983. PMID: 39763832; PMCID:
PMC11702569.
32: Banadaki MD, Rummel NG, Backus S, Butterfield DA, St Clair DK, Campbell JM,
Zhong W, Mayer K, Berry SM, Chaiswing L. Extraction of redox extracellular
vesicles using exclusion-based sample preparation. Anal Bioanal Chem. 2024
Nov;416(28):6317-6331. doi: 10.1007/s00216-024-05518-z. Epub 2024 Sep 7. Erratum
in: Anal Bioanal Chem. 2024 Dec;416(29):7187-7188. doi:
10.1007/s00216-024-05568-3. PMID: 39243301; PMCID: PMC11807383.
33: Velmurugan GV, Vekaria HJ, Hartz AMS, Bauer B, Hubbard WB. Oxidative stress
alters mitochondrial homeostasis in isolated brain capillaries. Fluids Barriers
CNS. 2024 Oct 15;21(1):81. doi: 10.1186/s12987-024-00579-9. PMID: 39407313;
PMCID: PMC11476969.
34: Krizan I, Solingapuram Sai KK, Damuka N, Macauley SL, Maria Thurman B, Long
M, Kavanagh K. Exploratory Dual PET imaging of [<sup>18</sup>F]
fluorodeoxyglucose and [<sup>11</sup>C]acetoacetate in type 2 diabetic nonhuman
primates. Bioorg Med Chem Lett. 2024 Oct 1;111:129906. doi:
10.1016/j.bmcl.2024.129906. Epub 2024 Jul 25. PMID: 39059565; PMCID:
PMC11403582.
35: Mobilia M, Karakashian A, Neupane KR, Hage O, Whitus C, Carter A, Voy C,
Johnson LA, Graf GA, Gordon SM. Enhancement of high-density lipoprotein-
associated protease inhibitor activity prevents atherosclerosis progression.
Atherosclerosis. 2024 Sep;396:118544. doi:
10.1016/j.atherosclerosis.2024.118544. Epub 2024 Jul 16. PMID: 39126769; PMCID:
PMC11404725.
36: Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek
O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang
Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog
SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E,
Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS,
Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM,
Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M,
Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger
SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM. Advancements in APOE and
dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
Alzheimers Dement. 2024 Sep;20(9):6590-6605. doi: 10.1002/alz.13877. Epub 2024
Jul 19. PMID: 39031528; PMCID: PMC11497726.
Publications 37 – 45
37: Johnson LA, Macauley SL. Alzheimer's and metabolism wed with IDO1. Science.
2024 Aug 23;385(6711):826-827. doi: 10.1126/science.adr5836. Epub 2024 Aug 22.
PMID: 39172856; PMCID: PMC11661799.
38: Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL,
Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. State of the Science on
Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease. Aging
Dis. 2024 Aug 1;15(4):1688-1725. doi: 10.14336/AD.2023.0814. PMID: 37611907;
PMCID: PMC11272209.
39: Kalimon OJ, Vekaria HJ, Prajapati P, Short SL, Hubbard WB, Sullivan PG. The
Uncoupling Effect of 17β-Estradiol Underlies the Resilience of Female-Derived
Mitochondria to Damage after Experimental TBI. Life (Basel). 2024 Jul
30;14(8):961. doi: 10.3390/life14080961. PMID: 39202703; PMCID: PMC11355196.
40: Valentine Y, Nikolajczyk BS. T cells in obesity-associated inflammation: The
devil is in the details. Immunol Rev. 2024 Jul;324(1):25-41. doi:
10.1111/imr.13354. Epub 2024 May 20. PMID: 38767210; PMCID: PMC11694249.
41: Taylor CE, Mendenhall LE, Sunshine MD, Wilson JN, Calulot CM, Sun RC,
Johnson LA, Alilain WJ. Sex and <i>APOE</i> genotype influence respiratory
function under hypoxic and hypoxic-hypercapnic conditions. J Neurophysiol. 2024
Jul 1;132(1):23-33. doi: 10.1152/jn.00255.2023. Epub 2024 May 15. PMID:
38748407; PMCID: PMC11918448.
