Funding
Summary of Extramural Funding for Center Faculty
Grants include at least one Center faculty as PD, PI, or co-I.
| PD/PI (Center co-I) | Grant / Title | Period | Total Award ($M) |
|---|---|---|---|
| T. W-M. Fan (Higashi, Moseley, Nantz) | 1R01ES022191-01 - Integrated Chemoselective and Informatic Platform for Large-Scale Metabolomics | 10/01/12 - 06/30/17 | 2.24 |
| A.N. Lane (Fan, Yan, Higashi, Moseley) | 1P01CA163223-01A1 - Systems Biochemistry in Lung Cancer: Toward a Mechanistic Understanding of NSCLC | 03/01/13 - 02/28/18 | 7.13 |
| H.N.B.Moseley | NSF 1252893 - CAREER:Developing Biochemoinformatics Tools for Large Scale Metabolomics Applications | 07/01/13 - 06/30/18 | 1.1 |
| R.M. Higashi (Fan, Lane, Moseley) | 1U24DK097215-01A1 - Resource Center for Stable Isotope-Resolved Metabolomics | 09/11/2013 - 08/31/2018 | 8.7 |
| T. W-M. Fan (Higashi, Moseley) | BCAL Ltd. Blood Exosomes in Breast Cancer (contract) | 1/14-6/17 | 0.63 |
| T. W-M. Fan, A.N. Lane | NCI Targetted Opportunity Collaborative Agreement | 9/1/14-8/31/17 | 1.25 |
| R.M. Higashi (Fan, Lane, Moseley) | U24 Administrative supplement-Ring Trial | 9/1/14-3/1/15 | 0.038 |
| J. Albrecht (Fan, Lane, Higashi) | NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation (subcontract) | 5/1/14-4/30/16 | 0.17 |
| T. W-M. Fan (S. Arnold, J. Martin, A. Lane) | KLCRP Biomarker Discovery by Interrogating Lung Cancer Lipid Metabolome | 7/15-6/17 | 0.15 |
| K. Ghoshal (T. Fan) | NIH R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice (subcontract) | 2/15-1/18 | 0.054 |
| T. W-M Fan, T. Izumi, X. Shi | 1R21 ES025669-01 Mitochondrial Metabolic Reprogramming and DNA Damage in Arsenic Carcinogenesis | 6/15-5/18 | 0.413 |
| D. St. Clair (PD), T. Fan, MPI | 2T32ES007266-26A1 Training Grant in Molecular Mechanisms of Toxicity | 7/16-6/21 | |
| C. Wang (PD), H. Moseley (MPI) | R21 CA205778 Statistical Detection and Biochemical Classification of Cancer Driver Mutation Patterns in Biological Networks | 08/01/16-07/31/18 | 0.564 |
| S. Biswal (T. Fan subcontract) | 1R01CA206155-01 Crosstalk of LKB1 and KEAP1 mutations in driving growth of lung adenocarcinoma | 4/15/16-3/31/17 | 0.05 |
| A.N. Lane (PD), T. Fan, S. Arnold | Administrative supplement to 1P01CA163223-01A1 - | 1/1/16-12/31/16 | 0.072 |
| C. Wang, R. Flight, H. Moseley | NCI R03CA211835 -01, Differential Abundance Methods for Large Heterogeneous-Featured Metabolomics Datasets | 9/14/16-8/31/17 | 0.145 |
| D. St. Clair (A. Lane, R. Higashi Metabolism Core Directors) | NIGMS P20GM121327, University of Kentucky Center for Cancer and Metabolism, Metabolism Core | 3/31/17-2/28/22 | 1.02 |
| J. Liu (PD) and R. Higashi (MPI) | 1 R03 CA222449-01, Algorithms for Accurate and Scalable Identification of Isotopologues from Mass Spectrometry Data | 2018-2019 | 0.15 |
| T. W-M. Fan (PI) & .M. Higashi (co-I) | 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure: subcontract | 2017-2021 | |
| E. Repasky (A.N. Lane & T. W-M. Fan subcontract) | R01 CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors: subcontract from RPMI/ E. Repasky | 2018-2023 | 0.45 |
| D. St. Clair (T. Fan, H. Moseley, co-Is) | 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD | 12/18/17-11/30/22 | |
| T. Barrett, UKy (A. Lane co-I) | 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease | 9/1/18-20 | |
| R. Wang (T.. Fan, A. Lane subcontract) | 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers | 09/17/2018 – 06/30/2023 | |
| 24.62 Total |
Center Supported
Summary of known extramural funding that is supported by the Center.
