Center for Environmental and Systems Biochemistry Research Funding Funding Summary of Extramural Funding for Center Faculty Grants include at least one Center faculty as PD, PI, or co-I. PD/PI (Center co-I) Grant / Title Period Total Award ($M) T. W-M. Fan (Higashi, Moseley, Nantz) 1R01ES022191-01 - Integrated Chemoselective and Informatic Platform for Large-Scale Metabolomics 10/01/12 - 06/30/17 2.24 A.N. Lane (Fan, Yan, Higashi, Moseley) 1P01CA163223-01A1 - Systems Biochemistry in Lung Cancer: Toward a Mechanistic Understanding of NSCLC 03/01/13 - 02/28/18 7.13 H.N.B.Moseley NSF 1252893 - CAREER:Developing Biochemoinformatics Tools for Large Scale Metabolomics Applications 07/01/13 - 06/30/18 1.1 R.M. Higashi (Fan, Lane, Moseley) 1U24DK097215-01A1 - Resource Center for Stable Isotope-Resolved Metabolomics 09/11/2013 - 08/31/2018 8.7 T. W-M. Fan (Higashi, Moseley) BCAL Ltd. Blood Exosomes in Breast Cancer (contract) 1/14-6/17 0.63 T. W-M. Fan, A.N. Lane NCI Targetted Opportunity Collaborative Agreement 9/1/14-8/31/17 1.25 R.M. Higashi (Fan, Lane, Moseley) U24 Administrative supplement-Ring Trial 9/1/14-3/1/15 0.038 J. Albrecht (Fan, Lane, Higashi) NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation (subcontract) 5/1/14-4/30/16 0.17 T. W-M. Fan (S. Arnold, J. Martin, A. Lane) KLCRP Biomarker Discovery by Interrogating Lung Cancer Lipid Metabolome 7/15-6/17 0.15 K. Ghoshal (T. Fan) NIH R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice (subcontract) 2/15-1/18 0.054 T. W-M Fan, T. Izumi, X. Shi 1R21 ES025669-01 Mitochondrial Metabolic Reprogramming and DNA Damage in Arsenic Carcinogenesis 6/15-5/18 0.413 D. St. Clair (PD), T. Fan, MPI 2T32ES007266-26A1 Training Grant in Molecular Mechanisms of Toxicity 7/16-6/21 C. Wang (PD), H. Moseley (MPI) R21 CA205778 Statistical Detection and Biochemical Classification of Cancer Driver Mutation Patterns in Biological Networks 08/01/16-07/31/18 0.564 S. Biswal (T. Fan subcontract) 1R01CA206155-01 Crosstalk of LKB1 and KEAP1 mutations in driving growth of lung adenocarcinoma 4/15/16-3/31/17 0.05 A.N. Lane (PD), T. Fan, S. Arnold Administrative supplement to 1P01CA163223-01A1 - 1/1/16-12/31/16 0.072 C. Wang, R. Flight, H. Moseley NCI R03CA211835 -01, Differential Abundance Methods for Large Heterogeneous-Featured Metabolomics Datasets 9/14/16-8/31/17 0.145 D. St. Clair (A. Lane, R. Higashi Metabolism Core Directors) NIGMS P20GM121327, University of Kentucky Center for Cancer and Metabolism, Metabolism Core 3/31/17-2/28/22 1.02 J. Liu (PD) and R. Higashi (MPI) 1 R03 CA222449-01, Algorithms for Accurate and Scalable Identification of Isotopologues from Mass Spectrometry Data 2018-2019 0.15 T. W-M. Fan (PI) & .M. Higashi (co-I) 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure: subcontract 2017-2021 E. Repasky (A.N. Lane & T. W-M. Fan subcontract) R01 CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors: subcontract from RPMI/ E. Repasky 2018-2023 0.45 D. St. Clair (T. Fan, H. Moseley, co-Is) 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD 12/18/17-11/30/22 T. Barrett, UKy (A. Lane co-I) 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease 9/1/18-20 R. Wang (T.. Fan, A. Lane subcontract) 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers 09/17/2018 – 06/30/2023 24.62 Total Center Supported Summary of known extramural funding that is supported by the Center. PD/PI Grant / Title Period Total Award ($M) X. Fu (U. Louisville) NSF CBET-1159829 - A Chemoselective Microreactor Device for Trace Carbonyl VOC Analysis 08/15/12 - 07/31/15 0.3 J. Albrecht (U. Minnesota) NIDDK R01 DK054921-15 Cyclin D1/CDK4 Complex in Hepatocyte Proliferation 5/1/14-4/30/16 1.5 T. Gao (U. Kentucky) NCI 2R01 CA133429-08 : The Role of PHLPP in Colon Cancer 11/14-10/19 1.68 K. Ghoshal (Ohio State U.) NIDDK R01 Role of miRNA-122 in hepatocarcinogenesis using conditional knock out mice 2/15-1/20 1.5 S.R. Allie (U. Alabama) NIH F32 Establishment and metabolic control of influenza-specific lung resident memory B cells 6/15-6/18 0.165 F. Onono (U. Kentucky) NCI K01CA197073 -01 "Intestinal phosphatidylcholine exposure and breast cancer risk" 7/1/15-6/30/20 0.702 P.P. Scaglioni (UT S. Western) CPRIT: Mutant KRAS reprograms lipid homeostasis in lung cancer establishing treatment opportunities 2015-2017 B.M. Evers (U. Kentucky) NIDDK 5R01 DK048498-21: "Mechanistic Impact of P13K /mTOR Signaling on Intestinal Homeostasis" 7/15-6/20 1.82 P. Hosein, R.M. Higashi (U. Kentucky) CCSG A pilot neoadjuvant study in patients with resectable pancreatic ductal adenocarcinoma as a platform for in-vivo testing of novel therapies 1/1/16-12/31/17 0.05 V. Ragnekar & B.M. Evers (U. Kentucky) NIH T32 Training Grant 5/1/16- M. Chen (U. Kentucky) KLCRP 2016-2018 0.15 E. Hahn (U. Kentucky) KLCRP " Radon and Tobacco Smoke Exposure Biomarkers of Lung Cancer Risk " 2016-2018 0.15 V. Boussiotis (BIDMC) NCI Effects of PGE2 on reconstitution of hematopoiesis and immunity in UCBT (supplement to parent grant: R01CA183605 -01) 2016-2017 D. St. Clair, UKY (Lane, Fan, Higashi co-Is) NIGMS P20GM121327 "University of Kentucky Center for Cancer and Metabolism" 3/2017-3/2022 11.12 Q. Wei, UKY (A. Lane Co-I) KLCRP "Sulfiredoxin-mediated Metabolic Alterations in non small cell lung cancer " 1/2018-12/2019 0.15 R. Xu, UKY (A. Lane co-I) NCI 1R01CA215095-01 "Roles of RORalpha in Breast Cancer Development and Progression" 7/17-6/22 1.72 X. Shi, UKY (T. Fan, R. Higashi co-Is) NIEHS 1P30ES026529-01A1 Center for Appalachian Research in Environmental Sciences 2017-2022 1.496 (annual) B. M. Evers, UKY NIDDK R01 DK103913 Neurotensin regulation, secretion and function in health and disease 2017-2022 B. M. Evers & T. Gao, UKY (R Higashi co-I) NCI R01 Altered Lipid Metabolism as a Novel Target for Colon Cancer Treatment 2017-2022 S. Rajagopalan (Case Western) 2R01ES019616-06 ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure 9/30/2017-7/31/2021 1.324 total E. Repasky (Roswell Park MI) NCI R01CA205246 Understanding how adrenergic signaling influences immune contexture of tumors and the efficacy of checkpoint inhibitors 2018-2023 D. St. Clair (UKY) 5R01 CA73599 Redox Regulation of Tumor Suppression by MnSOD 12/18/17-11/30/22 0.424 total annual M. Gentry/ R. Sun, UKy (A Lane co-I) KLCRP Contribution of EPM2A and glycogen in NCSLC metabolism and tumorigenesis 11/17-11/19 0.13 total T. Barrett, UKy 1 R21 DK118954-01 Peripheral Blood Exosome Lipids as Biomarkers of Disease Activity in Crohn’s Disease 9/1/18-20 0.425 total R. Wang (Nationwide Children's, Columbus) 1U01CA232488-01 Metabolic reprogramming of tumor microenvironment to maximize immunotherapy for pediatric cancers 09/17/2018 – 06/30/2023 B.M. Evers & N. Vanderford, UKy (T. Fan, A.Lane mentors) R25 Appalachian Career Training in Oncology (ACTION) Program 10/18-9/ Total = 24.806
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