42: Kalantar GH, Saraswat S, SantaCruz-Calvo S, Gholamrezaeinejad F, Javidan A,
Agrawal M, Liu R, Kern PA, Zhang XD, Nikolajczyk BS. Fasting and Glucose
Metabolism Differentially Impact Peripheral Inflammation in Human Type 2
Diabetes. Nutrients. 2024 May 7;16(10):1404. doi: 10.3390/nu16101404. PMID:
38794641; PMCID: PMC11124302.
43: Hubbard WB, Velmurugan GV, Sullivan PG. The role of mitochondrial uncoupling
in the regulation of mitostasis after traumatic brain injury. Neurochem Int.
2024 Mar;174:105680. doi: 10.1016/j.neuint.2024.105680. Epub 2024 Feb 3. PMID:
38311216; PMCID: PMC10922998.
44: Constantino NJ, Carroll CM, Williams HC, Yuede CM, Sheehan PW, Andy Snipes
J, Musiek ES, Johnson LA, Macauley SL. Kir6.2-K <sub>ATP</sub> channels alter
glycolytic flux to modulate cortical activity, arousal, and sleep-wake
homeostasis. bioRxiv [Preprint]. 2024 Feb 28:2024.02.23.581817. doi:
10.1101/2024.02.23.581817. Update in: Proc Natl Acad Sci U S A. 2025 Feb
25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. PMID: 38464274; PMCID:
PMC10925108.
45: Kilgore MO, Hubbard WB. Effects of Low-Level Blast on Neurovascular Health
and Cerebral Blood Flow: Current Findings and Future Opportunities in
Neuroimaging. Int J Mol Sci. 2024 Jan 4;25(1):642. doi: 10.3390/ijms25010642.
PMID: 38203813; PMCID: PMC10779081.
Publications 37 – 45
37: Johnson LA, Macauley SL. Alzheimer's and metabolism wed with IDO1. Science.
2024 Aug 23;385(6711):826-827. doi: 10.1126/science.adr5836. Epub 2024 Aug 22.
PMID: 39172856; PMCID: PMC11661799.
38: Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL,
Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. State of the Science on
Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease. Aging
Dis. 2024 Aug 1;15(4):1688-1725. doi: 10.14336/AD.2023.0814. PMID: 37611907;
PMCID: PMC11272209.
39: Kalimon OJ, Vekaria HJ, Prajapati P, Short SL, Hubbard WB, Sullivan PG. The
Uncoupling Effect of 17β-Estradiol Underlies the Resilience of Female-Derived
Mitochondria to Damage after Experimental TBI. Life (Basel). 2024 Jul
30;14(8):961. doi: 10.3390/life14080961. PMID: 39202703; PMCID: PMC11355196.
40: Valentine Y, Nikolajczyk BS. T cells in obesity-associated inflammation: The
devil is in the details. Immunol Rev. 2024 Jul;324(1):25-41. doi:
10.1111/imr.13354. Epub 2024 May 20. PMID: 38767210; PMCID: PMC11694249.
41: Taylor CE, Mendenhall LE, Sunshine MD, Wilson JN, Calulot CM, Sun RC,
Johnson LA, Alilain WJ. Sex and <i>APOE</i> genotype influence respiratory
function under hypoxic and hypoxic-hypercapnic conditions. J Neurophysiol. 2024
Jul 1;132(1):23-33. doi: 10.1152/jn.00255.2023. Epub 2024 May 15. PMID:
38748407; PMCID: PMC11918448.
42: Kalantar GH, Saraswat S, SantaCruz-Calvo S, Gholamrezaeinejad F, Javidan A,
Agrawal M, Liu R, Kern PA, Zhang XD, Nikolajczyk BS. Fasting and Glucose
Metabolism Differentially Impact Peripheral Inflammation in Human Type 2
Diabetes. Nutrients. 2024 May 7;16(10):1404. doi: 10.3390/nu16101404. PMID:
38794641; PMCID: PMC11124302.