| PD/PI | Grant / Title | Period | Total Award ($M) |
|---|---|---|---|
| X. Fu (U. Louisville) | NSF CBET-1159829 - A Chemoselective Microreactor Device for Trace Carbonyl VOC Analysis | 08/15/12 - 07/31/15 | 0.3 |
| J. Albrecht (U. Minnesota) | NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation | 5/1/14-4/30/16 | 1.5 |
| T. Gao (U. Kentucky) | NCI 2R01 CA133429-08 : The Role of PHLPP in Colon Cancer | 11/14-10/19 | 1.68 |
| K. Ghoshal (Ohio State U.) | NIDDK R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice | 2/15-1/20 | 1.5 |
| S.R. Allie (U. Alabama) | NIH F32 Establishment and metabolic control of influenza-specific lung resident memory B cells | 6/15-6/18 | 0.165 |
| F. Onono (U. Kentucky) | NCI K01CA197073 -01 "Intestinal phosphatidylcholine exposure and breast cancer risk" | 7/1/15-6/30/20 | 0.702 |
| P.P. Scaglioni (UT S. Western) | CPRIT: Mutant KRAS reprograms lipid homeostasis in lung cancer establishing treatment opportunities | 2015-2017 | |
| B.M. Evers (U. Kentucky) | NIDDK 5R01 DK048498-21: "Mechanistic Impact of P13K /mTOR Signaling on Intestinal Homeostasis" | 7/15-6/20 | 1.82 |
| P. Hosein, R.M. Higashi (U. Kentucky) | CCSG A pilot neoadjuvant study in patients with resectable pancreatic ductal adenocarcinoma as a platform for in-vivo testing of novel therapies | 1/1/16-12/31/17 | 0.05 |
| V. Ragnekar & B.M. Evers (U. Kentucky) | NIH T32 Training Grant | 5/1/16- | |
| M. Chen (U. Kentucky) | KLCRP | 2016-2018 | 0.15 |
| E. Hahn (U. Kentucky) | KLCRP " Radon and Tobacco Smoke Exposure Biomarkers of Lung Cancer Risk " | 2016-2018 | 0.15 |
| V. Boussiotis (BIDMC) | NCI Effects of PGE2 on reconstitution of hematopoiesis and immunity in UCBT (supplement to parent grant: R01CA183605 -01) | 2016-2017 | |
| D. St. Clair, UKY (Lane, Fan, Higashi co-Is) | NIGMS P20GM121327 "University of Kentucky Center for Cancer and Metabolism" | 3/2017-3/2022 | 11.12 |
| Q. Wei, UKY (A. Lane Co-I) | KLCRP "Sulfiredoxin-mediated Metabolic Alterations in non small cell lung cancer " | 1/2018-12/2019 | 0.15 |
| R. Xu, UKY (A. Lane co-I) | NCI 1R01CA215095-01 "Roles of RORalpha in Breast Cancer Development and Progression" | 7/17-6/22 | 1.72 |
| X. Shi, UKY (T. Fan, R. Higashi co-Is) | NIEHS 1P30ES026529-01A1 Center for Appalachian Research in Environmental Sciences | 2017-2022 | 1.496 (annual) |
| B. M. Evers, UKY | NIDDK R01 DK103913 Neurotensin regulation, secretion and function in health and disease | 2017-2022 | |
| B. M. Evers & T. Gao, UKY (R Higashi co-I) | NCI R01 Altered Lipid Metabolism as a Novel Target for Colon Cancer Treatment | 2017-2022 | |
| S. Rajagopalan (Case Western) | 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure | 9/30/2017-7/31/2021 | 1.324 total |
| E. Repasky (Roswell Park MI) | NCI R01CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors | 2018-2023 | |
| D. St. Clair (UKY) | 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD | 12/18/17-11/30/22 | 0.424 total annual |
| M. Gentry/ R. Sun, UKy (A Lane co-I) | KLCRP Contribution of EPM2A and glycogen in NCSLC metabolism and tumorigenesis | 11/17-11/19 | 0.13 total |
| T. Barrett, UKy | 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease | 9/1/18-20 | 0.425 total |
| R. Wang (Nationwide Children's, Columbus) | 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers | 09/17/2018 – 06/30/2023 | |
| B.M. Evers & N. Vanderford, UKy (T. Fan, A.Lane mentors) | R25 Appalachian Career Training in Oncology (ACTION) Program | 10/18-9/ | |
| Total = 24.806 |