43: Hubbard WB, Velmurugan GV, Sullivan PG. The role of mitochondrial uncoupling
in the regulation of mitostasis after traumatic brain injury. Neurochem Int.
2024 Mar;174:105680. doi: 10.1016/j.neuint.2024.105680. Epub 2024 Feb 3. PMID:
38311216; PMCID: PMC10922998.
44: Constantino NJ, Carroll CM, Williams HC, Yuede CM, Sheehan PW, Andy Snipes
J, Musiek ES, Johnson LA, Macauley SL. Kir6.2-K <sub>ATP</sub> channels alter
glycolytic flux to modulate cortical activity, arousal, and sleep-wake
homeostasis. bioRxiv [Preprint]. 2024 Feb 28:2024.02.23.581817. doi:
10.1101/2024.02.23.581817. Update in: Proc Natl Acad Sci U S A. 2025 Feb
25;122(8):e2416578122. doi: 10.1073/pnas.2416578122. PMID: 38464274; PMCID:
PMC10925108.
45: Kilgore MO, Hubbard WB. Effects of Low-Level Blast on Neurovascular Health
and Cerebral Blood Flow: Current Findings and Future Opportunities in
Neuroimaging. Int J Mol Sci. 2024 Jan 4;25(1):642. doi: 10.3390/ijms25010642.
PMID: 38203813; PMCID: PMC10779081.
Publications 46 – 52
46: Sims SL, Frazier HN, Case SL, Lin RL, Trosper JN, Vekaria HJ, Sullivan PG,
Thibault O. Variable bioenergetic sensitivity of neurons and astrocytes to
insulin and extracellular glucose. NPJ Metab Health Dis. 2024;2(1):33. doi:
10.1038/s44324-024-00037-y. Epub 2024 Nov 8. PMID: 39524535; PMCID: PMC11549053.
47: Burke BI, Goh J, Albathi FA, Valentino TR, Nolt GL, Joshi JK, Dungan CM,
Johnson LA, Wen Y, Ismaeel A, McCarthy JJ. ApoE isoform does not influence
skeletal muscle regeneration in adult mice. Front Physiol. 2023 Nov
22;14:1302695. doi: 10.3389/fphys.2023.1302695. PMID: 38074327; PMCID:
PMC10702509.
48: Hubbard WB, Vekaria HJ, Velmurugan GV, Kalimon OJ, Prajapati P, Brown E,
Geisler JG, Sullivan PG. Mitochondrial Dysfunction After Repeated Mild Blast
Traumatic Brain Injury Is Attenuated by a Mild Mitochondrial Uncoupling Prodrug.
J Neurotrauma. 2023 Nov;40(21-22):2396-2409. doi: 10.1089/neu.2023.0102. Epub
2023 Aug 25. PMID: 37476976; PMCID: PMC10653072.
49: Ren Y, Wang X, Zhang S, Hu H, Quicksall Z, Lee S, Morganti JM, Johnson LA,
Asmann YW, Zhao N. Deconvolution reveals cell-type-specific transcriptomic
changes in the aging mouse brain. Sci Rep. 2023 Oct 6;13(1):16855. doi:
10.1038/s41598-023-44183-7. PMID: 37803069; PMCID: PMC10558435.
50: Ruggiero AD, Vemuri R, Blawas M, Long M, DeStephanis D, Williams AG, Chen H,
Justice JN, Macauley SL, Day SM, Kavanagh K. Long-term dasatinib plus quercetin
effects on aging outcomes and inflammation in nonhuman primates: implications
for senolytic clinical trial design. Geroscience. 2023 Oct;45(5):2785-2803. doi:
10.1007/s11357-023-00830-5. Epub 2023 Jun 1. PMID: 37261678; PMCID: PMC10643765.
51: Kalimon OJ, Vekaria HJ, Velmurugan GV, Hubbard WB, Sullivan PG.
Characterizing Sex Differences in Mitochondrial Dysfunction After Severe
Traumatic Brain Injury in Mice. Neurotrauma Rep. 2023 Sep 25;4(1):627-642. doi:
10.1089/neur.2023.0046. PMID: 37752924; PMCID: PMC10518693.
52: Ahmed AJ, Gallegos ZA, Dinar MAM, Sullivan PG, DeRouchey JE, Patel SP,
Rabchevsky AG, Dziubla TD. Physicochemical Characterization of Hyaluronic Acid-
Methylcellulose Semi-Gels for Mitochondria Transplantation. J Biomed Mater Res B
Appl Biomater. 2025 Feb;113(2):e35537. doi: 10.1002/jbm.b.35537. PMID: 39907118.
Publications 46 – 52
46: Sims SL, Frazier HN, Case SL, Lin RL, Trosper JN, Vekaria HJ, Sullivan PG,
Thibault O. Variable bioenergetic sensitivity of neurons and astrocytes to
insulin and extracellular glucose. NPJ Metab Health Dis. 2024;2(1):33. doi:
10.1038/s44324-024-00037-y. Epub 2024 Nov 8. PMID: 39524535; PMCID: PMC11549053.
47: Burke BI, Goh J, Albathi FA, Valentino TR, Nolt GL, Joshi JK, Dungan CM,
Johnson LA, Wen Y, Ismaeel A, McCarthy JJ. ApoE isoform does not influence
skeletal muscle regeneration in adult mice. Front Physiol. 2023 Nov
22;14:1302695. doi: 10.3389/fphys.2023.1302695. PMID: 38074327; PMCID:
PMC10702509.
48: Hubbard WB, Vekaria HJ, Velmurugan GV, Kalimon OJ, Prajapati P, Brown E,
Geisler JG, Sullivan PG. Mitochondrial Dysfunction After Repeated Mild Blast
Traumatic Brain Injury Is Attenuated by a Mild Mitochondrial Uncoupling Prodrug.
J Neurotrauma. 2023 Nov;40(21-22):2396-2409. doi: 10.1089/neu.2023.0102. Epub
2023 Aug 25. PMID: 37476976; PMCID: PMC10653072.
49: Ren Y, Wang X, Zhang S, Hu H, Quicksall Z, Lee S, Morganti JM, Johnson LA,
Asmann YW, Zhao N. Deconvolution reveals cell-type-specific transcriptomic
changes in the aging mouse brain. Sci Rep. 2023 Oct 6;13(1):16855. doi:
10.1038/s41598-023-44183-7. PMID: 37803069; PMCID: PMC10558435.
50: Ruggiero AD, Vemuri R, Blawas M, Long M, DeStephanis D, Williams AG, Chen H,
Justice JN, Macauley SL, Day SM, Kavanagh K. Long-term dasatinib plus quercetin
effects on aging outcomes and inflammation in nonhuman primates: implications
for senolytic clinical trial design. Geroscience. 2023 Oct;45(5):2785-2803. doi:
10.1007/s11357-023-00830-5. Epub 2023 Jun 1. PMID: 37261678; PMCID: PMC10643765.
51: Kalimon OJ, Vekaria HJ, Velmurugan GV, Hubbard WB, Sullivan PG.
Characterizing Sex Differences in Mitochondrial Dysfunction After Severe
Traumatic Brain Injury in Mice. Neurotrauma Rep. 2023 Sep 25;4(1):627-642. doi:
10.1089/neur.2023.0046. PMID: 37752924; PMCID: PMC10518693.
52: Ahmed AJ, Gallegos ZA, Dinar MAM, Sullivan PG, DeRouchey JE, Patel SP,
Rabchevsky AG, Dziubla TD. Physicochemical Characterization of Hyaluronic Acid-
Methylcellulose Semi-Gels for Mitochondria Transplantation. J Biomed Mater Res B
Appl Biomater. 2025 Feb;113(2):e35537. doi: 10.1002/jbm.b.35537. PMID: 39907118.